Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 25, 2016, Pages 6851-6856

  Griffiths, Scott ^a   Mesarich, Carl H ^a,b   Saccomanno, Benedetta ^a   Vaisberg, Abraham ^c   De Wit, Pierre J G M ^a   Cox, Russell ^d,e   Collemare, Jérôme ^a,f  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MASSEY UNIVERSITY   (New Zealand)

^c UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^d LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f UNIVERSITÉ D'ANGERS   (France)

Author keywords

Cytoxicity; Emodin; Gene cluster; Nataloe emodin; Secondary metabolism

Indexed keywords

ALOE EMODIN; ANTHRAQUINONE; ATROCHRYSONE; BETA LACTAMASE; BETA LACTAMASE CLAF; CARBOXYLIC ACID; CHRYSOPHANIC ACID; CHRYSOPHANIC ACID DERIVATIVE; CLADOFULVIN; CYTOCHROME P450; CYTOTOXIC AGENT; EMODIN; ENDOCROCIN; HOMODIMER; HYDROLYASE; HYDROQUINONE DERIVATIVE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; ANTHRAQUINONE DERIVATIVE;

ANIMAL CELL; ARTICLE; ASPERGILLUS ORYZAE; CATALYST; CLAG GENE; CONTROLLED STUDY; DECARBOXYLATION; DELETION MUTANT; DIMERIZATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG PURIFICATION; DRUG SYNTHESIS; EMBRYO; FUNGAL GENE; GENE CLUSTER; GENETIC BACKGROUND; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; K562 CELL LINE; LIGHT SCATTERING; MOUSE; MOUSE EMBRYO; NONHUMAN; PASSALORA FULVA; PRIORITY JOURNAL; CHEMISTRY; CLADOSPORIUM; ENZYMOLOGY; METABOLISM;

ANTHRAQUINONES; CLADOSPORIUM; CYTOCHROME P-450 ENZYME SYSTEM; DIMERIZATION;

EID: 84975769872     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603528113     Document Type: Article

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