Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products

Nature

Volumn 568, Issue 7750, 2019, Pages 122-126

  Zhang, Bo ^a   Wang, Kai Biao ^a   Wang, Wen ^a   Wang, Xin ^b   Liu, Fang ^b   Zhu, Jiapeng ^c   Shi, Jing ^a   Li, Ling Yu ^a   Han, Hao ^a   Xu, Kuang ^a   Qiao, Hong Yun ^a   Zhang, Xiao ^b   Jiao, Rui Hua ^a   Houk, Kendall N ^d   Liang, Yong ^b   Tan, Ren Xiang ^a,c   Ge, Hui Ming ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; NATURAL PRODUCT; NGND PROTEIN; PERICYCLASE; POLYKETIDE; POLYKETIDE SYNTHASE; STREPTOSEOMYCIN; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; ENZYME;

BIOSYNTHESIS; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; COPE REARRANGEMENT; CRYSTAL STRUCTURE; CYCLOADDITION; ENZYME ACTIVITY; LETTER; MOLECULAR DYNAMICS; NOCARDIA; NOCARDIA ARGENTINENSIS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STREPTOMYCES; BIOCATALYSIS; CHEMISTRY; DENSITY FUNCTIONAL THEORY; GENETICS; METABOLISM; PROTEIN CONFORMATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALNUS;

BIOCATALYSIS; BIOLOGICAL PRODUCTS; CRYSTALLOGRAPHY, X-RAY; CYCLOADDITION REACTION; DENSITY FUNCTIONAL THEORY; ENZYMES; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 85063933632     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-019-1021-x     Document Type: Article

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