Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli

PLoS Biology

Volumn 17, Issue 7, 2019, Pages

  Cummings, Matthew ^a,c   Peters, Anna D ^a   Whitehead, George F S ^a   Menon, Binuraj R K ^a,b   Micklefield, Jason ^a   Webb, Simon J ^a   Takano, Eriko ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c CC Biotech Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACENE DERIVATIVE; ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; BENZOISOCHROMANEQUINONE DERIVATIVE; DIANTHRONE DERIVATIVE; NEOCHAETOMYCIN; NEOMEDICAMYCIN; POLYKETIDE; POLYKETIDE SYNTHASE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; BACTERIAL PROTEIN; POLYCYCLIC AROMATIC HYDROCARBON; RECOMBINANT PROTEIN;

ARTICLE; BACTERIUM; BACTERIUM IDENTIFICATION; BIODIVERSITY; BIOTECHNOLOGY; CONTROLLED STUDY; DRUG SYNTHESIS; ENDOPHYTIC FUNGUS; ESCHERICHIA COLI; GENETIC MANIPULATION; HIGH THROUGHPUT SCREENING; KTEDONOBACTER RACEMIFER; NONHUMAN; PHOTORHABDUS LUMINESCENS; PLANT; PROTEIN EXPRESSION; PSEUDOALTEROMONAS; PSEUDOALTEROMONAS LUTEOVIOLACEA; ROBOTICS; STREPTOCOCCUS; STREPTOMYCES; STREPTOMYCES RESISTOMYCIFICUS; BIOSYNTHESIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; GENETICS; METABOLISM; PHYLOGENY;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTHRAQUINONES; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; ESCHERICHIA COLI; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHYLOGENY; POLYCYCLIC AROMATIC HYDROCARBONS; POLYKETIDE SYNTHASES; POLYKETIDES; RECOMBINANT PROTEINS;

EID: 85070061002     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.3000347     Document Type: Article

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