Airway gene expression in chronic obstructive pulmonary disease

Proceedings of the American Thoracic Society

Volumn 6, Issue 8, 2009, Pages 697-700

  Steiling, Katrina ^a,b   Lenburg, Marc E ^a,b   Spira, Avrum ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Airway gene expression; Bioinformatics; Chronic obstructive pulmonary disease

Indexed keywords

CORTICOSTEROID;

AIRWAY; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; COMPREHENSION; DIAGNOSTIC PROCEDURE; GENE EXPRESSION; GENETIC HETEROGENEITY; HISTORY; HUMAN; LUNG CANCER; MOLECULAR BIOLOGY; PHENOTYPE; RESPIRATORY EPITHELIUM; SHORT SURVEY; TOBACCO;

GENE EXPRESSION; HUMANS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY SYSTEM; SMOKING;

EID: 74849091964     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200907-076DP     Document Type: Short Survey

References (41)

1. NHLBI disease statistics: 2008 NHLBI fact book. Bethesda, MD; NHLBI: 2008.
2. Murray JL, Lopez AD. Alternative projections of mortality and disability by cause, 1990-2020: Global Burden of Disease Study. Lancet 1997;349:1498-1504.
3. Celli BR, Thomas NE, Anderson JA, Ferguson GT, Jenkins CR, Jones PW, Vestbo J, Knobil K, Yates JC, Calverley P. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;178:332-338.
4. Tashkin DP, Celli B, Senn S, Burkhard D, Kesten S, Menjoge S, Decramer M. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008;359:1543-1554.
5. Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Yates JC, Vestbo J. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007; 356:775-789.
6. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Bethesda, MD: GOLD; 2008.
7. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott M, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-2653.
8. Hogg JC, Senior RM. Chronic obstructive pulmonary disease C2: pathology and biochemistry of emphysema. Thorax 2002;57:830-834.
9. Turato G, Zuin R, Miniati M, Baraldo S, Rea F, Beghe B, Monti S, Formichi B, Boschetto P, Harari S, et al. Airway inflammation in severe chronic obstructive pulmonary disease: relationship with lung function and radiologic emphysema. Am J Respir Crit Care Med 2002; 166:105-110.
10. Slaughter DP, Southwick HW, Smejkai W. "Field cancerization" in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 1953;6:693-698.
11. Franklin WA, Gazdar AF, Haney J, Wistuba II, LaRosa FG, Kennedy T, Ritchey DM, Miller YE. Widely dispersed P53 mutation in respiratory epithelium: a novel mechanism for field carcinogenesis. J Clin Invest 1997;100:2133-2137.
12. Tang X, Shigematsu H, Bekele BN, Roth JA, Minna JD, Hong WK, Gazdar AF, Wistuba II. EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res 2005;65:7568-7572.
13. Wistuba II, Lam S, Behrens C, Virmani AK, Fong KM, LeRiche J, Samet JM, Srivastava S, Minna JD, Gazdar AF. Molecular damage in the bronchial epithelium of current and former smokers. J Natl Cancer Inst 1997;89:1366-1373.
14. Mao L, Lee JS, Kurie JM, Fan YH, Lippman SM, Lee JJ, Ro JY, Broxson A, Yu R, Morice RC, et al. Clonal genetic alterations in the lungs of current and former smokers. J Natl Cancer Inst 1997;89:857-862.
15. Fliss MS, Usadel H, Caballero OL, Wu L, Buta MR, Eleff SM, Jen J, Sidransky D. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 2000;287:2017-2019.
16. Miyazu YM, Miyazawa T, Hiyama K, Kurimoto N, Iwamoto Y, Matsura H, Kanoh K, Kohno N, Nishiyama M, Hiyama E. Telomerase expression in noncancerous bronchial epithelia is a possible marker of early development of lung cancer. Cancer Res 2005;65:9623-9627.
17. Belinsky SA, Palmisano WA, Gilliland FD, Crooks LA, Divine KK, Winters SA, Grimes MJ, Harms HJ, Tellez CS, Smith TM, et al. Aberrant promotor methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res 2002;62:2370-2377.
18. Bhutani M, Pathak AK, Fan YH, Liu DD, Lee JJ, Tang H, Kurie JM, Morice RC, Kim ES, Hong WK, et al. Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs. Cancer Prevention Res 2008;1:39-44.
19. von Zeidler SV, Miracca EC, Nagai MA, Birman EG. Hypermethylation of the P16 gene in normal oral mucosa of smokers. Int J Mol Med 2004;14:807-811.
20. Steiling K, Ryan J, Brody JS, Spira A. The field of tissue injury in the lung and airway. Cancer Prev Res 2008;1:396-403.
21. Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J, Brody JS. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA 2004;101:10143-10148.
22. Hackett NR, Heguy A, Havey BG, O'Connor TP, Kuettich K, Rlieder DB, Kaplan R, Crystal RG. Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. Am J Respir Cell Mol Biol 2003;29:331-343.
23. Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, et al. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics 2008;9:259.
24. Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahman RQ, Brody JS, Lenburg ME, Steffen M, et al. Comparison of proteomic and transcriptomic profiles in the bronchial airway of current and never smokers. PLoS One 2009;4:e5043.
25. Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA (In press)
26. Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol 2007;8:R201.
27. Chari R, Lonergan KM, Ng RT, MacAulay C, Lam WL, Lam S. Effect of active smoking on the human bronchial epithelium transcriptome. BMC Genomics 2007;8:297.
28. Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med 2007;13:361-366.
29. Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prevention Res 2008; 1:56-64.
30. Warner KA, Grawford EL, Zaher A, Coombs RJ, Elsamaloty H, Roshong-Denk SL, Sharief I, Amurao GV, Yoon Y, Al-Astai AY, et al. The C-Myc x E2F21/P21 interactive gene expression index augments cytomorphologic diagnosis of lung cancer in fine-needle aspirate specimens. J Mol Diagn 2003;5:176-183.
31. Zeskind JE, Lenburg ME, Spira A. Translating the COPD transcriptome. Proc Am Thorac Soc 2009;5:834-841.
32. Pierrou S, Broberg P, O'Donnell RA, Pawlowski K, Virtala R, Lindqvist E, Richter A, Wilson SJ, Angco G, Moller S, et al. Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:577-586.
33. Tilley AE, Harvey BG, Heguy A, Hackett NR, Wang R, O'Connor TP, Crystal RG. Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009;179:457-466.
34. Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Behesti J, Bueno R, Gillette M, et al. Classification of human lung carcinomas by MRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001;98:13790-13795.
35. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidu SS, Dao-Pick TP, Pantoja C, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007;104:15858-15863.
36. Schwartz AC, Ruckdechel JC. Familial lung cancer: genetic susceptibility and relationship to chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;173:16-22.
37. Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, et al. Genome-wide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet 2002;70:1229-1239.
38. Wilk JB, Chen T, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, Myers RH, Borecki IB, Silverman EK, Weiss ST, et al. A genomewide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet 2009;5:e1000429.
39. Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Hersh CP, Bakke P, Gusvik A, Ruppert A, et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009;5:e1000421.
40. Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC, et al. Decreased histone deacetylase activity in chonic obstructive pulmonary disease. N Engl J Med 2005; 352:1967-1976.
41. Harvey BF, Heguy A, Leopold LP, Carolan BJ, Ferris B, Crystal RG. Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med 2006;85:39-53.