메뉴 건너뛰기




Volumn 6, Issue 1, 2017, Pages 1-9

Ketogenic diets and Alzheimer's disease

Author keywords

Alzheimer's disease; Ketogenic diet; Ketone bodies; Therapy

Indexed keywords


EID: 85068991767     PISSN: None     EISSN: 22134530     Source Type: Journal    
DOI: 10.1016/j.fshw.2016.10.003     Document Type: Review
Times cited : (34)

References (80)
  • 2
    • 61849157257 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Burns, A., Iliffe, S., Alzheimer's disease. BMJ, 338, 2009, b158.
    • (2009) BMJ , vol.338 , pp. b158
    • Burns, A.1    Iliffe, S.2
  • 5
    • 84899888646 scopus 로고    scopus 로고
    • Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia
    • Nyberg, J., Aberg, M.A., Schiöler, L., Nilsson, M., Wallin, A., Torén, K., Kuhn, H.G., Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia. Brain 137 (2014), 1514–1523.
    • (2014) Brain , vol.137 , pp. 1514-1523
    • Nyberg, J.1    Aberg, M.A.2    Schiöler, L.3    Nilsson, M.4    Wallin, A.5    Torén, K.6    Kuhn, H.G.7
  • 6
    • 84904264999 scopus 로고    scopus 로고
    • Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
    • Norton, S., Matthews, F.E., Barnes, D.E., Yaffe, K., Brayne, C., Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 13 (2014), 788–794.
    • (2014) Lancet Neurol. , vol.13 , pp. 788-794
    • Norton, S.1    Matthews, F.E.2    Barnes, D.E.3    Yaffe, K.4    Brayne, C.5
  • 8
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
    • Karran, E., Mercken, M., De Strooper, B., The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10 (2011), 698–712.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 9
    • 56349119351 scopus 로고    scopus 로고
    • Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
    • Duff, K., Small, S.A., Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron, 60, 2008.
    • (2008) Neuron , vol.60
    • Duff, K.1    Small, S.A.2
  • 10
    • 84919863377 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease
    • Guerreiro, R., Hardy, J., Genetics of Alzheimer's disease. Neurotherapeutics 11 (2014), 732–737.
    • (2014) Neurotherapeutics , vol.11 , pp. 732-737
    • Guerreiro, R.1    Hardy, J.2
  • 11
  • 13
    • 2342555602 scopus 로고    scopus 로고
    • Dietary fat intake and 6-year cognitive change in an older biracial community population
    • Morris, M.C., Evans, D.A., Bienias, J.L., Tangney, C.C., Wilson, R.S., Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 62 (2004), 1573–1579.
    • (2004) Neurology , vol.62 , pp. 1573-1579
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Wilson, R.S.5
  • 15
    • 0017177061 scopus 로고
    • Changes during development in transport processes of the blood-brain barrier
    • Cremer, J.E., Braun, L.D., Oldendorf, W.H., Changes during development in transport processes of the blood-brain barrier. Biochim. Biophys. Acta 448 (1976), 633–637.
    • (1976) Biochim. Biophys. Acta , vol.448 , pp. 633-637
    • Cremer, J.E.1    Braun, L.D.2    Oldendorf, W.H.3
  • 16
    • 19444376784 scopus 로고    scopus 로고
    • Cerebral ketone body metabolism
    • Morris, A.A., Cerebral ketone body metabolism. J. Inherit. Metab. Dis. 28 (2005), 109–121.
    • (2005) J. Inherit. Metab. Dis. , vol.28 , pp. 109-121
    • Morris, A.A.1
  • 17
    • 84903759041 scopus 로고    scopus 로고
    • The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo
    • Chowdury, G.M., Jiang, L., Rothman, D.L., Behar, K.L., The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo. J. Cereb. Blood Flow Metab. 34 (2014), 1233–1242.
    • (2014) J. Cereb. Blood Flow Metab. , vol.34 , pp. 1233-1242
    • Chowdury, G.M.1    Jiang, L.2    Rothman, D.L.3    Behar, K.L.4
  • 20
    • 0036177405 scopus 로고    scopus 로고
    • Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk
    • Hellerstein, M.K., Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk. Curr. Opin. Lipidol. 13 (2002), 33–40.
    • (2002) Curr. Opin. Lipidol. , vol.13 , pp. 33-40
    • Hellerstein, M.K.1
  • 21
    • 1942532069 scopus 로고    scopus 로고
    • High carbohydrate diets and Alzheimer's disease
    • Henderson, S.T., High carbohydrate diets and Alzheimer's disease. Med. Hypotheses 62 (2004), 689–700.
    • (2004) Med. Hypotheses , vol.62 , pp. 689-700
    • Henderson, S.T.1
  • 22
    • 2942702105 scopus 로고    scopus 로고
    • More fat and fewer seizures: dietary therapies for epilepsy
    • Kossoff, E.H., More fat and fewer seizures: dietary therapies for epilepsy. Lancet Neurol. 3 (2004), 415–420.
    • (2004) Lancet Neurol. , vol.3 , pp. 415-420
    • Kossoff, E.H.1
  • 26
    • 18444362777 scopus 로고    scopus 로고
    • The ketogenic diet
    • Sinha, S.R., Kossoff, E.H., The ketogenic diet. Neurologist 11 (2005), 161–170.
    • (2005) Neurologist , vol.11 , pp. 161-170
    • Sinha, S.R.1    Kossoff, E.H.2
  • 27
    • 58649103488 scopus 로고    scopus 로고
    • The ketogenic diet: uses in epilepsy and other neurologicai llnesses
    • Barañano, K.W., Hartman, A.L., The ketogenic diet: uses in epilepsy and other neurologicai llnesses. Curr. Treat Options Neurol. 10 (2008), 410–419.
    • (2008) Curr. Treat Options Neurol. , vol.10 , pp. 410-419
    • Barañano, K.W.1    Hartman, A.L.2
  • 28
    • 31544433431 scopus 로고    scopus 로고
    • The ketogenic diet: from molecular mechanisms to clinical effects
    • Freeman, J., Veggiotti, P., Lanzi, G., Tagliabue, A., Perucca, E., The ketogenic diet: from molecular mechanisms to clinical effects. Epilepsy Res. 68 (2006), 145–180.
    • (2006) Epilepsy Res. , vol.68 , pp. 145-180
    • Freeman, J.1    Veggiotti, P.2    Lanzi, G.3    Tagliabue, A.4    Perucca, E.5
  • 29
    • 33846250398 scopus 로고    scopus 로고
    • Anticonvulsant mechanisms of the ketogenic diet
    • Bough, K.J., Rho, J., Anticonvulsant mechanisms of the ketogenic diet. Epilepsia 48 (2007), 43–58.
    • (2007) Epilepsia , vol.48 , pp. 43-58
    • Bough, K.J.1    Rho, J.2
  • 30
    • 34147189503 scopus 로고    scopus 로고
    • Ketogenic diet metabolites reduce firing in central neurons by opening K (ATP) channels
    • Ma, W., Berg, J., Yellen, G., Ketogenic diet metabolites reduce firing in central neurons by opening K (ATP) channels. J. Neurosci. 27 (2007), 3618–3625.
    • (2007) J. Neurosci. , vol.27 , pp. 3618-3625
    • Ma, W.1    Berg, J.2    Yellen, G.3
  • 31
    • 33748272252 scopus 로고    scopus 로고
    • Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons
    • Bak, L.K., Schousboe, A., Sonnewald, U., Waagepetersen, H.S., Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons. J. Cereb. Blood Flow Metab. 26 (2006), 1285–1297.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1285-1297
    • Bak, L.K.1    Schousboe, A.2    Sonnewald, U.3    Waagepetersen, H.S.4
  • 32
    • 84935885840 scopus 로고    scopus 로고
    • Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function
    • Hertz, L., Chen, Y., Waagepetersen, H.S., Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function. J. Neurochem. 134 (2015), 7–20.
    • (2015) J. Neurochem. , vol.134 , pp. 7-20
    • Hertz, L.1    Chen, Y.2    Waagepetersen, H.S.3
  • 33
    • 67449116585 scopus 로고    scopus 로고
    • Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons
    • Lund, T.M., Risa, O., Sonnewald, U., Schousboe, A., Waagepetersen, H.S., Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons. J. Neurochem. 110 (2009), 80–91.
    • (2009) J. Neurochem. , vol.110 , pp. 80-91
    • Lund, T.M.1    Risa, O.2    Sonnewald, U.3    Schousboe, A.4    Waagepetersen, H.S.5
  • 34
    • 84904761024 scopus 로고    scopus 로고
    • Ketogenic diet in neuromuscular and neurodegenerative diseases
    • Paoli, A., Bianco, A., Damiani, E., Bosco, G., Ketogenic diet in neuromuscular and neurodegenerative diseases. BioMed. Res. Int., 2014, 2014, 474296.
    • (2014) BioMed. Res. Int. , vol.2014 , pp. 474296
    • Paoli, A.1    Bianco, A.2    Damiani, E.3    Bosco, G.4
  • 35
    • 0019783428 scopus 로고
    • Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography
    • Frackowiak, R.S., Pozzilli, C., Legg, N.J., Du Boulay, G.H., Marshall, J., Lenzi, G.L., Jones, T., Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain 104 (1981), 753–778.
    • (1981) Brain , vol.104 , pp. 753-778
    • Frackowiak, R.S.1    Pozzilli, C.2    Legg, N.J.3    Du Boulay, G.H.4    Marshall, J.5    Lenzi, G.L.6    Jones, T.7
  • 48
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech, R.L., The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fatty Acids 70 (2004), 309–319.
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 49
    • 0030862656 scopus 로고    scopus 로고
    • Substrate signaling by insulin: a ketone bodies ratio mimics insulin action in heart
    • Kashiwaya, Y., King, M.T., Veech, R.L., Substrate signaling by insulin: a ketone bodies ratio mimics insulin action in heart. Am. J. Cardiol. 80 (1997), 50A–64A.
    • (1997) Am. J. Cardiol. , vol.80 , pp. 50A-64A
    • Kashiwaya, Y.1    King, M.T.2    Veech, R.L.3
  • 51
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf, M., Rho, J.M., Mattson, M.P., The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res. Rev. 59 (2009), 293–315.
    • (2009) Brain Res. Rev. , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 55
    • 27744549328 scopus 로고    scopus 로고
    • A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease
    • Van der Auwera, I., Wera, S., van Leuven, F., Henderson, S.T., A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Nutr. Metab., 2, 2005, 28.
    • (2005) Nutr. Metab. , vol.2 , pp. 28
    • Van der Auwera, I.1    Wera, S.2    van Leuven, F.3    Henderson, S.T.4
  • 57
    • 84884177253 scopus 로고    scopus 로고
    • Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology
    • Brownlow, M.L., Benner, L., D'Agostino, D., Gordon, M.N., Morgan, D., Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PLoS One, 8, 2013, e75713.
    • (2013) PLoS One , vol.8 , pp. e75713
    • Brownlow, M.L.1    Benner, L.2    D'Agostino, D.3    Gordon, M.N.4    Morgan, D.5
  • 58
    • 33947264635 scopus 로고    scopus 로고
    • Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    • Halagappa, V.K., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R.G., Laferla, F.M., Mattson, M.P., Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 26 (2007), 212–220.
    • (2007) Neurobiol. Dis. , vol.26 , pp. 212-220
    • Halagappa, V.K.1    Guo, Z.2    Pearson, M.3    Matsuoka, Y.4    Cutler, R.G.5    Laferla, F.M.6    Mattson, M.P.7
  • 59
    • 48849092902 scopus 로고    scopus 로고
    • Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog
    • Studzinski, C.M., MacKay, W.A., Beckett, T.L., Henderson, S.T., Murphy, M.P., Sullivan, P.G., Burnham, W.M., Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Res. 1226 (2008), 209–217.
    • (2008) Brain Res. , vol.1226 , pp. 209-217
    • Studzinski, C.M.1    MacKay, W.A.2    Beckett, T.L.3    Henderson, S.T.4    Murphy, M.P.5    Sullivan, P.G.6    Burnham, W.M.7
  • 60
    • 68949158352 scopus 로고    scopus 로고
    • The neurodegenerative mitochondriopathies
    • Swerdlow, R.H., The neurodegenerative mitochondriopathies. J. Alzheimers Dis. 17 (2009), 737–751.
    • (2009) J. Alzheimers Dis. , vol.17 , pp. 737-751
    • Swerdlow, R.H.1
  • 61
    • 35848932091 scopus 로고    scopus 로고
    • Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders
    • Soane, L., Kahraman, S., Kristian, T., Fiskum, G., Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders. J. Neurosci. Res. 85 (2007), 3407–3415.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 3407-3415
    • Soane, L.1    Kahraman, S.2    Kristian, T.3    Fiskum, G.4
  • 62
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao, J., Irwin, R.W., Zhao, L., Nilsen, J., Hamilton, R.T., Brinton, R.D., Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 14670–14675.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 63
    • 79959802475 scopus 로고    scopus 로고
    • 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease
    • Yao, J., Chen, S., Mao, Z., Cadenasm, E., Brinton, R.D., 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One, 6, 2011, e21788.
    • (2011) PLoS One , vol.6 , pp. e21788
    • Yao, J.1    Chen, S.2    Mao, Z.3    Cadenasm, E.4    Brinton, R.D.5
  • 64
    • 84875253158 scopus 로고    scopus 로고
    • A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
    • Kashiwaya, Y., Bergman, C., Lee, J.H., Wan, R., King, M.T., Mughal, M.R., Okun, E., Clarke, K., Mattson, M.P., Veech, R.L., A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol. Aging 34 (2013), 1530–1539.
    • (2013) Neurobiol. Aging , vol.34 , pp. 1530-1539
    • Kashiwaya, Y.1    Bergman, C.2    Lee, J.H.3    Wan, R.4    King, M.T.5    Mughal, M.R.6    Okun, E.7    Clarke, K.8    Mattson, M.P.9    Veech, R.L.10
  • 65
    • 84876823225 scopus 로고    scopus 로고
    • Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease
    • Aso, E., Semakova, J., Joda, L., Semak, V., Halbaut, L., Calpena, A., Escolano, C., Perales, J.C., Ferrer, I., Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease. Alzheimer Res. 10 (2013), 290–297.
    • (2013) Alzheimer Res. , vol.10 , pp. 290-297
    • Aso, E.1    Semakova, J.2    Joda, L.3    Semak, V.4    Halbaut, L.5    Calpena, A.6    Escolano, C.7    Perales, J.C.8    Ferrer, I.9
  • 67
    • 0020420292 scopus 로고
    • Medium-chain triglycerides: an update
    • Bach, A.C., Babayan, V., Medium-chain triglycerides: an update. Am. J. Clin. Nutr. 36 (1982), 950–962.
    • (1982) Am. J. Clin. Nutr. , vol.36 , pp. 950-962
    • Bach, A.C.1    Babayan, V.2
  • 68
    • 69449085062 scopus 로고    scopus 로고
    • Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
    • Henderson, S.T., Vogel, J.L., Barr, L.J., Garvin, F., Jones, J.J., Costantini, L.C., Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr. Metab. (Lond.), 6, 2009, 31.
    • (2009) Nutr. Metab. (Lond.) , vol.6 , pp. 31
    • Henderson, S.T.1    Vogel, J.L.2    Barr, L.J.3    Garvin, F.4    Jones, J.J.5    Costantini, L.C.6
  • 69
    • 80053908399 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of the effects of polymorphisms in APOE IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study
    • Henderson, S.T., Poirier, J., Pharmacogenetic analysis of the effects of polymorphisms in APOE IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. BMC Med. Genet., 12, 2011, 137.
    • (2011) BMC Med. Genet. , vol.12 , pp. 137
    • Henderson, S.T.1    Poirier, J.2
  • 72
    • 84922709891 scopus 로고    scopus 로고
    • A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease
    • Newport, M.T., VanItallie, T.B., Kashiwaya, Y., King, M.T., Veech, R.L., A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease. Alzheimers Dement. 11 (2015), 99–103.
    • (2015) Alzheimers Dement. , vol.11 , pp. 99-103
    • Newport, M.T.1    VanItallie, T.B.2    Kashiwaya, Y.3    King, M.T.4    Veech, R.L.5
  • 74
    • 0013998644 scopus 로고
    • The regulation of the release of ketone bodies by the liver
    • Krebs, H.A., The regulation of the release of ketone bodies by the liver. Adv. Enzyme Regul. 4 (1966), 339–353.
    • (1966) Adv. Enzyme Regul. , vol.4 , pp. 339-353
    • Krebs, H.A.1
  • 77
    • 19044383697 scopus 로고    scopus 로고
    • Behavioral disturbances not cognitive deterioration, are associated with altered food selection in seniors with Alzheimer's disease
    • Greenwood, C.E., Tam, C., Chan, M., Young, K.W., Binns, M.A., van Reekum, R., Behavioral disturbances not cognitive deterioration, are associated with altered food selection in seniors with Alzheimer's disease. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005), 499–505.
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , pp. 499-505
    • Greenwood, C.E.1    Tam, C.2    Chan, M.3    Young, K.W.4    Binns, M.A.5    van Reekum, R.6
  • 78
    • 0036963532 scopus 로고    scopus 로고
    • Increased amyloidlevels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet
    • Levin-Allerhand, A., Lominska, C.E., Smith, J.D., Increased amyloidlevels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J. Nutr. Health Aging 6 (2002), 315–319.
    • (2002) J. Nutr. Health Aging , vol.6 , pp. 315-319
    • Levin-Allerhand, A.1    Lominska, C.E.2    Smith, J.D.3
  • 80
    • 84870566969 scopus 로고    scopus 로고
    • Preclinical sporadic Alzheimer's disease: target for personalized diagnosis and preventive intervention
    • Vanitallie, T.B., Preclinical sporadic Alzheimer's disease: target for personalized diagnosis and preventive intervention. Metabolism 62:Suppl. 1 (2013), S30–S33.
    • (2013) Metabolism , vol.62 , pp. S30-S33
    • Vanitallie, T.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.