Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 42, 2018, Pages E9869-E9878

  Sechet, Emmanuel ^a   Telford, Erica ^a   Bonamy, Clément ^a   Sansonetti, Philippe J ^a,b   Sperandio, Brice ^a  

^a INSTITUT PASTEUR   (France)

^b Centre de Recherche Interdisciplinaire en Biologie   (France)

Author keywords

Epithelial cell; Gene regulation; Natural inducer; Synergistic effect; defensin

Indexed keywords

ANDROGRAPHOLIDE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; BETA DEFENSIN; BETA-DEFENSIN 3, HUMAN; BIOLOGICAL PRODUCT; CHALCONE DERIVATIVE; DITERPENE; ENZYME INHIBITOR; ISOLIQUIRITIGENIN; KAURANE DERIVATIVE; ORIDONIN;

BACTERIUM; CELL CULTURE; COLON; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; INNATE IMMUNITY; METABOLISM;

ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; BACTERIA; BETA-DEFENSINS; BIOLOGICAL PRODUCTS; CELLS, CULTURED; CHALCONES; COLON; DITERPENES; DITERPENES, KAURANE; ENZYME INHIBITORS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE;

EID: 85054963519     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1805298115     Document Type: Article

References (52)

1. Sansonetti PJ (2006) The innate signaling of dangers and the dangers of innate signaling. Nat Immunol 7:1237-1242.
2. Janeway CA, Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197-216.
3. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA (1999) Phylogenetic perspectives in innate immunity. Science 284:1313-1318.
4. Zasloff M (2002) Antimicrobial peptides of multicellular organisms. Nature 415: 389-395.
5. Ganz T (2003) Defensins: Antimicrobial peptides of innate immunity. Nat Rev Immunol 3:710-720.
6. Vaishnava S, et al. (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334:255-258.
7. Radek K, Gallo R (2007) Antimicrobial peptides: Natural effectors of the innate immune system. Semin Immunopathol 29:27-43.
8. Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ (2004) Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 22:181-215.
9. Brogden KA (2005) Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 3:238-250.
10. Giacometti A, et al. (2002) Potential therapeutic role of cationic peptides in three experimental models of septic shock. Antimicrob Agents Chemother 46:2132-2136.
11. Rivas-Santiago B, Serrano CJ, Enciso-Moreno JA (2009) Susceptibility to infectious diseases based on antimicrobial peptide production. Infect Immun 77:4690-4695.
12. Hancock REW, Sahl H-G (2006) Antimicrobial and host-defense peptides as new antiinfective therapeutic strategies. Nat Biotechnol 24:1551-1557.
13. Fox JL (2013) Antimicrobial peptides stage a comeback. Nat Biotechnol 31:379-382.
14. Marr AK, Gooderham WJ, Hancock RE (2006) Antibacterial peptides for therapeutic use: Obstacles and realistic outlook. Curr Opin Pharmacol 6:468-472.
15. Abdelmohsen UR, et al. (2017) Potential of marine natural products against drugresistant fungal, viral, and parasitic infections. Lancet Infect Dis 17:e30-e41.
16. Nakajima S, et al. (2016) Fungus-derived neoechinulin B as a novel antagonist of liver X receptor, identified by chemical genetics using a hepatitis C virus cell culture system. J Virol 90:9058-9074.
17. Chen X, et al. (2015) Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur J Med Chem 93:182-195.
18. Kim K-S, et al. (2013) Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-κB and p38 MAPK pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules 18: 13245-13259.
19. Gu S, Pei J (2017) Innovating chinese herbal medicine: From traditional health practice to scientific drug discovery. Front Pharmacol 8:381.
20. Yuan H, Ma Q, Ye L, Piao G (2016) The traditional medicine and modern medicine from natural products. Molecules 21:E559.
21. Tan WSD, Liao W, Zhou S, Wong WSF (2017) Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action. Biochem Pharmacol 139:71-81.
22. Owona BA, Schluesener HJ (2015) Molecular insight in the multifunctional effects of oridonin. Drugs R D 15:233-244.
23. Peng F, et al. (2015) A review: The pharmacology of isoliquiritigenin. Phytother Res 29:969-977.
24. Chantret I, et al. (1994) Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: Evidence for glucose-dependent negative regulation. J Cell Sci 107:213-225.
25. Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18:2195-2224.
26. Sørensen OE, et al. (2005) Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol 174:4870-4879.
27. Hubbard SR, Miller WT (2007) Receptor tyrosine kinases: Mechanisms of activation and signaling. Curr Opin Cell Biol 19:117-123.
28. Wee P, Wang Z (2017) Epidermal growth factor receptor cell proliferation signaling pathways. Cancers (Basel) 9:E52.
29. Saccani S, Pantano S, Natoli G (2002) p38-dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 3:69-75.
30. Arbibe L, et al. (2007) An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol 8:47-56.
31. Fischer N, et al. (2016) Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge. Proc Natl Acad Sci USA 113:E2993-E3001.
32. Sato T, et al. (2011) Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 141:1762-1772.
33. Weake VM, Workman JL (2010) Inducible gene expression: Diverse regulatory mechanisms. Nat Rev Genet 11:426-437.
34. Donnarumma G, et al. (2007) Effects of AV119, a natural sugar from avocado, on Malassezia furfur invasiveness and on the expression of HBD-2 and cytokines in human keratinocytes. Exp Dermatol 16:912-919.
35. Sass V, et al. (2010) Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect Immun 78:2793-2800.
36. Paoletti I, et al. (2012) Patented natural avocado sugar modulates the HBD-2 and HBD-3 expression in human keratinocytes through toll-like receptor-2 and ERK/MAPK activation. Arch Dermatol Res 304:619-625.
37. Zhao Y, et al. (2018) GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3. Mucosal Immunol 11:752-762.
38. Li D, et al. (2013) A novel lipopeptide from skin commensal activates TLR2/CD36-p38 MAPK signaling to increase antibacterial defense against bacterial infection. PLoS One 8:e58288.
39. Fehlbaum P, Rao M, Zasloff M, Anderson GM (2000) An essential amino acid induces epithelial beta -defensin expression. Proc Natl Acad Sci USA 97:12723-12728.
40. Raqib R, et al. (2006) Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci USA 103:9178-9183.
41. Prenzel N, et al. (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888.
42. Leahy DJ (2004) Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors. Adv Protein Chem 68:1-27.
43. Krall JA, Beyer EM, MacBeath G (2011) High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways. PLoS One 6: E15945.
44. Boughan PK, et al. (2006) Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: Critical regulators of beta-defensins during Helicobacter pylori infection. J Biol Chem 281:11637-11648.
45. Dhople V, Krukemeyer A, Ramamoorthy A (2006) The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim Biophys Acta 1758: 1499-1512.
46. Darveau RP, et al. (1991) Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo. Antimicrob Agents Chemother 35:1153-1159.
47. Maisetta G, et al. (2003) Activity of human beta-defensin 3 alone or combined with other antimicrobial agents against oral bacteria. Antimicrob Agents Chemother 47: 3349-3351.
48. Tarleton JL, et al. (2006) Cognitive effects of diarrhea, malnutrition, and Entamoeba histolytica infection on school age children in Dhaka, Bangladesh. Am J Trop Med Hyg 74:475-481.
49. Wierzba TF, et al. (2001) The interrelationship of malnutrition and diarrhea in a periurban area outside Alexandria, Egypt. J Pediatr Gastroenterol Nutr 32:189-196.
50. Fellermann K, Wehkamp J, Herrlinger KR, Stange EF (2003) Crohn's disease: A defensin deficiency syndrome? Eur J Gastroenterol Hepatol 15:627-634.
51. Wiest R, Rath HC (2003) Gastrointestinal disorders of the critically ill. Bacterial translocation in the gut. Best Pract Res Clin Gastroenterol 17:397-425.
52. Midorikawa K, et al. (2003) Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes. Infect Immun 71:3730-3739.