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Volumn 9, Issue 11, 2011, Pages

Scientific Opinion on the risks for public health related to the presence of opium alkaloids in poppy seeds
[No Author Info available]

Author keywords

acute reference dose (ARfD); codeine; dietary exposure; morphine; pharmacology; poppy seeds; toxicity

Indexed keywords


EID: 85058651530     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2011.2405     Document Type: Article
Times cited : (145)

References (280)
  • 1
    • 0042377298 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea
    • Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A and Bui C, 2003. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ, 327, 523–528.
    • (2003) BMJ , vol.327 , pp. 523-528
    • Abernethy, A.P.1    Currow, D.C.2    Frith, P.3    Fazekas, B.S.4    McHugh, A.5    Bui, C.6
  • 2
    • 0019309777 scopus 로고
    • Cytotoxicity of acetaminophen and papaverine in primary cultures of rat hepatocytes
    • Acosta D, Anuforo DC and Smith RV, 1980. Cytotoxicity of acetaminophen and papaverine in primary cultures of rat hepatocytes. Toxicology and Applied Pharmacology, 53, 306–314.
    • (1980) Toxicology and Applied Pharmacology , vol.53 , pp. 306-314
    • Acosta, D.1    Anuforo, D.C.2    Smith, R.V.3
  • 5
    • 85039308661 scopus 로고
    • American Hospital Formulary Service
    • Ed, 7272 Wisconsin Avenue, Bethesda, MD 20814
    • AHFS (American Hospital Formulary Service), 1995. American Hospital Formulary Service. Ed McEvoy GK. American Society of Health-System Pharmacists. 7272 Wisconsin Avenue, Bethesda, MD 20814.
    • (1995) American Society of Health-System Pharmacists
    • McEvoy, G.K.1
  • 6
    • 0003392747 scopus 로고    scopus 로고
    • Ed, American Society of Health-System Pharmacists, 7272 Wisconsin Avenue, Bethesda, MD, 20814
    • AHFS (American Hospital Formulary Service), 2007. AHFS Drug Information, 2007. American Hospital Formulary Service. Ed McEvoy GK. American Society of Health-System Pharmacists. 7272 Wisconsin Avenue, Bethesda, MD 20814.
    • (2007) AHFS Drug Information, 2007. American Hospital Formulary Service
    • McEvoy, G.K.1
  • 9
    • 2942585148 scopus 로고    scopus 로고
    • Führt der Verzehr von Mohnsamen zu positiven Opiatbefunden in Urin, Blut und Haaren?
    • Andresen H and Schmoldt A, 2004. Führt der Verzehr von Mohnsamen zu positiven Opiatbefunden in Urin, Blut und Haaren? Blutalkohol, 4, 191–202.
    • (2004) Blutalkohol , vol.4 , pp. 191-202
    • Andresen, H.1    Schmoldt, A.2
  • 11
    • 85078380227 scopus 로고    scopus 로고
    • Available from, Retrieved on 12.04.2011
    • Anonymous, 2011. Poppy Seed Oil. Available from www.recipetips.com/glossary-term/t-36310/poppy-seed-oil.asp. Retrieved on 12.04.2011.
    • (2011) Poppy Seed Oil
  • 12
    • 67650755014 scopus 로고    scopus 로고
    • A comparison of long- and short-acting opioids for the treatment of chronic noncancer pain: tailoring therapy to meet patient needs
    • Argoff CE and Silvershein DI, 2009. A comparison of long- and short-acting opioids for the treatment of chronic noncancer pain: tailoring therapy to meet patient needs. Mayo Clinic Proceedings, 84, 602–612.
    • (2009) Mayo Clinic Proceedings , vol.84 , pp. 602-612
    • Argoff, C.E.1    Silvershein, D.I.2
  • 13
    • 0037369176 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: Theory and clinical reality, part I
    • Armstrong SC and Cozza KL, 2003. Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: Theory and clinical reality, part I. Psychosomatics, 44, 167–171.
    • (2003) Psychosomatics , vol.44 , pp. 167-171
    • Armstrong, S.C.1    Cozza, K.L.2
  • 17
    • 0024313808 scopus 로고
    • Difficult asthma
    • author reply 1031-1032
    • Barnes PJ and Chung KF, 1989. Difficult asthma. BMJ, 299, 695–698, author reply 1031-1032.
    • (1989) BMJ , vol.299 , pp. 695-698
    • Barnes, P.J.1    Chung, K.F.2
  • 19
    • 0018181350 scopus 로고
    • Metabolism of papaverine IV. Urinary elimination of papaverine metabolites in man
    • Belpaire FM, Rosseel MT and Bogaert MG, 1978. Metabolism of papaverine IV. Urinary elimination of papaverine metabolites in man. Xenobiotica, 8, 297–300.
    • (1978) Xenobiotica , vol.8 , pp. 297-300
    • Belpaire, F.M.1    Rosseel, M.T.2    Bogaert, M.G.3
  • 20
    • 70350184391 scopus 로고    scopus 로고
    • Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets
    • Berényi S, Csutorás C and Sipos A, 2009. Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets. Current Medicinal Chemistry, 16, 3215–3242.
    • (2009) Current Medicinal Chemistry , vol.16 , pp. 3215-3242
    • Berényi, S.1    Csutorás, C.2    Sipos, A.3
  • 22
    • 0013100407 scopus 로고    scopus 로고
    • Poppy: the genus Papaver
    • Ed, Bernáth J., Harwood Academic Publishers, Amsterdam, The Netherlands
    • Bernáth J, 1998. Poppy: the genus Papaver. Series: Medicinal and Aromatic Plants-Industrial Profiles. Ed Bernáth J. Harwood Academic Publishers, Amsterdam, The Netherlands.
    • (1998) Series: Medicinal and Aromatic Plants-Industrial Profiles
    • Bernáth, J.1
  • 24
    • 84902264306 scopus 로고    scopus 로고
    • Poppy, Oil Crops
    • Eds, Vollmann J, Rajcan I., Springer Science and Business Media
    • Bernáth J and Németh E, 2009. Poppy, Oil Crops. Handbook of Plant Breeding 4. Eds Vollmann J and Rajcan I. Springer Science and Business Media, 449–468.
    • (2009) Handbook of Plant Breeding 4 , pp. 449-468
    • Bernáth, J.1    Németh, E.2
  • 26
    • 0344393477 scopus 로고    scopus 로고
    • Morphine for management of refractory dyspnoea: opiates should be used with caution
    • author reply 1288-1289
    • Berrill JW and Linnasne SJ, 2003. Morphine for management of refractory dyspnoea: opiates should be used with caution. BMJ, 327, 1288; author reply 1288-1289.
    • (2003) BMJ , vol.327 , pp. 1288
    • Berrill, J.W.1    Linnasne, S.J.2
  • 29
    • 85078383695 scopus 로고    scopus 로고
    • Available from
    • 2O; Codeinphosphat. Available from www.bfarm.de.
    • (2007) 2O; Codeinphosphat
  • 32
    • 85078372469 scopus 로고    scopus 로고
    • Ed, Biruté I., Baltos Lankos, Lithuania
    • Biruté I, 1998. Lithuanian Traditional Foods. Ed Biruté I. Baltos Lankos, Lithuania. 109 pp.
    • (1998) Lithuanian Traditional Foods , pp. 109
    • Biruté, I.1
  • 37
    • 0030066612 scopus 로고    scopus 로고
    • Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: a controlled study in human volunteers
    • Borgbjerg FM, Nielsen K and Franks J, 1996. Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: a controlled study in human volunteers. Pain, 64, 123–128.
    • (1996) Pain , vol.64 , pp. 123-128
    • Borgbjerg, F.M.1    Nielsen, K.2    Franks, J.3
  • 39
    • 0030875341 scopus 로고    scopus 로고
    • Oral morphine as symptomatic treatment of dyspnoea in patients with advanced cancer
    • Boyd KJ and Kelly M, 1997. Oral morphine as symptomatic treatment of dyspnoea in patients with advanced cancer. Palliative Medicine, 11, 277–281.
    • (1997) Palliative Medicine , vol.11 , pp. 277-281
    • Boyd, K.J.1    Kelly, M.2
  • 43
    • 0019453115 scopus 로고
    • Exposure to prescribed drugs in pregnancy and association with congenital malformations
    • Bracken MB and Holford TR, 1981. Exposure to prescribed drugs in pregnancy and association with congenital malformations. Obstetrics and Gynecology, 58, 336–344.
    • (1981) Obstetrics and Gynecology , vol.58 , pp. 336-344
    • Bracken, M.B.1    Holford, T.R.2
  • 44
    • 34347203321 scopus 로고
    • Beitrag zur Bestimmung von Morphin in Mohnkapseln
    • Bratina A, Perpar M and Tišler M, 1957. Beitrag zur Bestimmung von Morphin in Mohnkapseln. Microchimica Acta, 45, 167–173.
    • (1957) Microchimica Acta , vol.45 , pp. 167-173
    • Bratina, A.1    Perpar, M.2    Tišler, M.3
  • 47
    • 33749189364 scopus 로고    scopus 로고
    • Recurrent hypoxemia in children is associated with increased analgesic sensitivity to opiates
    • Brown KA, Laferriere A, Lakheeram I and Moss IR, 2006. Recurrent hypoxemia in children is associated with increased analgesic sensitivity to opiates. Anesthesiology, 105, 665–669.
    • (2006) Anesthesiology , vol.105 , pp. 665-669
    • Brown, K.A.1    Laferriere, A.2    Lakheeram, I.3    Moss, I.R.4
  • 50
    • 0002718857 scopus 로고
    • Opioids in immunologic Processes
    • In Opioids II,, Ed, Herz A., Springer-Verlag, Berlin
    • Bryant HU and Holaday JW, 1993. Opioids in immunologic Processes. In: Opioids II, Handbook of Experimental Pharmacology. Ed Herz A. Springer-Verlag, Berlin, 361–392.
    • (1993) Handbook of Experimental Pharmacology , pp. 361-392
    • Bryant, H.U.1    Holaday, J.W.2
  • 51
    • 0036239777 scopus 로고    scopus 로고
    • Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial
    • Caldwell JR, Rapoport RJ, Davis JC, Offenberg HL, Marker HW, Roth SH, Yuan W, Eliot L, Babul N and Lynch PM, 2002. Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial. Journal of Pain and Symptom Management, 23, 278–291.
    • (2002) Journal of Pain and Symptom Management , vol.23 , pp. 278-291
    • Caldwell, J.R.1    Rapoport, R.J.2    Davis, J.C.3    Offenberg, H.L.4    Marker, H.W.5    Roth, S.H.6    Yuan, W.7    Eliot, L.8    Babul, N.9    Lynch, P.M.10
  • 53
    • 0033046088 scopus 로고    scopus 로고
    • Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects
    • Caraco Y, Sheller J and Wood AJ, 1999. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. The Journal of Pharmacology and Experimental Therapeutics, 290, 413–422.
    • (1999) The Journal of Pharmacology and Experimental Therapeutics , vol.290 , pp. 413-422
    • Caraco, Y.1    Sheller, J.2    Wood, A.J.3
  • 54
    • 0028866054 scopus 로고
    • Sedation and analgesia in children
    • Carbajal R and Simon N, 1995. Sedation and analgesia in children. Archives de Pediatrie, 2, 1089–1096.
    • (1995) Archives de Pediatrie , vol.2 , pp. 1089-1096
    • Carbajal, R.1    Simon, N.2
  • 55
    • 0036323862 scopus 로고    scopus 로고
    • Effects of intermediate- and long-term use of opioids on cognition in patients with chronic pain
    • Chapman SL, Byas-Smith MG and Reed BA, 2002. Effects of intermediate- and long-term use of opioids on cognition in patients with chronic pain. The Clinical Journal of Pain, 18, S83–90.
    • (2002) The Clinical Journal of Pain , vol.18 , pp. S83-90
    • Chapman, S.L.1    Byas-Smith, M.G.2    Reed, B.A.3
  • 56
    • 0025830147 scopus 로고
    • Mu receptor binding of some commonly used opioids and their metabolites
    • Chen ZR, Irvine RJ, Somogyi AA and Bochner F, 1991. Mu receptor binding of some commonly used opioids and their metabolites. Life Sciences, 48, 2165–2171.
    • (1991) Life Sciences , vol.48 , pp. 2165-2171
    • Chen, Z.R.1    Irvine, R.J.2    Somogyi, A.A.3    Bochner, F.4
  • 57
    • 0017275901 scopus 로고
    • Effects of morphine and methadone on serum testosterone and luteinizing hormone levels and on the secondary sex organs of the male rat
    • Cicero TJ, Meyer ER, Bell RD and Koch GA, 1976. Effects of morphine and methadone on serum testosterone and luteinizing hormone levels and on the secondary sex organs of the male rat. Endocrinology, 98, 367–372.
    • (1976) Endocrinology , vol.98 , pp. 367-372
    • Cicero, T.J.1    Meyer, E.R.2    Bell, R.D.3    Koch, G.A.4
  • 59
    • 0000268735 scopus 로고
    • The effect of maternal narcotic addiction on the newborn infant; review of literature and report of 22 cases
    • Cobrinik RW, Hood RT, Jr. and Chusid E, 1959. The effect of maternal narcotic addiction on the newborn infant; review of literature and report of 22 cases. Pediatrics, 24, 288–304.
    • (1959) Pediatrics , vol.24 , pp. 288-304
    • Cobrinik, R.W.1    Hood, R.T.2    Chusid, E.3
  • 60
    • 0031894377 scopus 로고    scopus 로고
    • The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
    • Coffman BL, King CD, Rios GR and Tephly TR, 1998. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metabolism and Disposition, 26, 73–77.
    • (1998) Drug Metabolism and Disposition , vol.26 , pp. 73-77
    • Coffman, B.L.1    King, C.D.2    Rios, G.R.3    Tephly, T.R.4
  • 63
    • 0001094566 scopus 로고
    • Effects of Opioids on the spontaneous Behavior of Animals
    • In Opioids II,, Ed, Herz A, Springer-Verlag, Berlin
    • Cowan A, 1993. Effects of Opioids on the spontaneous Behavior of Animals. In: Opioids II, Handbook of Experimental Pharmacology. Ed Herz A. Springer-Verlag, Berlin, 393–428.
    • (1993) Handbook of Experimental Pharmacology , pp. 393-428
    • Cowan, A.1
  • 66
    • 75749119701 scopus 로고    scopus 로고
    • Nichtinterventionelle multizentrische Studie zur Therapie des unproduktiven Reizhustens mit Noscapin im Vergleich zu Codein/Dihydrocodein (Non-interventional multicentre study on the treatment of unproductive dry cough with noscapine versus codeine/dihydrocodeine)
    • Dahlheim M, Schwartz T and Banffy-Josika E, 2010. Nichtinterventionelle multizentrische Studie zur Therapie des unproduktiven Reizhustens mit Noscapin im Vergleich zu Codein/Dihydrocodein (Non-interventional multicentre study on the treatment of unproductive dry cough with noscapine versus codeine/dihydrocodeine). Atemwegs- und Lungenkrankheiten, 36, 35–40.
    • (2010) Atemwegs- und Lungenkrankheiten , vol.36 , pp. 35-40
    • Dahlheim, M.1    Schwartz, T.2    Banffy-Josika, E.3
  • 68
    • 0025353809 scopus 로고
    • Toxicity assessment of papaverine hydrochloride and papaverine-derived metabolites in primary cultures of rat hepatocytes
    • Davila JC, Reddy CG, Davis PJ and Acosta D, 1990. Toxicity assessment of papaverine hydrochloride and papaverine-derived metabolites in primary cultures of rat hepatocytes. In Vitro Cellular & Developmental Biology, 26, 515–524.
    • (1990) In Vitro Cellular & Developmental Biology , vol.26 , pp. 515-524
    • Davila, J.C.1    Reddy, C.G.2    Davis, P.J.3    Acosta, D.4
  • 69
    • 84930751166 scopus 로고    scopus 로고
    • Breathlessness, cough, and other respiratory problems
    • nd edition, Eds, Fallon M, Hanks G., BMJ Publishing Group, London
    • nd edition. Eds Fallon M and Hanks G. BMJ Publishing Group, London, 13–16.
    • (2006) ABC of palliative care , pp. 13-16
    • Davis, C.1    Percy, G.2
  • 71
    • 0032555771 scopus 로고    scopus 로고
    • Effects of prolonged exposure to morphine and methadone on in vivo parameters of immune function in rats
    • De Waal EJ, Van Der Laan JW and Van Loveren H, 1998. Effects of prolonged exposure to morphine and methadone on in vivo parameters of immune function in rats. Toxicology, 129, 201–210.
    • (1998) Toxicology , vol.129 , pp. 201-210
    • De Waal, E.J.1    Van Der Laan, J.W.2    Van Loveren, H.3
  • 78
    • 84888669305 scopus 로고    scopus 로고
    • BfR risk assessment of alkaloids as ingredients and contaminants of food: Quinine, opium alkaloids, and senecio pyrrolizidine alkaloids
    • Ed DFG Senate commission on Food safety (SKLM). Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
    • Dusemund B, Appel K-E and Lampen A, 2010. BfR risk assessment of alkaloids as ingredients and contaminants of food: Quinine, opium alkaloids, and senecio pyrrolizidine alkaloids. In: Risk Assessment of Phytochemicals in Food. Ed DFG Senate commission on Food safety (SKLM). Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 382–390.
    • (2010) Risk Assessment of Phytochemicals in Food , pp. 382-390
    • Dusemund, B.1    Appel, K.-E.2    Lampen, A.3
  • 79
    • 0015542180 scopus 로고
    • Mass fragmentographic detection of normorphine in urine of man after codeine intake
    • Ebbighausen WOR, Mowat J and Vestergaard P, 1973. Mass fragmentographic detection of normorphine in urine of man after codeine intake. Journal of Pharmaceutical Sciences, 62, 146–148.
    • (1973) Journal of Pharmaceutical Sciences , vol.62 , pp. 146-148
    • Ebbighausen, W.O.R.1    Mowat, J.2    Vestergaard, P.3
  • 81
    • 33745584148 scopus 로고    scopus 로고
    • Development and evaluation of a generic physiologically based pharmacokinetic model for children
    • Edginton AN, Schmitt W and Willmann S, 2006. Development and evaluation of a generic physiologically based pharmacokinetic model for children. Clinical Pharmacokinetics, 45, 1013–1034.
    • (2006) Clinical Pharmacokinetics , vol.45 , pp. 1013-1034
    • Edginton, A.N.1    Schmitt, W.2    Willmann, S.3
  • 82
    • 44749086017 scopus 로고    scopus 로고
    • Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment
    • EFSA (European Food Safety Authority), 2006. Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment. The EFSA Journal, 438, 1–54.
    • (2006) The EFSA Journal , vol.438 , pp. 1-54
  • 83
    • 84888442809 scopus 로고    scopus 로고
    • Evaluation of the FoodEx, the food classification system applied to the development of the EFSA Comprehensive European Food Consumption Database
    • 1970
    • EFSA (European Food Safety Authority), 2011a. Evaluation of the FoodEx, the food classification system applied to the development of the EFSA Comprehensive European Food Consumption Database. EFSA Journal 2011; 9(3):1970. 27 pp.
    • (2011) EFSA Journal 2011; , vol.9 , Issue.3 , pp. 27
  • 84
    • 85077752327 scopus 로고    scopus 로고
    • Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment
    • EFSA (European Food Safety Authority), 2011b. Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment. EFSA Journal 2011;9(3):2097. 2097, 34 pp.
    • (2011) EFSA Journal 2011;9(3):2097 , vol.2097 , pp. 34
  • 85
    • 78751518777 scopus 로고    scopus 로고
    • Epidermal growth factor treatment switches delta-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism
    • Eisinger DA and Ammer H, 2011. Epidermal growth factor treatment switches delta-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism. Molecular Pharmacology, 79, 326–335.
    • (2011) Molecular Pharmacology , vol.79 , pp. 326-335
    • Eisinger, D.A.1    Ammer, H.2
  • 87
    • 0037331134 scopus 로고    scopus 로고
    • Sleep-disordered breathing associated with long-term opioid therapy
    • Farney RJ, Walker JM, Cloward TV and Rhondeau S, 2003. Sleep-disordered breathing associated with long-term opioid therapy. Chest, 123, 632–639.
    • (2003) Chest , vol.123 , pp. 632-639
    • Farney, R.J.1    Walker, J.M.2    Cloward, T.V.3    Rhondeau, S.4
  • 91
    • 0033961141 scopus 로고    scopus 로고
    • Immediate-type allergy caused by poppy seed
    • Frantzen B, Bröcker EB and Trautmann A, 2000. Immediate-type allergy caused by poppy seed. Allergy, 55, 97–98.
    • (2000) Allergy , vol.55 , pp. 97-98
    • Frantzen, B.1    Bröcker, E.B.2    Trautmann, A.3
  • 92
    • 0020837908 scopus 로고
    • Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems
    • Frenk H, 1983. Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems. Brain Research, 287, 197–210.
    • (1983) Brain Research , vol.287 , pp. 197-210
    • Frenk, H.1
  • 93
    • 0003485463 scopus 로고    scopus 로고
    • 3. Auflage, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart
    • Frohne D and Pfänder HJ, 1987. Giftpflanzen; 3. Auflage, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart.
    • (1987) Giftpflanzen;
    • Frohne, D.1    Pfänder, H.J.2
  • 94
    • 0003485463 scopus 로고    scopus 로고
    • 5. Auflage, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart
    • Frohne D and Pfänder HJ, 2004. Giftpflanzen; 5. Auflage, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart.
    • (2004) Giftpflanzen;
    • Frohne, D.1    Pfänder, H.J.2
  • 95
    • 79955467534 scopus 로고    scopus 로고
    • Distinct pharmacological properties of morphine metabolites at G(i)-protein and beta-arrestin signaling pathways activated by the human mu-opioid receptor
    • Frölich N, Dees C, Paetz C, Ren X, Lohse MJ, Nikolaev VO and Zenk MH, 2011. Distinct pharmacological properties of morphine metabolites at G(i)-protein and beta-arrestin signaling pathways activated by the human mu-opioid receptor. Biochemical Pharmacology, 81, 1248–1254.
    • (2011) Biochemical Pharmacology , vol.81 , pp. 1248-1254
    • Frölich, N.1    Dees, C.2    Paetz, C.3    Ren, X.4    Lohse, M.J.5    Nikolaev, V.O.6    Zenk, M.H.7
  • 96
    • 0023709398 scopus 로고
    • Teratogenic and postnatal developmental studies of morphine in Sprague-Dawley rats
    • Fujinaga M and Mazze RI, 1988. Teratogenic and postnatal developmental studies of morphine in Sprague-Dawley rats. Teratology, 38, 401–410.
    • (1988) Teratology , vol.38 , pp. 401-410
    • Fujinaga, M.1    Mazze, R.I.2
  • 97
    • 0025741556 scopus 로고
    • Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride
    • Gatehouse DG, Stemp G, Pascoe S, Wilcox P, Hawker J and Tweats DJ, 1991. Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride. Mutagenesis, 6, 279–283.
    • (1991) Mutagenesis , vol.6 , pp. 279-283
    • Gatehouse, D.G.1    Stemp, G.2    Pascoe, S.3    Wilcox, P.4    Hawker, J.5    Tweats, D.J.6
  • 98
    • 0016773967 scopus 로고
    • Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster
    • Geber WF and Schramm LC, 1975. Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster. American Journal of Obstetrics and Gynecology, 123, 705–713.
    • (1975) American Journal of Obstetrics and Gynecology , vol.123 , pp. 705-713
    • Geber, W.F.1    Schramm, L.C.2
  • 99
    • 84855372609 scopus 로고    scopus 로고
    • Untersuchungen zur Reduzierung von Morphin in Mohnsamen und Mohngebäcken mit praktikablen technologischen Massnahmen
    • General J, Unbehend G, Lindhauer MG, Kniel B and Moser M, 2007. Untersuchungen zur Reduzierung von Morphin in Mohnsamen und Mohngebäcken mit praktikablen technologischen Massnahmen. Getreidetechnologie, 61, 36–42.
    • (2007) Getreidetechnologie , vol.61 , pp. 36-42
    • General, J.1    Unbehend, G.2    Lindhauer, M.G.3    Kniel, B.4    Moser, M.5
  • 104
    • 0029131847 scopus 로고
    • Morphine sans morpheus
    • Hanks GW, 1995. Morphine sans morpheus. Lancet, 346, 652–653.
    • (1995) Lancet , vol.346 , pp. 652-653
    • Hanks, G.W.1
  • 106
    • 0019439185 scopus 로고
    • Unexpected complication of successful nerve block. Morphine induced respiratory depression precipitated by removal of severe pain
    • Hanks GW, Twycross RG and Lloyd JW, 1981. Unexpected complication of successful nerve block. Morphine induced respiratory depression precipitated by removal of severe pain. Anaesthesia, 36, 37–39.
    • (1981) Anaesthesia , vol.36 , pp. 37-39
    • Hanks, G.W.1    Twycross, R.G.2    Lloyd, J.W.3
  • 107
    • 0024413359 scopus 로고
    • Controlled-release morphine (MST contin) in advanced cancer-The European experience
    • Hanks GW, 1989. Controlled-release morphine (MST contin) in advanced cancer-The European experience. Cancer, 63, 2378–2382.
    • (1989) Cancer , vol.63 , pp. 2378-2382
    • Hanks, G.W.1
  • 110
    • 0014336004 scopus 로고
    • Morphine-induced fetal malformations. I. Exencephaly and axial skeletal fusions
    • Harpel HS, Jr. and Gautieri RF, 1968. Morphine-induced fetal malformations. I. Exencephaly and axial skeletal fusions. Journal of Pharmaceutical Sciences, 57, 1590–1597.
    • (1968) Journal of Pharmaceutical Sciences , vol.57 , pp. 1590-1597
    • Harpel, H.S.1    Gautieri, R.F.2
  • 112
    • 0023359268 scopus 로고
    • Concentrations of morphine and codeine in serum and urine after ingestion of poppy seeds
    • Hayes LW, Krasselt WG and Mueggler PA, 1987. Concentrations of morphine and codeine in serum and urine after ingestion of poppy seeds. Clinical Chemistry, 33, 806–808.
    • (1987) Clinical Chemistry , vol.33 , pp. 806-808
    • Hayes, L.W.1    Krasselt, W.G.2    Mueggler, P.A.3
  • 114
    • 29144442087 scopus 로고    scopus 로고
    • Multiple aspects of hair analysis for opiates: methodology, clinical and workplace populations, codeine, and poppy seed ingestion
    • Hill V, Cairns T, Cheng CC and Schaffer M, 2005. Multiple aspects of hair analysis for opiates: methodology, clinical and workplace populations, codeine, and poppy seed ingestion. Journal of Analytical Toxicology, 29, 696–703.
    • (2005) Journal of Analytical Toxicology , vol.29 , pp. 696-703
    • Hill, V.1    Cairns, T.2    Cheng, C.C.3    Schaffer, M.4
  • 117
    • 85078394350 scopus 로고
    • Available from
    • IPCS (International Programme on Chemical Safety), 1990. Codeine. Available from www.inchem.org/documents/pims/pharm/codeine.htm.
    • (1990) Codeine
  • 118
    • 85024285219 scopus 로고
    • Cytotoxicity test on medical drugs-chromosome aberration tests with Chinese hamster cells in vitro (author's transl)
    • Ishidate M, Jr., Hayashi M, Sawada M, Matsuoka A, Yoshikawa K, Ono M and Nakadate M, 1978. Cytotoxicity test on medical drugs-chromosome aberration tests with Chinese hamster cells in vitro (author's transl). Eisei Shikenjo Hokoku, 55–61.
    • (1978) Eisei Shikenjo Hokoku , pp. 55-61
    • Ishidate, M.1    Hayashi, M.2    Sawada, M.3    Matsuoka, A.4    Yoshikawa, K.5    Ono, M.6    Nakadate, M.7
  • 120
    • 64549097147 scopus 로고    scopus 로고
    • The opioid-exposed newborn: assessment and pharmacologic management
    • Jansson LM, Velez M and Harrow C, 2009. The opioid-exposed newborn: assessment and pharmacologic management. Journal of Opioid Management, 5, 47–55.
    • (2009) Journal of Opioid Management , vol.5 , pp. 47-55
    • Jansson, L.M.1    Velez, M.2    Harrow, C.3
  • 121
    • 0036845470 scopus 로고    scopus 로고
    • A systematic review of the use of opioids in the management of dyspnoea
    • Jennings AL, Davies AN, Higgins JP, Gibbs JS and Broadley KE, 2002. A systematic review of the use of opioids in the management of dyspnoea. Thorax, 57, 939–944.
    • (2002) Thorax , vol.57 , pp. 939-944
    • Jennings, A.L.1    Davies, A.N.2    Higgins, J.P.3    Gibbs, J.S.4    Broadley, K.E.5
  • 123
    • 0021943603 scopus 로고
    • The interference of naloxone hydrochloride in the teratogenic activity of opiates
    • Jurand A, 1985. The interference of naloxone hydrochloride in the teratogenic activity of opiates. Teratology, 31, 235–240.
    • (1985) Teratology , vol.31 , pp. 235-240
    • Jurand, A.1
  • 124
    • 11844262927 scopus 로고    scopus 로고
    • Mineral fertilisation of poppy (Papaver somniferum L.) on calcareous loamy chernozem soil. II
    • Kadar I, Foldesi D, Voros J, Szilagyi J and Lukacs D, 2001. Mineral fertilisation of poppy (Papaver somniferum L.) on calcareous loamy chernozem soil. II. Novenytermeles, 50, 467–468.
    • (2001) Novenytermeles , vol.50 , pp. 467-468
    • Kadar, I.1    Foldesi, D.2    Voros, J.3    Szilagyi, J.4    Lukacs, D.5
  • 125
    • 34548842800 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data
    • Kalvass JC, Olson ER, Cassidy MP, Selley DE and Pollack GM, 2007. Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data. The Journal of Pharmacology and Experimental Therapeutics, 323, 346–355.
    • (2007) The Journal of Pharmacology and Experimental Therapeutics , vol.323 , pp. 346-355
    • Kalvass, J.C.1    Olson, E.R.2    Cassidy, M.P.3    Selley, D.E.4    Pollack, G.M.5
  • 126
    • 0025351307 scopus 로고
    • Serum protein binding of noscapine: influence of a reversible hydrolysis
    • Karlsson MO and Dahlstrom B, 1990. Serum protein binding of noscapine: influence of a reversible hydrolysis. The Journal of Pharmacy and Pharmacology, 42, 140–143.
    • (1990) The Journal of Pharmacy and Pharmacology , vol.42 , pp. 140-143
    • Karlsson, M.O.1    Dahlstrom, B.2
  • 127
    • 33748125501 scopus 로고    scopus 로고
    • Poppy seed allergy: a case report and review of the literature
    • Keskin O and Sekerel BE, 2006. Poppy seed allergy: a case report and review of the literature. Allergy and Asthma Proceedings, 27, 396–398.
    • (2006) Allergy and Asthma Proceedings , vol.27 , pp. 396-398
    • Keskin, O.1    Sekerel, B.E.2
  • 129
    • 0021255477 scopus 로고
    • Maternal toxicity-a possible factor in fetal malformations in mice
    • Khera KS, 1984. Maternal toxicity-a possible factor in fetal malformations in mice. Teratology, 29, 411–416.
    • (1984) Teratology , vol.29 , pp. 411-416
    • Khera, K.S.1
  • 133
    • 0037223628 scopus 로고    scopus 로고
    • Immediate- or sustained-release morphine for dose finding during start of morphine to cancer patients: a randomized, double-blind trial
    • Klepstad P, Kaasa S, Jystad A, Hval B and Borchgrevin PC, 2003. Immediate- or sustained-release morphine for dose finding during start of morphine to cancer patients: a randomized, double-blind trial. Pain, 101, 193–198.
    • (2003) Pain , vol.101 , pp. 193-198
    • Klepstad, P.1    Kaasa, S.2    Jystad, A.3    Hval, B.4    Borchgrevin, P.C.5
  • 137
    • 84965184868 scopus 로고
    • Neure Gesichspunkte zur Pharmakologie des Narkotins (New viewpoints in the pharmacology of narcotine)
    • Konzett H, 1955. Neure Gesichspunkte zur Pharmakologie des Narkotins (New viewpoints in the pharmacology of narcotine). Wiener Klinische Wochenschrift, 67, 306–309.
    • (1955) Wiener Klinische Wochenschrift , vol.67 , pp. 306-309
    • Konzett, H.1
  • 139
    • 33747134323 scopus 로고    scopus 로고
    • Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
    • Koren G, Cairns J, Chitayat D, Gaedigk A and Leeder SJ, 2006. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet, 368, 704.
    • (2006) Lancet , vol.368 , pp. 704
    • Koren, G.1    Cairns, J.2    Chitayat, D.3    Gaedigk, A.4    Leeder, S.J.5
  • 140
    • 14644431809 scopus 로고    scopus 로고
    • Opioid medication and driving ability
    • Kress HG and Kraft B, 2005. Opioid medication and driving ability. European Journal of Pain, 9, 141–144.
    • (2005) European Journal of Pain , vol.9 , pp. 141-144
    • Kress, H.G.1    Kraft, B.2
  • 144
    • 0032853264 scopus 로고    scopus 로고
    • Effects of long-term opioid therapy on psychomotor function in patients with cancer pain or non-malignant pain
    • Larsen B, Otto H, Dorscheid E and Larsen R, 1999. Effects of long-term opioid therapy on psychomotor function in patients with cancer pain or non-malignant pain. Anaesthesist, 48, 613–624.
    • (1999) Anaesthesist , vol.48 , pp. 613-624
    • Larsen, B.1    Otto, H.2    Dorscheid, E.3    Larsen, R.4
  • 146
    • 0016588570 scopus 로고
    • Effects of certain abused drug s on hemolysin forming cells
    • Lefkowitz SS and Chiang CY, 1975. Effects of certain abused drug s on hemolysin forming cells. Life Sciences, 17, 1763–1767.
    • (1975) Life Sciences , vol.17 , pp. 1763-1767
    • Lefkowitz, S.S.1    Chiang, C.Y.2
  • 147
    • 0017286419 scopus 로고
    • Teratologic studies in rabbits and rats with the morphine derivate codeine
    • Lehman VH, 1976. Teratologic studies in rabbits and rats with the morphine derivate codeine. Arzneimittelforschung, 26, 551–554.
    • (1976) Arzneimittelforschung , vol.26 , pp. 551-554
    • Lehman, V.H.1
  • 148
    • 85078367748 scopus 로고
    • Die Toxizität von Bencyclan und Papaverin an Ratten. Eine vergleichende Untersuchung uber 45 Tage (The toxicity of bencyclane and papaverine in rats. A comparative study over 45 days)
    • Lehoczky Z, 1970a. Die Toxizität von Bencyclan und Papaverin an Ratten. Eine vergleichende Untersuchung uber 45 Tage (The toxicity of bencyclane and papaverine in rats. A comparative study over 45 days). Arzneimittelforschung, 20, 1394–1936.
    • (1970) Arzneimittelforschung , vol.20 , pp. 1394-1936
    • Lehoczky, Z.1
  • 149
    • 85034874793 scopus 로고
    • Die Toxizitat von Bencyclan und Papaverin an Hunden. Eine vergleichende Untersuchung uber 6 Monate (The toxicity of bencyclane and papaverine in dogs. A comparative study over 6 months)
    • Lehoczky Z, 1970b. Die Toxizitat von Bencyclan und Papaverin an Hunden. Eine vergleichende Untersuchung uber 6 Monate (The toxicity of bencyclane and papaverine in dogs. A comparative study over 6 months). Arzneimittelforschung, 20, 1396–1398.
    • (1970) Arzneimittelforschung , vol.20 , pp. 1396-1398
    • Lehoczky, Z.1
  • 151
    • 0031760631 scopus 로고    scopus 로고
    • Genetic toxicology of abused drugs: a brief review
    • Li JH and Lin LF, 1998. Genetic toxicology of abused drugs: a brief review. Mutagenesis, 13, 557–565.
    • (1998) Mutagenesis , vol.13 , pp. 557-565
    • Li, J.H.1    Lin, L.F.2
  • 152
    • 0016136591 scopus 로고
    • Effects of diazepam and codeine, alone and in combination with alcohol, on simulated driving
    • Linnoila M and Hakkinen S, 1974. Effects of diazepam and codeine, alone and in combination with alcohol, on simulated driving. Clinical Pharmacology and Therapeutics, 15, 368–373.
    • (1974) Clinical Pharmacology and Therapeutics , vol.15 , pp. 368-373
    • Linnoila, M.1    Hakkinen, S.2
  • 154
    • 0027097576 scopus 로고
    • Poppy seeds: implications of consumption
    • Lo DS and Chua TH, 1992. Poppy seeds: implications of consumption. Medicine, Science, and the Law, 32, 296–302.
    • (1992) Medicine, Science, and the Law , vol.32 , pp. 296-302
    • Lo, D.S.1    Chua, T.H.2
  • 155
    • 19344374700 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of opioids
    • Lötsch J, 2005. Pharmacokinetic-pharmacodynamic modeling of opioids. Journal of Pain and Symptom Management, 29, S90–S103.
    • (2005) Journal of Pain and Symptom Management , vol.29 , pp. S90-S103
    • Lötsch, J.1
  • 159
    • 0031994010 scopus 로고    scopus 로고
    • Evidence for morphine-induced galactorrhea in male cynomolgus monkeys
    • Malaivijitnond S and Varavudhi P, 1998. Evidence for morphine-induced galactorrhea in male cynomolgus monkeys. Journal of Medical Primatology, 27, 1–9.
    • (1998) Journal of Medical Primatology , vol.27 , pp. 1-9
    • Malaivijitnond, S.1    Varavudhi, P.2
  • 160
    • 0003777024 scopus 로고    scopus 로고
    • Thirty-fourth edition, Pharmaceutical Press
    • Martindale, 2005. The complete drug reference. Thirty-fourth edition, Pharmaceutical Press.
    • (2005) The complete drug reference
  • 161
    • 85078378530 scopus 로고    scopus 로고
    • The complete drug reference
    • online., Pharmaceutical Press, London, Date of monograph revision 20 August 2010. Available from
    • Martindale, 2010. The complete drug reference. Morphine; online. Pharmaceutical Press, London. Date of monograph revision: 20 August 2010. Available from www.medicinescomplete.com/mc/martindale/current/.
    • (2010) Morphine
  • 165
    • 33645203312 scopus 로고
    • Drugs in the First Trimester of Pregnancy and the Fetal Life of Homo Sapiens
    • Mellin GW, 1964. Drugs in the First Trimester of Pregnancy and the Fetal Life of Homo Sapiens. American Journal of Obstetrics and Gynecology, 90, S1169–S1180.
    • (1964) American Journal of Obstetrics and Gynecology , vol.90 , pp. S1169-S1180
    • Mellin, G.W.1
  • 167
    • 85078368816 scopus 로고    scopus 로고
    • Morphin Merck Tropfen 0.5%/2%., Rote Liste Service GmbH, Berlin, Germany
    • Merck, 2010. Fachinformation Merck, 2010. Morphin Merck Tropfen 0.5%/2%. Rote Liste Service GmbH, Berlin, Germany.
    • (2010) Fachinformation Merck, 2010
    • Merck1
  • 168
    • 79960934521 scopus 로고    scopus 로고
    • Methodological characteristics of the national dietary surveys carried out in the European Union as included in the European Food Safety Authority (EFSA) Comprehensive European Food Consumption Database
    • Merten C, Ferrari P, Bakker M, Boss A, Hearty A, Leclercq C, Lindtner O, Tlustos C, Verger P, Volatier JL and Arcella D, 2011. Methodological characteristics of the national dietary surveys carried out in the European Union as included in the European Food Safety Authority (EFSA) Comprehensive European Food Consumption Database. Food Additives and Contaminants. Part A, 28, 975–995.
    • (2011) Food Additives and Contaminants. Part A , vol.28 , pp. 975-995
    • Merten, C.1    Ferrari, P.2    Bakker, M.3    Boss, A.4    Hearty, A.5    Leclercq, C.6    Lindtner, O.7    Tlustos, C.8    Verger, P.9    Volatier, J.L.10    Arcella, D.11
  • 169
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer UA, 2000. Pharmacogenetics and adverse drug reactions. Lancet, 356, 1667–1671.
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 170
    • 0028836343 scopus 로고
    • Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes
    • Mignat C, Wille U and Ziegler A, 1995. Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes. Life Sciences, 56, 793–799.
    • (1995) Life Sciences , vol.56 , pp. 793-799
    • Mignat, C.1    Wille, U.2    Ziegler, A.3
  • 171
    • 0025989971 scopus 로고
    • Thebaine O-demethylation to oripavine: genetic differences between two rat strains
    • Mikus G, Somogyi AA, Bochner F and Eichelbaum M, 1991. Thebaine O-demethylation to oripavine: genetic differences between two rat strains. Xenobiotica, 21, 1501–1509.
    • (1991) Xenobiotica , vol.21 , pp. 1501-1509
    • Mikus, G.1    Somogyi, A.A.2    Bochner, F.3    Eichelbaum, M.4
  • 174
    • 0015944720 scopus 로고
    • Pharmacokinetics and metabolism of (3H) thebaine
    • Misra AL, Pontani RB and Mule SJ, 1974. Pharmacokinetics and metabolism of (3H) thebaine. Xenobiotica, 4, 17–32.
    • (1974) Xenobiotica , vol.4 , pp. 17-32
    • Misra, A.L.1    Pontani, R.B.2    Mule, S.J.3
  • 176
    • 70349518671 scopus 로고    scopus 로고
    • Screening of codeine, dextromethorphan & dextropropoxyphene for their genotoxicity in swiss albino mice
    • Mittal R, Patil PA and Torgal SS, 2009. Screening of codeine, dextromethorphan & dextropropoxyphene for their genotoxicity in swiss albino mice. Indian Journal of Medical Research, 129, 676–680.
    • (2009) Indian Journal of Medical Research , vol.129 , pp. 676-680
    • Mittal, R.1    Patil, P.A.2    Torgal, S.S.3
  • 177
    • 3042830671 scopus 로고    scopus 로고
    • Poppy seed consumption and toxicological analysis of blood and urine samples
    • Moeller MR, Hammer K and Engel O, 2004. Poppy seed consumption and toxicological analysis of blood and urine samples. Forensic Science International, 143, 183–186.
    • (2004) Forensic Science International , vol.143 , pp. 183-186
    • Moeller, M.R.1    Hammer, K.2    Engel, O.3
  • 179
    • 45949084395 scopus 로고    scopus 로고
    • Central sleep apnea induced by acute ingestion of opioids
    • Mogri M, Khan MI, Grant BJ and Mador MJ, 2008. Central sleep apnea induced by acute ingestion of opioids. Chest, 133, 1484–1488.
    • (2008) Chest , vol.133 , pp. 1484-1488
    • Mogri, M.1    Khan, M.I.2    Grant, B.J.3    Mador, M.J.4
  • 180
    • 0025734342 scopus 로고
    • Pharmakokinetische Einflusse auf die Morphintoxizitat mit Fallbeispielen (Pharmacokinetic effects in morphine toxicity, with case examples)
    • Morant R and Senn HJ, 1991. Pharmakokinetische Einflusse auf die Morphintoxizitat mit Fallbeispielen (Pharmacokinetic effects in morphine toxicity, with case examples). Schweizerische Rundschau fur Medizin Praxis/Revue suisse de medecine Praxis, 80, 719–722.
    • (1991) Schweizerische Rundschau fur Medizin Praxis/Revue suisse de medecine Praxis , vol.80 , pp. 719-722
    • Morant, R.1    Senn, H.J.2
  • 184
    • 0015093801 scopus 로고
    • The effects of morphine, morphinone and thebaine on the EEG and behavior of rabbits and cats
    • Navarro G and Elliott HW, 1971. The effects of morphine, morphinone and thebaine on the EEG and behavior of rabbits and cats. Neuropharmacology, 10, 367–377.
    • (1971) Neuropharmacology , vol.10 , pp. 367-377
    • Navarro, G.1    Elliott, H.W.2
  • 185
    • 79953068657 scopus 로고    scopus 로고
    • Evaluation of alkaloid profiles in hybrid generations of different poppy (Papaver somniferum L.) genotypes
    • Németh-Zámbori E, Jászberényi C, Rajhárt P and Bernáth J, 2011. Evaluation of alkaloid profiles in hybrid generations of different poppy (Papaver somniferum L.) genotypes. Industrial Crops and Products, 33, 690–696.
    • (2011) Industrial Crops and Products , vol.33 , pp. 690-696
    • Németh-Zámbori, E.1    Jászberényi, C.2    Rajhárt, P.3    Bernáth, J.4
  • 186
    • 0030944183 scopus 로고    scopus 로고
    • The rules of drug taking: wine and poppy derivatives in the ancient world. VI. Poppies as a source of food and drug
    • Nencini P, 1997. The rules of drug taking: wine and poppy derivatives in the ancient world. VI. Poppies as a source of food and drug. Substance Use & Misuse, 32, 757–766.
    • (1997) Substance Use & Misuse , vol.32 , pp. 757-766
    • Nencini, P.1
  • 187
    • 34848863094 scopus 로고    scopus 로고
    • Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors
    • Nikolaev VO, Boettcher C, Dees C, Bunemann M, Lohse MJ and Zenk MH, 2007. Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. The Journal of Biological Chemistry, 282, 27126–27132.
    • (2007) The Journal of Biological Chemistry , vol.282 , pp. 27126-27132
    • Nikolaev, V.O.1    Boettcher, C.2    Dees, C.3    Bunemann, M.4    Lohse, M.J.5    Zenk, M.H.6
  • 189
    • 33646559175 scopus 로고    scopus 로고
    • Cross-sensitization between poppy seed and buckwheat in a food-allergic patient with poppy seed anaphylaxis
    • Oppel T, Thomas P and Wollenberg A, 2006. Cross-sensitization between poppy seed and buckwheat in a food-allergic patient with poppy seed anaphylaxis. International Archives of Allergy and Immunology, 140, 170–173.
    • (2006) International Archives of Allergy and Immunology , vol.140 , pp. 170-173
    • Oppel, T.1    Thomas, P.2    Wollenberg, A.3
  • 192
    • 0030474791 scopus 로고    scopus 로고
    • Gas chromatographic/mass spectrometric detection of narcotine, papaverine, and thebaine in seeds of Papaver somniferum
    • Paul BD, Dreka C, Knight ES and Smith ML, 1996. Gas chromatographic/mass spectrometric detection of narcotine, papaverine, and thebaine in seeds of Papaver somniferum. Planta Medica, 62, 544–547.
    • (1996) Planta Medica , vol.62 , pp. 544-547
    • Paul, B.D.1    Dreka, C.2    Knight, E.S.3    Smith, M.L.4
  • 193
    • 0029942449 scopus 로고    scopus 로고
    • Poppy seeds: differences in morphine and codeine content and variation in inter- and intra-individual excretion
    • Pelders MG and Ros JJ, 1996. Poppy seeds: differences in morphine and codeine content and variation in inter- and intra-individual excretion. Journal of Forensic Sciences, 41, 209–212.
    • (1996) Journal of Forensic Sciences , vol.41 , pp. 209-212
    • Pelders, M.G.1    Ros, J.J.2
  • 195
    • 48249112969 scopus 로고    scopus 로고
    • Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone)
    • Pergolizzi J, Boger RH, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa RB and Sacerdote P, 2008. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Practice, 8, 287–313.
    • (2008) Pain Practice , vol.8 , pp. 287-313
    • Pergolizzi, J.1    Boger, R.H.2    Budd, K.3    Dahan, A.4    Erdine, S.5    Hans, G.6    Kress, H.G.7    Langford, R.8    Likar, R.9    Raffa, R.B.10    Sacerdote, P.11
  • 199
    • 0031862803 scopus 로고    scopus 로고
    • The effect of sustained-release morphine on breathlessness and quality of life in severe chronic obstructive pulmonary disease
    • Poole PJ, Veale AG and Black PN, 1998. The effect of sustained-release morphine on breathlessness and quality of life in severe chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 157, 1877–1880.
    • (1998) American Journal of Respiratory and Critical Care Medicine , vol.157 , pp. 1877-1880
    • Poole, P.J.1    Veale, A.G.2    Black, P.N.3
  • 201
    • 0013790469 scopus 로고
    • Alkaloidvorkommen in Mohnsamen (Papaver somniferum L.)
    • Preininger VL, Vrublovsky P and Štastny VL, 1965. Alkaloidvorkommen in Mohnsamen (Papaver somniferum L.). Pharmazie, 20, 439–441.
    • (1965) Pharmazie , vol.20 , pp. 439-441
    • Preininger, V.L.1    Vrublovsky, P.2    Štastny, V.L.3
  • 202
    • 84910421355 scopus 로고
    • The pharmacology and toxicology of the alkaloids from the plants of the family Papaveraceae
    • Preininger V, 1972. The pharmacology and toxicology of the alkaloids from the plants of the family Papaveraceae. Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 61, 213–254.
    • (1972) Acta Universitatis Palackianae Olomucensis Facultatis Medicae , vol.61 , pp. 213-254
    • Preininger, V.1
  • 203
    • 84898455835 scopus 로고    scopus 로고
    • Hacettepe Universitesi, Saglik Bilimleri Fakultesi, Beslenme ve Diyetetik Bolumu, Ankara, 2009
    • Rakicioglu N, Tek NA, Ayaz A and Pekcan G, 2009. Yemek ve besin fotograf katalogu. Hacettepe Universitesi, Saglik Bilimleri Fakultesi, Beslenme ve Diyetetik Bolumu, Ankara 2009. 132 pp.
    • (2009) Yemek ve besin fotograf katalogu , pp. 132
    • Rakicioglu, N.1    Tek, N.A.2    Ayaz, A.3    Pekcan, G.4
  • 205
    • 0017590984 scopus 로고
    • Fetal growth retardation following maternal morphine administration-Nutritional or drug effect
    • Raye JR, Dubin JW and Blechner JN, 1977. Fetal growth retardation following maternal morphine administration-Nutritional or drug effect. Biology of the Neonate, 32, 222–228.
    • (1977) Biology of the Neonate , vol.32 , pp. 222-228
    • Raye, J.R.1    Dubin, J.W.2    Blechner, J.N.3
  • 207
    • 0021926445 scopus 로고
    • In vivo opiate receptor binding of oripavines to mu, delta and kappa sites in rat brain as determined by an ex vivo labeling method
    • Richards ML and Sadée W, 1985. In vivo opiate receptor binding of oripavines to mu, delta and kappa sites in rat brain as determined by an ex vivo labeling method. European Journal of Pharmacology, 114, 343–353.
    • (1985) European Journal of Pharmacology , vol.114 , pp. 343-353
    • Richards, M.L.1    Sadée, W.2
  • 209
    • 33747022195 scopus 로고    scopus 로고
    • Erhöhte Morphingehalte in Mohnprodukten und deren Folgen
    • Rochholz G, Westphal F and Kuhlmann A, 2005. Erhöhte Morphingehalte in Mohnprodukten und deren Folgen. Getreidetechnologie, 59, 239–243.
    • (2005) Getreidetechnologie , vol.59 , pp. 239-243
    • Rochholz, G.1    Westphal, F.2    Kuhlmann, A.3
  • 210
    • 3543096779 scopus 로고    scopus 로고
    • Opiat-Nachweis in Urin, Blut und Haaren nach Verzehr mohnsamenhaltiger Backwaren
    • Rochholz G, Westphal F, Wiesbrock UO and Schütz HW, 2004. Opiat-Nachweis in Urin, Blut und Haaren nach Verzehr mohnsamenhaltiger Backwaren. Blutalkohol, 41, 319–329.
    • (2004) Blutalkohol , vol.41 , pp. 319-329
    • Rochholz, G.1    Westphal, F.2    Wiesbrock, U.O.3    Schütz, H.W.4
  • 211
    • 0345994749 scopus 로고    scopus 로고
    • Arzneimittelverzeichnis für Deutschland, Frankfurt/Main, Germany
    • Rote Liste, 2011. Rote Liste Service GmbH. Arzneimittelverzeichnis für Deutschland, Frankfurt/Main, Germany.
    • (2011) Rote Liste Service GmbH
    • Liste, R.1
  • 213
    • 85078375497 scopus 로고    scopus 로고
    • 115-37-7. Document number RTQN0350000
    • RTECS (Registry of Toxic Effects of Chemical Substances), 2003. Thebaine, CAS No. 115-37-7. Document number RTQN0350000.
    • (2003) Thebaine, CAS No
  • 214
    • 56049091233 scopus 로고    scopus 로고
    • Effects of maternal oral administration of morphine sulfate on developing rat fetal cerebrum: a morphometrical evaluation
    • Sadraie SH, Kaka GR, Sahraei H, Dashtnavard H, Bahadoran H, Mofid M, Nasab HM and Jafari F, 2008. Effects of maternal oral administration of morphine sulfate on developing rat fetal cerebrum: a morphometrical evaluation. Brain Research, 1245, 36–40.
    • (2008) Brain Research , vol.1245 , pp. 36-40
    • Sadraie, S.H.1    Kaka, G.R.2    Sahraei, H.3    Dashtnavard, H.4    Bahadoran, H.5    Mofid, M.6    Nasab, H.M.7    Jafari, F.8
  • 216
    • 0003573091 scopus 로고
    • New York, Van Nostrand Reinhold
    • th ed. New York, Van Nostrand Reinhold, 944–945.
    • (1989) th ed , pp. 944-945
    • Sax, N.I.1    Lewis, R.J.2
  • 217
    • 0016638138 scopus 로고
    • Association between oral clefts and drugs taken during pregnancy
    • Saxen I, 1975. Association between oral clefts and drugs taken during pregnancy. International Journal of Epidemiology, 4, 37–44.
    • (1975) International Journal of Epidemiology , vol.4 , pp. 37-44
    • Saxen, I.1
  • 219
    • 0035875535 scopus 로고    scopus 로고
    • Epidemiology concerning the effect of oral administration of morphine in patients with emphysema from pink puffer type
    • Schönhofer B, Suchi S, Haidl P and Kohler D, 2001. Epidemiology concerning the effect of oral administration of morphine in patients with emphysema from pink puffer type. Medizinische Klinik, 96, 325–330.
    • (2001) Medizinische Klinik , vol.96 , pp. 325-330
    • Schönhofer, B.1    Suchi, S.2    Haidl, P.3    Kohler, D.4
  • 220
    • 0025037468 scopus 로고
    • Pharmacokinetics of codeine after parenteral and oral dosing in the rat
    • Shah J and Mason WD, 1990. Pharmacokinetics of codeine after parenteral and oral dosing in the rat. Drug Metabolism and Disposition, 18, 670–673.
    • (1990) Drug Metabolism and Disposition , vol.18 , pp. 670-673
    • Shah, J.1    Mason, W.D.2
  • 221
    • 0026924498 scopus 로고
    • Congenital cardiac anomalies relative to selected maternal exposures and conditions during early pregnancy
    • Shaw GM, Malcoe LH, Swan SH, Cummins SK and Schulman J, 1992. Congenital cardiac anomalies relative to selected maternal exposures and conditions during early pregnancy. European Journal of Epidemiology, 8, 757–760.
    • (1992) European Journal of Epidemiology , vol.8 , pp. 757-760
    • Shaw, G.M.1    Malcoe, L.H.2    Swan, S.H.3    Cummins, S.K.4    Schulman, J.5
  • 222
    • 0031911338 scopus 로고    scopus 로고
    • Maternal illness, including fever and medication use as risk factors for neural tube defects
    • Shaw GM, Todoroff K, Velie EM and Lammer EJ, 1998. Maternal illness, including fever and medication use as risk factors for neural tube defects. Teratology, 57, 1–7.
    • (1998) Teratology , vol.57 , pp. 1-7
    • Shaw, G.M.1    Todoroff, K.2    Velie, E.M.3    Lammer, E.J.4
  • 223
    • 33846494352 scopus 로고    scopus 로고
    • Evidence that oxymorphone-induced increases in micronuclei occur secondary to hyperthermia
    • Shuey DL, Gudi R, Krsmanovic L and Gerson RJ, 2007. Evidence that oxymorphone-induced increases in micronuclei occur secondary to hyperthermia. Toxicological Sciences, 95, 369–375.
    • (2007) Toxicological Sciences , vol.95 , pp. 369-375
    • Shuey, D.L.1    Gudi, R.2    Krsmanovic, L.3    Gerson, R.J.4
  • 225
    • 0029261407 scopus 로고
    • Morphine induces reproductive changes in female rats and their male offspring
    • Siddiqui A, Haq S, Shaharyar S and Haider SG, 1995. Morphine induces reproductive changes in female rats and their male offspring. Reproductive Toxicology, 9, 143–151.
    • (1995) Reproductive Toxicology , vol.9 , pp. 143-151
    • Siddiqui, A.1    Haq, S.2    Shaharyar, S.3    Haider, S.G.4
  • 228
    • 33747020099 scopus 로고    scopus 로고
    • Optimized LC/MS/MS analysis of morphine and codeine in poppy seed and evaluation of their fate during food processing as a basis for risk analysis
    • Sproll C, Perz RC and Lachenmeier DW, 2006. Optimized LC/MS/MS analysis of morphine and codeine in poppy seed and evaluation of their fate during food processing as a basis for risk analysis. Journal of Agricultural and Food Chemistry, 54, 5292–5298.
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , pp. 5292-5298
    • Sproll, C.1    Perz, R.C.2    Lachenmeier, D.W.3
  • 229
    • 10844248488 scopus 로고    scopus 로고
    • Analgesic effects of codeine-6–glucuronide after intravenous administration
    • Srinivasan V, Wielbo D and Tebbett IR, 1997. Analgesic effects of codeine-6–glucuronide after intravenous administration. European Journal of Pain, 1, 185–190.
    • (1997) European Journal of Pain , vol.1 , pp. 185-190
    • Srinivasan, V.1    Wielbo, D.2    Tebbett, I.R.3
  • 230
    • 51749088099 scopus 로고    scopus 로고
    • The presence of endogenous morphine signaling in animals
    • Stefano GB, Cadet P, Kream RM and Zhu W, 2008. The presence of endogenous morphine signaling in animals. Neurochemical Research, 33, 1933–1939.
    • (2008) Neurochemical Research , vol.33 , pp. 1933-1939
    • Stefano, G.B.1    Cadet, P.2    Kream, R.M.3    Zhu, W.4
  • 231
    • 33747014029 scopus 로고    scopus 로고
    • Neue morphinarme Sorte ermöglicht grossflächigen Anbau von Blaumohn
    • Stolzenburg K, 2006. Neue morphinarme Sorte ermöglicht grossflächigen Anbau von Blaumohn. Landinfo, 3, 26–28.
    • (2006) Landinfo , vol.3 , pp. 26-28
    • Stolzenburg, K.1
  • 237
    • 0037260142 scopus 로고    scopus 로고
    • Urinary concentrations of morphine and codeine after consumption of poppy seeds
    • Thevis M, Opfermann G and Schanzer W, 2003. Urinary concentrations of morphine and codeine after consumption of poppy seeds. Journal of Analytical Toxicology, 27, 53–56.
    • (2003) Journal of Analytical Toxicology , vol.27 , pp. 53-56
    • Thevis, M.1    Opfermann, G.2    Schanzer, W.3
  • 239
    • 28544444120 scopus 로고    scopus 로고
    • Positive Opiatbefunde nach Aufnahme von Mohnprodukten-Analytische Möglichkeiten zur Differenzierung einer Heroin- oder Mohnaufnahme
    • Trafkowski J, Musshoff F and Madea B, 2005. Positive Opiatbefunde nach Aufnahme von Mohnprodukten-Analytische Möglichkeiten zur Differenzierung einer Heroin- oder Mohnaufnahme. Blutalkohol, 42, 431–441.
    • (2005) Blutalkohol , vol.42 , pp. 431-441
    • Trafkowski, J.1    Musshoff, F.2    Madea, B.3
  • 240
    • 0028809922 scopus 로고
    • Determination of morphine and related alkaloids in crude morphine, poppy straw and opium preparations by micellar electrokinetic capillary chromatography
    • Trenerry VC, Wells RJ and Robertson J, 1995. Determination of morphine and related alkaloids in crude morphine, poppy straw and opium preparations by micellar electrokinetic capillary chromatography. Journal of Chromatography. Part A, 718, 217–225.
    • (1995) Journal of Chromatography. Part A , vol.718 , pp. 217-225
    • Trenerry, V.C.1    Wells, R.J.2    Robertson, J.3
  • 243
    • 33846186786 scopus 로고    scopus 로고
    • Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards
    • Tweats DJ, Blakey D, Heflich RH, Jacobs A, Jacobsen SD, Morita T, Nohmi T, O'Donovan MR, Sasaki YF, Sofuni T and Tice R, 2007. Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards. Mutation Research, 627, 78–91.
    • (2007) Mutation Research , vol.627 , pp. 78-91
    • Tweats, D.J.1    Blakey, D.2    Heflich, R.H.3    Jacobs, A.4    Jacobsen, S.D.5    Morita, T.6    Nohmi, T.7    O'Donovan, M.R.8    Sasaki, Y.F.9    Sofuni, T.10    Tice, R.11
  • 244
    • 51249170949 scopus 로고
    • Pain treatment in cancer patients
    • Twycross R, 1990. Pain treatment in cancer patients. Schmerz, 4, 65–74.
    • (1990) Schmerz , vol.4 , pp. 65-74
    • Twycross, R.1
  • 247
    • 0029144375 scopus 로고
    • Driving ability in cancer patients receiving long-term morphine analgesia
    • Vainio A, Ollila J, Matikainen E, Rosenberg P and Kalso E, 1995. Driving ability in cancer patients receiving long-term morphine analgesia. Lancet, 346, 667–670.
    • (1995) Lancet , vol.346 , pp. 667-670
    • Vainio, A.1    Ollila, J.2    Matikainen, E.3    Rosenberg, P.4    Kalso, E.5
  • 249
    • 0023816325 scopus 로고
    • Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine
    • Van der Laan JW and De Groot G, 1988. Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine. Drug Alcohol Dependence, 22, 133–140.
    • (1988) Drug Alcohol Dependence , vol.22 , pp. 133-140
    • Van der Laan, J.W.1    De Groot, G.2
  • 252
    • 0030158785 scopus 로고    scopus 로고
    • Comparison of the in vivo effects of morphine and methadone on natural killer cell activity in spleen, peritoneal cavity, and lungs in rats
    • Van der Laan JW, Timmerman H and Van Loveren H, 1996. Comparison of the in vivo effects of morphine and methadone on natural killer cell activity in spleen, peritoneal cavity, and lungs in rats. International Journal of Immunopharmacology, 18, 401–407.
    • (1996) International Journal of Immunopharmacology , vol.18 , pp. 401-407
    • Van der Laan, J.W.1    Timmerman, H.2    Van Loveren, H.3
  • 254
    • 49649085555 scopus 로고    scopus 로고
    • Morphine-6–glucuronide: potency and safety compared with morphine
    • van Dorp EL, Morariu A and Dahan A, 2008. Morphine-6–glucuronide: potency and safety compared with morphine. Expert Opinion on Pharmacotherapy, 9, 1955–1961.
    • (2008) Expert Opinion on Pharmacotherapy , vol.9 , pp. 1955-1961
    • van Dorp, E.L.1    Morariu, A.2    Dahan, A.3
  • 255
    • 0036136747 scopus 로고    scopus 로고
    • Prenatal opiate exposure: long-term CNS consequences in the stress system of the offspring
    • Vathy I, 2002. Prenatal opiate exposure: long-term CNS consequences in the stress system of the offspring. Psychoneuroendocrinology, 27, 273–283.
    • (2002) Psychoneuroendocrinology , vol.27 , pp. 273-283
    • Vathy, I.1
  • 260
    • 33846215988 scopus 로고    scopus 로고
    • Opioids, sleep architecture and sleep-disordered breathing
    • Wang D and Teichtahl H, 2007. Opioids, sleep architecture and sleep-disordered breathing. Sleep Medicine Reviews, 11, 35–46.
    • (2007) Sleep Medicine Reviews , vol.11 , pp. 35-46
    • Wang, D.1    Teichtahl, H.2
  • 261
    • 0027956428 scopus 로고
    • Gas chromatographic-mass spectrometric procedures used for the identification and determination of morphine, codeine and 6–monoacetylmorphine
    • Wasels R and Belleville F, 1994. Gas chromatographic-mass spectrometric procedures used for the identification and determination of morphine, codeine and 6–monoacetylmorphine. Journal of Chromatography. Part A, 674, 225–234.
    • (1994) Journal of Chromatography. Part A , vol.674 , pp. 225-234
    • Wasels, R.1    Belleville, F.2
  • 262
    • 31444452720 scopus 로고    scopus 로고
    • Morphin und Codein im Blut nach Genuss von Mohnsamen-weiterführende systematische Untersuchungen
    • Westphal F, Rochholz G, Gheorghiu D, Leinenkugel A and Schütz HW, 2006. Morphin und Codein im Blut nach Genuss von Mohnsamen-weiterführende systematische Untersuchungen. Blutalkohol, 43, 14–27.
    • (2006) Blutalkohol , vol.43 , pp. 14-27
    • Westphal, F.1    Rochholz, G.2    Gheorghiu, D.3    Leinenkugel, A.4    Schütz, H.W.5
  • 263
    • 0019154432 scopus 로고
    • The dependence potential of thebaine; Report of a WHO Advisory Group
    • Available from
    • WHO (World Health Organization), 1980. The dependence potential of thebaine; Report of a WHO Advisory Group. Bulletin on Narcotics, 32, 45–54. Available from www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1980-01-01_1_page006.html.
    • (1980) Bulletin on Narcotics , vol.32 , pp. 45-54
  • 266
    • 77949422594 scopus 로고    scopus 로고
    • Harmonisation project document 6. 92 4 156376 5
    • WHO/IPCS (World Health Organization/International Program on Chemical Safety)), 2008. Uncertainty and data quality in exposure assessment. Harmonisation project document No. 6. ISBN 978 92 4 156376 5.
    • (2008) Uncertainty and data quality in exposure assessment
  • 268
    • 70450240777 scopus 로고    scopus 로고
    • Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study
    • Willmann S, Edginton AN, Coboeken K, Ahr G and Lippert J, 2009. Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study. Clinical Pharmacology and Therapeutics, 86, 634–643.
    • (2009) Clinical Pharmacology and Therapeutics , vol.86 , pp. 634-643
    • Willmann, S.1    Edginton, A.N.2    Coboeken, K.3    Ahr, G.4    Lippert, J.5
  • 271
    • 33744936323 scopus 로고    scopus 로고
    • Role of morphine's metabolites in analgesia: concepts and controversies
    • Wittwer E and Kern SE, 2006. Role of morphine's metabolites in analgesia: concepts and controversies. The AAPS Journal, 8, E348–E352.
    • (2006) The AAPS Journal , vol.8 , pp. E348-E352
    • Wittwer, E.1    Kern, S.E.2
  • 272
    • 0018289617 scopus 로고
    • Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes
    • Wybran J, Appelboom T, Famaey JP and Govaerts A, 1979. Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes. Journal of Immunology, 123, 1068–1070.
    • (1979) Journal of Immunology , vol.123 , pp. 1068-1070
    • Wybran, J.1    Appelboom, T.2    Famaey, J.P.3    Govaerts, A.4
  • 273
    • 0020960895 scopus 로고
    • Effects of codeine and morphine on the primary humoral immunity of the respiratory tract
    • Yanaura S, Nishimura T and Misawa M, 1983. Effects of codeine and morphine on the primary humoral immunity of the respiratory tract. Nippon Yakurigaku Zasshi, 81, 315–322.
    • (1983) Nippon Yakurigaku Zasshi , vol.81 , pp. 315-322
    • Yanaura, S.1    Nishimura, T.2    Misawa, M.3
  • 277
    • 0031413420 scopus 로고    scopus 로고
    • Quantification of the O- and N-demethylated and the glucuronidated metabolites of codeine relative to the debrisoquine metabolic ratio in urine in ultrarapid, rapid, and poor debrisoquine hydroxylators
    • Yue QY, Alm C, Svensson JO and Sawe J, 1997. Quantification of the O- and N-demethylated and the glucuronidated metabolites of codeine relative to the debrisoquine metabolic ratio in urine in ultrarapid, rapid, and poor debrisoquine hydroxylators. Therapeutic Drug Monitoring, 19, 539–542.
    • (1997) Therapeutic Drug Monitoring , vol.19 , pp. 539-542
    • Yue, Q.Y.1    Alm, C.2    Svensson, J.O.3    Sawe, J.4
  • 279
    • 0001951914 scopus 로고
    • An overview of the neurobehavioral sequelae of perinatal opioid exposure
    • Ed, Yanai J., Elsevier, New York
    • Zagon IS and McLaughlin PJ, 1984. An overview of the neurobehavioral sequelae of perinatal opioid exposure. In: Neurobehavioral Teratology. Ed Yanai J. Elsevier, New York, 197–234.
    • (1984) Neurobehavioral Teratology , pp. 197-234
    • Zagon, I.S.1    McLaughlin, P.J.2


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