Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

Intensive Care Medicine

Volumn 44, Issue 11, 2018, Pages 1849-1858

  Reilly, John P ^a   Wang, Fan ^b   Jones, Tiffanie K ^a   Palakshappa, Jessica A ^c   Anderson, Brian J ^a   Shashaty, Michael G S ^a   Dunn, Thomas G ^a   Johansson, Erik D ^a   Riley, Thomas R ^a   Lim, Brian ^a   Abbott, Jason ^d   Ittner, Caroline A G ^a   Cantu, Edward ^a   Lin, Xihong ^e   Mikacenic, Carmen ^f   Wurfel, Mark M ^f   Christiani, David C ^e,g   Calfee, Carolyn S ^h   Matthay, Michael A ^d   Christie, Jason D ^a,i   Feng, Rui ⁱ   Meyer, Nuala J ^a   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e HARVARD UNIVERSITY   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Angiopoietin 2; Mediation analysis; Mendelian randomization analysis; Respiratory distress syndrome, adult

Indexed keywords

ANGIOPOIETIN 2; ANGPT2 PROTEIN, HUMAN; BIOLOGICAL MARKER;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AFRICAN; AGED; ANGPT2 GENE; AORTA; APACHE; ARTICLE; ASIAN; BLOOD VESSEL PERMEABILITY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; EUROPEAN; EXPRESSION QUANTITATIVE TRAIT LOCUS; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPROMISED PATIENT; INTENSIVE CARE UNIT; LIVER CIRRHOSIS; LUNG; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; POSITIVE END EXPIRATORY PRESSURE; PROTEIN BLOOD LEVEL; QUANTITATIVE TRAIT LOCUS; RISK FACTOR; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SINGLE NUCLEOTIDE POLYMORPHISM; TIBIAL ARTERY; TIDAL VOLUME; BLOOD; CAUCASIAN; COHORT ANALYSIS; COMPLICATION; ETHNIC GROUP; GENETICS; MENDELIAN RANDOMIZATION ANALYSIS; STATISTICAL MODEL;

AGED; ANGIOPOIETIN-2; BIOMARKERS; COHORT STUDIES; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS;

EID: 85055567947     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-018-5328-0     Document Type: Article

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