A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

Journal of Allergy and Clinical Immunology

Volumn 143, Issue 6, 2019, Pages 2108-2119.e12

  Yu, Jinlei ^a   Luo, Yang ^b   Zhu, Zhenlai ^a   Zhou, Yufeng ^c   Sun, Licheng ^c   Gao, Jixin ^a   Sun, Jinlv ^e   Wang, Gang ^a   Yao, Xu ^b   Li, Wei ^a,d  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF DERMATOLOGY   (China)

^c Children's Hospital and Institute of Biomedical Sciences   (China)

^d FUDAN UNIVERSITY   (China)

^e PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

aryl hydrocarbon receptor; Atopic dermatitis; indole 3 aldehyde; metabolites; microbiota; skin; thymic stromal lymphopoietin; tryptophan

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CALCIPOTRIOL; INDOLE 3 ALDEHYDE; INDOLE DERIVATIVE; MESSENGER RNA; THYMIC STROMAL LYMPHOPOIETIN; UNCLASSIFIED DRUG; CALCITRIOL; CYTOKINE; INDOLE-3-CARBALDEHYDE; TRYPTOPHAN;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; BAGG ALBINO MOUSE; C57BL 6 MOUSE; CLINICAL ARTICLE; CONTROLLED STUDY; EXPERIMENTAL DERMATITIS; FEMALE; GEL PATCH METHOD; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCEDURES; PROMOTER REGION; SEX; SKIN FLORA; SKIN SURFACE; TRYPTOPHAN METABOLISM; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY; SKIN; UPREGULATION;

ANIMALS; CALCITRIOL; CELLS, CULTURED; CYTOKINES; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; HUMANS; INDOLES; KERATINOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; RECEPTORS, ARYL HYDROCARBON; SKIN; TRYPTOPHAN; UP-REGULATION;

EID: 85060007649     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2018.11.036     Document Type: Article

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