메뉴 건너뛰기




Volumn 2, Issue 1, 2016, Pages

Class I HDAC inhibitor mocetinostat induces apoptosis by activation of miR-31 expression and suppression of E2F6

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85071831761     PISSN: None     EISSN: 20587716     Source Type: Journal    
DOI: 10.1038/cddiscovery.2016.36     Document Type: Article
Times cited : (38)

References (38)
  • 1
    • 0035862199 scopus 로고    scopus 로고
    • The human histone deacetylase family
    • COI: 1:CAS:528:DC%2BD3MXnsVWi
    • Gray SG, Ekstrom TJ. The human histone deacetylase family. Exp Cell Res 2001; 262: 75–83.
    • (2001) Exp Cell Res , vol.262 , pp. 75-83
    • Gray, S.G.1    Ekstrom, T.J.2
  • 2
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • COI: 1:STN:280:DC%2BD3c7gt1arsQ%3D%3D
    • Strahl BD, Allis CD. The language of covalent histone modifications. Nature 2000; 403: 41–45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 3
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • COI: 1:CAS:528:DC%2BD28Xht1GgsA%3D%3D
    • Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006; 6: 38–51.
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 4
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • COI: 1:CAS:528:DC%2BD1MXps1Ogt70%3D
    • Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009; 325: 834–840.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3    Nielsen, M.L.4    Rehman, M.5    Walther, T.C.6
  • 5
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: implications for disease and therapy
    • COI: 1:CAS:528:DC%2BD1cXhsFWis7bI
    • Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10: 32–42.
    • (2009) Nat Rev Genet , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 6
    • 38549157208 scopus 로고    scopus 로고
    • Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis
    • COI: 1:CAS:528:DC%2BD1cXhsVOnu7c%3D
    • Weichert W, Roske A, Gekeler V, Beckers T, Ebert MP, Pross M et al. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol 2008; 9: 139–148.
    • (2008) Lancet Oncol , vol.9 , pp. 139-148
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Ebert, M.P.5    Pross, M.6
  • 7
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • COI: 1:CAS:528:DC%2BD1cXhs1Krsbo%3D
    • Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 2008; 98: 604–610.
    • (2008) Br J Cancer , vol.98 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6
  • 8
    • 41549159879 scopus 로고    scopus 로고
    • Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD1cXjtlejt7o%3D
    • Weichert W, Roske A, Niesporek S, Noske A, Buckendahl AC, Dietel M et al. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res 2008; 14: 1669–1677.
    • (2008) Clin Cancer Res , vol.14 , pp. 1669-1677
    • Weichert, W.1    Roske, A.2    Niesporek, S.3    Noske, A.4    Buckendahl, A.C.5    Dietel, M.6
  • 9
    • 84891837817 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors
    • COI: 1:CAS:528:DC%2BC3sXhvFOms7vJ
    • Slingerland M, Guchelaar HJ, Gelderblom H. Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors. Anti-cancer Drugs 2014; 25: 140–149.
    • (2014) Anti-cancer Drugs , vol.25 , pp. 140-149
    • Slingerland, M.1    Guchelaar, H.J.2    Gelderblom, H.3
  • 10
    • 42249084230 scopus 로고    scopus 로고
    • MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD1cXks1Gms70%3D
    • Fournel M, Bonfils C, Hou Y, Yan PT, Trachy-Bourget MC, Kalita A et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther 2008; 7: 759–768.
    • (2008) Mol Cancer Ther , vol.7 , pp. 759-768
    • Fournel, M.1    Bonfils, C.2    Hou, Y.3    Yan, P.T.4    Trachy-Bourget, M.C.5    Kalita, A.6
  • 11
    • 50349087906 scopus 로고    scopus 로고
    • Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay
    • COI: 1:CAS:528:DC%2BD1cXmslygsbk%3D
    • Bonfils C, Kalita A, Dubay M, Siu LL, Carducci MA, Reid G et al. Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay. Clin Cancer Res 2008; 14: 3441–3449.
    • (2008) Clin Cancer Res , vol.14 , pp. 3441-3449
    • Bonfils, C.1    Kalita, A.2    Dubay, M.3    Siu, L.L.4    Carducci, M.A.5    Reid, G.6
  • 12
    • 79957993618 scopus 로고    scopus 로고
    • The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling
    • PID: 21317455
    • Sikandar S, Dizon D, Shen X, Li Z, Besterman J, Lipkin SM. The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling. Oncotarget 2010; 1: 596–605.
    • (2010) Oncotarget , vol.1 , pp. 596-605
    • Sikandar, S.1    Dizon, D.2    Shen, X.3    Li, Z.4    Besterman, J.5    Lipkin, S.M.6
  • 13
    • 77952168284 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade
    • COI: 1:CAS:528:DC%2BC3cXlslekt7Y%3D
    • El-Khoury V, Moussay E, Janji B, Palissot V, Aouali N, Brons NH et al. The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade. Mol Cancer Ther 2010; 9: 1349–1360.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1349-1360
    • El-Khoury, V.1    Moussay, E.2    Janji, B.3    Palissot, V.4    Aouali, N.5    Brons, N.H.6
  • 14
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • COI: 1:CAS:528:DC%2BD1MXhs1Kiuro%3D
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215–233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 15
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • COI: 1:CAS:528:DC%2BD2cXhtVals7o%3D
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281–297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 16
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • COI: 1:CAS:528:DC%2BD1MXps1eiurg%3D
    • Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137: 1005–1017.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O'Donnell, K.A.3    Wentzel, E.A.4    Montgomery, C.L.5    Hwang, H.W.6
  • 17
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • COI: 1:CAS:528:DC%2BD3sXhtVWhs7zE
    • Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303: 83–86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 18
    • 66549101276 scopus 로고    scopus 로고
    • Patterns of microRNA expression characterize stages of human B-cell differentiation
    • COI: 1:CAS:528:DC%2BD1MXnvVyqtbc%3D
    • Zhang J, Jima DD, Jacobs C, Fischer R, Gottwein E, Huang G et al. Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood 2009; 113: 4586–4594.
    • (2009) Blood , vol.113 , pp. 4586-4594
    • Zhang, J.1    Jima, D.D.2    Jacobs, C.3    Fischer, R.4    Gottwein, E.5    Huang, G.6
  • 19
    • 9144270691 scopus 로고    scopus 로고
    • A pancreatic islet-specific microRNA regulates insulin secretion
    • COI: 1:CAS:528:DC%2BD2cXpsF2gt78%3D
    • Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature 2004; 432: 226–230.
    • (2004) Nature , vol.432 , pp. 226-230
    • Poy, M.N.1    Eliasson, L.2    Krutzfeldt, J.3    Kuwajima, S.4    Ma, X.5    Macdonald, P.E.6
  • 20
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • COI: 1:CAS:528:DC%2BD2sXhtFChurfF
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007; 449: 682–688.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 21
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ 2009; 17: 193–199.
    • (2009) Cell Death Differ , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 22
    • 79959811503 scopus 로고    scopus 로고
    • Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells
    • COI: 1:CAS:528:DC%2BC3MXht1Kku7s%3D
    • Bhatnagar N, Li X, Padi SK, Zhang Q, Tang MS, Guo B. Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. Cell Death Dis 2010; 1: e105.
    • (2010) Cell Death Dis , vol.1
    • Bhatnagar, N.1    Li, X.2    Padi, S.K.3    Zhang, Q.4    Tang, M.S.5    Guo, B.6
  • 23
    • 84873507539 scopus 로고    scopus 로고
    • Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression
    • COI: 1:CAS:528:DC%2BC3sXhvV2ktrs%3D
    • Lin PC, Chiu YL, Banerjee S, Park K, Mosquera JM, Giannopoulou E et al. Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression. Cancer Res 2013; 73: 1232–1244.
    • (2013) Cancer Res , vol.73 , pp. 1232-1244
    • Lin, P.C.1    Chiu, Y.L.2    Banerjee, S.3    Park, K.4    Mosquera, J.M.5    Giannopoulou, E.6
  • 24
    • 67449113768 scopus 로고    scopus 로고
    • Cancer DNA methylation: molecular mechanisms and clinical implications
    • COI: 1:CAS:528:DC%2BD1MXntlOisrY%3D
    • McCabe MT, Brandes JC, Vertino PM. Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 2009; 15: 3927–3937.
    • (2009) Clin Cancer Res , vol.15 , pp. 3927-3937
    • McCabe, M.T.1    Brandes, J.C.2    Vertino, P.M.3
  • 25
    • 33847258674 scopus 로고    scopus 로고
    • Discovery and development of SAHA as an anticancer agent
    • COI: 1:CAS:528:DC%2BD2sXitVKhsL4%3D
    • Marks PA. Discovery and development of SAHA as an anticancer agent. Oncogene 2007; 26: 1351–1356.
    • (2007) Oncogene , vol.26 , pp. 1351-1356
    • Marks, P.A.1
  • 26
    • 33947359114 scopus 로고    scopus 로고
    • E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1
    • COI: 1:CAS:528:DC%2BD2sXjt1Sku7g%3D
    • Yang WW, Wang ZH, Zhu Y, Yang HT. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ 2007; 14: 807–817.
    • (2007) Cell Death Differ , vol.14 , pp. 807-817
    • Yang, W.W.1    Wang, Z.H.2    Zhu, Y.3    Yang, H.T.4
  • 27
    • 55549125229 scopus 로고    scopus 로고
    • E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1
    • COI: 1:CAS:528:DC%2BD1cXhtFKntLzM
    • Yang WW, Shu B, Zhu Y, Yang HT. E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1. Mol Biol Cell 2008; 19: 3691–3700.
    • (2008) Mol Biol Cell , vol.19 , pp. 3691-3700
    • Yang, W.W.1    Shu, B.2    Zhu, Y.3    Yang, H.T.4
  • 28
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • COI: 1:CAS:528:DC%2BD2cXhtValsrY%3D
    • Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116: 205–219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 29
    • 34247325105 scopus 로고    scopus 로고
    • p53 and Bad: remote strangers become close friends
    • COI: 1:CAS:528:DC%2BD2sXkt1Chur4%3D
    • Jiang P, Du W, Wu M. p53 and Bad: remote strangers become close friends. Cell research 2007; 17: 283–285.
    • (2007) Cell research , vol.17 , pp. 283-285
    • Jiang, P.1    Du, W.2    Wu, M.3
  • 30
    • 68149107692 scopus 로고    scopus 로고
    • BAD: undertaker by night, candyman by day
    • COI: 1:CAS:528:DC%2BD1MXpt1Whu78%3D
    • Danial NN. BAD: undertaker by night, candyman by day. Oncogene 2008; 27: S53–S70.
    • (2008) Oncogene , vol.27 , pp. S53-S70
    • Danial, N.N.1
  • 31
    • 84884816663 scopus 로고    scopus 로고
    • Searching for prostate cancer stem cells: markers and methods
    • COI: 1:CAS:528:DC%2BC3sXhsFGqu7bE
    • Sharpe B, Beresford M, Bowen R, Mitchard J, Chalmers AD. Searching for prostate cancer stem cells: markers and methods. Stem Cell Rev 2013; 9: 721–730.
    • (2013) Stem Cell Rev , vol.9 , pp. 721-730
    • Sharpe, B.1    Beresford, M.2    Bowen, R.3    Mitchard, J.4    Chalmers, A.D.5
  • 32
    • 84964282524 scopus 로고    scopus 로고
    • Cancer stem cells: the promise and the potential
    • COI: 1:CAS:528:DC%2BC2MXmt1SrsrY%3D
    • Ajani JA, Song S, Hochster HS, Steinberg IB. Cancer stem cells: the promise and the potential. Semin Oncol 2015; 42: S3–S17.
    • (2015) Semin Oncol , vol.42 , pp. S3-S17
    • Ajani, J.A.1    Song, S.2    Hochster, H.S.3    Steinberg, I.B.4
  • 33
    • 84920860653 scopus 로고    scopus 로고
    • A phase II study of mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in patients with myelodysplastic syndrome (MDS)
    • abstr
    • Luger SM, O'Connell CL, LKlimek V, Cooper MA, Besa EC, Rossetti JM et al. A phase II study of mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in patients with myelodysplastic syndrome (MDS). J Clin Oncol 2013; 31(suppl): abstr 7116.
    • (2013) J Clin Oncol , vol.7116
    • Luger, S.M.1    O'connell, C.L.2    Lklimek, V.3    Cooper, M.A.4    Besa, E.C.5    Rossetti, J.M.6
  • 34
    • 82555187781 scopus 로고    scopus 로고
    • Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial
    • COI: 1:CAS:528:DC%2BC3MXhsFGjt77O
    • Younes A, Oki Y, Bociek RG, Kuruvilla J, Fanale M, Neelapu S et al. Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial. Lancet Oncol 2011; 12: 1222–1228.
    • (2011) Lancet Oncol , vol.12 , pp. 1222-1228
    • Younes, A.1    Oki, Y.2    Bociek, R.G.3    Kuruvilla, J.4    Fanale, M.5    Neelapu, S.6
  • 35
    • 70350448445 scopus 로고    scopus 로고
    • Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia
    • COI: 1:CAS:528:DC%2BD1MXhsFKjtbzM
    • Blum KA, Advani A, Fernandez L, Van Der Jagt R, Brandwein J, Kambhampati S et al. Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia. Br J Haematol 2009; 147: 507–514.
    • (2009) Br J Haematol , vol.147 , pp. 507-514
    • Blum, K.A.1    Advani, A.2    Fernandez, L.3    Van Der Jagt, R.4    Brandwein, J.5    Kambhampati, S.6
  • 36
    • 27544446991 scopus 로고    scopus 로고
    • Life in the balance: how BH3-only proteins induce apoptosis
    • COI: 1:CAS:528:DC%2BD2MXhtFyksL%2FO
    • Willis SN, Adams JM. Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005; 17: 617–625.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 617-625
    • Willis, S.N.1    Adams, J.M.2
  • 37
    • 84861905616 scopus 로고    scopus 로고
    • Stem-like cells with luminal progenitor phenotype survive castration in human prostate cancer
    • COI: 1:CAS:528:DC%2BC38XhtVWjsLrJ
    • Germann M, Wetterwald A, Guzman-Ramirez N, van der Pluijm G, Culig Z, Cecchini MG et al. Stem-like cells with luminal progenitor phenotype survive castration in human prostate cancer. Stem Cells 2012; 30: 1076–1086.
    • (2012) Stem Cells , vol.30 , pp. 1076-1086
    • Germann, M.1    Wetterwald, A.2    Guzman-Ramirez, N.3    van der Pluijm, G.4    Culig, Z.5    Cecchini, M.G.6
  • 38
    • 49649117149 scopus 로고    scopus 로고
    • Azacitidine and the beginnings of therapeutic epigenetic modulation
    • COI: 1:CAS:528:DC%2BD1cXos1Chu7w%3D
    • O'Dwyer K, Maslak P. Azacitidine and the beginnings of therapeutic epigenetic modulation. Expert Opin Pharmacother 2008; 9: 1981–1986.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1981-1986
    • O'Dwyer, K.1    Maslak, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.