Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7 - A Population-Based Cohort Study

Schizophrenia Bulletin

Volumn 45, Issue 6, 2019, Pages 1218-1230

  Christiani, Camilla Jerlang ^a,b   Jepsen, Jens R M ^a,b,c,d   Thorup, Anne ^a,b   Hemager, Nicoline ^a,b,c   Ellersgaard, Ditte ^a,b   Spang, Katrine S ^b,c   Burton, Birgitte K ^b,c   Gregersen, Maja ^a,b   Søndergaard, Anne ^a,b   Greve, Aja N ^b,e   Gantriis, Ditte L ^b,e   Poulsen, Gry ^b,f   Uddin, Md Jamal ^b,f   Seidman, Larry J ^g   Mors, Ole ^b,e   Plessen, Kerstin J ^b,c,h   Nordentoft, Merete ^a,b,i  

^a University Mental Health Centre   (Denmark)

^b Lundbeck Foundation Initiative for Integrative Psychiatric Research   (Denmark)

^c Child and Adolescent Mental Health Center   (Denmark)

^d Neuropsychiatric Schizophrenia Research Mental Health Services in the Capital Region of Denmark   (Denmark)

^e AARHUS UNIVERSITY HOSPITAL   (Denmark)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^h LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

ⁱ UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

facial affect identification; language; neurodevelopment; offspring; social functioning; theory of mind

Indexed keywords

AGE; ARTICLE; BIPOLAR DISORDER; CHILD; CHILD PSYCHIATRY; COGNITIVE DEFECT; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; EMOTION; FEMALE; FUNCTIONAL DISEASE; HIGH RISK PATIENT; HUMAN; LANGUAGE; LANGUAGE DISABILITY; MAJOR CLINICAL STUDY; MALE; MEDICAL GEOGRAPHY; OUTCOME ASSESSMENT; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOLOGICAL RESILIENCE; SCHIZOPHRENIA; SCHOOL CHILD; SEX; SOCIAL ADAPTATION; SOCIAL BEHAVIOR; SOCIAL COGNITION; SOCIAL INTERACTION; SOCIAL PSYCHIATRY; SOCIAL PSYCHOLOGY; THEORY OF MIND; VULNERABLE POPULATION; CASE CONTROL STUDY; CHILD OF IMPAIRED PARENTS; DENMARK; PERCEPTION; RISK;

BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHILD; CHILD OF IMPAIRED PARENTS; COHORT STUDIES; DENMARK; FEMALE; HUMANS; LANGUAGE; MALE; RISK; SCHIZOPHRENIA; SOCIAL ADJUSTMENT; SOCIAL BEHAVIOR; SOCIAL PERCEPTION;

EID: 85067109144     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbz001     Document Type: Article

References (73)

1. Lichtenstein P, Yip BH, Björk C, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study. Lancet. 2009;373:234-239.
2. Wray NR, Gottesman II. Using summary data from the Danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. Front Genet. 2012;3:118.
3. Insel TR. Rethinking schizophrenia. Nature. 2010;468:187-193.
4. Craddock N, Owen MJ. The Kraepelinian dichotomy-going, going. but still not gone. Br J Psychiatry. 2010;196:92-95.
5. Fusar-Poli P. Predicting the development of schizophrenia. Br J Psychiatry. 2012;200:254-5; author reply 255.
6. Hameed MA, Lewis AJ. Offspring of parents with schizophrenia: A systematic review of developmental features across childhood. Harv Rev Psychiatry. 2016;24:104-117.
7. Niemi LT, Suvisaari JM, Tuulio-Henriksson A, Lönnqvist JK. Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophr Res. 2003;60:239-258.
8. Mollon J, Reichenberg A. Cognitive development prior to onset of psychosis. Psychol Med. 2018;48:392-403.
9. Laurens KR, Luo L, Matheson SL, et al. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry. 2015;15:205.
10. Bora E, Lin A, Wood SJ, Yung AR, McGorry PD, Pantelis C. Cognitive deficits in youth with familial and clinical high risk to psychosis: A systematic review and meta-Analysis. Acta Psychiatr Scand. 2014;130:1-15.
11. Bora E, Pantelis C. Meta-Analysis of cognitive impairment in first-episode bipolar disorder: comparison with firstepisode schizophrenia and healthy controls. Schizophr Bull. 2015;41:1095-1104.
12. Maziade M, Rouleau N, Gingras N, et al. Shared neurocognitive dysfunctions in young offspring at extreme risk for schizophrenia or bipolar disorder in eastern Quebec multigenerational families. Schizophr Bull. 2009;35:919-930.
13. Seidman LJ, Nordentoft M. New targets for prevention of schizophrenia: is it time for interventions in the premorbid phase? Schizophr Bull. 2015;41:795-800.
14. Liu CH, Tronick E, Seidman LJ. Perinatal risks and childhood premorbid indicators of later psychosis: next steps for early psychosocial interventions. Schizophr Bull. 2015;41:801-816.
15. Agnew-Blais J, Seidman LJ. Neurocognition in youth and young adults under age 30 at familial risk for schizophrenia: A quantitative and qualitative review. Cogn Neuropsychiatry. 2013;18:44-82.
16. Bora E, Pantelis C. Social cognition in schizophrenia in comparison to bipolar disorder: A meta-Analysis. Schizophr Res. 2016;175:72-78.
17. Cannon M, Caspi A, Moffitt TE, et al. Evidence for earlychildhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch Gen Psychiatry. 2002;59:449-456.
18. Green MF, Bearden CE, Cannon TD, et al. Social cognition in schizophrenia, Part 1: performance across phase of illness. Schizophr Bull. 2012;38:854-864.
19. Tarbox SI, Pogue-Geile MF. Development of social functioning in preschizophrenia children and adolescents: A systematic review. Psychol Bull. 2008;134:561-583.
20. Green MF, Bearden CE, Cannon TD, et al. Social cognition in schizophrenia, Part 1: performance across phase of illness. Schizophr Bull. 2012;38:854-864.
21. Green MF, Penn DL, Bentall R, et al. Social cognition in schizophrenia: An NIMH workshop on definitions, assessment, and research opportunities. Schizophr Bull. 2008;34:1211-1220.
22. Gibson CM, Penn DL, Prinstein MJ, Perkins DO, Belger A. Social skill and social cognition in adolescents at genetic risk for psychosis. Schizophr Res. 2010;122:179-184.
23. Davidson CA, Piskulic D, Addington J, et al. Age-related trajectories of social cognition in youth at clinical high risk for psychosis: An exploratory study. Schizophr Res. 2018;201:130-136.
24. Blakemore SJ, Choudhury S. Development of the adolescent brain: implications for executive function and social cognition. J Child Psychol Psychiatry. 2006;47:296-312.
25. Piskulic D, Liu L, Cadenhead KS, et al. Social cognition over time in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophr Res. 2016;171:176-181.
26. Seidman LJ, Giuliano AJ, Smith CW, et al. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies. Schizophr Bull. 2006;32:507-524.
27. Bearden CE, Rosso IM, Hollister JM, Sanchez LE, Hadley T, Cannon TD. A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia. Schizophr Bull. 2000;26:395-410.
28. Riglin L, Collishaw S, Richards A, et al. Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: A population-based cohort study. Lancet Psychiatry. 2017;4:57-62.
29. Horton LE, Tarbox SI, Olino TM, Haas GL. Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study. Psychiatry Res. 2015;227:339-346.
30. Velthorst E, Fett AJ, Reichenberg A, et al. The 20-year longitudinal trajectories of social functioning in individuals with psychotic disorders. Am J Psychiatry. 2017;174:1075-1085.
31. Bora E. A comparative meta-Analysis of neurocognition in first-degree relatives of patients with schizophrenia and bipolar disorder. Eur Psychiatry. 2017;45:121-128.
32. Bora E, Özerdem A. A meta-Analysis of neurocognition in youth with familial high risk for bipolar disorder. Eur Psychiatry. 2017;44:17-23.
33. Whitney J, Howe M, Shoemaker V, et al. Socio-emotional processing and functioning of youth at high risk for bipolar disorder. J Affect Disord. 2013;148:112-117.
34. McCormack C, Green MJ, Rowland JE, et al. Neuropsychological and social cognitive function in young people at genetic risk of bipolar disorder. Psychol Med. 2016;46:745-758.
35. Reichart CG, der Ende J, Wals M, et al. Social functioning of bipolar offspring. J Affect Disord. 2007;98:207-213.
36. Goldstein TR, Birmaher B, Axelson D, et al. Psychosocial functioning among bipolar youth. J Affect Disord. 2009;114:174-183.
37. Mollon J, David AS, Zammit S, Lewis G, Reichenberg A. Course of cognitive development from infancy to early adulthood in the psychosis spectrum. JAMA Psychiatry. 2018;75:270-279.
38. Mors O, Perto GP, Mortensen PB. The Danish psychiatric central research register. Scand J Public Health. 2011;39:54-57.
39. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish civil registration system. A cohort of eight million persons. Dan Med Bull. 2006;53:441-449.
40. Thorup AA, Ellersgaard DV, et al. The Danish high risk and resilience study-VIA 7-A cohort study of 520 7-year-old children born of parents diagnosed with either schizophrenia, bipolar disorder or neither of these two mental disorders. BMC Psychiatry. 2015;15:233.
41. Cambridge Neuropsychological Testing Automated Battery. Cambridge Cognition. Cambridge, UK: Cambridge Cognition Limited; 2012.
42. White S, Hill E, Happé F, Frith U. Revisiting the strange stories: revealing mentalizing impairments in autism. Child Dev. 2009;80:1097-1117.
43. Castelli F, Frith C, Happé F, Frith U. Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain. 2002;125:1839-1849.
44. White SJ, Coniston D, Rogers R, Frith U. Developing the Frith-Happé animations: A quick and objective test of Theory of Mind for adults with autism. Autism Res. 2011;4:149-154.
45. Abell F, Happé F, Frith U. Do triangles play tricks? Attribution of mental states to animated shapes in normal and abnormal development. Cognitive Development 2000;15:1-16.
46. Wong D, Maybery M, Bishop DV, Maley A, Hallmayer J. Profiles of executive function in parents and siblings of individuals with autism spectrum disorders. Genes Brain Behav. Sweden, Danish version 2006;5:561-576.
47. Bishop DVM. Test for Reception of Grammar. Sweden, Danish version: Pearson, 2010.
48. Bishop DVM. The Children?s Communication Checklist-2. Sweden, Danish version: Pearson, 2012.
49. Vangkilde A, Schmock H, et al. Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome. J Neurodev Disord. 2016;8:42.
50. Constantino JN, Davis SA, Todd RD, et al. Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. J Autism Dev Disord. 2003;33:427-433.
51. Sparrow SS, Cincchetti DV, Balla DA. Vineland-II Vineland Adaptive Behavior Scales. 2nd ed. Stockholm, Sweden: Pearson education, Inc., 2006.
52. STATA version 13. College Station, TX: StataCorp; 2018.
53. IBM SPSS Statistics for Windows, Version 22.0. Amonk, NY: IBM Corp; 2013.
54. Field A. Everything you never wanted to now about statistics. Discovering Statistics Using IBM SPSS Statistics. 4th ed. London, UK: SAGE Publications Ltd; 2013;79-83.
55. Plumpton CO, Morris T, Hughes DA, White IR. Multiple imputation of multiple multi-item scales when a full imputation model is infeasible. BMC Res Notes. 2016;9:45.
56. Mackinnon A. The use and reporting of multiple imputation in medical research-A review. J Intern Med. 2010;268:586-593.
57. Lumley T, Diehr P, Emerson S, Chen L. The importance of the normality assumption in large public health data sets. Annu Rev Public Health. 2002;23:151-169.
58. Rasic D, Hajek T, Alda M, Uher R. Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: A meta-Analysis of family high-risk studies. Schizophr Bull. 2014;40:28-38.
59. Bora E. Differences in cognitive impairment between schizophrenia and bipolar disorder: considering the role of heterogeneity. Psychiatry Clin Neurosci. 2016;70:424-433.
60. Moessnang C, Schäfer A, Bilek E, et al. Specificity, reliability and sensitivity of social brain responses during spontaneous mentalizing. Soc Cogn Affect Neurosci. 2016;11:1687-1697.
61. Eack SM, Mermon DE, Montrose DM, et al. Social cognition deficits among individuals at familial high risk for schizophrenia. Schizophr Bull. 2010;36:1081-1088.
62. Mar RA. The neural bases of social cognition and story comprehension. Annu Rev Psychol. 2011;62:103-134.
63. Germine L, Robinson EB, Smoller JW, et al. Association between polygenic risk for schizophrenia, neurocognition and social cognition across development. Transl Psychiatry. 2016;6:e924.
64. Eack SM, Greeno CG, Pogue-Geile MF, Newhill CE, Hogarty GE. Assessing social-cognitive deficits in schizophrenia with the Mayer-Salovey-Caruso Emotional Intelligence Test. Schizophr Bull. 2010;36:370-380.
65. Kohler CG, Richard JA, Brensinger CM, et al. Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis. Psychiatry Res. 2014;216:206-212.
66. Brotman MA, Guyer AE, Lawson ES, et al. Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder. Am J Psychiatry. 2008;165:385-389.
67. Hanford LC, Sassi RB, Hall GB. Accuracy of emotion labeling in children of parents diagnosed with bipolar disorder. J Affect Disord. 2016;194:226-233.
68. Reichenberg A, Caspi A, Harrington H, et al. Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: A 30-year study. Am J Psychiatry. 2010;167:160-169.
69. Tan EJ, Yelland GW, Rossell SL. Characterising receptive language processing in schizophrenia using word and sentence tasks. Cogn Neuropsychiatry. 2016;21:14-31.
70. Roche E, Segurado R, Renwick L, et al. Language disturbance and functioning in first episode psychosis. Psychiatry Res. 2016;235:29-37.
71. Sabb FW, Erp TG, Hardt ME, et al. Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosis. Schizophr Res. 2010;116:173-183.
72. Blokland GAM, Mesholam-Gately RI, Toulopoulou T, et al.; GENUS Consortium. Heritability of neuropsychological measures in schizophrenia and nonpsychiatric populations: A systematic review and meta-Analysis. Schizophr Bull. 2017;43:788-800.
73. Riglin L, Collishaw S, Richards A, et al. The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age. Psychol Med. 2018;48:2153-2158.