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Volumn 1, Issue 20, 2016, Pages

Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine

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EID: 85055600654     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.89289     Document Type: Article
Times cited : (27)

References (57)
  • 1
    • 0014433598 scopus 로고
    • Cellular and humoral immunity to different types of human neoplasms
    • Hellström I, Hellström KE, Pierce GE, Yang JP. Cellular and humoral immunity to different types of human neoplasms. Nature. 1968;220(5174):1352–1354.
    • (1968) Nature , vol.220 , Issue.5174 , pp. 1352-1354
    • Hellström, I1    Hellström, KE2    Pierce, GE3    Yang, JP.4
  • 2
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry EJ, et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007;27(4):670–684.
    • (2007) Immunity , vol.27 , Issue.4 , pp. 670-684
    • Wherry, EJ1
  • 3
    • 79957925314 scopus 로고    scopus 로고
    • Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
    • Baitsch L, et al. Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients. J Clin Invest. 2011;121(6):2350–2360.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2350-2360
    • Baitsch, L1
  • 4
    • 84858613590 scopus 로고    scopus 로고
    • Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells
    • Engelhardt JJ, et al. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012;21(3):402–417.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 402-417
    • Engelhardt, JJ1
  • 5
    • 84920921528 scopus 로고    scopus 로고
    • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
    • Gubin MM, et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature. 2014;515(7528):577–581.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 577-581
    • Gubin, MM1
  • 6
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
    • Gros A, et al. PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. J Clin Invest. 2014;124(5):2246–2259.
    • (2014) J Clin Invest , vol.124 , Issue.5 , pp. 2246-2259
    • Gros, A1
  • 7
    • 84911937777 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
    • Broz ML, et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014;26(5):638–652.
    • (2014) Cancer Cell , vol.26 , Issue.5 , pp. 638-652
    • Broz, ML1
  • 8
    • 84978872467 scopus 로고    scopus 로고
    • Critical role for CD103(+)/CD141(+) dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma
    • Roberts EW, et al. Critical role for CD103(+)/CD141(+) dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma. Cancer Cell. 2016;30(2):324–336.
    • (2016) Cancer Cell , vol.30 , Issue.2 , pp. 324-336
    • Roberts, EW1
  • 9
    • 0033558363 scopus 로고    scopus 로고
    • Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
    • Yee C, Savage PA, Lee PP, Davis MM, Greenberg PD. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J Immunol. 1999;162(4):2227–2234.
    • (1999) J Immunol , vol.162 , Issue.4 , pp. 2227-2234
    • Yee, C1    Savage, PA2    Lee, PP3    Davis, MM4    Greenberg, PD.5
  • 10
    • 0033056073 scopus 로고    scopus 로고
    • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
    • Lee PP, et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med. 1999;5(6):677–685.
    • (1999) Nat Med , vol.5 , Issue.6 , pp. 677-685
    • Lee, PP1
  • 11
    • 84902184973 scopus 로고    scopus 로고
    • Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction
    • Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM, Mempel TR. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest. 2014;124(6):2425–2440.
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2425-2440
    • Bauer, CA1    Kim, EY2    Marangoni, F3    Carrizosa, E4    Claudio, NM5    Mempel, TR.6
  • 12
    • 84873051750 scopus 로고    scopus 로고
    • CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network
    • Boissonnas A, et al. CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network. Neoplasia. 2013;15(1):85–94.
    • (2013) Neoplasia , vol.15 , Issue.1 , pp. 85-94
    • Boissonnas, A1
  • 13
    • 33646356996 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: building on success
    • Gattinoni L, Powell DJ, Rosenberg SA, Restifo NP. Adoptive immunotherapy for cancer: building on success. Nat Rev Immunol. 2006;6(5):383–393.
    • (2006) Nat Rev Immunol , vol.6 , Issue.5 , pp. 383-393
    • Gattinoni, L1    Powell, DJ2    Rosenberg, SA3    Restifo, NP.4
  • 14
    • 84959464101 scopus 로고    scopus 로고
    • T cell migration, search strategies and mechanisms
    • Krummel MF, Bartumeus F, Gérard A. T cell migration, search strategies and mechanisms. Nat Rev Immunol. 2016;16(3):193–201.
    • (2016) Nat Rev Immunol , vol.16 , Issue.3 , pp. 193-201
    • Krummel, MF1    Bartumeus, F2    Gérard, A.3
  • 15
    • 0005448458 scopus 로고    scopus 로고
    • Polarity of T cell shape, motility, and sensitivity to antigen
    • Negulescu PA, Krasieva TB, Khan A, Kerschbaum HH, Cahalan MD. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity. 1996;4(5):421–430.
    • (1996) Immunity , vol.4 , Issue.5 , pp. 421-430
    • Negulescu, PA1    Krasieva, TB2    Khan, A3    Kerschbaum, HH4    Cahalan, MD.5
  • 16
    • 0030888235 scopus 로고    scopus 로고
    • Antigen receptor engagement delivers a stop signal to migrating T lymphocytes
    • Dustin ML, Bromley SK, Kan Z, Peterson DA, Unanue ER. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci USA. 1997;94(8):3909–3913.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.8 , pp. 3909-3913
    • Dustin, ML1    Bromley, SK2    Kan, Z3    Peterson, DA4    Unanue, ER.5
  • 17
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller MJ, Wei SH, Parker I, Cahalan MD. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 2002;296(5574):1869–1873.
    • (2002) Science , vol.296 , Issue.5574 , pp. 1869-1873
    • Miller, MJ1    Wei, SH2    Parker, I3    Cahalan, MD.4
  • 18
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 2004;427(6970):154–159.
    • (2004) Nature , vol.427 , Issue.6970 , pp. 154-159
    • Mempel, TR1    Henrickson, SE2    Von Andrian, UH.3
  • 19
    • 78649396525 scopus 로고    scopus 로고
    • Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics
    • Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010;207(12):2733–2749.
    • (2010) J Exp Med , vol.207 , Issue.12 , pp. 2733-2749
    • Friedman, RS1    Beemiller, P2    Sorensen, CM3    Jacobelli, J4    Krummel, MF.5
  • 20
    • 84864139002 scopus 로고    scopus 로고
    • Integration of the movement of signaling microclusters with cellular motility in immunological synapses
    • Beemiller P, Jacobelli J, Krummel MF. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol. 2012;13(8):787–795.
    • (2012) Nat Immunol , vol.13 , Issue.8 , pp. 787-795
    • Beemiller, P1    Jacobelli, J2    Krummel, MF.3
  • 21
    • 84865372949 scopus 로고    scopus 로고
    • Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo
    • Moreau HD, et al. Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo. Immunity. 2012;37(2):351–363.
    • (2012) Immunity , vol.37 , Issue.2 , pp. 351-363
    • Moreau, HD1
  • 22
    • 34548780292 scopus 로고    scopus 로고
    • Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces
    • Woolf E, et al. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol. 2007;8(10):1076–1085.
    • (2007) Nat Immunol , vol.8 , Issue.10 , pp. 1076-1085
    • Woolf, E1
  • 23
    • 84883153623 scopus 로고    scopus 로고
    • Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV
    • Overstreet MG, et al. Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV. Nat Immunol. 2013;14(9):949–958.
    • (2013) Nat Immunol , vol.14 , Issue.9 , pp. 949-958
    • Overstreet, MG1
  • 24
    • 33748866330 scopus 로고    scopus 로고
    • Surface-bound chemokines capture and prime T cells for synapse formation
    • Friedman RS, Jacobelli J, Krummel MF. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol. 2006;7(10):1101–1108.
    • (2006) Nat Immunol , vol.7 , Issue.10 , pp. 1101-1108
    • Friedman, RS1    Jacobelli, J2    Krummel, MF.3
  • 25
    • 34047158654 scopus 로고    scopus 로고
    • Tyrosine kinase receptor RET is a key regulator of Peyer’s patch organogenesis
    • Veiga-Fernandes H, et al. Tyrosine kinase receptor RET is a key regulator of Peyer’s patch organogenesis. Nature. 2007;446(7135):547–551.
    • (2007) Nature , vol.446 , Issue.7135 , pp. 547-551
    • Veiga-Fernandes, H1
  • 26
    • 84870280593 scopus 로고    scopus 로고
    • Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
    • Enouz S, Carrié L, Merkler D, Bevan MJ, Zehn D. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med. 2012;209(10):1769–1779.
    • (2012) J Exp Med , vol.209 , Issue.10 , pp. 1769-1779
    • Enouz, S1    Carrié, L2    Merkler, D3    Bevan, MJ4    Zehn, D.5
  • 27
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung S, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. 2000;20(11):4106–4114.
    • (2000) Mol Cell Biol , vol.20 , Issue.11 , pp. 4106-4114
    • Jung, S1
  • 28
    • 77956202725 scopus 로고    scopus 로고
    • T cell and APC dynamics in situ control the outcome of vaccination
    • Khanna KM, Blair DA, Vella AT, McSorley SJ, Datta SK, Lefrançois L. T cell and APC dynamics in situ control the outcome of vaccination. J Immunol. 2010;185(1):239–252.
    • (2010) J Immunol , vol.185 , Issue.1 , pp. 239-252
    • Khanna, KM1    Blair, DA2    Vella, AT3    McSorley, SJ4    Datta, SK5    Lefrançois, L.6
  • 29
    • 77955389719 scopus 로고    scopus 로고
    • Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
    • Thompson ED, Enriquez HL, Fu YX, Engelhard VH. Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J Exp Med. 2010;207(8):1791–1804.
    • (2010) J Exp Med , vol.207 , Issue.8 , pp. 1791-1804
    • Thompson, ED1    Enriquez, HL2    Fu, YX3    Engelhard, VH.4
  • 30
    • 78449287872 scopus 로고    scopus 로고
    • A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity
    • Au-Yeung BB, et al. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010;11(12):1085–1092.
    • (2010) Nat Immunol , vol.11 , Issue.12 , pp. 1085-1092
    • Au-Yeung, BB1
  • 31
    • 84902807661 scopus 로고    scopus 로고
    • Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development
    • Au-Yeung BB, et al. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014;15(7):687–694.
    • (2014) Nat Immunol , vol.15 , Issue.7 , pp. 687-694
    • Au-Yeung, BB1
  • 32
    • 58149352396 scopus 로고    scopus 로고
    • Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    • Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2009;457(7226):191–195.
    • (2009) Nature , vol.457 , Issue.7226 , pp. 191-195
    • Kim, JV1    Kang, SS2    Dustin, ML3    McGavern, DB.4
  • 33
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15(8):486–499.
    • (2015) Nat Rev Immunol , vol.15 , Issue.8 , pp. 486-499
    • Wherry, EJ1    Kurachi, M.2
  • 34
    • 0037197925 scopus 로고    scopus 로고
    • IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    • Liu K, Catalfamo M, Li Y, Henkart PA, Weng NP. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc Natl Acad Sci USA. 2002;99(9):6192–6197.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.9 , pp. 6192-6197
    • Liu, K1    Catalfamo, M2    Li, Y3    Henkart, PA4    Weng, NP.5
  • 35
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008;29(6):848–862.
    • (2008) Immunity , vol.29 , Issue.6 , pp. 848-862
    • Surh, CD1    Sprent, J.2
  • 36
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 2012;12(4):253–268.
    • (2012) Nat Rev Immunol , vol.12 , Issue.4 , pp. 253-268
    • Gabrilovich, DI1    Ostrand-Rosenberg, S2    Bronte, V.3
  • 37
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41(1):49–61.
    • (2014) Immunity , vol.41 , Issue.1 , pp. 49-61
    • Noy, R1    Pollard, JW.2
  • 38
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity. 2009;30(5):636–645.
    • (2009) Immunity , vol.30 , Issue.5 , pp. 636-645
    • Shevach, EM.1
  • 39
    • 84907486438 scopus 로고    scopus 로고
    • The programmed death-1 immune-suppressive pathway: barrier to antitumor immunity
    • Ostrand-Rosenberg S, Horn LA, Haile ST. The programmed death-1 immune-suppressive pathway: barrier to antitumor immunity. J Immunol. 2014;193(8):3835–3841.
    • (2014) J Immunol , vol.193 , Issue.8 , pp. 3835-3841
    • Ostrand-Rosenberg, S1    Horn, LA2    Haile, ST.3
  • 41
    • 84941344937 scopus 로고    scopus 로고
    • Metabolic Competition in the tumor microenvironment is a driver of cancer progression
    • Chang CH, et al. Metabolic Competition in the tumor microenvironment is a driver of cancer progression. Cell. 2015;162(6):1229–1241.
    • (2015) Cell , vol.162 , Issue.6 , pp. 1229-1241
    • Chang, CH1
  • 42
    • 84874273811 scopus 로고    scopus 로고
    • The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells
    • Marangoni F, et al. The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity. 2013;38(2):237–249.
    • (2013) Immunity , vol.38 , Issue.2 , pp. 237-249
    • Marangoni, F1
  • 43
    • 77649255627 scopus 로고    scopus 로고
    • Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes
    • Azar GA, Lemaître F, Robey EA, Bousso P. Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci U S A. 2010;107(8):3675–3680.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.8 , pp. 3675-3680
    • Azar, GA1    Lemaître, F2    Robey, EA3    Bousso, P.4
  • 44
    • 78649396525 scopus 로고    scopus 로고
    • Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics
    • Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010;207(12):2733–2749.
    • (2010) J Exp Med , vol.207 , Issue.12 , pp. 2733-2749
    • Friedman, RS1    Beemiller, P2    Sorensen, CM3    Jacobelli, J4    Krummel, MF.5
  • 45
    • 84886805255 scopus 로고    scopus 로고
    • Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
    • Bos PD, Plitas G, Rudra D, Lee SY, Rudensky AY. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med. 2013;210(11):2435–2466.
    • (2013) J Exp Med , vol.210 , Issue.11 , pp. 2435-2466
    • Bos, PD1    Plitas, G2    Rudra, D3    Lee, SY4    Rudensky, AY.5
  • 46
    • 84977109113 scopus 로고    scopus 로고
    • Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities
    • Kovacsovics-Bankowski M, et al. Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities. J Immunother Cancer. 2014;2(1):38.
    • (2014) J Immunother Cancer , vol.2 , Issue.1 , pp. 38
    • Kovacsovics-Bankowski, M1
  • 47
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med. 1997;186(1):47–55.
    • (1997) J Exp Med , vol.186 , Issue.1 , pp. 47-55
    • Shuford, WW1
  • 48
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude SL, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371(16):1507–1517.
    • (2014) N Engl J Med , vol.371 , Issue.16 , pp. 1507-1517
    • Maude, SL1
  • 49
    • 84941312389 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells against CD19 for multiple myeloma
    • Garfall AL, et al. Chimeric antigen receptor T cells against CD19 for multiple myeloma. N Engl J Med. 2015;373(11):1040–1047.
    • (2015) N Engl J Med , vol.373 , Issue.11 , pp. 1040-1047
    • Garfall, AL1
  • 50
    • 84942910678 scopus 로고    scopus 로고
    • Phase I hepatic immunotherapy for metastases study of intra-arterial chimeric antigen receptor-modified T-cell therapy for CEA+ liver metastases
    • Katz SC, et al. Phase I hepatic immunotherapy for metastases study of intra-arterial chimeric antigen receptor-modified T-cell therapy for CEA+ liver metastases. Clin Cancer Res. 2015;21(14):3149–3159.
    • (2015) Clin Cancer Res , vol.21 , Issue.14 , pp. 3149-3159
    • Katz, SC1
  • 51
    • 84933513655 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 (HER2) -specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma
    • Ahmed N, et al. Human epidermal growth factor receptor 2 (HER2) -specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma. J Clin Oncol. 2015;33(15):1688–1696.
    • (2015) J Clin Oncol , vol.33 , Issue.15 , pp. 1688-1696
    • Ahmed, N1
  • 52
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science. 2015;348(6230):62–68.
    • (2015) Science , vol.348 , Issue.6230 , pp. 62-68
    • Rosenberg, SA1    Restifo, NP.2
  • 53
    • 42349091974 scopus 로고    scopus 로고
    • Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells
    • Epardaud M, et al. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 2008;68(8):2972–2983.
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2972-2983
    • Epardaud, M1
  • 54
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon KC, et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin Oncol. 2015;33(1):74–82.
    • (2015) J Clin Oncol , vol.33 , Issue.1 , pp. 74-82
    • Conlon, KC1
  • 55
    • 84960166465 scopus 로고    scopus 로고
    • Comparison of the superagonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models
    • Rhode PR, et al. Comparison of the superagonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models. Cancer Immunol Res. 2016;4(1):49–60.
    • (2016) Cancer Immunol Res , vol.4 , Issue.1 , pp. 49-60
    • Rhode, PR1
  • 56
    • 84971667832 scopus 로고    scopus 로고
    • IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas
    • Kim PS, et al. IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas. Oncotarget. 2016;7(13):16130–16145.
    • (2016) Oncotarget , vol.7 , Issue.13 , pp. 16130-16145
    • Kim, PS1
  • 57
    • 84907228126 scopus 로고    scopus 로고
    • A sharp T-cell antigen receptor signaling threshold for T-cell proliferation
    • Au-Yeung BB, et al. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014;111(35):E3679–E3688.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.35 , pp. E3679-E3688
    • Au-Yeung, BB1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.