Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: A controlled study in human volunteers

Pain

Volumn 64, Issue 1, 1996, Pages 123-128

  Borgbjerg, Finn Molke ^a   Nielsen, Kurt ^a   Franks, Jan ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Analgesia: Morphine; CO2 response; Experimental; Pain; Respiration

Indexed keywords

CARBON DIOXIDE; MORPHINE; NALOXONE;

ADULT; ANALGESIA; ARTICLE; BREATHING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PAIN; PRIORITY JOURNAL; RESPIRATION CONTROL;

EID: 0030066612     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(95)00088-7     Document Type: Article

References (17)

1. Arita, H., Kogo, N. and Ichikawa, K., Locations of medullary neurons with non-phasic discharges excited by stimulation of central and/or peripheral chemoreceptors and by activation of nociceptors in cat, Brain Res., 442 (1988) 1-10.
2. 2 sensitivity after intravenous and epidural morphine in volunteers, Anesth. Analg., 62 (1983) 633-640.
3. Catley, D.M., Thornton, C., Jordan, C., Lehane, J.R., Royston, D. and Jones J.G., Pronounced, episodic oxygen desaturation in the postoperative period: its association with ventilatory pattern and analgesic regimen, Anesthesiology, 63 (1985) 20-28.
4. Eckenhoff, J.E. and Oech, S.R., The effects of narcotics and antagonists upon respiration and circulation in man: a review, Clin. Pharmacol. Ther., 1 (1960) 483.
5. Eger, E.I., Dolan, W.M., Stevens, W.C., Miller, R.D. and Way, W.L., Surgical stimulation antagonizes the respiratory depression produced by Forane, Anesthesiology, 36 (1972) 544-549.
6. Hagenouw, R., Bridenbaugh, P.O., van Egmond, J. and Stuebing, R., Tourniquet pain, Anesth. Analg., 65 (1986) 1175-1180.
7. Hanks, G.W., Twycross, R.G. and Lloyd, J.W., Unexpected complications of successful nerve block, Anaesthesia, 36 (1981) 37-35.
8. Keats, A.S. and Girgis, K.Z., Respiratory depression associated with relief of pain by narcotics, Anesthesiology, 29 (1968) 1006-1013.
9. Lam, A.M., Clement, J.L. and Knill, R.L., Surgical stimulation does not enhance ventilatory chemoreflexes during enflurane anaesthesia in man, Can. Anaesth. Soc. J., 27 (1980) 22-28.
10. Madej, T.H., Wheatley, R.G., Jackson, I.J.B. and Hunter, D., Hypoxaemia and pain relief after lower abdominal surgery: comparison of extradural and patient-controlled analgesia, Br. J. Anaesth., 69 (1992) 554-557.
11. McQuay, H.J., Letter. Br. J. Anaesth., 61 (1988) 121.
12. Molke Jensen, F., Madsen, J.B., Guldager, H., Christensen, A.A. and Eriksen, H., Respiratory depression after epidural morphine in the postoperative period. Influence of posture, Acta Anaesth. Scand., 28 (1984) 600-602.
13. Nishino, T. and Kochi, T., Effects of surgical stimulation on the apnoeic thresholds for carbon dioxide during anaesthesia with sevoflurane, Br. J. Anaesth., 73 (1994) 583-586.
14. Read, D.J.C., A clinical method for assessing the ventilatory response to carbon dioxide, Aust. Ann. Med., 16 (1967) 20-32.
15. Wells, C.J., Lipton, S. and Lahuerta, J., Respiratory depression after percutaneus cervical anterolateral cordotomy in patients on slow-release oral morphine, Lancet, i (1984) 739.
16. Wheatley, R.G., Shepherd, D., Jackson, I.J.B., Madej, T.H. and Hunter, D., Hypoxaemia and pain relief after upper abdominal surgery: comparison of i.m. and patient-controlled analgesia, Br. J. Anaesth., 69 (1992) 558-561.
17. Whitelaw, W.A., Derenne, J.-P. and Milic-Emili, J., Occlusion pressure as a measure of respiratory center output in conscious man, Resp. Physiol., 23 (1975) 181-199.