Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: Results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial

Journal of Pain and Symptom Management

Volumn 23, Issue 4, 2002, Pages 278-291

  Caldwell, Jacques R ^a   Rapoport, Ronald J ^b   Davis, Jeffrey C ^c   Offenberg, Howard L ^a   Marker, Howard W ^d   Roth, Sanford H ^e   Yuan, William ^f   Eliot, Lise ^f   Babul, Najib ^g   Lynch, Pia Mikkelsen ^h  

^a RADIANT RESEARCH   (United States)

^b Truesdale Clinic   (United States)

^c Capstone Clinical Trials Inc   (United States)

^d Memphis Medical Specialists   (United States)

^e ArthoCare   (United States)

^f LIGAND PHARMACEUTICALS INC   (United States)

^g Theraquest Biosciences   (United States)

^h Elan Pharmaceutical Research Corporation   (United States)

Author keywords

Controlled release; Extended release; Morphine sulfate; Once daily; Osteoarthritis; Pain; Randomized clinical trial; Sustained release

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; MORPHELAN; MORPHINE SULFATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO; STEROID; UNCLASSIFIED DRUG;

ADULT; AGED; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; OSTEOARTHRITIS; PAIN; RANDOMIZED CONTROLLED TRIAL; SLEEP; TREATMENT OUTCOME;

AGED; ANALGESICS, OPIOID; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; SLEEP;

EID: 0036239777     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0885-3924(02)00383-4     Document Type: Article

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