Serum eosinophil-derived neurotoxin: Correlation with persistent airflow limitation in adults with house-dust mite allergic asthma

Allergy and Asthma Proceedings

Volumn 36, Issue 6, 2015, Pages e113-e120

  Gon, Yasuhiro ^a   Ito, Reiko ^a   Hattori, Tomohiro ^a   Hiranuma, Hisato ^a   Kumasawa, Fumio ^a   Kozu, Yutaka ^a   Endo, Daisuke ^a   Koyama, Daisuke ^a   Shintani, Yoshitaka ^a   Eriko, Tsuboi ^a   Soda, Kaori ^a   Maruoka, Shuichiro ^a   Hashimoto, Shu ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; EOSINOPHIL PROTEIN X; IMMUNOGLOBULIN E ANTIBODY; NITRIC OXIDE; OMALIZUMAB; ANTIASTHMATIC AGENT; BIOLOGICAL MARKER;

ADULT; ALLERGIC ASTHMA; ARTICLE; ASTHMA CONTROL QUESTIONNAIRE; CORRELATIONAL STUDY; CROSS-SECTIONAL STUDY; DERMATOPHAGOIDES; DISEASE SEVERITY; EOSINOPHIL COUNT; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PERSISTENT AIRFLOW LIMITATION; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RESPIRATORY AIRFLOW; RESPIRATORY TRACT DISEASE ASSESSMENT; SYMPTOM; ANIMAL; ASTHMA; BLOOD; IMMUNOLOGY; LUNG FUNCTION TEST; MIDDLE AGED; PATHOPHYSIOLOGY; PYROGLYPHIDAE; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BIOMARKERS; CROSS-SECTIONAL STUDIES; EOSINOPHIL CATIONIC PROTEIN; EOSINOPHIL-DERIVED NEUROTOXIN; FEMALE; HUMANS; MALE; MIDDLE AGED; OMALIZUMAB; PYROGLYPHIDAE; RESPIRATORY FUNCTION TESTS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84948688265     PISSN: 10885412     EISSN: 15396304     Source Type: Journal    
DOI: 10.2500/aap.2015.36.3884     Document Type: Article

References (28)

1. Martinez FD, and Vercelli D. Asthma. Lancet 382:1360-1372, 2013.
2. Holgate ST. Pathogenesis of asthma. Clin Exp Allergy 38:872-897, 2008.
3. Lloyd CM, and Saglani S. T cells in asthma: influences of genetics, environment, and T-cell plasticity. J Allergy Clin Immunol 131:1267-1274, quiz 1275, 2013.
4. Kaiko GE, and Foster PS. New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma. Curr Opin Allergy Clin Immunol 11:39-45, 2011.
5. Felton JM, Lucas CD, Rossi AG, and Dransfield I. Eosinophils in the lung: Modulating apoptosis and efferocytosis in airway inflammation. Front Immunol 5:302, 2014.
6. Douwes J, Gibson P, Pekkanen J, and Pearce N. Non-eosinophilic asthma: Importance and possible mechanisms. Thorax 57:643-648, 2002.
7. Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: Insights from clinical studies. Proc Am Thorac Soc 6:256-259, 2009.
8. Acharya KR, and Ackerman SJ. Eosinophil granule proteins: Form and function. J Biol Chem 289:17406-17415, 2014.
9. Hogan SP, Rosenberg HF, Moqbel R, et al. Eosinophils: Biological properties and role in health and disease. Clin Exp Allergy 38:709-750, 2008.
10. Kato M, Ishioka T, Kita H, et al. Eosinophil granular proteins damage bronchial epithelial cells infected with respiratory syncytial virus. Int Arch Allergy Immunol 158(suppl. 1):11-18, 2012.
11. Koh GC, Shek LP, Goh DY, et al. Eosinophil cationic protein: Is it useful in asthma? A systematic review. Respir Med 101:696-705, 2007.
12. Kim KW, Lee KE, Kim ES, et al. Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma. Lung 185: 97-103, 2007.
13. Kim CK, Callaway Z, Fletcher R, and Koh YY. Eosinophilderived neurotoxin in childhood asthma: Correlation with disease severity. J Asthma 47:568-573, 2010.
14. Kim CK. Eosinophil-derived neurotoxin: A novel biomarker for diagnosis and monitoring of asthma. Korean J Pediatr 56:8-12, 2013.
15. Kim CK, Callaway Z, Kim DW, and Kita Hl. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. J Asthma 48:994-1000, 2011.
16. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2013. Available online at http://www.ginasthma.org; accessed July 2, 2015.
17. Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 127:355-360, 2011.
18. Kim HY, DeKruyff RH, and Umetsu DT. The many paths to asthma: Phenotype shaped by innate and adaptive immunity. Nat Immunol 11:577-584, 2010.
19. Ying S, Zhang G, Gu S, and Zhao J. How much do we know about atopic asthma: Where are we now? Cell Mol Immunol 3:321-332, 2006.
20. Blaiss MS. Epidemiology and pathophysiology of immunoglobulin E-mediated asthma. Allergy Asthma Proc 26:423-427, 2005.
21. Humbert M, Menz G, Ying S, et al. The immunopathology of extrinsic (atopic) and intrinsic (non-Atopic) asthma: More similarities than differences. Immunol Today 20:528-533, 1999.
22. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Resp Dis 146:500-506, 1992.
23. Humbert M, Grant JA, Taborda-Barata L, et al. High-Affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. Am J Resp Crit Care Med 153: 1931-1937, 1996.
24. Korsgaard J. House-dust mites and asthma. A review on housedust mites as a domestic risk factor for mite asthma. Allergy 53(suppl.):77-83, 1998.
25. van der Heide S, Dubois AE, Kauffman HF, and de Monchy JG. Allergy to mites: Relation to lung function and airway hyperresponsiveness. Allergy 53(suppl.):104-107, 1998.
26. Pégorier S, Wagner LA, Gleich GJ, and Pretolani M. Eosinophilderived cationic proteins activate the synthesis of remodeling factors by airway epithelial cells. J Immunol 177:4861-4869, 2006.
27. Jung JW, Kang HR, Lee HS, et al. Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation. Tohoku J Exp Med 233:49-56, 2014.
28. Sullivan SD, and Turk F. An evaluation of the cost-effectiveness of omalizumab for the treatment of severe allergic asthma. Allergy 63:670-684, 2008.