Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 19, 2016, Pages 4739-4742

  Miyagawa, Masayoshi ^a   Akiyama, Toshiyuki ^a   Mikamiyama Iwata, Minako ^a   Hattori, Kazunari ^a   Kurihara, Naoko ^a   Taoda, Yoshiyuki ^a   Takahashi Kageyama, Chika ^a   Kurose, Noriyuki ^a   Mikamiyama, Hidenori ^a   Suzuki, Naoyuki ^a   Takaya, Kenji ^a   Tomita, Kenji ^a   Matsuo, Kenji ^a   Morimoto, Kenji ^a   Yoshida, Ryu ^a   Shishido, Takao ^a   Yoshinaga, Tomokazu ^a   Sato, Akihiko ^a   Kawai, Makoto ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Anti influenza drug; Cap dependent endonuclease; Chelator; Pyridone; Virtual modeling

Indexed keywords

4 PYRIDONE DERIVATIVE; 5 HYDROXY 4 PYRIDONE 3 CARBOXY ACID DERIVATIVE; ANTIVIRUS AGENT; CAP DEPENDENT ENDONUCLEASE INHIBITOR; CHELATE; ESTERASE INHIBITOR; UNCLASSIFIED DRUG; 4-PYRIDONE; CARBOXYLIC ACID; ENDONUCLEASE; ENZYME INHIBITOR; PYRIDONE DERIVATIVE;

ARTICLE; CHELATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROPHOBICITY; IC50; IN VITRO STUDY; INFLUENZA VIRUS; LIPOPHILICITY; MOLECULAR LIBRARY; MOLECULAR MODEL; NONHUMAN; PROTEIN DOMAIN; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; MOLECULAR DOCKING; ORTHOMYXOVIRIDAE;

ANTIVIRAL AGENTS; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ENDONUCLEASES; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; ORTHOMYXOVIRIDAE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84985995054     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.08.038     Document Type: Article

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