Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 1, 2011, Pages 37-43.e12

  Galanter, Joshua M ^a   Torgerson, Dara ^a   Gignoux, Christopher R ^b   Sen, Saunak ^a   Roth, Lindsey A ^a   Via, Marc ^c   Aldrich, Melinda C ^d   Eng, Celeste ^a   Huntsman, Scott ^a   Rodriguez Santana, Jose ^e   Rodriguez Cintrón, William ^f   Chapela, Rocio ^g   Ford, Jean G ^h   Burchard, Esteban G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b San Francisco   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e Centro de Neumolo ia Pediatrica   (Puerto Rico)

^f VA MEDICAL CENTER   (Puerto Rico)

^g INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

^h JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Asthma; candidate genes; effect heterogeneity; genetics; genome wide association; Hispanics; Latinos; Mexicans; Puerto Ricans; replication

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHILD; DNA MICROARRAY; ETHNIC DIFFERENCE; FEMALE; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; GENOME ANALYSIS; GENOTYPE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; MEXICO; POPULATION GENETICS; PRIORITY JOURNAL; PUERTO RICO; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 80955177163     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.03.050     Document Type: Article

References (46)

1. M. Lara, L. Akinbami, G. Flores, and H. Morgenstern Heterogeneity of childhood asthma among Hispanic children: Puerto Rican children bear a disproportionate burden Pediatrics 117 2006 43 53 (Pubitemid 46050518)
2. D.M. Homa, D.M. Mannino, and M. Lara Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990-1995 Am J Respir Crit Care Med 161 2000 504 509 (Pubitemid 30129460)
3. E. Chen, L.S. Chim, R.C. Strunk, and G.E. Miller The role of the social environment in children and adolescents with asthma Am J Respir Crit Care Med 176 2007 644 649 (Pubitemid 47503071)
4. C. Ober, and E.E. Thompson Rethinking genetic models of asthma: the role of environmental modifiers Curr Opin Immunol 17 2005 670 678 (Pubitemid 41506914)
5. S.R. Kleeberger, and D. Peden Gene-environment interactions in asthma and other respiratory diseases Annu Rev Med 56 2005 383 400 (Pubitemid 40299789)
6. N.C. Freeman, D. Schneider, and P. McGarvey Household exposure factors, asthma, and school absenteeism in a predominantly Hispanic community J Expo Anal Environ Epidemiol 13 2003 169 176 (Pubitemid 36753833)
7. M. Naqvi, S. Thyne, S. Choudhry, H.J. Tsai, D. Navarro, and R.A. Castro Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma J Asthma 44 2007 639 648 (Pubitemid 47621480)
8. S. Choudhry, N. Ung, P.C. Avila, E. Ziv, S. Nazario, and J. Casal Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma Am J Respir Crit Care Med 171 2005 563 570 (Pubitemid 40365410)
9. S. Wang, N. Ray, W. Rojas, M.V. Parra, G. Bedoya, and C. Gallo Geographic patterns of genome admixture in Latin American Mestizos PLoS Genet 4 2008 e1000037
10. K. Bryc, C. Velez, T. Karafet, A. Moreno-Estrada, A. Reynolds, and A. Auton Colloquium paper: genome-wide patterns of population structure and admixture among Hispanic/Latino populations Proc Natl Acad Sci U S A 107 suppl 2 2010 8954 8961
11. C. Ober Perspectives on the past decade of asthma genetics J Allergy Clin Immunol 116 2005 274 278 (Pubitemid 41096530)
12. S.T. Weiss, B.A. Raby, and A. Rogers Asthma genetics and genomics 2009 Curr Opin Genet Dev 19 2009 279 282
13. T. Aoki, T. Hirota, M. Tamari, K. Ichikawa, K. Takeda, and T. Arinami An association between asthma and TNF-308G/A polymorphism: meta-analysis J Hum Genet 51 2006 677 685 (Pubitemid 44354679)
14. F. Nishimura, M. Shibasaki, K. Ichikawa, T. Arinami, and E. Noguchi Failure to find an association between CD14-159C/T polymorphism and asthma: a family-based association test and meta-analysis Allergol Int 55 2006 55 58
15. Y. Finkelstein, F.G. Bournissen, J.R. Hutson, and M. Shannon Polymorphism of the ADRB2 gene and response to inhaled beta- agonists in children with asthma: a meta-analysis J Asthma 46 2009 900 905
16. D.B. Hancock, I. Romieu, M. Shi, J.J. Sienra-Monge, H. Wu, and G.Y. Chiu Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children PLoS Genet 5 2009 e1000623
17. B.E. Himes, G.M. Hunninghake, J.W. Baurley, N.M. Rafaels, P. Sleiman, and D.P. Strachan Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene Am J Hum Genet 84 2009 581 593
18. X. Li, T.D. Howard, S.L. Zheng, T. Haselkorn, S.P. Peters, and D.A. Meyers Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions J Allergy Clin Immunol 125 2010 328 335 e11
19. R.A. Mathias, A.V. Grant, N. Rafaels, T. Hand, L. Gao, and C. Vergara A genome-wide association study on African-ancestry populations for asthma J Allergy Clin Immunol 125 2010 336 346 e4
20. M.F. Moffatt, M. Kabesch, L. Liang, A.L. Dixon, D. Strachan, and S. Heath Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma Nature 448 2007 470 473 (Pubitemid 47123521)
21. P.M. Sleiman, J. Flory, M. Imielinski, J.P. Bradfield, K. Annaiah, and S.A. Willis-Owen Variants of DENND1B associated with asthma in children N Engl J Med 362 2010 36 44
22. M.F. Moffatt, I.G. Gut, F. Demenais, D.P. Strachan, E. Bouzigon, and S. Heath A large-scale, consortium-based genome-wide association study of asthma N Engl J Med 363 2010 1211 1221
23. C. Ober, and S. Hoffjan Asthma genetics 2006: the long and winding road to gene discovery Genes Immun 7 2006 95 100 (Pubitemid 43336051)
24. C.C. Spencer, Z. Su, P. Donnelly, and J. Marchini Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip PLoS Genet 5 2009 e1000477
25. K.C. Siontis, N.A. Patsopoulos, and J.P. Ioannidis Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies Eur J Hum Genet 18 2010 832 837
26. H. Wu, I. Romieu, M. Shi, D.B. Hancock, H. Li, and J.J. Sienra-Monge Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans J Allergy Clin Immunol 125 2010 321 327 e13
27. A.J. Rogers, B.A. Raby, J.A. Lasky-Su, A. Murphy, R. Lazarus, and B.J. Klanderman Assessing the reproducibility of asthma candidate gene associations, using genome-wide data Am J Respir Crit Care Med 179 2009 1084 1090
28. E.G. Burchard, P.C. Avila, S. Nazario, J. Casal, A. Torres, and J.R. Rodriguez-Santana Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma Am J Respir Crit Care Med 169 2004 386 392 (Pubitemid 38134819)
29. B.L. Browning, and S.R. Browning A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals Am J Hum Genet 84 2009 210 223
30. K.A. Frazer, D.G. Ballinger, D.R. Cox, D.A. Hinds, L.L. Stuve, and R.A. Gibbs A second generation human haplotype map of over 3.1 million SNPs Nature 449 2007 851 861 (Pubitemid 47598626)
31. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, and D. Bender PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575 (Pubitemid 47330214)
32. K.D. Pruitt, T. Tatusova, and D.R. Maglott NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins Nucleic Acids Res 33 2005 D501 D504
33. J. Galanter, S. Choudhry, C. Eng, S. Nazario, J.R. Rodriguez-Santana, and J. Casal ORMDL3 gene is associated with asthma in three ethnically diverse populations Am J Respir Crit Care Med 177 2008 1194 1200 (Pubitemid 351860927)
34. K.A. Frazer, S.S. Murray, N.J. Schork, and E.J. Topol Human genetic variation and its contribution to complex traits Nat Rev Genet 10 2009 241 251
35. D. Keen-Kim, C.A. Mathews, V.I. Reus, T.L. Lowe, L.D. Herrera, and C.L. Budman Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses Hum Mol Genet 15 2006 3324 3328 (Pubitemid 44649118)
36. H. Tcheurekdjian, M. Via, A. De Giacomo, H. Corvol, C. Eng, and S. Thyne ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos J Allergy Clin Immunol 126 2010 853 858
37. C.M. Lewis Genetic association studies: design, analysis and interpretation Brief Bioinform 3 2002 146 153
38. J.P. Ioannidis, E.E. Ntzani, and T.A. Trikalinos "Racial" differences in genetic effects for complex diseases Nat Genet 36 2004 1312 1318 (Pubitemid 39577941)
39. B.G. Ferris Epidemiology Standardization Project (American Thoracic Society) Am Rev Respir Dis 118 1978 1 120
40. D.H. Alexander, J. Novembre, and K. Lange Fast model-based estimation of ancestry in unrelated individuals Genome Res 19 2009 1655 1664
41. K.A. Frazer, D.G. Ballinger, D.R. Cox, D.A. Hinds, L.L. Stuve, and R.A. Gibbs A second generation human haplotype map of over 3.1 million SNPs Nature 449 2007 851 861 (Pubitemid 47598626)
42. X. Mao, A.W. Bigham, R. Mei, G. Gutierrez, K.M. Weiss, and T.D. Brutsaert A genome-wide admixture mapping panel for Hispanic/Latino populations Am J Hum Genet 80 2007 1171 1178 (Pubitemid 47579352)
43. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, and D. Bender PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575 (Pubitemid 47330214)
44. K.G. Becker, K.C. Barnes, T.J. Bright, and S.A. Wang The genetic association database Nat Genet 36 2004 431 432
45. W. Yu, M. Gwinn, M. Clyne, A. Yesupriya, and M.J. Khoury A navigator for human genome epidemiology Nat Genet 40 2008 124 125
46. W. Viechtbauer Conducting meta-analyses in R with the metafor Package J Stat Software 36 2010 1 48