Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 5, 2016, Pages 1364-1369.e2

  Wells, Karen E ^a   Cajigal, Sonia ^a   Peterson, Edward L ^a   Ahmedani, Brian K ^a   Kumar, Rajesh ^b   Lanfear, David E ^a   Burchard, Esteban G ^c,d   Williams, L Keoki ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adherence; African Continental Ancestry Group; asthma; Inhaled corticosteroids; medication; respiratory function tests

Indexed keywords

BECLOMETASONE DIPROPIONATE; BRONCHODILATING AGENT; CORTICOSTEROID; SALBUTAMOL SULFATE; ANTIASTHMATIC AGENT;

ADOLESCENT; ADULT; AFRICAN AMERICAN; ARTICLE; ASSESSMENT OF HUMANS; ASTHMA; ASTHMA CONTROL TEST SCORE; CHILD; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DEMOGRAPHY; DOSE RESPONSE; EUROPEAN AMERICAN; FEMALE; FORCED EXPIRATORY VOLUME; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEREDITY; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MONITOR; PATIENT COMPLIANCE; PHENOTYPE; PRIORITY JOURNAL; RACE DIFFERENCE; RISK FACTOR; SOCIAL ASPECT; TREATMENT DURATION; TREATMENT RESPONSE; CAUCASIAN; ETHNOLOGY; GENETICS; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOPHYSIOLOGY; SELF REPORT; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; AFRICAN AMERICANS; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; SELF REPORT; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84962193040     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.12.1334     Document Type: Article

References (39)

1. B. Bender, H. Milgrom, and A. Apter Adherence intervention research: what have we learned and what do we do next? J Allergy Clin Immunol 112 2003 489 494
2. A.J. Apter, S.T. Reisine, G. Affleck, E. Barrows, and R.L. ZuWallack The influence of demographic and socioeconomic factors on health-related quality of life in asthma J Allergy Clin Immunol 103 1999 72 78
3. L.K. Williams, C.L. Joseph, E.L. Peterson, K. Wells, M. Wang, V.K. Chowdhry, and et al. Patients with asthma who do not fill their inhaled corticosteroids: A study of primary nonadherence J Allergy Clin Immunol 120 2007 1153 1159
4. L.K. Williams, M. Pladevall, H. Xi, E.L. Peterson, C. Joseph, J.E. Lafata, and et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma J Allergy Clin Immunol 114 2004 1288 1293
5. L.K. Williams, E.L. Peterson, K. Wells, B.K. Ahmedani, R. Kumar, E.G. Burchard, and et al. Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence J Allergy Clin Immunol 128 2011 1185 1191
6. K.E. Wells, E.L. Peterson, B.K. Ahmedani, R.K. Severson, J. Gleason-Comstock, and L.K. Williams The relationship between combination inhaled corticosteroid and long-acting beta-agonist use and severe asthma exacerbations in a diverse population J Allergy Clin Immunol 129 2012 1274 1279
7. L.K. Williams, C.L. Joseph, E.L. Peterson, C. Moon, H. Xi, R. Krajenta, and et al. Race-ethnicity, crime, and other factors associated with adherence to inhaled corticosteroids J Allergy Clin Immunol 119 2007 168 175
8. A.J. Apter, R.C. Boston, M. George, A.L. Norfleet, T. Tenhave, J.C. Coyne, and et al. Modifiable barriers to adherence to inhaled steroids among adults with asthma: it's not just black and white J Allergy Clin Immunol 111 2003 1219 1226
9. W. Gould, E.L. Peterson, G. Karungi, A. Zoratti, J. Gaggin, G. Toma, and et al. Factors predicting inhaled corticosteroid responsiveness in African American patients with asthma J Allergy Clin Immunol 126 2010 1131 1138
10. M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, and et al. Standardisation of spirometry Eur Respir J 26 2005 319 338
11. J.L. Hankinson, J.R. Odencrantz, and K.B. Fedan Spirometric reference values from a sample of the general U.S. population Am J Respir Crit Care Med 159 1999 179 187
12. A.M. Levin, Y. Wang, K.E. Wells, B. Padhukasahasram, J.J. Yang, E.G. Burchard, and et al. Nocturnal asthma and the importance of race/ethnicity and genetic ancestry Am J Respir Crit Care Med 190 2014 266 273
13. S. Sankararaman, S. Sridhar, G. Kimmel, and E. Halperin Estimating local ancestry in admixed populations Am J Hum Genet 82 2008 290 303
14. B. Pasaniuc, S. Sankararaman, G. Kimmel, and E. Halperin Inference of locus-specific ancestry in closely related populations Bioinformatics 25 2009 i213 i221
15. R.A. Nathan, C.A. Sorkness, M. Kosinski, M. Schatz, J.T. Li, P. Marcus, and et al. Development of the asthma control test: A survey for assessing asthma control J Allergy Clin Immunol 113 2004 59 65
16. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma - summary report 2007 J Allergy Clin Immunol 120 suppl 2007 S94 S138
17. SAS/STAT user's guide. Version 9.2 2008 SAS Institute Cary (NC)
18. S.J. Szefler, R.J. Martin, T.S. King, H.A. Boushey, R.M. Cherniack, V.M. Chinchilli, and et al. Significant variability in response to inhaled corticosteroids for persistent asthma J Allergy Clin Immunol 109 2002 410 418
19. R.J. Martin, S.J. Szefler, T.S. King, M. Kraft, H.A. Boushey, V.M. Chinchilli, and et al. The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial J Allergy Clin Immunol 119 2007 73 80
20. K.G. Tantisira, S. Lake, E.S. Silverman, L.J. Palmer, R. Lazarus, E.K. Silverman, and et al. Corticosteroid pharmacogenetics: Association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids Hum Mol Genet 13 2004 1353 1359
21. F. Onyirimba, A. Apter, S. Reisine, M. Litt, C. McCusker, M. Connors, and et al. Direct clinician-to-patient feedback discussion of inhaled steroid use: its effect on adherence Ann Allergy Asthma Immunol 90 2003 411 415
22. M. Pladevall, C. Brotons, R. Gabriel, A. Arnau, C. Suarez, M. de la Figuera, and et al. Multicenter cluster-randomized trial of a multifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study) Circulation 122 2010 1183 1191
23. H.K. Reddel, B.G. Toelle, G.B. Marks, S.I. Ware, C.R. Jenkins, and A.J. Woolcock Analysis of adherence to peak flow monitoring when recording of data is electronic BMJ 324 2002 146 147
24. J.A. Rumpel, B.K. Ahmedani, E.L. Peterson, K.E. Wells, M. Yang, A.M. Levin, and et al. Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma J Allergy Clin Immunol 130 2012 1302 1306
25. R. Kumar, M.A. Seibold, M.C. Aldrich, L.K. Williams, A.P. Reiner, L. Colangelo, and et al. Genetic ancestry in lung-function predictions N Engl J Med 363 2010 321 330
26. D.M. Mannino, D.M. Homa, L.J. Akinbami, J.E. Moorman, C. Gwynn, and S.C. Redd Surveillance for asthma - United States, 1980-1999 MMWR Surveill Summ 51 2002 1 13
27. Asthma prevalence and control characteristics by race/ethnicity - United States, 2002 MMWR Morb Mortal Wkly Rep 53 2004 145 148
28. K. Drozda, S. Wong, S.R. Patel, A.P. Bress, E.A. Nutescu, R.A. Kittles, and et al. Poor warfarin dose prediction with pharmacogenetic algorithms that exclude genotypes important for African Americans Pharmacogenet Genomics 25 2015 73 81
29. L.J. Dickmann, A.E. Rettie, M.B. Kneller, R.B. Kim, A.J. Wood, C.M. Stein, and et al. Identification and functional characterization of a new CYP2C9 variant (CYP2C9∗5) expressed among African Americans Mol Pharmacol 60 2001 382 387
30. J.S. Davis, S.T. Weiss, and K.G. Tantisira Asthma pharmacogenomics: 2015 update Curr Allergy Asthma Rep 15 2015 42
31. S.A. Tishkoff, F.A. Reed, F.R. Friedlaender, C. Ehret, A. Ranciaro, A. Froment, and et al. The genetic structure and history of Africans and African Americans Science 324 2009 1035 1044
32. K. Bryc, A. Auton, M.R. Nelson, J.R. Oksenberg, S.L. Hauser, S. Williams, and et al. Genome-wide patterns of population structure and admixture in West Africans and African Americans Proc Natl Acad Sci U S A 107 2010 786 791
33. J.J. Yang, E.G. Burchard, S. Choudhry, C.C. Johnson, D.R. Ownby, D. Favro, and et al. Differences in allergic sensitization by self-reported race and genetic ancestry J Allergy Clin Immunol 122 2008 820 827
34. M. Sinha, E.K. Larkin, R.C. Elston, and S. Redline Self-reported race and genetic admixture N Engl J Med 354 2006 421 422
35. P. Chen, J.J. Lin, C.S. Lu, C.T. Ong, P.F. Hsieh, C.C. Yang, and et al. Carbamazepine-induced toxic effects and HLA-B∗1502 screening in Taiwan N Engl J Med 364 2011 1126 1133
36. H. Takahashi, G.R. Wilkinson, E.A. Nutescu, T. Morita, M.D. Ritchie, M.G. Scordo, and et al. Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans Pharmacogenet Genomics 16 2006 101 110
37. P. Carson, S. Ziesche, G. Johnson, and J.N. Cohn Racial differences in response to therapy for heart failure: Analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group J Card Fail 5 1999 178 187
38. L.J. Akinbami, J.E. Moorman, A.E. Simon, and K.C. Schoendorf Trends in racial disparities for asthma outcomes among children 0 to 17 years, 2001-2010 J Allergy Clin Immunol 134 2014 547 553.e5
39. L.J. Akinbami, J.E. Moorman, C. Bailey, H.S. Zahran, M. King, C.A. Johnson, and et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010 NCHS Data Brief 94 2012 1 8