Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host

Journal of Antibiotics

Volumn 64, Issue 12, 2011, Pages 759-762

  Fitzgerald, Jay T ^a   Ridley, Christian P ^b   Khosla, Chaitan ^a  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

Author keywords

antiparasitic antibiotic; biosynthesis; engineering; frenolicin; polyketide

Indexed keywords

ANTIPARASITIC AGENT; FRENOLICIN B; FRENOLICIN B DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GENE; BIOENGINEERING; BIOSYNTHESIS; CYTOTOXICITY TEST; FEASIBILITY STUDY; GENE CLUSTER; GENE IDENTIFICATION; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; SHUTTLE VECTOR; STREPTOMYCES COELICOLOR; TOXOPLASMA GONDII;

ANIMALS; ANTIPARASITIC AGENTS; CELL LINE; CLONING, MOLECULAR; GENETIC ENGINEERING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NAPHTHOQUINONES; STREPTOMYCES COELICOLOR; TOXOPLASMA;

EID: 84255188709     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2011.86     Document Type: Article

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