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Volumn 10, Issue 3, 2013, Pages 290-297

Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease

Author keywords

Alzheimer's disease; Anaplerotic diet; APP PS1 transgenic mice; Ketone bodies; Mitochondria; Triheptanoin

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA INTERFERON; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; TRIHEPTANOIN;

EID: 84876823225     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/15672050112099990128     Document Type: Article
Times cited : (41)

References (38)
  • 1
    • 28044442099 scopus 로고    scopus 로고
    • Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation
    • Aubert A, Costalat R, Magistretti PJ, Pellerin L. Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation. Proc Natl Acad Sci USA 102: 16448-53 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16448-16453
    • Aubert, A.1    Costalat, R.2    Magistretti, P.J.3    Pellerin, L.4
  • 2
    • 55149103502 scopus 로고    scopus 로고
    • Brain energetics (thought needs food)
    • Pellerin L. Brain energetics (thought needs food). Curr Opin Clin Nutr Metab Care 11: 701-5 (2008).
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 701-705
    • Pellerin, L.1
  • 3
    • 19444376784 scopus 로고    scopus 로고
    • Cerebral ketone body metabolism
    • Morris AA. Cerebral ketone body metabolism. J Inherit Metab Dis 28: 109-21 (2005).
    • (2005) J Inherit Metab Dis , vol.28 , pp. 109-121
    • Morris, A.A.1
  • 4
    • 33748298884 scopus 로고    scopus 로고
    • Neuroprotective and disease-modifying effects of the ketogenic diet
    • Gasior M, Rogawski MA, Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol 17: 431-9 (2006).
    • (2006) Behav Pharmacol , vol.17 , pp. 431-439
    • Gasior, M.1    Rogawski, M.A.2    Hartman, A.L.3
  • 5
    • 33745105118 scopus 로고    scopus 로고
    • Anaplerotic molecules: Current and future
    • Brunengraber H, Roe CR. Anaplerotic molecules: current and future. J Inherit Metab Dis 29: 327-31 (2006).
    • (2006) J Inherit Metab Dis , vol.29 , pp. 327-331
    • Brunengraber, H.1    Roe, C.R.2
  • 6
    • 70350453589 scopus 로고    scopus 로고
    • Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver
    • Deng S, Zhang GF, Kasumov T, Roe CR, Brunengraber H. Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver. J Biol Chem 284: 27799-807 (2009).
    • (2009) J Biol Chem , vol.284 , pp. 27799-27807
    • Deng, S.1    Zhang, G.F.2    Kasumov, T.3    Roe, C.R.4    Brunengraber, H.5
  • 8
    • 84859325175 scopus 로고    scopus 로고
    • Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia
    • Ferrer I. Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia. Prog Neurobiol 97: 38-51 (2012).
    • (2012) Prog Neurobiol , vol.97 , pp. 38-51
    • Ferrer, I.1
  • 9
    • 0035693924 scopus 로고    scopus 로고
    • Inflammation, autotoxicity and Alzheimer disease
    • McGeer PL, McGeer EG. Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22: 799-809 (2001).
    • (2001) Neurobiol Aging , vol.22 , pp. 799-809
    • McGeer, P.L.1    McGeer, E.G.2
  • 10
    • 9744222883 scopus 로고    scopus 로고
    • Protein quality control in Alzheimer's disease by the ubiquitin proteasome system
    • de Vrij FM, Fischer DF, van Leeuwen FW, Hol EM. Protein quality control in Alzheimer's disease by the ubiquitin proteasome system. Prog Neurobiol 74: 249-70 (2004).
    • (2004) Prog Neurobiol , vol.74 , pp. 249-270
    • de Vrij, F.M.1    Fischer, D.F.2    van Leeuwen, F.W.3    Hol, E.M.4
  • 12
    • 70449435581 scopus 로고    scopus 로고
    • Altered mitochondria, energy metabolism, voltagedependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease
    • Ferrer I. Altered mitochondria, energy metabolism, voltagedependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease. J Bioenerg Biomembr 41: 425-31 (2009).
    • (2009) J Bioenerg Biomembr , vol.41 , pp. 425-431
    • Ferrer, I.1
  • 13
    • 75149118997 scopus 로고    scopus 로고
    • Role of oxidative stress in the progression of Alzheimer's disease
    • Sultana R, Butterfield DA. Role of oxidative stress in the progression of Alzheimer's disease. J Alzheimers Dis 19: 341-53 (2010).
    • (2010) J Alzheimers Dis , vol.19 , pp. 341-353
    • Sultana, R.1    Butterfield, D.A.2
  • 14
    • 84861502237 scopus 로고    scopus 로고
    • Alzheimer's Disease Facts and Figures
    • Alzheimer's Association
    • Alzheimer's Association. Alzheimer's Disease Facts and Figures. Alzheimer's & Dementia 6: 9-14 (2010).
    • (2010) Alzheimer's & Dementia , vol.6 , pp. 9-14
  • 15
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
    • Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19: 939-945 (1997).
    • (1997) Neuron , vol.19 , pp. 939-945
    • Borchelt, D.R.1    Ratovitski, T.2    van Lare, J.3    Lee, M.K.4    Gonzales, V.5    Jenkins, N.A.6
  • 16
    • 84865516784 scopus 로고    scopus 로고
    • Amyloid generation and dysfunctional immunoproteasome activation with disease progression in an animal model of familial Alzheimer's disease
    • Aso E, Lomoio S, López-González I, Joda L, Carmona M, Fernández-Yagüe N, et al. Amyloid generation and dysfunctional immunoproteasome activation with disease progression in an animal model of familial Alzheimer's disease. Brain Pathol 22(5): 636-53 (2012).
    • (2012) Brain Pathol , vol.22 , Issue.5 , pp. 636-653
    • Aso, E.1    Lomoio, S.2    López-González, I.3    Joda, L.4    Carmona, M.5    Fernández-Yagüe, N.6
  • 17
    • 27744549328 scopus 로고    scopus 로고
    • A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease
    • Van der Auwera I, Wera S, Van Leuven F, Henderson ST. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Nutr Metab (Lond) 2: 28 (2005).
    • (2005) Nutr Metab (Lond) , vol.2 , pp. 28
    • van der Auwera, I.1    Wera, S.2    van Leuven, F.3    Henderson, S.T.4
  • 18
    • 69449085062 scopus 로고    scopus 로고
    • Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: A randomized, double-blind, placebocontrolled, multicenter trial
    • Henderson ST, Vogel JL, Barr LJ, Garvin F, Jones JJ, Costantini LC. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebocontrolled, multicenter trial. Nutr Metab (Lond) 6: 31 (2009).
    • (2009) Nutr Metab (Lond) , vol.6 , pp. 31
    • Henderson, S.T.1    Vogel, J.L.2    Barr, L.J.3    Garvin, F.4    Jones, J.J.5    Costantini, L.C.6
  • 19
    • 79959802475 scopus 로고    scopus 로고
    • 2-Deoxy-Dglucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease
    • Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-Deoxy-Dglucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One 6: e21788 (2011).
    • (2011) PLoS One , vol.6
    • Yao, J.1    Chen, S.2    Mao, Z.3    Cadenas, E.4    Brinton, R.D.5
  • 20
    • 84865287216 scopus 로고    scopus 로고
    • Formulation of solid triheptanoin-rich ketogenic diet for rodents. Triheptanoin synthesis and pharmaceutical formulation
    • Semak V, Semakova J, Halbaut L, et al. Formulation of solid triheptanoin-rich ketogenic diet for rodents. Triheptanoin synthesis and pharmaceutical formulation. Eur J Lipid Sci Technol 114: 889-895 (2012).
    • (2012) Eur J Lipid Sci Technol , vol.114 , pp. 889-895
    • Semak, V.1    Semakova, J.2    Halbaut, L.3
  • 21
    • 77954556798 scopus 로고    scopus 로고
    • Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging
    • Mosconi L, Berti V, Glodzik L, Pupi A, De Santi S, de Leon MJ. Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. J Alzheimers Dis 20: 843-54 (2010).
    • (2010) J Alzheimers Dis , vol.20 , pp. 843-854
    • Mosconi, L.1    Berti, V.2    Glodzik, L.3    Pupi, A.4    de Santi, S.5    de Leon, M.J.6
  • 23
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106: 14670-5 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 24
    • 77949882290 scopus 로고    scopus 로고
    • Mitochondrial energetics and therapeutics
    • Wallace DC, Fan W, Procaccio V. Mitochondrial energetics and therapeutics. Annu Rev Pathol 5: 297-348 (2010).
    • (2010) Annu Rev Pathol , vol.5 , pp. 297-348
    • Wallace, D.C.1    Fan, W.2    Procaccio, V.3
  • 27
    • 1042265019 scopus 로고    scopus 로고
    • The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders
    • Cullingford TE. The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. Prostaglandins Leukot Essent Fatty Acids 70: 253-64 (2004).
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 253-264
    • Cullingford, T.E.1
  • 28
    • 0026020414 scopus 로고
    • Fatty acid oxidation and ketogenesis by astrocytes in primary culture
    • Auestad N, Korsak RA, Morrow JW, Edmond J. Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J Neurochem 56: 1376-86 (1991).
    • (1991) J Neurochem , vol.56 , pp. 1376-1386
    • Auestad, N.1    Korsak, R.A.2    Morrow, J.W.3    Edmond, J.4
  • 29
    • 0035346949 scopus 로고    scopus 로고
    • Is there an astrocyte-neuron ketone body shuttle?
    • Guzmán M, Blázquez C. Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol Metab 12: 169-73 (2001).
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 169-173
    • Guzmán, M.1    Blázquez, C.2
  • 30
    • 34447128136 scopus 로고    scopus 로고
    • Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults
    • Escartin C, Pierre K, Colin A, Brouillet E, Delzescaux T, Guillermier M, et al. Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. J Neurosci 27: 7094-104 (2007).
    • (2007) J Neurosci , vol.27 , pp. 7094-7104
    • Escartin, C.1    Pierre, K.2    Colin, A.3    Brouillet, E.4    Delzescaux, T.5    Guillermier, M.6
  • 31
    • 0142026832 scopus 로고    scopus 로고
    • Potential roles of insulin and IGF-1 in Alzheimer's disease
    • Gasparini L, Xu H. Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 8: 404-6 (2003).
    • (2003) Trends Neurosci , vol.8 , pp. 404-406
    • Gasparini, L.1    Xu, H.2
  • 32
    • 79951686964 scopus 로고    scopus 로고
    • The sirtuin pathway in ageing and Alzheimer disease: Mechanistic and therapeutic considerations
    • Bonda DJ, Lee HG, Camins A, Pallàs M, Casadesus G, Smith MA, et al. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurology 10: 275-9 (2011).
    • (2011) Lancet Neurology , vol.10 , pp. 275-279
    • Bonda, D.J.1    Lee, H.G.2    Camins, A.3    Pallàs, M.4    Casadesus, G.5    Smith, M.A.6
  • 33
    • 0037387772 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 activity promotes NF-aaB-driven transcription and microglial activation: Implication for neurodegenerative disorders
    • Chiarugi A, Moskowitz MA. Poly(ADP-ribose) polymerase-1 activity promotes NF-aaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J Neurochem 85: 306-317 (2003).
    • (2003) J Neurochem , vol.85 , pp. 306-317
    • Chiarugi, A.1    Moskowitz, M.A.2
  • 34
    • 84455161651 scopus 로고    scopus 로고
    • SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid rrrprotein oligomerization and memory loss in mouse model of Alzheimer disease
    • Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, et al. SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid rrrprotein oligomerization and memory loss in mouse model of Alzheimer disease. J Biol Chem 286: 44557-68 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 44557-44568
    • Murakami, K.1    Murata, N.2    Noda, Y.3    Tahara, S.4    Kaneko, T.5    Kinoshita, N.6
  • 35
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 70: 309-19 (2004).
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 36
    • 1042288103 scopus 로고    scopus 로고
    • Ketone body synthesis in the brain: Possible neuroprotective effects
    • Guzmán M, Blázquez C. Ketone body synthesis in the brain: possible neuroprotective effects. Prostaglandins Leukot Essent Fatty Acids 70: 287-92 (2004).
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 287-292
    • Guzmán, M.1    Blázquez, C.2
  • 37
    • 33644889356 scopus 로고    scopus 로고
    • Acetoacetate protects neuronal cells from oxidative glutamate toxicity
    • Noh HS, Hah YS, Nilufar R, Han J, Bong JH, Kang SS, et al. Acetoacetate protects neuronal cells from oxidative glutamate toxicity. J Neurosci Res 83: 702-9 (2006).
    • (2006) J Neurosci Res , vol.83 , pp. 702-709
    • Noh, H.S.1    Hah, Y.S.2    Nilufar, R.3    Han, J.4    Bong, J.H.5    Kang, S.S.6
  • 38
    • 12244277597 scopus 로고    scopus 로고
    • The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice
    • Noh HS, Kim YS, Lee HP, Chung KM, Kim DW, Kang SS, et al. The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice. Epilepsy Res 53: 119-28 (2003).
    • (2003) Epilepsy Res , vol.53 , pp. 119-128
    • Noh, H.S.1    Kim, Y.S.2    Lee, H.P.3    Chung, K.M.4    Kim, D.W.5    Kang, S.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.