An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins

Nature Chemical Biology

Volumn 11, Issue 4, 2015, Pages 259-265

  Tian, Zhenhua ^a   Sun, Peng ^a,b   Yan, Yan ^a   Wu, Zhuhua ^a   Zheng, Qingfei ^a   Zhou, Shuaixiang ^a   Zhang, Hua ^a   Yu, Futao ^a   Jia, Xinying ^a   Chen, Dandan ^c   Mándi, Attila ^d   Kurtán, Tibor ^d   Liu, Wen ^a,c  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Huzhou Center of Bio Synthetic Innovation   (China)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRROLIDONE DERIVATIVE; ALKENE; BACTERIAL DNA; BIOLOGICAL PRODUCT; CYCLOHEXENE DERIVATIVE; ISOMERASE; MACROLIDE; RECOMBINANT PROTEIN;

CATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; METABOLISM; MUTATION; PLASMID; PROCEDURES; STEREOISOMERISM; STREPTOMYCES; SYNTHESIS;

ALKENES; BIOLOGICAL PRODUCTS; CATALYSIS; CHEMISTRY; CYCLIZATION; CYCLOHEXENES; DNA, BACTERIAL; INTRAMOLECULAR LYASES; MACROLIDES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MUTATION; PLASMIDS; PYRROLIDINONES; RECOMBINANT PROTEINS; STEREOISOMERISM; STREPTOMYCES;

EID: 84926453060     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1769     Document Type: Article

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