Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells

EBioMedicine

Volumn 46, Issue , 2019, Pages 290-304

  Ringh, Mikael V ^a   Hagemann Jensen, Michael ^a   Needhamsen, Maria ^a   Kular, Lara ^a   Breeze, Charles E ^b,c   Sjöholm, Louise K ^a   Slavec, Lara ^a   Kullberg, Susanna ^a,d   Wahlström, Jan ^a   Grunewald, Johan ^a   Brynedal, Boel ^a   Liu, Yun ^e   Almgren, Malin ^a   Jagodic, Maja ^a   Öckinger, Johan ^a   Ekström, Tomas J ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Altius Institute for Biomedical Sciences   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e FUDAN UNIVERSITY   (China)

Author keywords

Alveolar macrophages; DNA hydroxymethylation; DNA methylation; Enhancers; EPIC; Epigenetics; Oxidative stress; Smoking

Indexed keywords

BISULFITE; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

ADULT; ARTICLE; BLOOD CELL COUNT; BRONCHOSCOPY; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE CONTROL; GENE EXPRESSION; GENE ONTOLOGY; GENE PROBE; GENETIC VARIABILITY; HUMAN; IMMUNE RESPONSE; IMMUNOBLOTTING; LIPID METABOLISM; LUNG LAVAGE; MALE; NORMAL HUMAN; PLATELET COUNT; PRIORITY JOURNAL; QUESTIONNAIRE; RNA EXTRACTION; SIGNAL TRANSDUCTION; SMOKING; TUMOR ASSOCIATED LEUKOCYTE; UPREGULATION; ADVERSE EVENT; ANTIBODY SPECIFICITY; BIOLOGY; CPG ISLAND; EPIGENETICS; GENETIC EPIGENESIS; GENETICS; GENOMICS; IMMUNOLOGY; LYMPHOCYTE; MACROPHAGE; METABOLISM; MOLECULAR GENETICS; PROCEDURES; YOUNG ADULT;

ADULT; BRONCHOALVEOLAR LAVAGE; COMPUTATIONAL BIOLOGY; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; GENE EXPRESSION; GENE ONTOLOGY; GENOMICS; HEALTHY VOLUNTEERS; HUMANS; LYMPHOCYTES; MACROPHAGES; MALE; MOLECULAR SEQUENCE ANNOTATION; ORGAN SPECIFICITY; TOBACCO SMOKING; YOUNG ADULT;

EID: 85068700253     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2019.07.006     Document Type: Article

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