-
2
-
-
0037903823
-
Darstellung der reinen Mohnsaure (Opiumsaure) nebst einer chemischen Untersuchung des Opiums mit vorzuglicher Hinsicht auf einen darin neu entdeckten Stoff und die dahin gehorigen Bemerkungen
-
Serturner, F. W.: Darstellung der reinen Mohnsaure (Opiumsaure) nebst einer chemischen Untersuchung des Opiums mit vorzuglicher Hinsicht auf einen darin neu entdeckten Stoff und die dahin gehorigen Bemerkungen. J Pharm Arzte Apotheker Chem. 14 (1), 47-93 (1806).
-
(1806)
J Pharm Arzte Apotheker Chem.
, vol.14
, Issue.1
, pp. 47-93
-
-
Serturner, F.W.1
-
3
-
-
84977496150
-
Uber das Morphium, eine neue salzfahige Grundlage, und die Mekonsaure, als Hauptbestandtheile des Opiums
-
Serturner, F. W.: Uber das Morphium, eine neue salzfahige Grundlage, und die Mekonsaure, als Hauptbestandtheile des Opiums. Ann Phys. 25, 56-90 (1817).
-
(1817)
Ann Phys.
, vol.25
, pp. 56-90
-
-
Serturner, F.W.1
-
4
-
-
26144465845
-
Uber ein neues Pflanzenalkali (Alkaloid)
-
Meissner, W.: Uber ein neues Pflanzenalkali (Alkaloid). J Chem. Phys. 25, 379-381 (1819).
-
(1819)
J Chem. Phys.
, vol.25
, pp. 379-381
-
-
Meissner, W.1
-
6
-
-
37049043810
-
A Cristallographic Examination of the Structure of Morphine
-
MacKay, M., D. C. Hodgkin: A Cristallographic Examination of the Structure of Morphine. J. Chem Soc., 3261-3267 (1955)
-
(1955)
J. Chem Soc.
, pp. 3261-3267
-
-
MacKay, M.1
Hodgkin, D.C.2
-
9
-
-
0021813261
-
Opioid Peptides and their Receptors
-
Kosterlitz, H. W.: Opioid Peptides and their Receptors, Proc. R. Soc Lond. (Biol.) 225, 27-40 (1985).
-
(1985)
Proc. R. Soc Lond. (Biol.)
, vol.225
, pp. 27-40
-
-
Kosterlitz, H.W.1
-
10
-
-
0016701344
-
Identification of two Related Pentapeptides from the Brain with Potent Opiate Agonist Activity
-
Hughes, J., T. W. Smith et al.: Identification of two Related Pentapeptides from the Brain with Potent Opiate Agonist Activity. Nature 258, 577-579 (1974).
-
(1974)
Nature
, vol.258
, pp. 577-579
-
-
Hughes, J.1
Smith, T.W.2
-
12
-
-
0022431709
-
Has Morphine a Physiological Function in the Animal Kingdom?
-
Kosterlitz, H. W.: Has Morphine a Physiological Function in the Animal Kingdom? Nature 317, 671-672 (1985).
-
(1985)
Nature
, vol.317
, pp. 671-672
-
-
Kosterlitz, H.W.1
-
13
-
-
0023658665
-
Biosynthesis of Morphine in the Animal Kingdom
-
Kosterlitz, H W.: Biosynthesis of Morphine in the Animal Kingdom Nature 330, 606 (1987).
-
(1987)
Nature
, vol.330
, pp. 606
-
-
Kosterlitz, H.W.1
-
14
-
-
3342910870
-
L'Action Cataleptique de la Morphine chez les Rats. Contribution a la Theorie Toxique de la Catalepsie
-
Mavrojannis, M . L'Action Cataleptique de la Morphine chez les Rats. Contribution a la Theorie Toxique de la Catalepsie. Comptes rendues Soc Biol. 55, 1092-1094 (1903).
-
(1903)
Comptes Rendues Soc Biol.
, vol.55
, pp. 1092-1094
-
-
Mavrojannis, M.1
-
15
-
-
84916044439
-
Biological and Behavioral Approaches to Drug Dependence
-
Addiction Research Foundation, Toronto
-
Goldstein, A.: Biological and Behavioral Approaches to Drug Dependence. Proceedings International Symposium on Alcohol and Drug Research. Addiction Research Foundation, Toronto 1975, p. 27-41.
-
(1975)
Proceedings International Symposium on Alcohol and Drug Research
, pp. 27-41
-
-
Goldstein, A.1
-
16
-
-
0011864141
-
Antibodies as a Means of Isolating and Characterizing Biologically Active Substances: Presence of a Non-Peptide, Morphine-Like Compound in the Central Nervous System
-
Gintzler, A., A. Levy et al : Antibodies as a Means of Isolating and Characterizing Biologically Active Substances: Presence of a Non-Peptide, Morphine-Like Compound in the Central Nervous System Proc Natl Acad. Sci. USA 73, 2132-2136 (1976)
-
(1976)
Proc Natl Acad. Sci. USA
, vol.73
, pp. 2132-2136
-
-
Gintzler, A.1
Levy, A.2
-
17
-
-
0018137148
-
A Non-peptide Morphine-Like Compound: Immunocytochemical Localization in the Mouse Brain
-
Gintzler, A. R., M. D Gershon et al.: A Non-peptide Morphine-Like Compound: Immunocytochemical Localization in the Mouse Brain. Science 199, 447-448 (1978).
-
(1978)
Science
, vol.199
, pp. 447-448
-
-
Gintzler, A.R.1
Gershon, M.D.2
-
18
-
-
0008413087
-
Binding of the Endogenous Nonpeptide Morphine-Like Compound to Opiate Receptors
-
Blume, A. J Shorr et al., Binding of the Endogenous Nonpeptide Morphine-Like Compound to Opiate Receptors Proc. Natl. Acad. Sci. USA 74, 4927-4931 (1977)
-
(1977)
Proc. Natl. Acad. Sci. USA
, vol.74
, pp. 4927-4931
-
-
Blume, A.1
Shorr, J.2
-
19
-
-
0019457964
-
A Non-Peptide Morphine-Like Compound from Brain
-
Killian, A. K., C. R Schuster et al.: A Non-Peptide Morphine-Like Compound from Brain. Life Sci 28, 811-817 (1981).
-
(1981)
Life Sci
, vol.28
, pp. 811-817
-
-
Killian, A.K.1
Schuster, C.R.2
-
20
-
-
0018218927
-
Presence of a Non-Peptide Morphine-Like Compound in Human Cerebrospinal Fluid
-
Shorr, J., K. Foley et al.: Presence of a Non-Peptide Morphine-Like Compound in Human Cerebrospinal Fluid. Life Sci. 23, 2057-2062 (1978).
-
(1978)
Life Sci.
, vol.23
, pp. 2057-2062
-
-
Shorr, J.1
Foley, K.2
-
22
-
-
0000690734
-
Morphine and other Opiates from Beef Brain and Adrenal
-
Goldstein, A., R. W. Barrett et al: Morphine and other Opiates from Beef Brain and Adrenal. Proc Natl. Acad Sci. USA 82, 5203-5207 (1985).
-
(1985)
Proc Natl. Acad Sci. USA
, vol.82
, pp. 5203-5207
-
-
Goldstein, A.1
Barrett, R.W.2
-
23
-
-
0023066768
-
Morphine and Codeine are Endogenous Components of Human Cerebrospinal Fluid
-
Cardinale, G. J., J. Donnerer et al.: Morphine and Codeine are Endogenous Components of Human Cerebrospinal Fluid. Life Sci. 40, 301-306 (1987)
-
(1987)
Life Sci.
, vol.40
, pp. 301-306
-
-
Cardinale, G.J.1
Donnerer, J.2
-
24
-
-
0019890247
-
Morphine in Cow and Human Milk: Could Dietary Morphine Constitute a Ligand for Specific Morphine (μ)-Receptors?
-
Hazum, E., J. J Sabatka et al.: Morphine in Cow and Human Milk: Could Dietary Morphine Constitute a Ligand for Specific Morphine (μ)-Receptors? Science 213, 1010-1012 (1981)
-
(1981)
Science
, vol.213
, pp. 1010-1012
-
-
Hazum, E.1
Sabatka, J.J.2
-
25
-
-
0014943286
-
Alcohol, Amines and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction
-
Davis, V. E., M. J Walsh: Alcohol, Amines and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction. Science 167, 1005-1007 (1970).
-
(1970)
Science
, vol.167
, pp. 1005-1007
-
-
Davis, V.E.1
Walsh, M.J.2
-
26
-
-
0040363205
-
Some Biogenetic Aspects of Phenol Oxidation
-
Birkhauser Verlag, Basel
-
Barton, D. H. R., T. Cohen: Some Biogenetic Aspects of Phenol Oxidation. Festschrift Arthur Stoll. S.117-144. Birkhauser Verlag, Basel 1957
-
(1957)
Festschrift Arthur Stoll.
, pp. 117-144
-
-
Barton, D.H.R.1
Cohen, T.2
-
27
-
-
13344267827
-
Investigations on the Biosynthesis of Morphine Alkaloids
-
Barton, D. H. R., G. W. Kirby et al: Investigations on the Biosynthesis of Morphine Alkaloids. J. Chem. Soc., 2423-2438 (1965).
-
(1965)
J. Chem. Soc.
, pp. 2423-2438
-
-
Barton, D.H.R.1
Kirby, G.W.2
-
28
-
-
0024845487
-
Phenol Oxidative Coupling of Benzylisoquinoline Alkaloids is catalysed by Regio- And Stereo-selective Cytochrome P-450 linked Plant Enzymes. Salutaridine and Berbamunine
-
Zenk, M H., R. Gerardy et al., Phenol Oxidative Coupling of Benzylisoquinoline Alkaloids is catalysed by Regio- and Stereo-selective Cytochrome P-450 linked Plant Enzymes. Salutaridine and Berbamunine. J. Chem Soc., Chem. Commun, 1725-1727 (1989).
-
(1989)
J. Chem Soc., Chem. Commun
, pp. 1725-1727
-
-
Zenk, M.H.1
Gerardy, R.2
-
29
-
-
44049113918
-
Formation of Salutaridine from (R)-Reticuline by a membrane-bound Cytochrome P-450 Enzyme from Papaver somniferum
-
Gerardy, R., M. H. Zenk. Formation of Salutaridine from (R)-Reticuline by a membrane-bound Cytochrome P-450 Enzyme from Papaver somniferum Phytochemistry 32, 79-86 (1993).
-
(1993)
Phytochemistry
, vol.32
, pp. 79-86
-
-
Gerardy, R.1
Zenk, M.H.2
-
30
-
-
0023658664
-
Synthesis of the Skeleton of the Morphine Molecule by Mammalian Liver
-
Weitz, C. J., K. F. Faull et al.: Synthesis of the Skeleton of the Morphine Molecule by Mammalian Liver Nature 330, 674-677 (1987).
-
(1987)
Nature
, vol.330
, pp. 674-677
-
-
Weitz, C.J.1
Faull, K.F.2
-
31
-
-
0025826559
-
Formation of the Morphine Precursor Salutaridine is Catalyzed by a Cytochrome P-450 Enzyme in Mammalian Livers
-
Amann, T., M. H. Zenk: Formation of the Morphine Precursor Salutaridine is Catalyzed by a Cytochrome P-450 Enzyme in Mammalian Livers. Tetrahedron Lett. 32, 3675-3678 (1991).
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 3675-3678
-
-
Amann, T.1
Zenk, M.H.2
-
32
-
-
0000923803
-
Purification and Characterization of a Cytochrome P450 Enzyme from Pig Liver. Catalyzing the Phenoloxidative Coupling of (R)-Reticuline to Salutaridine, the Critical Step in Morphine Biosynthesis
-
Amann, T., P. H Roos et al.: Purification and Characterization of a Cytochrome P450 Enzyme from Pig Liver. Catalyzing the Phenoloxidative Coupling of (R)-Reticuline to Salutaridine, the Critical Step in Morphine Biosynthesis. Heterocycles 40, 425-440 (1995).
-
(1995)
Heterocycles
, vol.40
, pp. 425-440
-
-
Amann, T.1
Roos, P.H.2
-
33
-
-
0010264512
-
Presence and Formation of Codeine and Morphine in the Rat
-
Donnerer, J., K. Oka et al : Presence and Formation of Codeine and Morphine in the Rat. Proc. Natl. Acad. Sci. USA 83, 4566-4567 (1986).
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4566-4567
-
-
Donnerer, J.1
Oka, K.2
-
34
-
-
0000613388
-
Purification and Characterization of Salutaridine: NADPH 7-Oxidoreductase from Papaver somniferum
-
Gerardy, R., M. H. Zenk: Purification and Characterization of Salutaridine: NADPH 7-Oxidoreductase from Papaver somniferum. Phytochemistry 34, 125-132 (1993).
-
(1993)
Phytochemistry
, vol.34
, pp. 125-132
-
-
Gerardy, R.1
Zenk, M.H.2
-
35
-
-
0026525248
-
Revision of the Configuration at C-7 of Salutaridinol-I, the Natural intermediate in Morphine Biosynthesis
-
Lotter, H., J. Gollwitzer et al.: Revision of the Configuration at C-7 of Salutaridinol-I, the Natural intermediate in Morphine Biosynthesis. Tetrahedron Lett, 33, 2443-2446 (1992).
-
(1992)
Tetrahedron Lett
, vol.33
, pp. 2443-2446
-
-
Lotter, H.1
Gollwitzer, J.2
-
36
-
-
0028245117
-
Closure of the Oxide Bridge in Morphine Biosynthesis
-
Lenz, R., M. H. Zenk: Closure of the Oxide Bridge in Morphine Biosynthesis Tetrahedron Lett. 35, 3897-3900 (1994).
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 3897-3900
-
-
Lenz, R.1
Zenk, M.H.2
-
37
-
-
0024494732
-
Identification of the Convulsant Opiate Thebaine in Mammalian Brain
-
Kodaira, H., C. A. Lisek et al.: Identification of the Convulsant Opiate Thebaine in Mammalian Brain. Proc. Natl. Acad. Sci. USA 86, 716-719 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 716-719
-
-
Kodaira, H.1
Lisek, C.A.2
-
38
-
-
37049138283
-
Alkaloid Biosynthesis. Part X. Terminal Steps in the Biosynthesis of the Morphine Alkaloids
-
Battersby, A. R., J. A. Martin et al., Alkaloid Biosynthesis. Part X. Terminal Steps in the Biosynthesis of the Morphine Alkaloids. J. Chem. Soc., (C) 1785-1788 (1967).
-
(1967)
J. Chem. Soc., (C)
, pp. 1785-1788
-
-
Battersby, A.R.1
Martin, J.A.2
-
39
-
-
0014203723
-
Codeinone as the Intermediate in the Biosynthetic Conversion of Thebaine to Codeine
-
Blaschke, G , H. J. Parker et al.: Codeinone as the Intermediate in the Biosynthetic Conversion of Thebaine to Codeine. J. Am. Chem. Soc. 89, 1540-1541 (1967).
-
(1967)
J. Am. Chem. Soc.
, vol.89
, pp. 1540-1541
-
-
Blaschke, G.1
Parker, H.J.2
-
40
-
-
0015520397
-
Biosynthetic Conversion of Thebaine to Codeine
-
Parker, H I., G Blaschke et al Biosynthetic Conversion of Thebaine to Codeine. J Am. Chem. Soc. 94, 1276-1282 (1972)
-
(1972)
J Am. Chem. Soc.
, vol.94
, pp. 1276-1282
-
-
Parker, H.I.1
Blaschke, G.2
-
41
-
-
0027209527
-
The Transformation of Neopinone to Codeinone in Morphine Biosynthesis Proceeds Non-Enzymatically
-
Gollwitzer, J . R. Lenz el al.: The Transformation of Neopinone to Codeinone in Morphine Biosynthesis Proceeds Non-Enzymatically. Tetrahedron Lett. 34, 5703-5706 (1993).
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 5703-5706
-
-
Gollwitzer, J.1
Lenz, R.2
-
42
-
-
0021123010
-
A Second Pathway for the Terminal Steps in the Biosynthesis of Morphine
-
Brochmann-Hanssen, E.: A Second Pathway for the Terminal Steps in the Biosynthesis of Morphine. Planta Med. 50, 343-345 (1984).
-
(1984)
Planta Med.
, vol.50
, pp. 343-345
-
-
Brochmann-Hanssen, E.1
-
43
-
-
0000465151
-
Transformation of Thebaine to Oripavine, Codeine and Morphine by Rat Liver. Kidney and Brain Microsomes
-
Kodaira, H., S. Spector: Transformation of Thebaine to Oripavine, Codeine and Morphine by Rat Liver. Kidney and Brain Microsomes, Proc. Natl. Acad. Sci. USA 85, 1267-1271 (1988)
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 1267-1271
-
-
Kodaira, H.1
Spector, S.2
-
44
-
-
0021872250
-
Purification and Characterization of Guinea Pig Liver Morphine 6-Dehydrogenase
-
Yamano, S., E. Kageura et al. Purification and Characterization of Guinea Pig Liver Morphine 6-Dehydrogenase. J. Biol. Chem. 260, 5259-5264 (1985).
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 5259-5264
-
-
Yamano, S.1
Kageura, E.2
-
45
-
-
0026638361
-
Increased Urinary Morphine. Codeine and Tetrahydropapaveroline in Parkinsonian Patient Undergoing L-3,4-Dihydroxyphenylalanine Therapy: A Possible Biosynthetic Pathway of Morphine from L-3.4-Dihydroxyphenylalanine in Humans
-
Matsubara, K., S Fukushima el al.: Increased Urinary Morphine. Codeine and Tetrahydropapaveroline in Parkinsonian Patient Undergoing L-3,4-Dihydroxyphenylalanine Therapy: A Possible Biosynthetic Pathway of Morphine from L-3.4-Dihydroxyphenylalanine in Humans. J Pharmacol Exp. Ther 260, 974-978 (1992).
-
(1992)
J Pharmacol Exp. Ther
, vol.260
, pp. 974-978
-
-
Matsubara, K.1
Fukushima, S.2
-
46
-
-
0003150195
-
Chasing the Enzymes of Alkaloid Biosynthesis
-
The Royal Society of Chemistry. Newcastle upon Tyne
-
Zenk, M. H . Chasing the Enzymes of Alkaloid Biosynthesis. Organic Reactivity Physical and Biological Aspects The Royal Society of Chemistry. Newcastle upon Tyne 1995, p 89-109.
-
(1995)
Organic Reactivity Physical and Biological Aspects
, pp. 89-109
-
-
Zenk, M.H.1
-
47
-
-
77957766616
-
Mammalian Alkaloids II
-
Brossi. A.: Mammalian Alkaloids II. The Alkaloids. 119-183 (1993).
-
(1993)
The Alkaloids
, pp. 119-183
-
-
Brossi, A.1
-
48
-
-
0023261822
-
Chemical Characterization and Regulation of Endogenous Morphine and Codeine in the Rat
-
Donnerer, J , G. Cardinale et al.: Chemical Characterization and Regulation of Endogenous Morphine and Codeine in the Rat. J. Pharmacol. Exp. Ther. 242, 583-587 (1987)
-
(1987)
J. Pharmacol. Exp. Ther.
, vol.242
, pp. 583-587
-
-
Donnerer, J.1
Cardinale, G.2
-
49
-
-
0021881067
-
Analgesic Potencies of Morphine 3- And 6-Sultates after Intracerebroventricular Administration in Mice: Relationship to Structural Characteristics Defined by Mass Spectrometry and Nuclear Magnetic Resonance
-
Brown, C. E., S. C. Roerig et al.: Analgesic Potencies of Morphine 3- and 6-Sultates after Intracerebroventricular Administration in Mice: Relationship to Structural Characteristics Defined by Mass Spectrometry and Nuclear Magnetic Resonance J. Pharm. Sci. 74, 821-824 (1985).
-
(1985)
J. Pharm. Sci.
, vol.74
, pp. 821-824
-
-
Brown, C.E.1
Roerig, S.C.2
-
50
-
-
0026754070
-
Pharmacological Effects of Drug Conjugates: Is Morphine 6-glucuronide an Exception?'
-
Mulder, G.: Pharmacological Effects of Drug Conjugates: is Morphine 6-glucuronide an Exception?' TIPS 13, 302-304 (1992)
-
(1992)
TIPS
, vol.13
, pp. 302-304
-
-
Mulder, G.1
-
51
-
-
0028207482
-
Endogenous Codeine and Morphine in Poor and Extensive Metabolisers, of the CYP2D6 (Debrisoquine/Sparteine) Polymorphism
-
Mikus, G., F. Bochner et al.: Endogenous Codeine and Morphine in Poor and Extensive Metabolisers, of the CYP2D6 (Debrisoquine/Sparteine) Polymorphism. J. Pharmacol. Exp. Ther. 268, 546-551 (1994)
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.268
, pp. 546-551
-
-
Mikus, G.1
Bochner, F.2
|