Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions

Pain

Volumn 152, Issue 1, 2011, Pages 140-149

  Zhang, Xi Chun ^a   Kainz, Vanessa ^a   Burstein, Rami ^a   Levy, Dan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

COX; Meningeal nociceptor; Migraine headache; P38; Sensitization; TNF

Indexed keywords

CYCLOOXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; EVOKED RESPONSE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MENINX; NERVE FIBER; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR SENSITIVITY; SENSITIZATION; TRIGEMINUS GANGLION; VASCULAR ENDOTHELIUM;

ACTION POTENTIALS; ANIMALS; CYCLOOXYGENASE 1; DISEASE MODELS, ANIMAL; DURA MATER; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HYPERALGESIA; IMIDAZOLES; MALE; MEMBRANE PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYSICAL STIMULATION; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SENSORY RECEPTOR CELLS; TIME FACTORS; TRIGEMINAL GANGLION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78650420551     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2010.10.002     Document Type: Article

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