Secretory immunity with special reference to the oral cavity

Journal of Oral Microbiology

Volumn 5, Issue 2013, 2013, Pages

  Brandtzaeg, Per ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Crevicular fluid; Gut associated lymphoid tissue (GALT); IgA; IgG; Mucosa associated lymphoid tissue (MALT); Mucosal vaccination; Nasopharynx associated lymphoid tissue (NALT); Polymeric Ig receptor (pIgR); Salivary glands; Secretory component (SC)

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; SECRETORY COMPONENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADENOID; ALLERGY; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BREAST FEEDING; CERVICAL LYMPH NODE; DENTAL CARIES; DISEASE ASSOCIATION; EFFECTOR CELL; ENZYME ACTIVATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN DEFICIENCY; IMMUNOSTIMULATION; INTESTINE LYMPHATIC TISSUE; MEMBRANE BIOLOGY; MEMORY CELL; MOUTH CAVITY; NONHUMAN; NUTRITION; PALATINE TONSIL; PERIODONTAL DISEASE; PROTEIN EXPRESSION; RESPIRATORY TRACT INFECTION; SALIVA ANALYSIS; SALIVA LEVEL; SALIVATION;

EID: 84879309314     PISSN: None     EISSN: 20002297     Source Type: Journal    
DOI: 10.3402/jom.v5i0.20401     Document Type: Article

References (195)

1. Gordon BL. The romance of medicine. The story of the evolution of medicine from occult practices and primitive times. Philadelphia: Davis Co.; 1945.
2. Besredka A. De la vaccination contre les états typhoides par la voie buccale. Ann Inst Pasteur 1919; 33: 882-903.
3. Davies A. An investigation into the serological properties of dysentery stools. Lancet 1922; 2: 1009-12.
4. Besredka A. Local immunization. Baltimore: Williams & Wilkins Company; 1927.
5. Pierce AE. Specific antibodies at mucous surfaces. Vet Rev Annot 1959; 5: 17-36.
6. Ellison SA, Mashimo PA, Mandel ID. Immunochemical studies of human saliva. I. The demonstration of serum proteins in whole and parotid saliva. J Dent Res 1960; 39: 892-8.
7. Hanson Lå , Brandtzaeg P. The discovery of secretory IgA and the mucosal immune system. Immunol Today 1993; 14: 416-7.
8. Tomasi TB, Tan EM, Solomon A, Prendergast RA. Characteristics of an immune system common to certain external secretions. J Exp Med 1965; 121: 101-24.
9. Crabbé PA, Carbonara AO, Heremans JF. The normal human intestinal mucosa as a major source of plasma cells containing gA-immunoglobulin. Lab Invest 1965; 14: 235-48.
10. Brandtzaeg P. Two types of IgA immunocytes in man. Nat New Biol 1973; 243: 142-3.
11. Brandtzaeg P. Presence of J chain in human immunocytes containing various immunoglobulin classes. Nature 1974; 252: 418-20.
12. Brandtzaeg P, Fjellanger I, Gjeruldsen ST. Immunoglobulin M: local synthesis and selective secretion in patients with immunoglobulin A deficiency. Science 1968; 160: 789-91.
13. Brandtzaeg P, Fjellanger I, Gjeruldsen ST. Human secretory immunoglobulins. I. Salivary secretions from individuals with normal or low levels of serum immunoglobulins. Scand J Haematol Suppl 1970; 12: 1-83.
14. Brandtzaeg P. Human secretory immunoglobulin M. An immunochemical and immunohistochemical study. Immunology 1975; 29: 559-70.
15. Nagura H, Brandtzaeg P, Nakane PK, Brown WR. Ultrastructural localization of J chain in human intestinal mucosa. J Immunol 1979; 123: 1044-50.
16. Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique. Immunology 1974; 26: 1101-4.
17. Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components. Differential localization of free and bound SC in secretory epithelial cells. J Immunol 1974; 112: 1553-9.
18. Brandtzaeg P, Prydz H. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 1984; 311: 71-3.
19. Krajci̧ P, Grzeschik KH, Geurts van Kessel AHM, Olaisen B, Brandtzaeg P. The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization. Hum Genet 1991; 87: 642-8.
20. Johansen F-E, Brandtzaeg P. Transcriptional regulation of the mucosal IgA system. Trends Immunol 2004; 25: 150-7.
21. Brandtzaeg P, Halstensen TS, Huitfeldt HS, Krajci K, Kvale D, Scott H, et al. Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract. Ann NY Acad Sci 1992; 664: 157-79.
22. Piskurich JF, Youngman KR, Phillips KM, Hempen PM, Blanchard MH, France JA, et al. Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon- g. Molec Immunol 1997; 34: 75-91.
23. Cao AT, Yao S, Gong B, Elson CO, Cong Y. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. J Immunol 2012; 189: 4666-73.
24. Brandtzaeg P. Gate-keeper function of the intestinal epithelium. Benef Microbes 2013; 4: 67-82.
25. Sletten K, Christensen TB, Brandtzaeg P. Human secretory component - III. Carbohydrates, amino acids and N-terminal sequence. Immunochemistry 1975; 12: 783-5.
26. Corthésy B. Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces. Future Microbiol 2010; 5: 817-29.
27. Brandtzaeg P, Kiyono H, Pabst R, Russell MW. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol 2008; 1: 31-7.
28. Brandtzaeg P. Human secretory immunoglobulins. 4. Quantitation of free secretory piece. Acta Pathol Microbiol Scand B Microbiol Immunol 1971; 79: 189-203.
29. Norderhaug IN, Johansen F-E, Schjerven H, Brandtzaeg P. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol 1999; 19: 481-508.
30. Brandtzaeg P. Human secretory component - VI. Immunoglobulin-binding properties. Immunochemistry 1977; 14: 179-88.
31. Vaerman J-P, Langendries AE, Giffroy DA, Kaetzel CS, Fiani CM, Moro I, et al. Antibody against the human J chain inhibits polymeric Ig receptor-mediated biliary and epithelial transport of human polymeric IgA. Eur J Immunol 1998; 28: 171-82.
32. Johansen F-E, Braathen R, Brandtzaeg P. The J chain is essential for polymeric Ig receptor-mediated epithelial transport of IgA. J Immunol 2001; 167: 5185-92.
33. Braathen R, Hohman VS, Brandtzaeg P, Johansen FE. Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians. J Immunol 2007; 178: 1589-97.
34. Brandtzaeg P, Johansen FE. Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol Rev 2005; 206: 32-63.
35. Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996; 272: 54-60.
36. Johansen FE, Braathen R, Brandtzaeg P. Role of J chain in secretory immunoglobulin formation. Scand J Immunol 2000; 52: 240-8.
37. Mosmann TR, Gravel Y, Williamson AR, Baumal R. Modification and fate of J chain in myeloma cells in the presence and absence of polymeric immunoglobulin secretion. Eur J Immunol 1978; 8: 94-101.
38. Brandtzaeg P, Berdal P. J chain in malignant human IgG immunocytes. Scand J Immunol 1975; 4: 403-7.
39. Brandtzaeg P. Human secretory immunoglobulins. VII. Concentrations of parotid IgA and other secretory proteins in relation to the rate of flow and duration of secretory stimulus. Arch Oral Biol 1971; 16: 1295-310.
40. Brandtzaeg P. Salivary immunoglobulins. In: Tenovuo JO, ed. Human saliva: clinical chemistry and microbiology, vol. II. Boca Raton, FL: CRC Press; 1989. p. 1-54.
41. Natvig IB, Johansen FE, Nordeng TW, Haraldsen G, Brandtzaeg P. Mechanism for enhanced external transfer of dimeric IgA over pentameric IgM: studies of diffusion, binding to the human polymeric Ig receptor, and epithelial transcytosis. J Immunol 1997; 159: 4330-40.
42. Delacroix DL, Vaerman JP. Function of the human liver in IgA homeostasis in plasma. Ann NY Acad Sci 1983; 409: 383-401.
43. Brandtzaeg P. Immunohistochemical characterization of intracellular J-chain and binding site for secretory component (SC) in human immunoglobulin (Ig)-producing cells. Mol Immunol 1983; 20: 941-66.
44. Brandtzaeg P. Local formation and transport of immunoglobulins related to the oral cavity. In: MacPhee IT, ed. Host resistance to commensal bacteria. London: Churchill Livingstone; 1972. p. 116-50.
45. Booth CK, Dwyer DB, Pacque PF, Ball MJ. Measurement of immunoglobulin A in saliva by particle-enhanced nephelometric immunoassay: sample collection, limits of quantitation, precision, stability and reference range. Ann Clin Biochem 2009; 46: 401-6.
46. Thrane PS, Rognum TO, Brandtzaeg P. Ontogenesis of the secretory immune system and innate defence factors in human parotid glands. Clin Exp Immunol 1991; 86: 342-8.
47. Brandtzaeg P, Nilssen DE, Rognum TO, Thrane PS. Ontogeny of the mucosal immune system and IgA deficiency. Gastroenterol Clin North Am 1991; 20: 397-439.
48. Mellander L, Carlsson B, Jalil F, Soderstrom T, Hanson LA. Secretory IgA antibody response against Escherichia coli antigens in infants in relation to exposure. J Pediatr 1985; 107: 430-3.
49. Bosch JA. Stress and salivary defense systems. The effects of acute stressors on salivary composition and salivary function. Vrije University, the Netherlands: Print partners Ipskamp B.V.; Research Thesis (Academisch Proefschrift), ISBN 90- 9015363-2, 2001, p. 213.
50. Mandel ID, Khurana HS. The relation of human salivary gA globulin and albumin to flow rate. Arch Oral Biol 1969; 14: 1433-5.
51. Oon CH, Lee J. A controlled quantitative study of parotid salivary secretory IgA-globulin in normal adults. J Immunol Methods 1972; 2: 45-8.
52. Grönblad EA. Concentration of immunoglobulins in human whole saliva: effect of physiological stimulation. Acta Odontol Scand 1982; 40: 87-95.
53. Rudney JD, Smith QT. Relationships between levels of lysozyme, lactoferrin, salivary peroxidase, and secretory immunoglobulin A in stimulated parotid saliva. Infect Immun 1985; 49: 469-75.
54. Stuchell RN, Mandel ID. Studies of secretory IgA in cariesresistant and caries-susceptible adults. Adv Exp Med Biol 1978; 107: 341-8.
55. Gahnberg L, Krasse B. Salivary immunoglobulin A antibodies reacting with antigens from oral streptococci: longitudinal study in humans. Infect Immun 1981; 33: 697-703.
56. Rudney JD, Kajander KC, Smith QT. Correlations between human salivary levels of lysozyme, lactoferrin, salivary peroxidase and secretory immunoglobulin A with different stimulatory states and over time. Arch Oral Biol 1985; 30: 765-71.
57. Korsrud FR, Brandtzaeg P. Characterization of epithelial elements in human major salivary glands by functional markers: localization of amylase, lactoferrin, lysozyme, secretory component and secretory immunoglobulins by paired immunofluorescence staining. J Histochem Cytochem 1982; 20: 657-66.
58. Deslauriers N, Oudghiri M, Seguin J, Trudel L. The oral immune system: dynamics of salivary immunoglobulin production in the inbred mouse. Immunol Invest 1986; 15: 339-49.
59. Aase A, Sinnadurai K, Sack D, Fleckenstein JM, Sommerfelt H, Brandtzaeg P. The use of multiplex immunoassay and flow cytometry to measure salivary IgA against multiple enterotoxigenic Escherichia coli antigens. Abstract, 7th Conference on Global Health and Vaccination Research, Trondheim, 26-27 September, 2012.
60. Widerström L, Bratthall D. Increased IgA levels in saliva during pregnancy. Scand J Dent Res 1984; 92: 33-7.
61. Kerr AC. The physiological regulation of salivary secretions in man. In: Greulich RC, MacDonald JB, Rushton MA, eds. International series of monographs on oral biology, vol. 1. Oxford: Pergamon Press; 1961.
62. Tenovuo J, Lehtonen OP, Aaltonen AS, Vilja P, Tuohimaa P. Antimicrobial factors in whole saliva of human infants. Infect Immun 1986; 51: 49-53.
63. Crawford JM, Taubman MA, Smith DJ. Minor salivary glands as a major source of secretory immunoglobin A in the human oral cavity. Science 1975; 190: 1206-9.
64. Sonesson M, Hamberg K, Wallengren ML, Matsson L, Ericson D. Salivary IgA in minor-gland saliva of children, adolescents, and young adults. Eur J Oral Sci 2011; 119: 15-20.
65. Müller F, Frøland ss, Hvatum M, Radl J, Brandtzaeg P. Both IgA subclasses are reduced in parotid saliva from patients with AIDS. Clin Exp Immunol 1991; 83: 203-9.
66. Brandtzaeg P, Fjellanger I, Gjeruldsen ST. Adsorption of immunoglobulin A onto oral bacteria in vivo. J Bacteriol 1968; 96: 242-9.
67. Kristiansen BE. Collection of mucosal secretion by synthetic discs for quantitation of secretory IgA and bacteria. J Immunol Methods 1984; 73: 251-7.
68. Berg E, Tjell JC. Paraffin chewing as a saliva-stimulating agent. J Dent Res 1969; 48: 325.
69. Johansen FE, Pekna M, Norderhaug IN, Haneberg B, Hietala MA, Krajci P, et al. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J Exp Med 1999; 190: 915-22.
70. Korsrud FR, Brandtzaeg P. Quantitative immunohistochemistry of immunoglobulin- and J-chain-producing cells in human parotid and submandibular salivary glands. Immunology 1980; 39: 129-40.
71. Brandtzaeg P. The secretory immune system of lactating human mammary glands compared with other exocrine organs. Ann NY Acad Sci 1983; 409: 353-81.
72. Brandtzaeg P. Immunohistochemical studies of various aspects of glandular immunoglobulin transport in man. Histochem J 1977; 9: 553-72.
73. Moro I, Umemura S, Cargo ss, Mestecky J. Immunohistochemical distribution of immmunoglobulins, lactoferrin, and lysozyme in human minor salivary glands. J Oral Pathol 1984; 13: 97-104.
74. Matthews JB, Potts AJC, Basu MK. Immunoglobulincontaining cells in normal human labial salivary glands. Int Arch Allergy Appl Immunol 1985; 77: 374-6.
75. Thrane PS, Sollid LM, Haanes HR, Brandtzaeg P. Clustering of IgA-producing immunocytes related to HLA-DR-positive ducts in normal and inflamed salivary glands. Scand J Immunol 1992; 35: 43-51.
76. Kilian M, Reinholdt J, Lomholt H, Poulsen K, Frandsen EV. Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence. APMIS 1996; 104: 321-38.
77. Kett K, Brandtzaeg P, Radl J, Haaijman JJ. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. J Immunol 1986; 136: 3631-5.
78. Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ. Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity. Mucosal Immunol 2009; 2: 74-84.
79. Brandtzaeg P. Function of mucosa-associated lymphoid tissue in antibody formation. Immunol Invest 2010; 39: 303-55.
80. Agnello D, Denimal D, Lavaux A, Blondeau-Germe L, Lu B, Gerard NP, et al. Intra-rectal immunization and IgA antibodysecreting cell homing to the small intestine. J Immunol In press.
81. Johansen F-E, Baekkevold ES, Carlsen HS, Farstad IN, Soler D, Brandtzaeg P. Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils. Blood 2005; 106: 593-600.
82. Mestecky J, McGhee JR, Arnold RR, Michalek SM, Prince SJ, Babb JL. Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. J Clin Invest 1978; 61: 731-7.
83. Weisz-Carrington P, Roux ME, McWilliams M, Phillips- Quagliata JM, Lamm ME. Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system. J Immunol 1979; 123: 1705-8.
84. Jackson DE, Lally ET, Nakamura MC, Montgomery PC. Migration of IgA-bearing lymphocytes into salivary glands. Cell Immunol 1981; 63: 203-9.
85. Czerkinsky C, Svennerholm AM, Quiding M, Jonsson R, Holmgren J. Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans. Infect Immun 1991; 59: 996-1001.
86. al-Bayaty HF, Aldred MJ, Walker DM, Newcombe RG, Swift G, Smith PM, et al. Salivary and serum antibodies to gliadin in the diagnosis of celiac disease. J Oral Pathol Med 1989; 18: 578-81.
87. Hakeem V, Fifield R, al-Bayaty HF, Aldred MJ, Walker DM, Williams J, et al. Salivary IgA antigliadin antibody as a marker for coeliac disease. Arch Dis Child 1992; 67: 724-7.
88. Jertborn M, Svennerholm AM, Holmgren J. Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease. J Clin Microbiol 1986; 24: 203-9.
89. Brandtzaeg P. Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways. Am J Respir Crit Care Med 2011; 183: 1595-604.
90. Brandtzaeg P. Immunology of tonsils and adenoids: everything the ENT surgeon needs to know. Int J Pediatr Otorhinolaryngol 2003; 67(Suppl. 1): S69-76.
91. Kiyono H, Fukuyama S. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol 2004; 4: 699-710.
92. Kuper CF, Koornstra PJ, Hameleers DM, Biewenga J, Spit BJ, Duijvestijn AM, et al. The role of nasopharyngeal lymphoid tissue. Immunol Today 1992; 13: 219-24.
93. Nair PNR, Schroeder HE. Duct-associated lymphoid tissue (DALT) of minor salivary glands and mucosal immunity. Immunology 1986; 57: 171-80.
94. Fukuizumi T, Inoue H, Tsujisawa T, Uchiyama C. Tonsillar application of formalin-killed cells of Streptococcus sobrinus reduces experimental dental caries in rabbits. Infect Immun 1999; 67: 426-8.
95. Sun Y, Shi W, Yang JY, Zhou DH, Chen YQ, Zhang Y, et al. Flagellin-PAc fusion protein is a high-efficacy anti-caries mucosal vaccine. J Dent Res 2012; 91: 941-7.
96. Quiding-Järbrink M, Granström G, Nordström I, Holmgren J, Czerkinsky C. Induction of compartmentalized B-cell responses in human tonsils. Infect Immun 1995; 63: 853-7.
97. Stoltenberg L, Vege A, Saugstad OD, Rognum TO. Changes in the concentration and distribution of immunoglobulinproducing cells in SIDS palatine tonsils. Pediatr Allergy Immunol 1995; 6: 48-55.
98. Thrane P, Rognum TO, Brandtzaeg P. Increased immune response in upper respiratory and digestive tracts in SIDS. Lancet 1990; 335: 229-30.
99. Gleeson M, Clancy RL, Cripps AW. Mucosal immune response in a case of sudden infant death syndrome. Pediatr Res 1993; 33: 554-6.
100. Brandtzaeg P. Regionalized immune function of tonsils and adenoids. Immunol Today 1999; 20: 383-4.
101. Czerkinsky C, Cuburu N, Kweon MN, Anjuere F, Holmgren J. Sublingual vaccination. Hum Vaccin 2011; 7: 110-4.
102. Kulis M, Saba K, Kim EH, Bird JA, Kamilaris N, Vickery BP, et al. Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy. J Allergy Clin Immunol 2012; 129: 1159-62.
103. Ogra PL. Effect of tonsillectomy and adenoidectomy on nasopharyngeal antibody response to poliovirus. New Engl J Med 1971; 284: 59-64.
104. Jeschke R, Ströder J. Verlaufsbeobachtung klinischer und immunologischer Parameter, insbesondere des Speichel-IgA, bei tonsillektomierten. Kindern Klin Pädiat 1980; 192: 51-60.
105. D'Amelio R, Palmisano L, Le Moli S, Seminara R, Aiuti F. Serum and salivary IgA levels in normal subjects: comparison between tonsillectomized and non-tonsillectomized subjects. Int Archs Allergy Appl Immunol 1982; 68: 256-9.
106. Cantani A, Bellioni P, Salvinelli F, Businco L. Serum immunoglobulins and secretory IgA deficiency in tonsillectomized children. Ann Allergy 1986; 57: 413-6.
107. Lenander-Lumikari M, Tenovuo J, Puhakka HJ, Malvaranta T, Ruuskanen O, Meurman O, et al. Salivary antimicrobial proteins and mutans streptococci in tonsillectomized children. Pediatr Dent 1992; 14: 86-91.
108. Kirstila V, Tenovuo J, Ruuskanen O, Suonpaa J, Meurman O, Vilja P. Longitudinal analysis of human salivary immunoglobulins, non-immune antimicrobial agents, and microflora after tonsillectomy. Clin Immunol Immunopathol 1996; 80: 110-5.
109. Östergaard PA. IgA levels and carrier rate of pathogenic bacteria in 27 children previously tonsillectomized. Acta Path Microbiol Scand Sect C 1977; 85: 178-86.
110. Hess M, Kugler J, Haake D, Lamprecht J. Reduced concentration of secretory IgA indicates changes of local immunity in children with adenoid hyperplasia and secretory otitis media. ORL J Otorhinolaryngol Relat Spec 1991; 53: 339-41.
111. Gleeson M, Cripps AW, Clancy RL. Modifiers of the human mucosal immune system. Immunol Cell Biol 1995; 73: 397-404.
112. Mellander L, Carlsson B, Hanson LA. Secretory IgA and IgM antibodies to E. coli O and poliovirus type I antigens occur in amniotic fluid, meconium and saliva from newborns. A neonatal immune response without antigenic exposure: a result of anti-idiotypic induction? Clin Exp Immunol 1986; 63: 555-61.
113. Bjerke K, Brandtzaeg P. Terminally differentiated human intestinal B cells. IgA and IgG subclass-producing immunocytes in the distal ileum, including Peyer's patches, compared with lymph nodes and palatine tonsils. Scand J Immunol 1990; 32: 61-7.
114. Fitzsimmons SP, Evans MK, Pearce CL, Sheridan MJ, Wientzen R, Cole MF. Immunoglobulin A subclasses in infants' saliva and in saliva and milk from their mothers. J Pediatr 1994; 124: 566-73.
115. Burgio GR, Lanzavecchia A, Plebani A, Jayakar S, Ugazio AG. Ontogeny of secretory immunity: levels of secretory IgA and natural antibodies in saliva. Pediatr Res 1980; 14: 1111-4.
116. Roberts SA, Wincup G, Harries DA. Mucosal receptor for IgA in the breast-fed neonate. Early Hum Dev 1980; 4: 161-6.
117. Cripps AW, Gleeson M, Clancy RL. Molecular characteristics of IgA in infant saliva. Scand J Immunol 1989; 29: 317-24.
118. Smith DJ, King WF, Taubman MA. Isotype, subclass and molecular size of immunoglobulins in salivas from young infants. Clin Exp Immunol 1989; 76: 97-102.
119. Fagerås M, Tomici̧ć S, Voor T, Björkstén B, Jenmalm MC. Slow salivary secretory IgA maturation may relate to low microbial pressure and allergic symptoms in sensitized children. Pediatr Res 2011; 70: 572-7.
120. Carlsson B, Zaman S, Mellander L, Jalil F, Hanson LA. Secretory and serum immunoglobulin class-specific antibodies to poliovirus after vaccination. J Infect Dis 1985; 152: 1238-44.
121. Mellander L, Carlsson B, Hanson LA. Appearance of secretory IgM and IgA antibodies to Escherichia coli in saliva during early infancy and childhood. J Pediatr 1984; 104: 564-8.
122. Avanzini MA, Plebani A, Monafo V, Pasinetti G, Teani M, Colombo A, et al. A comparison of secretory antibodies in breast-fed and formula-fed infants over the first six months of life. Acta Paediatr 1992; 81: 296-301.
123. Stephensen CB, Moldoveanu Z, Gangopadhyay NN. Vitamin A deficiency diminishes the salivary immunoglobulin A response and enhances the serum immunoglobulin G response to influenza A virus infection in BALB/c mice. J Nutr 1996; 126: 94-102.
124. Glass RI, Svennerholm AM, Stoll BJ, Khan MR, Huda S, Huq MI, et al. Effects of undernutrition on infection with Vibrio cholerae O1 and on response to oral cholera vaccine. Pediatr Infect Dis J 1989; 8: 105-9.
125. Ma JK, Hikmat BY, Wycoff K, Vine ND, Chargelegue D, Yu L, et al. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nat Med 1998; 4: 601-6.
126. Brown TA, Mestecky J. Immunoglobulin A sublass distribution of naturally occurring salivary antibodies to microbial antigens. Infect Immun 1985; 49: 459-62.
127. Mansa B, Kilian M. Retained antigen-binding activity of Fab fragments of human monoclonal immunoglobulin A1 (IgA1) cleaved by IgA1 protease. Infect Immun 1986; 52: 171-4.
128. Weiser JN, Bae D, Fasching C, Scamurra RW, Ratner AJ, Janoff EN. Antibody-enhanced pneumococcal adherence requires IgA1 protease. Proc Natl Acad Sci USA 2003; 100: 4215-20.
129. Taylor HP, Dimmock NJ. Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG. J Exp Med 1985; 161: 198-209.
130. Brandtzaeg P. Mucosal immunity: induction, dissemination, and effector functions. Scand J Immunol 2009; 70: 505-15.
131. Tsuruta T, Inoue R, Nojima I, Tsukahara T, Hara H, Yajima T. The amount of secreted IgA may not determine the secretory IgA coating ratio of gastrointestinal bacteria. FEMS Immunol Med Microbiol 2009; 56: 185-9.
132. Christensen P, Oxelius V-A. A reaction between some streptococci and IgA myeloma proteins. Acta Pathol Microbiol Scand C 1975; 83: 184-8.
133. Bollinger RR, Everett ML, Wahl SD, Lee YH, Orndorff PE, Parker W. Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili. Mol Immunol 2006; 43: 378-87.
134. Murthy AK, Chaganty BK, Troutman T, Guentzel MN, Yu JJ, Ali SK, et al. Mannose-containing oligosaccharides of nonspecific human secretory immunoglobulin A mediate inhibition of Vibrio cholerae biofilm formation. PLoS One 2011; 6: e16847.
135. Renegar KB, Jackson GD, Mestecky J. In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA. J Immunol 1998; 160: 1219-23.
136. Biesbrock AR, Reddy MS, Levine MJ. Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect Immun 1991; 59: 3492-7.
137. Bonner A, Furtado PB, Almogren A, Kerr MA, Perkins SJ. Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy. J Immunol 2008; 180: 1008-18.
138. Quan C, Berneman A, Pires R, Avrameas S, Bouvet JP. Natural polyreactive secretory immunoglobulin A autoantibodies as a possible immune barrier in humans. Infect Immun 1997; 65: 3997-4004.
139. Benckert J, Schmolka N, Kreschel C, Zoller MJ, Sturm A, Wiedenmann B, et al. The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific. J Clin Invest 2011; 121: 1946-55.
140. Di Niro R, Mesin L, Zheng NY, Stamnaes J, Morrissey M, Lee JH, et al. High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nat Med 2012; 18: 441-5.
141. Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, et al. Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med 2012; 209: 2079-97.
142. Rogosch T, Kerzel S, Hoss K, Hoersch G, Zemlin C, Heckmann M, et al. IgA response in preterm neonates shows little evidence of antigen-driven selection. J Immunol 2012; 189: 5449-56.
143. Nogueira RD, Sesso ML, Borges MC, Mattos-Graner RO, Smith DJ, Ferriani VP. Salivary IgA antibody responses to Streptococcus mitis and Streptococcus mutans in preterm and fullterm newborn children. Arch Oral Biol 2012; 57: 647-53.
144. Dunn-Walters DK, Hackett M, Boursier L, Ciclitira PJ, Morgan P, Challacombe SJ, et al. Characteristics of human IgA and IgM genes used by plasma cells in the salivary gland resemble those used in duodenum but not those used in the spleen. J Immunol 2000; 164: 1595-601.
145. Stoel M, Evenhuis WN, Kroese FG, Bos NA. Rat salivary gland reveals a more restricted IgA repertoire than ileum. Mol Immunol 2008; 45: 719-27.
146. Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science 2012; 336: 485-9.
147. van der Waaij LA, Limburg PC, Mesander G, van der Waaij D. In vivo IgA coating of anaerobic bacteria in human faeces. Gut 1996; 38: 348-54.
148. De Palma G, Nadal I, Medina M, Donat E, Ribes-Koninckx C, Calabuig M, et al. Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children. BMC Microbiol 2010; 10: 63.
149. Peterson DA, McNulty NP, Guruge JL, Gordon JI. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2007; 2: 328-39.
150. Spencer J, Klavinskis LS, Fraser LD. The human intestinal IgA response; burning questions. Front Immunol 2012; 3: 108.
151. Brandtzaeg P. The oral secretory immune system with special emphasis on its relation to dental caries. Proc Finn Dent Soc 1983; 79: 71-84.
152. Russell MW, Mestecky J. Potential for immunological intervention against dental caries. J Biol Buccale 1986; 14: 159-75.
153. Brandtzaeg P. Immunology of inflammatory periodontal lesions. Int Dent J 1973; 23: 438-54.
154. Nikfarjam J, Pourpak Z, Shahrabi M, Nikfarjam L, Kouhkan A, Moazeni M, et al. Oral manifestations in selective IgA deficiency. Int J Dent Hyg 2004; 2: 19-25.
155. Fernandes FR, Nagao AT, Mayer MP, Zelante F, Carneiro- Sampaio MM. Compensatory levels of salivary IgM anti- Streptococcus mutans antibodies in IgA-deficient patients. J Investig Allergol Clin Immunol 1995; 5: 151-5.
156. Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 2009; 325: 617-20.
157. Macpherson AJ, Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 2004; 303: 1662-5.
158. Ørstavik D, Brandtzaeg P. Secretion of parotid IgA in relation to gingival inflammation and dental caries experience in man. Arch Oral Biol 1975; 20: 701-4.
159. Taubman MA, Smith DJ. Significance of salivary antibody in dental disease. Ann NY Acad Sci 1993; 694: 202-15.
160. Nogueira RD, Alves AC, Napimoga MH, Smith DJ, Mattos- Graner RO. Characterization of salivary immunoglobulin A responses in children heavily exposed to the oral bacterium Streptococcus mutans: influence of specific antigen recognition in infection. Infect Immun 2005; 73: 5675-84.
161. Gregory RL, Filler SJ. Protective secretory immunoglobulin A antibodies in humans following oral immunization with Streptococcus mutans. Infect Immun 1987; 55: 2409-15.
162. Gregory RL, Michalek SM, Filler SJ, Mestecky J, McGhee JR. Prevention of Streptococcus mutans colonization by salivary IgA antibodies. J Clin Immunol 1985; 5: 55-62.
163. Russell MW, Childers NK, Michalek SM, Smith DJ, Taubman MA. A caries vaccine? The state of the science of immunization against dental caries. Caries Res 2004; 38: 230-5.
164. Parisotto TM, King WF, Duque C, Mattos-Graner RO, Steiner-Oliveira C, Nobre-Dos-Santos M, et al. Immunological and microbiologic changes during caries development in young children. Caries Res 2011; 45: 377-85.
165. Ranadheer E, Nayak UA, Reddy NV, Rao VA. The relationship between salivary IgA levels and dental caries in children. J Indian Soc Pedod Prev Dent 2011; 29: 106-12.
166. Smith DJ, Ebersole JL, Taubman MA, Gadalla L. Salivary IgA antibody to Actinobacillus actinomyetemcomitans in young adult population. J Periodontal Res 1985; 20: 8-11.
167. Sato M, Nagata A, Maehara R, Endo J, Hinode D, Nakamura R. Salivary IgA antibody to Bacteroides gingivalis and Actinobacillus actinomycetemcomitans in patients with adult marginal periodontitis. J Dent Health 1987; 37: 244-9. (in Japanese)
168. Napimoga MH, Nunes LH, Maciel AA, Demasi AP, Benatti BB, Santos VR, et al. Possible involvement of IL-21 and IL-10 on salivary IgA levels in chronic periodontitis subjects. Scand J Immunol 2011; 74: 596-602.
169. Lie MA, Myint MM, Schenck K, Timmerman MF, van der Velden U, van der Weijden GA, et al. Parotid salivary S-IgA antibodies during experimental gingivitis in smokers and nonsmokers. J Periodontal Res 2002; 37: 86-92.
170. Olayanju OA, Rahamon SK, Joseph IO, Arinola OG. Salivary immunoglobulin classes in Nigerian smokers with periodontitis. World J Biol Chem 2012; 3: 180-3.
171. Brandtzaeg P, Nilssen DE. Mucosal aspects of primary B-cell deficiency and gastrointestinal infections. Curr Opin Gastroenterol 1995; 11: 532-40.
172. Östergaard PA. Predictable clinical disorders related to serum and saliva Ig-levels and the number of circulating T cells in asthmatic children. Clin Allergy 1980; 10: 277-84.
173. Mellander L, Björkander J, Carlsson B, Hanson LA. Secretory antibodies in IgA-deficient and immunosuppressed individuals. J Clin Immunol 1986; 6: 284-91.
174. Brandtzaeg P, Karlsson G, Hansson G, Petruson B, Björkander J, Hanson LA. The clinical condition of IgAdeficient patients is related to the proportion of IgD- and IgM-producing cells in their nasal mucosa. Clin Exp Immunol 1987; 67: 626-36.
175. Nakamura C, Akimoto T, Suzuki S, Kono I. Daily changes of salivary secretory immunoglobulin A and appearance of upper respiratory symptoms during physical training. J Sports Med Phys Fitness 2006; 46: 152-7.
176. van Asperen PP, Gleeson M, Kemp AS, Cripps AW, Geraghty SB, Mellis CM, et al. The relationship between atopy and salivary IgA deficiency in infancy. Clin Exp Immunol 1985; 62: 753-7.
177. Gleeson M, Clancy RL, Hensley MJ, Cripps AW, Henry RL, Wlodarczyk JH, et al. Development of bronchial hyperreactivity following transient absence of salivary IgA. Am J Respir Crit Care Med 1996; 153: 1785-9.
178. Lehtonen O-P J, Tenovuo J, Aaltonen AS, Vilja P. Immunoglobulins and innate factors of immunity in saliva of children prone to respiratory infections. Acta Pathol Microbiol Scand C 1987; 95: 35-40.
179. Östergaard PA. Oral bacterial flora and secretory IgA in small children after repeated courses of antibiotics. Scand J Infect Dis 1983; 15: 115-8.
180. Groopman JE, Salahuddin SZ, Sarngadharan MG, Markham PD, Gonda M, Sliski A, et al. HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science 1984; 226: 447-9.
181. Pekovic D, Ajdukovic D, Tsoukas C, Lapointe N, Michaud J, Gilmore N, et al. Detection of human immunosuppressive virus in salivary lymphocytes from dental patients with AIDS. Am J Med 1987; 52: 188-9.
182. Challacombe SJ, Naglik JR. The effects of HIV infection on oral mucosal immunity. Adv Dent Res 2006; 19: 29-35.
183. Atkinson JC, Yeh C, Oppenheim FG, Bermudez D, Baum BJ, Fox PC. Elevation of salivary antimicrobial proteins following HIV-1 infection. J Acquir Immune Defic Syndr 1990; 3: 41-8.
184. Mandel ID, Barr CE, Turgeon L. Longitudinal study of parotid saliva in HIV-1 infection. J Oral Pathol Med 1992; 21: 209-13.
185. Nilssen DE, Øktedalen O, Brandtzaeg P. Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapy. Gut 2004; 53: 487-93.
186. Sweet SP, Rahman D, Challacombe SJ. IgA subclasses in HIV disease: dichotomy between raised levels in serum and decreased secretion rates in saliva. Immunology 1995; 86: 556-9.
187. Matsuda S, Oka S, Honda M, Takebe Y, Takemori T. Characteristics of IgA antibodies against HIV-1 in sera and saliva from HIV-seropositive individuals in different clinical stages. Scand J Immunol 1993; 38: 428-34.
188. Myint MM, Steinsvoll S, Odden K, Dobloug J, Schenck K. Salivary IgA responses to bacteria in dental plaque as related to periodontal and HIV infection status. Eur J Oral Sci Dec 1997; 105: 562-70.
189. Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol 2005; 2: 416-22.
190. Brandtzaeg P, Tolo K. Mucosal penetrability enhanced by serum-derived antibodies. Nature 1977; 266: 262-3.
191. Persson CG, Erjefalt JS, Greiff L, Erjefält I, Korsgren M, Linden M, et al. Contribution of plasma-derived molecules to mucosal immune defence, disease and repair in the airways. Scand J Immunol 1998; 47: 302-13.
192. Lu XS, Delfraissy JF, Grangeot-Keros L, Rannou MT, Pillot J. Rapid and constant detection of HIV antibody response in saliva of HIV-infected patients; selective distribution of anti-HIV activity in the IgG isotype. Res Virol 1994; 145: 369-77.
193. Hunt AJ, Connell J, Christofinis G, Parry JV, Weatherburn P, Hickson FC, et al. The testing of saliva samples for HIV-1 antibodies: reliability in a non-clinic setting. Genitourin Med 1993; 69: 29-30.
194. Wright AA, Katz IT. Home testing for HIV. N Engl J Med 2006; 354: 437-40.
195. Nielsen AA, Nielsen JN, Schmedes A, Brandslund I, Hey H. Saliva interleukin-6 in patients with inflammatory bowel disease. Scand J Gastroenterol 2005; 40: 1444-8.