IL 1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 9, 2013, Pages 950-959

  Meyer, Nuala J ^a   Feng, Rui ^a   Li, Mingyao ^a   Zhao, Yang ^b   Sheu, Chau Chyun ^b,c   Tejera, Paula ^b   Gallop, Robert ^a   Bellamy, Scarlett ^a   Rushefski, Melanie ^a   Lanken, Paul N ^a   Aplenc, Richard ^a   O'Keefe, Grant E ^d   Wurfel, Mark M ^d   Christiani, David C ^b,e   Christie, Jason D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d UNIVERSITY OF WASHINGTON   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Functional genetic polymorphism; IL 1 receptor antagonist; Replication

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CRITICALLY ILL PATIENT; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; IL1RN GENE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT; BLOOD; DRUG ANTAGONISM; GENETIC PREDISPOSITION; GENETICS; INTENSIVE CARE UNIT; MIDDLE AGED; PATHOPHYSIOLOGY; RISK; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

ADULT; AGED; CASE-CONTROL STUDIES; COHORT STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTENSIVE CARE UNITS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-1; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

MLCS; MLOWN;

EID: 84877152034     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201208-1501OC     Document Type: Article

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