Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

Nature

Volumn 473, Issue 7345, 2011, Pages 109-112

  Kim, Hak Joong ^a   Ruszczycky, Mark W ^a   Choi, Sei Hyun ^a   Liu, Yung Nan ^a   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; CYCLOHEXENE DERIVATIVE; HYDROLYASE; MACROPHOMATE SYNTHASE; POLYKETIDE SYNTHASE; PROTEIN SPNF; PROTEIN SPNL; PROTEIN SPNM; RIBOFLAVIN SYNTHASE; SOLANAPYRONE SYNTHASE; SPINOSYN A; SYNTHETASE; UNCLASSIFIED DRUG;

CATALYSIS; CATALYST; ENZYME ACTIVITY; TRANSFORMATION;

ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CATALYSIS; COMPLEX FORMATION; CYCLIZATION; CYCLOADDITION; DIELS ALDER REACTION; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; PRIORITY JOURNAL; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA SPINOSA; STEREOCHEMISTRY;

BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; KINETICS; MACROLIDES; SACCHAROPOLYSPORA;

ALNUS; SACCHAROPOLYSPORA SPINOSA;

EID: 79955642774     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09981     Document Type: Article

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