Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines

European Journal of Pharmacology

Volumn 844, Issue , 2019, Pages 87-94

  Conti, Pio ^a   D'Ovidio, Cristian ^a   Conti, Chiara ^a   Gallenga, Carla Enrica ^b   Lauritano, Dorina ^c   Caraffa, Alessandro ^d   Kritas, Spiros K ^e   Ronconi, Gianpaolo ^f  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF PERUGIA   (Italy)

^e ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^f FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Cytokines; IL 37; Inflammation; Mast cells; Migraine

Indexed keywords

ARACHIDONIC ACID; CYTOKINE; HISTAMINE; INTERLEUKIN 1; INTERLEUKIN 37; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

ANGIOGENESIS; CENTRAL NERVOUS SYSTEM; DENDRITIC CELL; DISEASE EXACERBATION; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MAST CELL; MICROGLIA; MIGRAINE; NERVOUS SYSTEM INFLAMMATION; NOCICEPTIVE STIMULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; ANIMAL; IMMUNOLOGY;

ANIMALS; CYTOKINES; DISEASE PROGRESSION; HUMANS; MAST CELLS; MIGRAINE DISORDERS;

EID: 85058220014     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2018.12.004     Document Type: Review

References (90)

1. Aich, A., Afrin, L.B., Gupta, K., Mast cell-mediated mechanisms of nociception. Int. J. Mol. Sci. 16:12 (2015), 29069–29092, 10.3390/ijms161226151.
2. Barbagallo, M., Vitaliti, G., Greco, F., Pavone, P., Matin, N., Panta, G., Lubrano, R., Falsaperla, R., Idiopathic intracranial hypertension in a paediatric population: a retrospective observational study on epidemiology, symptoms and treatment. J. Biol. Regul. Homeost. Agents 31:1 (2017), 195–200.
3. Barnes, P.J., Pathophysiology of allergic inflammation. Immunol. Rev. 242:1 (2011), 31–50.
4. Barua, R.S., Sharma, M., Dileepan, K.N., Cigarette smoke amplifies inflammatory response and atherosclerosis progression through activation of the H1R-TLR2/4-COX2 Axis. Front. Immunol., 6, 2015, 572.
5. Bell, R.D., Mechanism and management of headache. Ann. Intern. Med. 130:8 (1999), 703–704.
6. Benemei, S., Fusi, C., Trevisan, G., Geppetti, P., The TRPA1 channel in migraine mechanism and treatment. Br. J. Pharmacol. 171:10 (2014), 2552–2567.
7. Blumenfeld, A., Gennings, C., Cady, R., Pharmacological synergy: the next frontier on therapeutic advancement for migraine. Headache 52:4 (2012), 636–647.
8. Caraffa, A., Conti, C., D'Ovidio, C., Gallenga, C.E., Tettamanti, L., Mastrangelo, F., Ronconi, G., Kritas, S.K., Conti, P., New concepts in neuroinflammation: mast cells pro-inflammatory and anti-inflammatory cytokine mediators. J. Biol. Regul. Homeost. Agents 32:3 (2018), 449–454.
9. Cavalli, G., Dinarello, C.A., Suppression of inflammation and acquired immunity by IL-37. Immunol. Rev. 281:1 (2018), 179–190, 10.1111/imr.12605.
10. Chikahisa, S., Kodama, T., Soya, A., Sagawa, Y., Ishimaru, Y., Séi, H., Nishino, S., Histamine from brain resident mast cells promotes wakefulness and modulates behavioral states. PLoS One, 8(10), 2013, e78434.
11. Choi, J.E., Di Nardo, A., Skin neurogenic inflammation. Semin. Immunopathol. 40:3 (2018), 249–259, 10.1007/s00281-018-0675-z (Epub 2018 Apr 30).
12. Christy, A.L., Walker, M.E., Hessner, M.J., Brown, M.A., Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE. J. Autoimmun. 42 (2013), 50–61, 10.1016/j.jaut.2012.11.003.
13. Clark, I.A., Vissel, B., Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents. J. Neuroinflamm., 13(1), 2016, 236.
14. Conti, P., Caraffa, A., Ronconi, G., Conti, C.M., Kritas, S.K., Mastrangelo, F., Tettamanti, L., Theoharides, T.C., Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers). Immunol. Res., 2018, 10.1007/s12026-018-9004-9.
15. Conti, P., Caraffa, A., Ronconi, G., Kritas, S.K., Mastrangelo, F., Tettamanti, L., Theoharides, T.C., Impact of mast cells in mucosal immunity of intestinal inflammation: inhibitory effect of IL-37. Eur. J. Pharmacol. 818 (2018), 294–299, 10.1016/j.ejphar.2017.09.044.
16. Conti, P., Caraffa, A., Ronconi, G., Kritas, S.K., Mastrangelo, F., Tettamanti, L., Frydas, I., Theoharides, T.C., Mast cells participate in allograft rejection: can IL-37 play an inhibitory role?. Inflamm. Res. 67:9 (2018), 747–755, 10.1007/s00011-018-1166-3.
17. Conti, P., Caraffa, Al, Kritas, S.K., Ronconi, G., Lessiani, G., Toniato, E., Theoharides, T.C., Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues. J. Biol. Regul. Homeost. Agents 31:2 (2017), 263–267.
18. Conti, P., Ronconi, G., Kritas, S.K., Caraffa, A., Theoharides, T.C., Activated mast cells mediate low-grade inflammation in type 2 diabetes: interleukin-37 could be beneficial. Can. J. Diabetes, 2018, 10.1016/j.jcjd.2018.01.008.
19. Conti, P., Tettamanti, L., Mastrangelo, F., Ronconi, G., Frydas, I., Kritas, S.K., Caraffa, A., Pandolfi, F., Impact of fungi on immune responses. Clin. Ther. 40:6 (2018), 885–888, 10.1016/j.clinthera.2018.04.010.
20. Cseh, A., Farkas, K.M., Derzbach, L., Muller, K., Vasarhelyi, B., Szalay, B., Treszl, A., Farkas, V., Lymphocyte subsets in pediatric migraine. Neurol. Sci. 34:7 (2013), 1151–1155.
21. De Feo, D., Merlini, A., Brambilla, E., Ottoboni, L., Laterza, C., Menon, R., Srinivasan, S., Farina, C., Garcia Manteiga, J.M., Butti, E., Bacigaluppi, M., Comi, G., Greter, M., Martino, G., Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J. Clin. Investig. 127:11 (2017), 3937–3953, 10.1172/JCI92387.
22. Dinarello, C.A., Interleukin-1. Rev. Infect. Dis. 6:1 (1984), 51–95.
23. Dinarello, C.A., Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27 (2009), 519–550.
24. Dinarello, C.A., Cannon, J.G., Wolff, S.M., New concepts on the pathogenesis of fever. Rev. Infect. Dis. 10:1 (1988), 168–189.
25. Dinarello, C.A., Nold-Petry, C., Nold, M., Fujita, M., Li, S., Kim, S., Bufler, P., Suppression of innate inflammation and immunity by interleukin-37. Eur. J. Immunol. 46:5 (2016), 1067–1081.
26. Downer, E.J., Johnston, D.G., Lynch, M.A., Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia. Mol. Cell. Neurosci. 56 (2013), 148–158.
27. Facci, L., Barbierato, M., Marinelli, C., Argentini, C., Skaper, S.D., Giusti, P., Toll-like receptors 2, −3 and −4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1β release. Sci. Rep., 4, 2014, 6824.
28. Fernández-de-las-Peñas, C., Cuadrado, M.L., Arendt-Nielsen, L., Simons, D.G., Parej,a, J.A., Myofascial trigger points and sensitization: an updated pain model for tension-type headache. Cephalalgia 27:5 (2007), 383–393.
29. Frick, L., Rapanelli, M., Abbasi, E., Ohtsu, H., Pittenger, C., Histamine regulation of microglia: gene-environment interaction in the regulation of central nervous system inflammation. Brain Behav. Immun. 57 (2016), 326–337.
30. Galli, S.J., Kalesnikoff, J., Grimbaldeston, M.A., Piliponsky, A.M., Williams, C.M., Tsai, M., Mast cells as “tunable” effector and immunoregulatory cells: recent advances. Annu. Rev. Immunol. 23 (2005), 749–786.
31. Georgin-Lavialle, S., Gaillard, R., Moura, D., Hermine, O., Mastocytosis in adulthood and neuropsychiatric disorders. Transl. Res., 174(77–85), 2016, e1, 10.1016/j.trsl.2016.03.013.
32. Guerrero-García, J.J., The role of astrocytes in multiple sclerosis pathogenesis. Neurologia, 2017, 10.1016/j.nrl.2017.07.021.
33. Gupta, K., Harvima, I.T., Mast cell-neural interactions contribute to pain and itch. Immunol. Rev. 282:1 (2018), 168–187, 10.1111/imr.12622.
34. Gürkan, F., Ece, A., Haspolat, K., Dikici, B., Parental history of migraine and bronchial asthma in children. Allergol. Immunopathol. 28:1 (2000), 15–17.
35. Hallgren, J., Gurish, M.F., Granule maturation in mast cells: histamine in control. Eur. J. Immunol. 44:1 (2014), 33–36.
36. Hanisch, U.K., Microglia as a source and target of cytokines. Glia 40:2 (2002), 140–155.
37. Hendrix, S., Kramer, P., Pehl, D., Warnke, K., Boato, F., Nelissen, S., Lemmens, E., Pejler, G., Metz, M., Siebenhaar, F., Maurer, M., Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J. 27:3 (2013), 920–929, 10.1096/fj.12-204800.
38. Hu, W.W., Chen, Z., Role of histamine and its receptors in cerebral ischemia. ACS Chem. Neurosci. 3:4 (2012), 238–247.
39. Jack, C.S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., Crea, E., Shapiro, A., Antel, J.P., TLR signaling tailors innate immune responses in human microglia and astrocytes. J. Immunol. 175:7 (2005), 4320–4330.
40. Jawdat, D.M., Rowden, G., Marshall, J.S., Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan. J. Immunol. 177:3 (2006), 1755–1762.
41. Karlsen, T.V., Bletsa, A., Gjerde, E.A., Reed, R.K., Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells. Am. J. Physiol. Heart Circ. Physiol. 292:4 (2007), H1821–H1827.
42. Kempuraj, D., Thangavel, R., Natteru, P.A., Selvakumar, G.P., Saeed, D., Zahoor, H., Zaheer, S., Iyer, S.S., Zaheer, A., Neuroinflammation induces neurodegeneration. J. Neurol. Neurosurg. Spine, 1(1), 2016.
43. Kigerl, K.A., de Rivero Vaccari, J.P., Dietrich, W.D., Popovich, P.G., Keane, R.W., Pattern recognition receptors and central nervous system repair. Exp. Neurol. 258 (2014), 5–16.
44. Kilinc, E., Dagistan, Y., Kotan, B., Cetinkaya, A., Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats. Physiol. Int. 104:1 (2017), 15–24.
45. Kivisäkk, P., Mahad, D.J., Callahan, M.K., Trebst, C., Tucky, B., Wei, T., Wu, L., Baekkevold, E.S., Lassmann, H., Staugaitis, S.M., Campbell, J.J., Ransohoff, R.M., Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc. Natl. Acad. Sci. USA 100:14 (2003), 8389–8394.
46. Kritas, S.K., Gallenga, C.E., D'Ovidio, C., Ronconi, G., Caraffa, A., Toniato, E., Lauritano, D., Conti, P., Impact of mold on mast cell-cytokine immune response. J. Biol. Regul. Homeost. Agents 32:4 (2018), 763–768.
47. Leme, J.G., Bechara, G.H., Sudo, L.S., The proinflammatory function of lymphocytes in non-immune inflammation: effect of steroidal and non-steroidal anti-inflammatory agents. Br. J. Exp. Pathol. 58:6 (1977), 703–711.
48. Levy, D., Migraine pain, meningeal inflammation, and mast cells. Curr. Pain. Headache Rep. 13:3 (2009), 237–240.
49. Levy, D., Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression. Curr. Pain. Headache Rep. 16:3 (2012), 270–277, 10.1007/s11916-012-0255-1.
50. Liu, L.L., Li, X., Chang, G., Wang, Z.G., Zhang, S.J., Ju, X.N., Sibelium in combination with dibazole in the treatment of angioneurotic headache. J. Biol. Regul. Homeost. Agents 31:3 (2017), 653–657.
51. Majewski, K., Agier, J., Kozłowska, E., Brzezińska-Błaszczyk, E., Status of cathelicidin IL-37, cytokine TNF, and vitamin D in patients with pulmonary tuberculosis. J. Biol. Regul. Homeost. Agents 32:2 (2018), 321–325.
52. Makabe-Kobayashi, Y., Hori, Y., Adachi, T., Ishigaki-Suzuki, S., Kikuchi, Y., Kagaya, Y., Shirato, K., Nagy, A., Ujike, A., Takai, T., Watanabe, T., Ohtsu, H., The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis. J. Allergy Clin. Immunol. 110:2 (2002), 298–303.
53. Marshall, J.S., McCurdy, J.D., Olynych, T., Toll-like receptor-mediated activation of mast cells: implications for allergic disease?. Int. Arch. Allergy Immunol. 132:2 (2003), 87–97.
54. Mastrangelo, F., Frydas, I., Ronconi, G., Kritas, S.K., Tettamanti, L., Caraffa, A., D'Ovidio, C., Younes, A., Gallenga, C.E., Conti, P., Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37. J. Biol. Regul. Homeost. Agents 32:2 (2018), 195–198.
55. Miller, S.D., McRae, B.L., Vanderlugt, C.L., Nikcevich, K.M., Pope, J.G., Pope, L., Karpus, W.J., Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol. Rev. 144 (1995), 225–244 (Review).
56. Moretti, S., Bozza, S., Oikonomou, V., Renga, G., Casagrande, A., Iannitti, R.G., Puccetti, M., Garlanda, C., Kim, S., Li, S., van de Veerdonk, F.L., Dinarello, C.A., Romani, L., IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog., 10(11), 2014, e1004462, 10.1371/journal.ppat.1004462.
57. Mukai, K., Tsai, M., Saito, H., Galli, S.J., Mast cells as sources of cytokines, chemokines, and growth factors. Immunol. Rev. 282:1 (2018), 121–150.
58. Musio, S., Costanza, M., Poliani, P.L., Fontana, E., Cominelli, M., Abolafio, G., Steinman, L., Pedotti, R., Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin. Neurol. Neuroimmunol. Neuroinflamm., 4(3), 2017, e342.
59. Niimi, M., Yamamoto, Y., Takemori, H., Uno, A., Kondo, Y., Yamatodani, A., Lipopolysaccharide and interleukin-1beta augmented histidine decarboxylase activity in cultured cells of the rat embryonic brain. J. Neurochem. 69:2 (1997), 851–858.
60. Perry, C.J., Blake, P., Buettner, C., Papavassiliou, E., Schain, A.J., Bhasin, M.K., Burstein, R., Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: implications for extracranial origin of headache. Ann. Neurol. 79:6 (2016), 1000–1013.
61. Pinho-Ribeiro, F.A., Verri, W.A. Jr, Chiu, I.M., Nociceptor sensory neuron-immune interactions in pain and inflammation. Trends Immunol. 38:1 (2017), 5–19, 10.1016/j.it.2016.10.001.
62. Rafiei, A., Abedini, M., Hosseini, S.H., Hosseini-Khah, Z., Bazrafshan, B., Tehrani, M., Toll like receptor-4 896A/G gene variation, a risk factor for migraine headaches. Iran. J. Immunol. 9:3 (2012), 159–167.
63. Ransohoff, R.M., Brown, M.A., Innate immunity in the central nervous system. J. Clin. Investig. 122:4 (2012), 1164–1171, 10.1172/JCI58644.
64. Re Dinarello, C.A., Conti, P., Mier, J.W., Effects of human interleukin-1 on natural killer cell activity: is fever a host defense mechanism for tumor killing?. Yale. J. Biol. Med. 59:2 (1986), 97–106.
65. Riol-Blanco, L., Ordovas-Montanes, J., Perro, M., Naval, E., Thiriot, A., Alvarez, D., Paust, S., Wood, J.N., von Andrian, U.H., Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature 510:7503 (2014), 157–161.
66. Robuffo, I., Toniato, E., Tettamanti, L., Mastrangelo, F., Ronconi, G., Frydas, I., Caraffa, A., Kritas, S.K., Conti, P., Mast cell in innate immunity mediated by proinflammatory and antiinflammatory IL-1 family members. J. Biol. Regul. Homeost. Agents 31:4 (2017), 837–842.
67. Rocha, S.M., Saraiva, T., Cristóvão, A.C., Ferreira, R., Santos, T., Esteves, M., Saraiva, C., Je, G., Cortes, L., Valero, J., Alves, G., Klibanov, A., Kim, Y.S., Bernardino, L., Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation. J. Neuroinflamm., 13(1), 2016, 137.
68. Roerink, M.E., van der Schaaf, M.E., Dinarello, C.A., Knoop, H., van der Meer, J.W., Interleukin-1 as a mediator of fatigue in disease: a narrative review. J. Neuroinflamm., 14(1), 2017, 16, 10.1186/s12974-017-0796-7.
69. Sander, L.E., Lorentz, A., Sellge, G., Coëffier, M., Neipp, M., Veres, T., Frieling, T., Meier, P.N., Manns, M.P., Bischoff, S.C., Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 55:4 (2006), 498–504.
70. Saraav, I., Singh, S., Sharma, S., Outcome of Mycobacterium tuberculosis and Toll-like receptor interaction: immune response or immune evasion?. Immunol. Cell. Biol. 92:9 (2014), 741–746.
71. Schroeter, M., Jander, S., T-cell cytokines in injury-induced neural damage and repair. Neuromol. Med. 7:3 (2005), 83–95.
72. Shi, F., Yang, L., Kouadir, M., Yang, Y., Wang, J., Zhou, X., Yin, X., Zhao, D., The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. J. Neuroinflamm., 9, 2012, 73, 10.1186/1742-2094-9-73.
73. Sicuteri, F., Fanciullacci, M., Nicolodi, M., Geppetti, P., Fusco, B.M., Marabini, S., Alessandri, M., Campagnolo, V., Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Headache 30:2 (1990), 69–79.
74. Skaper, S.D., Nerve growth factor: a neuroimmune crosstalk mediator for all seasons. Immunology 151:1 (2017), 1–15.
75. Skaper, S.D., Giusti, P., Facci, L., Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J. 26:8 (2012), 3103–3117.
76. Srikiatkhachorn, A., le Grand, S.M., Supornsilpchai, W., Storer, R.J., Pathophysiology of medication overuse headache–an update. Headache 54:1 (2014), 204–210.
77. Stephenson, J., Nutma, E., van der Valk, P., Amor, S., Inflammation in CNS neurodegenerative diseases. Immunology 154:2 (2018), 204–219.
78. Supajatura, V., Ushio, H., Nakao, A., Okumura, K., Ra, C., Ogawa, H., Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J. Immunol. 167:4 (2001), 2250–2256.
79. Taracanova, A., Alevizos, M., Karagkouni, A., Weng, Z., Norwitz, E., Conti, P., Leeman, S.E., Theoharides, T.C., SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc. Natl. Acad. Sci. USA 114:20 (2017), E4002–E4009.
80. Tettamanti, L., Caraffa, Al, Mastrangelo, F., Ronconi, G., Kritas, S., Frydas, I., Conti, P., Different signals induce mast cell inflammatory activity: inhibitory effect of Vitamin E. J. Biol. Regul. Homeost. Agents 32:1 (2018), 13–19.
81. Tettamanti, L., Kritas, S.K., Gallenga, C.E., D'Ovidio, C., Mastrangelo, F., Ronconi, G., Caraffa, A., Toniato, E., Conti, P., IL-33 mediates allergy through mast cell activation: potential inhibitory effect of certain cytokines. J. Biol. Regul. Homeost. Agents 32:5 (2018), 1061–1065.
82. Theoharides, T.C., Zhang, B., Kempuraj, D., Tagen, M., Vasiadi, M., Angelidou, A., Alysandratos, K.D., Kalogeromitros, D., Asadi, S., Stavrianeas, N., Peterson, E., Leeman, S., Conti, P., IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc. Natl. Acad. Sci. USA 107:9 (2010), 4448–4453.
83. Theoharides, T.C., Kempuraj, D., Iliopoulou, B.P., Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. Adv. Exp. Med. Biol. 601 (2007), 423–430.
84. Theoharides, T.C., Stewart, J.M., Hatziagelaki, E., Kolaitis, G., Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front. Neurosci., 9, 2015, 225, 10.3389/fnins.2015.00225.
85. Toniato, E., Frydas, I., Robuffo, I., Ronconi, G., Caraffa, Al, Kritas, S.K., Conti, P., Activation and inhibition of adaptive immune response mediated by mast cells. J. Biol. Regul. Homeost. Agents 31:3 (2017), 543–548.
86. Vainchtein, I.D., Chin, G., Cho, F.S., Kelley, K.W., Miller, J.G., Chien, E.C., Liddelow, S.A., Nguyen, P.T., Nakao-Inoue, H., Dorman, L.C., Akil, O., Joshita, S., Barres, B.A., Paz, J.T., Molofsky, A.B., Molofsky, A.V., Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science 359:6381 (2018), 1269–1273.
87. Williamson, D.J., Hargreaves, R.J., Neurogenic inflammation in the context of migraine. Microsc. Res. Tech. 53:3 (2001), 167–178.
88. Yuan, H., Silberstein, S.D., Histamine and migraine. Headache 58:1 (2018), 184–193, 10.1111/head.13164.
89. Zhan, Q., Zeng, Q., Song, R., Zhai, Y., Xu, D., Fullerton, D.A., Dinarello, C.A., Meng, X., IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells. Mol. Med. 23 (2017), 83–91, 10.2119/molmed.2017.00022.
90. Zhang, X.C., Kainz, V., Burstein, R., Lev,y, D., Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain 152:1 (2011), 140–149, 10.1016/j.pain.2010.10.002.