The oral microbiome

Emerging Topics in Life Sciences

Volumn 1, Issue 4, 2017, Pages 287-296

  Shaw, Liam P ^a,b   Smith, Andrew M ^a   Roberts, Adam P ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85064896630     PISSN: 23978554     EISSN: 23978562     Source Type: Journal    
DOI: 10.1042/ETLS20170040     Document Type: Review

References (99)

1. van Leeuwenhoek, A. (1683) Letter of 17 September 1683 to the Royal Society, London. Royal Society, MS. 1898. L 1. 69. Available at http://www. dbnl.org/tekst/leeu027alle04_01/leeu027alle04_01_0008.php#b0076 [Accessed 30th October 2017]
2. Woo, P.C.Y., Lau, S.K.P., Teng, J.L.L., Tse, H. and Yuen, K.-Y. (2008) Then and now: Use of 16S rDNA gene sequencing for bacterial identification and discovery of novel bacteria in clinical microbiology laboratories. Clin. Microbiol. Infect. 14, 908-934 https://doi.org/10.1111/j.1469-0691.2008.02070.x
3. Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K. et al. (2010) QIIME allows analysis of high-throughput community sequencing data. Nat. Methods 7, 335-336 https://doi.org/10.1038/nmeth.f.303
4. Morgan, X.C. and Huttenhower, C. (2012) Chapter 12: Human microbiome analysis. PLoS Comput. Biol. 8, e1002808 https://doi.org/10.1371/journal. pcbi.1002808
5. Chu, D.M., Ma, J., Prince, A.L., Antony, K.M., Seferovic, M.D. and Aagaard, K.M. (2017) Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat. Med. 23, 314-326 https://doi.org/10.1038/nm.4272
6. Cephas, K.D., Kim, J., Mathai, R.A., Barry, K.A., Dowd, S.E., Meline, B.S. et al. (2011) Comparative analysis of salivary bacterial microbiome diversity in edentulous infants and their mothers or primary care givers using pyrosequencing. PLoS ONE 6, e23503 https://doi.org/10.1371/journal.pone.0023503
7. Sampaio-Maia, B. and Monteiro-Silva, F. (2014) Acquisition and maturation of oral microbiome throughout childhood: An update. Dent. Res. J. 11, 291-301 11, 291-301 PMID:25097637
8. Zaura, E., Brandt, B.W., Teixeira de Mattos, M.J., Buijs, M.J., Caspers, M.P.M., Rashid, M.-U. et al. (2015) Same exposure but two radically different responses to antibiotics: Resilience of the salivary microbiome versus long-Term microbial shifts in feces. mBio 6, e01693-15 https://doi.org/10.1128/mBio.01693-15
9. Zaura, E., Nicu, E.A., Krom, B.P. and Keijser, B.J.F. (2014) Acquiring and maintaining a normal oral microbiome: Current perspective. Front. Cell. Infect. Microbiol. 4, 85 https://doi.org/10.3389/fcimb.2014.00085
10. Ruby, J. and Barbeau, J. (2002) The buccale puzzle: The symbiotic nature of endogenous infections of the oral cavity. Can. J. Infect. Dis. 13, 34-41 https://doi.org/10.1155/2002/492656
11. Wade, W.G. (2013) The oral microbiome in health and disease. Pharmacol. Res. 69, 137-143 https://doi.org/10.1016/j.phrs.2012.11.006
12. Teles, R., Teles, F., Frias-Lopez, J., Paster, B. and Haffajee, A. (2013) Lessons learned and unlearned in periodontal microbiology. Periodontology 2000 62, 95-162 https://doi.org/10.1111/prd.12010
13. Krishnan, K., Chen, T. and Paster, B.J. (2017) A practical guide to the oral microbiome and its relation to health and disease. Oral Dis. 23, 276-286 https://doi.org/10.1111/odi.12509
14. Warinner, C., Speller, C. and Collins, M.J. (2015) A new era in palaeomicrobiology: Prospects for ancient dental calculus as a long-term record of the human oral microbiome. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370, 20130376 https://doi.org/10.1098/rstb.2013.0376
15. Mark Welch, J.L., Rossetti, B.J., Rieken, C.W., Dewhirst, F.E. and Borisy, G.G. (2016) Biogeography of a human oral microbiome at the micron scale. Proc. Natl Acad. Sci. U.S.A. 113, E791-E800 https://doi.org/10.1073/pnas.1522149113
16. Vartoukian, S.R., Adamowska, A., Lawlor, M., Moazzez, R., Dewhirst, F.E. and Wade, W.G. (2016) In vitro cultivation of 'Unculturable' oral bacteria, facilitated by community culture and media supplementation with siderophores. PLoS ONE 11, e0146926 https://doi.org/10.1371/journal.pone.0146926
17. Eren, A.M., Borisy, , G.G., Huse, S.M. and Mark Welch, J.L. (2014) Oligotyping analysis of the human oral microbiome. Proc. Natl Acad. Sci. U.S.A. 111, E2875-E2884 https://doi.org/10.1073/pnas.1409644111
18. Morales, S.E. and Holben, W.E. (2009) Empirical testing of 16S rRNA gene PCR primer pairs reveals variance in target specificity and efficacy not suggested by in silico analysis. Appl. Environ. Microbiol. 75, 2677-2683 https://doi.org/10.1128/AEM.02166-08
19. Cai, L., Ye, L., Tong, A.H.Y., Lok, S. and Zhang, T. (2013) Biased diversity metrics revealed by bacterial 16S pyrotags derived from different primer sets. PLoS ONE 8, e53649 https://doi.org/10.1371/journal.pone.0053649
20. Kumar, P.S., Brooker, M.R., Dowd, S.E. and Camerlengo, T. (2011) Target region selection is a critical determinant of community fingerprints generated by 16S pyrosequencing. PLoS ONE 6, e20956 https://doi.org/10.1371/journal.pone.0020956
21. Eren, A.M., Maignien, L., Sul, W.J., Murphy, L.G., Grim, S.L., Morrison, H.G. et al. (2013) Oligotyping: Differentiating between closely related microbial taxa using 16S rRNA gene data. Methods Ecol. Evol. 4, 1111-1119 https://doi.org/10.1111/2041-210X.12114
22. Eren, A.M., Morrison, H.G., Lescault, P.J., Reveillaud, J., Vineis, J.H. and Sogin, M.L. (2014) Minimum entropy decomposition: Unsupervised oligotyping for sensitive partitioning of high-throughput marker gene sequences. ISME J. 9, 968-979 https://doi.org/10.1038/ismej.2014.195
23. Berry, M.A., White, J.D., Davis, T.W., Jain, S., Johengen, T.H., Dick, G.J. et al. (2017) Are oligotypes meaningful ecological and phylogenetic units? A case study of microcystis in freshwater lakes. Front. Microbiol. 8, 365 https://doi.org/10.3389/fmicb.2017.00365
24. Tansirichaiya, S., Rahman, M.A., Antepowicz, A., Mullany, P. and Roberts, A.P. (2016) Detection of novel integrons in the metagenome of human saliva. PLoS ONE 11, e0157605 https://doi.org/10.1371/journal.pone.0157605
25. Wu, Y.-W., Rho, M., Doak, T.G. and Ye, Y. (2012) Oral spirochetes implicated in dental diseases are widespread in normal human subjects and carry extremely diverse integron gene cassettes. Appl. Environ. Microbiol. 78, 5288-5296 https://doi.org/10.1128/AEM.00564-12
26. Aminov, R.I. (2011) Horizontal gene exchange in environmental microbiota. Front. Microbiol. 2, 158 https://doi.org/10.3389/fmicb.2011.00158
27. Peterson, G., Kumar, A., Gart, E. and Narayanan, S. (2011) Catecholamines increase conjugative gene transfer between enteric bacteria. Microb. Pathog. 51, 1-8 https://doi.org/10.1016/j.micpath.2011.03.002
28. Donsì, F. and Ferrari, G. (2016) Essential oil nanoemulsions as antimicrobial agents in food. J. Biotechnol. 233, 106-120 https://doi.org/10.1016/j. jbiotec.2016.07.005
29. Wu, D., Kong, Y., Han, C., Chen, J., Hu, L., Jiang, H. et al. (2008) d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int. J. Antimicrob. Agents 32, 421-426 https://doi.org/10.1016/j.ijantimicag.2008.06.010
30. Brading, M.G. and Marsh, P.D. (2003) The oral environment: The challenge for antimicrobials in oral care products. Int. Dent. J. 53, 353-362 https://doi.org/10.1111/j.1875-595X.2003.tb00910.x
31. Sommer, M.O.A., Dantas, G. and Church, G.M. (2009) Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325, 1128-1131 https://doi.org/10.1126/science.1176950
32. Seville, L.A, Patterson, A.J., Scott, K.P., Mullany, P., Quail, M.A., Parkhill, J. et al. (2009) Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. Microb. Drug Resist. 15, 159-166 https://doi.org/10.1089/mdr.2009.0916
33. Ciric, L., Ellatif, M., Sharma, P., Patel, R., Song, X., Mullany, P. et al. (2012) Tn916-like elements from human, oral, commensal streptococci possess a variety of antibiotic and antiseptic resistance genes. Int. J. Antimicrob. Agents 39, 360-361 https://doi.org/10.1016/j.ijantimicag.2011.12.007
34. Roberts, A.P. and Mullany, P. (2010) Oral biofilms: A reservoir of transferable, bacterial, antimicrobial resistance. Expert Rev. Anti. Infect. Ther. 8, 1441-1450 https://doi.org/10.1586/eri.10.106
35. Diaz-Torres, M.L., McNab, R., Spratt, D.A., Villedieu, A., Hunt, N., Wilson, M. et al. (2003) Novel tetracycline resistance determinant from the oral metagenome. Antimicrob. Agents Chemother. 47, 1430-1432 https://doi.org/10.1128/AAC.47.4.1430-1432.2003
36. Reynolds, L.J., Roberts, A.P. and Anjum, M.F. (2016) Effux in the oral metagenome: The discovery of a novel tetracycline and tigecycline ABC transporter. Front. Microbiol. 7, 1923 https://doi.org/10.3389/fmicb.2016.01923
37. Tansirichaiya, S., Reynolds, L.J., Cristarella, G., Wong, L.C., Rosendahl, K. and Roberts, A.P. (2017) Reduced susceptibility to antiseptics Is conferred by heterologous housekeeping genes. Microb. Drug Resist. June 2017, ahead of print https://doi.org/10.1089/mdr.2017.0105
38. Furi, L., Haigh, R., Al Jabri, Z.J.H., Morrissey, I., Ou, H.-Y., León-Sampedro, R. et al. (2016) Dissemination of novel antimicrobial resistance mechanisms through the insertion sequence mediated spread of metabolic genes. Front. Microbiol. 7, 1008 https://doi.org/10.3389/fmicb.2016.01008
39. Utter, D.R., Mark Welch, J.L. and Borisy, G.G. (2016) Individuality, stability, and variability of the plaque microbiome. Front. Microbiol. 7, 564 https://doi. org/10.3389/fmicb.2016.00564
40. David, L.A., Materna, A.C., Friedman, J., Campos-Baptista, M.I., Blackburn, M.C., Perrotta, A. et al. (2014) Host lifestyle affects human microbiota on daily timescales. Genome Biol. 15, R89 https://doi.org/10.1186/gb-2014-15-7-r89
41. Mark Welch, J.L., Utter, D.R., Rossetti, B.J., Mark Welch, D.B., Eren, A.M. and Borisy, G.G. (2014) Dynamics of tongue microbial communities with single-nucleotide resolution using oligotyping. Front. Microbiol. 5, 568 https://doi.org/10.3389/fmicb.2014.00568
42. Abeles, S.R., Robles-Sikisaka, R., Ly, M., Lum, A.G., Salzman, J., Boehm, T.K. et al. (2014) Human oral viruses are personal, persistent and gender-consistent. ISME J. 8, 1753-1767 https://doi.org/10.1038/ismej.2014.31
43. Wang, J., Gao, Y. and Zhao, F. (2016) Phage-bacteria interaction network in human oral microbiome. Environ. Microbiol. 18, 2143-2158 https://doi. org/10.1111/1462-2920.12923
44. Chen, T., Yu, W.-H., Izard, J., Baranova, O.V., Lakshmanan, A. and Dewhirst, F.E. (2010) The human oral microbiome database: A web accessible resource for investigating oral microbe taxonomic and genomic information. Database 2010, baq013 https://doi.org/10.1093/database/baq013
45. Dewhirst, F.E, Chen, T., Izard, J., Paster, B.J, Tanner, A.C.R., Yu, W.-H. et al. (2010) The human oral microbiome. J. Bacteriol. 192, 5002-5017 https://doi.org/10.1128/JB.00542-10
46. Nasidze, I., Li, J., Quinque, D., Tang, K. and Stoneking, M. (2009) Global diversity in the human salivary microbiome. Genome Res. 19, 636-643 https://doi.org/10.1101/gr.084616.108
47. Marsh, P.D. (2003) Are dental diseases examples of ecological catastrophes? Microbiology 149, 279-294 https://doi.org/10.1099/mic.0.26082-0
48. Cordain, L., Eaton, S.B, Sebastian, A., Mann, N., Lindeberg, S., Watkins, B.A. et al. (2005) Origins and evolution of the Western diet: Health implications for the 21st century. Am. J. Clin. Nutr. 81, 341-354 PMID:15699220
49. Adler, C.J., Dobney, K., Weyrich, L.S., Kaidonis, J., Walker, A.W., Haak, W. et al. (2013) Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions. Nat. Genet. 45, 450-455 https://doi.org/10.1038/ng.2536
50. Wu, J., Peters, B.A, Dominianni, C., Zhang, Y., Pei, Z., Yang, L. et al. (2016) Cigarette smoking and the oral microbiome in a large study of American adults. ISME J. 10, 2435-2446 https://doi.org/10.1038/ismej.2016.37
51. Nociti, F.H, Casati, M.Z. and Duarte, P.M. (2015) Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontology 2000. 67, 187-210 https://doi.org/10.1111/prd.12063
52. Bonder, M.J, Kurilshikov, A., Tigchelaar, E.F, Mujagic, Z., Imhann, F., Vila, A.V. et al. (2016) The effect of host genetics on the gut microbiome. Nat. Genet. 48, 1407-1412 https://doi.org/10.1038/ng.3663
53. Nunes, T., Fiorino, G., Danese, S. and Sans, M. (2011) Familial aggregation in inflammatory bowel disease: Is it genes or environment? World J. Gastroenterol. 17, 2715-2722 https://doi.org/10.3748/wjg.v17.i22.2715
54. Lax, S., Smith, D.P., Hampton-Marcell, J., Owens, S.M., Handley, K.M., Scott, N.M. et al. (2014) Longitudinal analysis of microbial interaction between humans and the indoor environment. Science 345, 1048-1052 https://doi.org/10.1126/science.1254529
55. Abeles, S.R., Jones, M.B., Santiago-Rodriguez, T.M., Ly, M., Klitgord, N., Yooseph, S. et al. (2016) Microbial diversity in individuals and their household contacts following typical antibiotic courses. Microbiome 4, 39 https://doi.org/10.1186/s40168-016-0187-9
56. Song, S.J., Lauber, C., Costello, E.K., Lozupone, C.A., Humphrey, G., Berg-Lyons, D. et al. (2013) Cohabiting family members share microbiota with one another and with their dogs. eLife 2, e00458 https://doi.org/10.7554/eLife.00458
57. Costello, E.K., Lauber, C.L., Hamady, M., Fierer, N., Gordon, J.I., Knight, R. (2009) Bacterial community variation in human body habitats across space and time. Science 326, 1694-1697 https://doi.org/10.1126/science.1177486
58. Stahringer, S.S., Clemente, J.C., Corley, R.P., Hewitt, J., Knights, D., Walters, W.A. et al. (2012) Nurture trumps nature in a longitudinal survey of salivary bacterial communities in twins from early adolescence to early adulthood. Genome Res. 22, 2146-2152 https://doi.org/10.1101/gr.140608. 112
59. Turnbaugh, P.J., Hamady, M., Yatsunenko, T., Cantarel, B.L., Duncan, A., Ley, R.E. et al. (2009) A core gut microbiome in obese and lean twins. Nature 457, 480-484 https://doi.org/10.1038/nature07540
60. Takeshita, T., Matsuo, K., Furuta, M., Shibata, Y., Fukami, K., Shimazaki, Y. et al. (2014) Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults. Sci. Rep. 4, 6990 https://doi.org/10.1038/srep06990
61. Mason, M.R., Nagaraja, H.N., Camerlengo, T., Joshi, V. and Kumar, P.S. (2013) Deep sequencing identifies ethnicity-specific bacterial signatures in the oral microbiome. PLoS ONE 8, e77287 https://doi.org/10.1371/journal.pone.0077287
62. Blekhman, R., Goodrich, J.K., Huang, K., Sun, Q., Bukowski, R., Bell, J.T. et al. (2015) Host genetic variation impacts microbiome composition across human body sites. Genome Biol. 16, 191 https://doi.org/10.1186/s13059-015-0759-1
63. La Cava, A. and Matarese, G. (2004) The weight of leptin in immunity. Nat. Rev. Immunol. 4, 371-379 https://doi.org/10.1038/nri1350
64. Shaw, L., Ribeiro, A.L.R., Levine, A.P, Pontikos, N., Balloux, F., Segal, A.W. et al. (2017) The human oral microbiome is shaped by shared environment rather than genetics: Evidence from a large family of closely related individuals. mBio 8, e01237-17 https://doi.org/10.1128/mBio.01237-17
65. Igartua, C., Davenport, E.R, Gilad, Y., Nicolae, D.L, Pinto, J. and Ober, C. (2017) Host genetic variation in mucosal immunity pathways influences the upper airway microbiome. Microbiome 5, 16 https://doi.org/10.1186/s40168-016-0227-5
66. Fábián, T.K, Hermann, P., Beck, A., Fejérdy, P. and Fábián, G. (2012) Salivary defense proteins: Their network and role in innate and acquired oral immunity. Int. J. Mol. Sci. 13, 4295-4320 https://doi.org/10.3390/ijms13044295
67. Brandtzaeg, P. (2013) Secretory immunity with special reference to the oral cavity. J. Oral Microbiol. 5, 20401 https://doi.org/10.3402/jom.v5i0.20401
68. Mathews, S.A., Kurien, B.T. and Scofield, R.H. (2008) Oral manifestations of Sjögren's syndrome. J. Dent. Res. 87, 308-318 https://doi.org/10.1177/154405910808700411
69. Entesarian, M., Dahlqvist, J., Shashi, V., Stanley, C.S., Falahat, B., Reardon, W. et al. (2007) FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG). Eur. J. Hum. Genet. 15, 379-382 https://doi.org/10.1038/sj.ejhg.5201762
70. Kawai, T. and Akira, S. (2009) The roles of TLRs, RLRs and NLRs in pathogen recognition. Int. Immunol. 21, 317-337 https://doi.org/10.1093/intimm/dxp017
71. Crome, S.Q., Wang, A.Y. and Levings, M.K. (2010) Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease. Clin. Exp. Immunol. 159, 109-119 https://doi.org/10.1111/j.1365-2249.2009.04037.x
72. Matsui, K. and Sano, H. (2017) T helper 17 cells in primary Sjögren's syndrome. J. Clin. Med. 6, 65 https://doi.org/10.3390/jcm6070065
73. Luo, Z., Wang, H., Wu, Y., Sun, Z. and Wu, Y. (2014) Clinical significance of IL-23 regulating IL-17A and/or IL-17F positive Th17 cells in chronic periodontitis. Mediat. Inflamm. 2014, 1-9 https://doi.org/10.1155/2014/627959
74. Wang, K., Miao, T., Lu, W., He, J., Cui, B., Li, J. et al. (2015) Analysis of oral microbial community and Th17-associated cytokines in saliva of patients with oral lichen planus. Microbiol. Immunol. 59, 105-113 https://doi.org/10.1111/1348-0421.12232
75. Dutzan, N., Abusleme, L., Bridgeman, H., Greenwell-Wild, T., Zangerle-Murray, T., Fife, M.E. et al. (2017) On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier. Immunity 46, 133-147 https://doi.org/10.1016/j.immuni.2016.12.010
76. Tesmer, L.A., Lundy, S.K., Sarkar, S. and Fox, D.A. (2008) Th17 cells in human disease. Immunol. Rev. 223, 87-113 https://doi.org/10.1111/j. 1600-065X.2008.00628.x
77. Meurman, J.H. and Stamatova, I. (2007) Probiotics: Contributions to oral health. Oral Dis. 13, 443-451 https://doi.org/10.1111/j.1601-0825.2007.01386.x
78. Gruner, D., Paris, S. and Schwendicke, F. (2016) Probiotics for managing caries and periodontitis: Systematic review and meta-analysis. J. Dent. 48, 16-25 https://doi.org/10.1016/j.jdent.2016.03.002
79. Darveau, R.P. (2010) Periodontitis: A polymicrobial disruption of host homeostasis. Nat. Rev. Microbiol. 8, 481-490 https://doi.org/10.1038/nrmicro2337
80. Bartold, P.M. and Van Dyke, T.E. (2013) Periodontitis: A host-mediated disruption of microbial homeostasis. unlearning learned concepts. Periodontology 2000 62, 203-217 https://doi.org/10.1111/j.1600-0757.2012.00450.x
81. Laudenbach, J.M. and Simon, Z. (2014) Common dental and periodontal diseases. Med. Clin. North Am. 98, 1239-1260 https://doi.org/10.1016/j. mcna.2014.08.002
82. Takahashi, N. and Nyvad, B. (2011) The role of bacteria in the caries process. J. Dent. Res. 90, 294-303 https://doi.org/10.1177/0022034510379602
83. Miller, W.D. (1890) The Micro-Organisms of the Human Mouth: The Local and General Diseases Which are Caused by them. Philadelphia: The S.S. White Dental MFG. Co. Available at: https://archive.org/stream/microorganismsof00mill [Accessed 30th October 2017]
84. Rugg-Gunn, A. (2013) Dental caries: Strategies to control this preventable disease. Acta Med. Acad. 42, 117-130 https://doi.org/10.5644/ama2006-124.80
85. Moynihan, P.J. and Kelly, S.A.M. (2014) Effect on caries of restricting sugars intake: Systematic review to inform WHO guidelines. J. Dent. Res. 93, 8-18 https://doi.org/10.1177/0022034513508954
86. Bradshaw, D.J. and Lynch, R.J.M. (2013) Diet and the microbial aetiology of dental caries: new paradigms. Int. Dent. J. 63(suppl. 2), 64-72 https://doi.org/10.1111/idj.12082
87. Moynihan, P. (2016) Sugars and dental caries: Evidence for setting a recommended threshold for intake. Adv. Nutr. An. Int. Rev. J. 7, 149-156 https://doi.org/10.3945/an.115.009365
88. Cochran, D.L. (2008) Inflammation and bone loss in periodontal disease. J. Periodontol. 79, 1569-1576 https://doi.org/10.1902/jop.2008.080233
89. Hajishengallis, G. and Lamont, R.J. (2012) Beyond the red complex and into more complexity: The polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol. Oral Microbiol. 27, 409-419 https://doi.org/10.1111/j.2041-1014.2012.00663.x
90. Kakuta, E., Nomura, Y., Morozumi, T., Nakagawa, T., Nakamura, T., Noguchi, K. et al. (2017) Assessing the progression of chronic periodontitis using subgingival pathogen levels: A 24-month prospective multicenter cohort study. BMC Oral Health 17, 46 https://doi.org/10.1186/s12903-017-0337-x
91. Sheets, S.M., Robles-Price, A.G., McKenzie, R.M.E., Casiano, C.A. and Fletcher, H.M. (2008) Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis. Front. Biosci. 13, 3215-3238 https://doi.org/10.2741/2922
92. Mydel, P., Takahashi, Y., Yumoto, H., Sztukowska, M., Kubica, M., Gibson, F.C. et al. (2006) Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog. 2, e76 https://doi.org/10.1371/journal.ppat.0020076
93. Beck, J., Garcia, R., Heiss, G., Vokonas, P.S. and Offenbacher, S. (1996) Periodontal disease and cardiovascular disease. J. Periodontol. 67, 1123-1137 https://doi.org/10.1902/jop.1996.67.10s.1123
94. Choi, Y.S., Kim, Y., Yoon, H.-J., Baek, K.J., Alam, J., Park, H.K. et al. (2016) The presence of bacteria within tissue provides insights into the pathogenesis of oral lichen planus. Sci. Rep. 6, 29186 https://doi.org/10.1038/srep29186
95. Wang, K., Lu, W., Tu, Q., Ge, Y., He, J., Zhou, Y. et al. (2016) Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus. Sci. Rep. 6, 22943 https://doi.org/10.1038/srep22943
96. He, Y., Gong, D., Shi, C., Shao, F., Shi, J. and Fei, J. (2017) Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus. Oral Dis. 23, 674-682 https://doi.org/10.1111/odi.12657
97. Ertugrul, A.S., Arslan, U., Dursun, R. and Hakki, S.S. (2013) Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis. Int. J. Oral Sci. 5, 92-97 https://doi.org/10.1038/ijos.2013.30
98. Heron, S.E. and Elahi, S. (2017) HIV infection and compromised mucosal immunity: Oral manifestations and systemic inflammation. Front. Immunol. 8, 241 https://doi.org/10.3389/fimmu.2017.00241
99. Kistler, J.O, Arirachakaran, P., Poovorawan, Y., Dahlén, G. and Wade, W.G. (2015) The oral microbiome in human immunodeficiency virus (HIV)-positive individuals. J. Med. Microbiol. 64, 1094-1101 https://doi.org/10.1099/jmm.0.000128