Integrative approach identifies corticosteroid response variant in diverse populations with asthma

Journal of Allergy and Clinical Immunology

Volumn 143, Issue 5, 2019, Pages 1791-1802

  Levin, Albert M ^a   Gui, Hongsheng ^a   Hernandez Pacheco, Natalia ^b   Yang, Mao ^a   Xiao, Shujie ^a   Yang, James J ^c   Hochstadt, Samantha ^a   Barczak, Andrea J ^d   Eckalbar, Walter L ^d   Rynkowski, Dean ^a   Samedy, Lesly Anne ^d,e   Kwok, Pui Yan ^d   Pino Yanes, Maria ^b,f,g   Erle, David J ^d,e   Lanfear, David E ^a   Burchard, Esteban G ^d,e   Williams, L Keoki ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

EDDM3B; eosinophil derived neurotoxin; eosinophils; Pharmacogenetics; RNASE2; transcriptome

Indexed keywords

CORTICOSTEROID; DEOXYRIBONUCLEASE II; EOSINOPHIL PROTEIN X; RNASE2 PROTEIN, HUMAN;

ADULT; AFRICAN AMERICAN; ALLELE; ARTICLE; ASTHMA; DISEASE CONTROL; DISEASE EXACERBATION; EOSINOPHIL COUNT; EXPRESSION QUANTITATIVE TRAIT LOCUS; FEMALE; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; PHARMACOGENETIC VARIANT; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; ADOLESCENT; CHILD; COHORT ANALYSIS; EOSINOPHIL; GENETICS; GENOME-WIDE ASSOCIATION STUDY; IMMUNOLOGY; LEUKOCYTE COUNT; METERED DOSE INHALER; MIDDLE AGED; PHENOTYPE; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; AFRICAN AMERICANS; ASTHMA; CHILD; COHORT STUDIES; DISEASE PROGRESSION; EOSINOPHIL-DERIVED NEUROTOXIN; EOSINOPHILS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HISPANIC AMERICANS; HUMANS; LEUKOCYTE COUNT; MALE; METERED DOSE INHALERS; MIDDLE AGED; PHARMACOGENOMIC VARIANTS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

EID: 85057173222     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2018.09.034     Document Type: Article

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