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Volumn 29, Issue 7, 2015, Pages 969-977

A Review: The Pharmacology of Isoliquiritigenin

Author keywords

isoliquiritigenin; natural medicine; pharmacological properties

Indexed keywords

2,4,4' DIACETOXY 2' HYDROXYCHALCONE; 3,2,4' DIMETHOXY 4 HYDROXYCHALCONE; 4 ACETOXY 2',4' DIMETHOXYCHALCONE; 5,4 BENZOYLOXY 2',4' DIMETHOXYCHALCONE; 6,2',4' DIMETHOXYCHALCONE; CYCLOPHOSPHAMIDE; DOXORUBICIN; ISOLIQUIRITIGENIN; LIQUIRITIGENIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; CHALCONE DERIVATIVE; FLAVANONE DERIVATIVE; PLANT EXTRACT;

EID: 84936866336     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5348     Document Type: Article
Times cited : (229)

References (85)
  • 1
    • 0141505057 scopus 로고    scopus 로고
    • Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin
    • Abdollahi M, Chan TS, Subrahmanyam V, O'Brien PJ,. 2003. Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol Cell Biochem 252: 205-211.
    • (2003) Mol Cell Biochem , vol.252 , pp. 205-211
    • Abdollahi, M.1    Chan, T.S.2    Subrahmanyam, V.3    O'Brien, P.J.4
  • 2
    • 84879782898 scopus 로고    scopus 로고
    • Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus
    • Arai T, Maejima Y, Muroya S, Yada T,. 2013. Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. Neuropeptides 47: 225-230.
    • (2013) Neuropeptides , vol.47 , pp. 225-230
    • Arai, T.1    Maejima, Y.2    Muroya, S.3    Yada, T.4
  • 3
    • 46849110600 scopus 로고    scopus 로고
    • Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    • Asl MN, Hosseinzadeh H,. 2008. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 22: 709-724.
    • (2008) Phytother Res , vol.22 , pp. 709-724
    • Asl, M.N.1    Hosseinzadeh, H.2
  • 4
    • 35448944356 scopus 로고    scopus 로고
    • Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II
    • Brown AK, Papaemmanouil A, Bhowruth V, Bhatt A, Dover LG, Besra GS,. 2007. Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. Microbiology 153: 3314-3322.
    • (2007) Microbiology , vol.153 , pp. 3314-3322
    • Brown, A.K.1    Papaemmanouil, A.2    Bhowruth, V.3    Bhatt, A.4    Dover, L.G.5    Besra, G.S.6
  • 6
    • 84885845183 scopus 로고    scopus 로고
    • Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation
    • Chen H, Zhang B, Yuan X, et al., 2013. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int 37: 1215-1224.
    • (2013) Cell Biol Int , vol.37 , pp. 1215-1224
    • Chen, H.1    Zhang, B.2    Yuan, X.3
  • 7
    • 84870158803 scopus 로고    scopus 로고
    • NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin
    • Chen H, Zhang B, Yao Y, et al., 2012a. NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin. Molecules 117: 13424-13438.
    • (2012) Molecules , vol.117 , pp. 13424-13438
    • Chen, H.1    Zhang, B.2    Yao, Y.3
  • 8
    • 84868156761 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling
    • Chen X, Wu Y, Jiang Y, et al., 2012b. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med 90: 1311-1319.
    • (2012) J Mol Med , vol.90 , pp. 1311-1319
    • Chen, X.1    Wu, Y.2    Jiang, Y.3
  • 9
    • 84872150727 scopus 로고    scopus 로고
    • Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line Hindawi Publishing Corporation
    • 2012
    • Chen X, Zhang B, Yuan X, et al., 2012c. Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line Hindawi Publishing Corporation. Oxid Med Cell Longev 2012. doi: 10.1155/2012/534934.
    • (2012) Oxid Med Cell Longev
    • Chen, X.1    Zhang, B.2    Yuan, X.3
  • 10
    • 34250692468 scopus 로고    scopus 로고
    • Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra)
    • Chin YW, Jung HA, Liu Y, et al., 2007. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Agric Food Chem 55: 4691-4697.
    • (2007) J Agric Food Chem , vol.55 , pp. 4691-4697
    • Chin, Y.W.1    Jung, H.A.2    Liu, Y.3
  • 11
    • 21344445244 scopus 로고    scopus 로고
    • Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids
    • Chowdhury SA, Kishino K, Satoh R, et al., 2005. Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anticancer Res 25: 2055-2063.
    • (2005) Anticancer Res , vol.25 , pp. 2055-2063
    • Chowdhury, S.A.1    Kishino, K.2    Satoh, R.3
  • 12
    • 77949764073 scopus 로고    scopus 로고
    • Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice
    • Cuendet M, Guo J, Luo Y, et al., 2010. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila) 3: 221-232.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 221-232
    • Cuendet, M.1    Guo, J.2    Luo, Y.3
  • 13
    • 33645993864 scopus 로고    scopus 로고
    • Quinone reductase induction as a biomarker for cancer chemoprevention
    • Cuendet M, Oteham CP, Moon RC, Pezzuto JM,. 2006. Quinone reductase induction as a biomarker for cancer chemoprevention. J Nat Prod 69: 460-463.
    • (2006) J Nat Prod , vol.69 , pp. 460-463
    • Cuendet, M.1    Oteham, C.P.2    Moon, R.C.3    Pezzuto, J.M.4
  • 14
    • 22544469706 scopus 로고    scopus 로고
    • Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC - Polyurethane membranes
    • De Bartolo L, Morelli S, Gallo MC, et al., 2005. Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC-polyurethane membranes. Biomaterials 26: 6625-6634.
    • (2005) Biomaterials , vol.26 , pp. 6625-6634
    • De Bartolo, L.1    Morelli, S.2    Gallo, M.C.3
  • 15
    • 80053187762 scopus 로고    scopus 로고
    • Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential 1
    • Feldman M, Santos J, Grenier D,. 2011. Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential 1. J Nat Prod 74: 1862-1867.
    • (2011) J Nat Prod , vol.74 , pp. 1862-1867
    • Feldman, M.1    Santos, J.2    Grenier, D.3
  • 16
    • 77956685640 scopus 로고    scopus 로고
    • Liquiritigenin derivatives and their hepatoprotective activity
    • Gaur R, Kumar S, Trivedi P, et al., 2010. Liquiritigenin derivatives and their hepatoprotective activity. Nat Prod Commun 5: 1243-1246.
    • (2010) Nat Prod Commun , vol.5 , pp. 1243-1246
    • Gaur, R.1    Kumar, S.2    Trivedi, P.3
  • 17
    • 84897394794 scopus 로고    scopus 로고
    • In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin
    • Gaur R, Yadav KS, Verma RK, Yadav NP, Bhakuni RS,. 2014. In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. Phytomedicine 21: 415-422.
    • (2014) Phytomedicine , vol.21 , pp. 415-422
    • Gaur, R.1    Yadav, K.S.2    Verma, R.K.3    Yadav, N.P.4    Bhakuni, R.S.5
  • 18
    • 37249052455 scopus 로고    scopus 로고
    • Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition
    • Hattori T, Sadakane C, Koseki J, Kase Y, Takeda S,. 2007. Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition. Clin Exp Nephrol 11: 275-282.
    • (2007) Clin Exp Nephrol , vol.11 , pp. 275-282
    • Hattori, T.1    Sadakane, C.2    Koseki, J.3    Kase, Y.4    Takeda, S.5
  • 19
    • 84889595124 scopus 로고    scopus 로고
    • Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca ski cells
    • Hirchaud F, et al., 2013. Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca ski cells. Planta Med 79: 1628-1635.
    • (2013) Planta Med , vol.79 , pp. 1628-1635
    • Hirchaud, F.1
  • 20
    • 3843137373 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer a549 cells
    • Hsu YL, Kuo PL, Chiang LC, Lin CC,. 2004. Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer a549 cells. Clin Exp Pharmacol Physiol 31: 414-418.
    • (2004) Clin Exp Pharmacol Physiol , vol.31 , pp. 414-418
    • Hsu, Y.L.1    Kuo, P.L.2    Chiang, L.C.3    Lin, C.C.4
  • 21
    • 18844373926 scopus 로고    scopus 로고
    • Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells
    • Hsu YL, Kuo PL, Lin CC,. 2005a. Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells. Life Sci 77: 279-292.
    • (2005) Life Sci , vol.77 , pp. 279-292
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 22
    • 14944347709 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells
    • Hsu YL, Kuo PL, Lin LT, Lin CC,. 2005b. Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. Planta Med 71: 130-134.
    • (2005) Planta Med , vol.71 , pp. 130-134
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, L.T.3    Lin, C.C.4
  • 23
    • 1842577637 scopus 로고    scopus 로고
    • CIP1/WAF1 expression in human lung cancer cells by isoliquiritigenin
    • CIP1/WAF1 expression in human lung cancer cells by isoliquiritigenin. Cancer Lett 207: 27-35.
    • (2004) Cancer Lett , vol.207 , pp. 27-35
    • Ii, T.1    Satomi, Y.2    Katoh, D.3
  • 24
    • 44149088046 scopus 로고    scopus 로고
    • Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABAB receptor
    • Jang EY, Choe ES, Hwang M, et al., 2008. Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABAB receptor. Eur J Pharmacol 587: 124-128.
    • (2008) Eur J Pharmacol , vol.587 , pp. 124-128
    • Jang, E.Y.1    Choe, E.S.2    Hwang, M.3
  • 25
    • 0038188723 scopus 로고    scopus 로고
    • Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (Tonka bean)
    • Jang DS, Park EJ, Hawthorne ME, et al., 2003. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (Tonka bean). J Nat Prod 66: 583-587.
    • (2003) J Nat Prod , vol.66 , pp. 583-587
    • Jang, D.S.1    Park, E.J.2    Hawthorne, M.E.3
  • 26
    • 80052128201 scopus 로고    scopus 로고
    • Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models
    • Jhanji V, Liu H, Law K, et al., 2011. Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. Br J Ophthalmol 95: 1309-1315.
    • (2011) Br J Ophthalmol , vol.95 , pp. 1309-1315
    • Jhanji, V.1    Liu, H.2    Law, K.3
  • 27
    • 34250353135 scopus 로고    scopus 로고
    • Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells
    • Jung JI, Chung E, Seon MR, et al., 2006a. Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. Biofactors 28: 159-168.
    • (2006) Biofactors , vol.28 , pp. 159-168
    • Jung, J.I.1    Chung, E.2    Seon, M.R.3
  • 28
    • 33748586228 scopus 로고    scopus 로고
    • Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells
    • Jung JI, Lim SS, Choi HJ, et al., 2006b. Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells. J Nutr Biochem 17: 689-696.
    • (2006) J Nutr Biochem , vol.17 , pp. 689-696
    • Jung, J.I.1    Lim, S.S.2    Choi, H.J.3
  • 29
    • 0037628974 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits the growth of prostate cancer
    • Kanazawa M, Satomi Y, Mizutani Y, et al., 2003. Isoliquiritigenin inhibits the growth of prostate cancer. Eur Urol 43: 580-586.
    • (2003) Eur Urol , vol.43 , pp. 580-586
    • Kanazawa, M.1    Satomi, Y.2    Mizutani, Y.3
  • 30
    • 71749083439 scopus 로고    scopus 로고
    • Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases
    • Kang SW, Choi JS, Choi YJ, et al., 2010. Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. J Nutr Biochem 21: 55-65.
    • (2010) J Nutr Biochem , vol.21 , pp. 55-65
    • Kang, S.W.1    Choi, J.S.2    Choi, Y.J.3
  • 31
    • 45749142839 scopus 로고    scopus 로고
    • Induction of growth inhibition and apoptosis in human uterine leiomyoma cells by isoliquiritigenin
    • Kim DC, et al., 2008. Induction of growth inhibition and apoptosis in human uterine leiomyoma cells by isoliquiritigenin. Reprod Sci 15: 552-558.
    • (2008) Reprod Sci , vol.15 , pp. 552-558
    • Kim, D.C.1
  • 32
    • 33746238114 scopus 로고    scopus 로고
    • Isoliquiritigenin selectively inhibits H2 histamine receptor signaling
    • Kim DC, Choi SY, Kim SH, et al., 2006. Isoliquiritigenin selectively inhibits H2 histamine receptor signaling. Mol Pharmacol 70: 493-500.
    • (2006) Mol Pharmacol , vol.70 , pp. 493-500
    • Kim, D.C.1    Choi, S.Y.2    Kim, S.H.3
  • 33
    • 78049384496 scopus 로고    scopus 로고
    • Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition
    • Kim YM, Kim TH, Kim YW, et al., 2010. Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. Free Radic Biol Med 49: 1722-1734.
    • (2010) Free Radic Biol Med , vol.49 , pp. 1722-1734
    • Kim, Y.M.1    Kim, T.H.2    Kim, Y.W.3
  • 34
    • 68249127978 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: Possible mediation by decreased JNK/AP-1 signaling
    • Kwon GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH,. 2009. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem 20: 663-676.
    • (2009) J Nutr Biochem , vol.20 , pp. 663-676
    • Kwon, G.T.1    Cho, H.J.2    Chung, W.Y.3    Park, K.K.4    Moon, A.5    Park, J.H.6
  • 35
    • 33846849163 scopus 로고    scopus 로고
    • Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappa B signal disruption
    • Kwon HM, Choi YJ, Choi JS, et al., 2007. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappa B signal disruption. Exp Biol Med (Maywood) 232: 235-245.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 235-245
    • Kwon, H.M.1    Choi, Y.J.2    Choi, J.S.3
  • 36
    • 77952929257 scopus 로고    scopus 로고
    • The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line
    • Lau GT, Ye L, Leung LK,. 2010. The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line. Planta Med 76: 780-785.
    • (2010) Planta Med , vol.76 , pp. 780-785
    • Lau, G.T.1    Ye, L.2    Leung, L.K.3
  • 37
    • 84862851692 scopus 로고    scopus 로고
    • Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons
    • Lee HK, Yang EJ, Kim JY, Song KS, Seong YH,. 2012. Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons. Arch Pharm Res 35: 897-904.
    • (2012) Arch Pharm Res , vol.35 , pp. 897-904
    • Lee, H.K.1    Yang, E.J.2    Kim, J.Y.3    Song, K.S.4    Seong, Y.H.5
  • 38
    • 70350511470 scopus 로고    scopus 로고
    • Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice
    • Lee MJ, Yang CH, Jeon JP, Hwang M,. 2009a. Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice. J Pharmacol Sci 2: 216-220.
    • (2009) J Pharmacol Sci , vol.2 , pp. 216-220
    • Lee, M.J.1    Yang, C.H.2    Jeon, J.P.3    Hwang, M.4
  • 39
    • 84890565299 scopus 로고    scopus 로고
    • The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction
    • Lee SK, Park KK, Park JH, Lim SS, Chung WY,. 2013. The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction. Phytother Res 27: 1776-1783.
    • (2013) Phytother Res , vol.27 , pp. 1776-1783
    • Lee, S.K.1    Park, K.K.2    Park, J.H.3    Lim, S.S.4    Chung, W.Y.5
  • 40
    • 65549152471 scopus 로고    scopus 로고
    • Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages
    • Lee SH, Kim JY, Seo GS, Kim YC, Sohn DH,. 2009b. Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages. Inflamm Res 58: 257-262.
    • (2009) Inflamm Res , vol.58 , pp. 257-262
    • Lee, S.H.1    Kim, J.Y.2    Seo, G.S.3    Kim, Y.C.4    Sohn, D.H.5
  • 42
    • 64949183401 scopus 로고    scopus 로고
    • Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin
    • Lee YM, Lim do Y, Choi HJ, Jung JI, Chung WY, Park JH,. 2009c. Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. J Med Food 12: 8-14.
    • (2009) J Med Food , vol.12 , pp. 8-14
    • Lee, Y.M.1    Lim Do, Y.2    Choi, H.J.3    Jung, J.I.4    Chung, W.Y.5    Park, J.H.6
  • 43
    • 77649180814 scopus 로고    scopus 로고
    • Isoliquiritigenin 20-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1
    • Lee YM, Jeong GS, Lim HD, An RB, Kim YC, Kim EC,. 2010b. Isoliquiritigenin 20-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1. Toxicol In Vitro 24: 776-782.
    • (2010) Toxicol in Vitro , vol.24 , pp. 776-782
    • Lee, Y.M.1    Jeong, G.S.2    Lim, H.D.3    An, R.B.4    Kim, Y.C.5    Kim, E.C.6
  • 44
    • 60449102681 scopus 로고    scopus 로고
    • Isoliquiritigenin induces monocytic differentiation of HL-60 cells
    • Li D, et al., 2009a. Isoliquiritigenin induces monocytic differentiation of HL-60 cells. Free Radic Biol Med 46: 731-736.
    • (2009) Free Radic Biol Med , vol.46 , pp. 731-736
    • Li, D.1
  • 45
    • 77949421410 scopus 로고    scopus 로고
    • Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation
    • Li J, Kang SW, Kim JL, Sung HY, Kwun IS, Kang YH,. 2010a. Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation. J Agric Food Chem 58: 3205-3212.
    • (2010) J Agric Food Chem , vol.58 , pp. 3205-3212
    • Li, J.1    Kang, S.W.2    Kim, J.L.3    Sung, H.Y.4    Kwun, I.S.5    Kang, Y.H.6
  • 46
    • 84894082617 scopus 로고    scopus 로고
    • Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells
    • Li W, Sun YN, Yan XT, et al., 2014. Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. Arch Pharm Res 37: 186-192.
    • (2014) Arch Pharm Res , vol.37 , pp. 186-192
    • Li, W.1    Sun, Y.N.2    Yan, X.T.3
  • 47
    • 77956173930 scopus 로고    scopus 로고
    • Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities
    • Li S, Li W, Wang Y, Asada Y, Koike K,. 2010b. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett 20: 5398-5401.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 5398-5401
    • Li, S.1    Li, W.2    Wang, Y.3    Asada, Y.4    Koike, K.5
  • 48
    • 77949314572 scopus 로고    scopus 로고
    • Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip
    • Li X, Xue X, Li PC,. 2009b. Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip. Integr Biol 1: 90-98.
    • (2009) Integr Biol , vol.1 , pp. 90-98
    • Li, X.1    Xue, X.2    Li, P.C.3
  • 49
    • 84882761693 scopus 로고    scopus 로고
    • Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer
    • Li Y, Zhao H, Wang Y, et al., 2013. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol 272: 37-48.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 37-48
    • Li, Y.1    Zhao, H.2    Wang, Y.3
  • 50
    • 84875133881 scopus 로고    scopus 로고
    • Novel plant-derived target drugs: A step forward from licorice?
    • Lorusso V, Marech I,. 2013. Novel plant-derived target drugs: a step forward from licorice? Expert Opin Ther Targets 17: 333-335.
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 333-335
    • Lorusso, V.1    Marech, I.2
  • 51
    • 84856570690 scopus 로고    scopus 로고
    • Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: Potential therapy for cholera and polycystic kidney disease
    • Muanprasat C, Sirianant L, Soodvilai S, Chokchaisiri R, Suksamrarn A, Chatsudthipong V,. 2012. Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease. J Pharmacol Sci 118: 82-91.
    • (2012) J Pharmacol Sci , vol.118 , pp. 82-91
    • Muanprasat, C.1    Sirianant, L.2    Soodvilai, S.3    Chokchaisiri, R.4    Suksamrarn, A.5    Chatsudthipong, V.6
  • 52
    • 0037467028 scopus 로고    scopus 로고
    • Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots
    • Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S,. 2003. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem 51: 1201-1207.
    • (2003) J Agric Food Chem , vol.51 , pp. 1201-1207
    • Nerya, O.1    Vaya, J.2    Musa, R.3    Izrael, S.4    Ben-Arie, R.5    Tamir, S.6
  • 53
    • 58149147487 scopus 로고    scopus 로고
    • Inhibitory effects of isoliquiritigenin and licorice extract on voltage-dependent K+ currents in H9c2 cells
    • Noguchi C, Yang J, Sakamoto K, et al., 2008. Inhibitory effects of isoliquiritigenin and licorice extract on voltage-dependent K+ currents in H9c2 cells. J Pharmacol Sci 108: 439-445.
    • (2008) J Pharmacol Sci , vol.108 , pp. 439-445
    • Noguchi, C.1    Yang, J.2    Sakamoto, K.3
  • 54
    • 84883295940 scopus 로고    scopus 로고
    • Evaluation of cytotoxicity and tumor-specificity of licorice flavonoids based on chemical structure
    • Ohno H, et al., 2013. Evaluation of cytotoxicity and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res 33: 3061-3068.
    • (2013) Anticancer Res , vol.33 , pp. 3061-3068
    • Ohno, H.1
  • 55
    • 62749157517 scopus 로고    scopus 로고
    • Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition
    • Park I, Park KK, Park JH, Chung WY,. 2009a. Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. Cancer Lett 277: 174-181.
    • (2009) Cancer Lett , vol.277 , pp. 174-181
    • Park, I.1    Park, K.K.2    Park, J.H.3    Chung, W.Y.4
  • 56
    • 72449207972 scopus 로고    scopus 로고
    • Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages
    • Park SJ, Song HY, Youn HS,. 2009b. Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages. Mol Cells 28: 365-368.
    • (2009) Mol Cells , vol.28 , pp. 365-368
    • Park, S.J.1    Song, H.Y.2    Youn, H.S.3
  • 57
    • 77956345011 scopus 로고    scopus 로고
    • Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin
    • Park SJ, Youn HS,. 2010a. Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin. Phytochemistry 71: 1736-1740.
    • (2010) Phytochemistry , vol.71 , pp. 1736-1740
    • Park, S.J.1    Youn, H.S.2
  • 58
    • 77951262990 scopus 로고    scopus 로고
    • Isoliquiritigenin suppresses the toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of toll-like receptors by targeting TBK1
    • Park SJ, Youn HS,. 2010b. Isoliquiritigenin suppresses the toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of toll-like receptors by targeting TBK1. J Agric Food Chem 58: 4701-4705.
    • (2010) J Agric Food Chem , vol.58 , pp. 4701-4705
    • Park, S.J.1    Youn, H.S.2
  • 59
    • 74349130089 scopus 로고    scopus 로고
    • Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis
    • Ryu YB, Kim JH, Park SJ, et al., 2010. Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorg Med Chem Lett 20: 971-974.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 971-974
    • Ryu, Y.B.1    Kim, J.H.2    Park, S.J.3
  • 60
    • 84866069562 scopus 로고    scopus 로고
    • Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra
    • Shi Y, et al., 2012. Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. Phytother Res 26: 1410-1417.
    • (2012) Phytother Res , vol.26 , pp. 1410-1417
    • Shi, Y.1
  • 61
    • 84875221485 scopus 로고    scopus 로고
    • Isoliquiritigenin enhances radio sensitivity of HepG2 cells via disturbance of redox status
    • Sun C, Zhang H, Ma XF, et al., 2013. Isoliquiritigenin enhances radio sensitivity of HepG2 cells via disturbance of redox status. Cell Biochem Biophys 65: 433-444.
    • (2013) Cell Biochem Biophys , vol.65 , pp. 433-444
    • Sun, C.1    Zhang, H.2    Ma, X.F.3
  • 62
    • 77954942475 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: Its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase
    • Sun ZJ, Chen G, Zhang W, et al., 2010. Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. J Pharmacol Exp Ther 334: 500-512.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 500-512
    • Sun, Z.J.1    Chen, G.2    Zhang, W.3
  • 63
    • 73649123558 scopus 로고    scopus 로고
    • Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition
    • Takeda H, Muto S, Hattori T, et al., 2010. Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. Endocrinology 151: 244-252.
    • (2010) Endocrinology , vol.151 , pp. 244-252
    • Takeda, H.1    Muto, S.2    Hattori, T.3
  • 64
    • 29844446274 scopus 로고    scopus 로고
    • Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells
    • Takahashia T, Baba M, Nishino H, Okuyama T,. 2006. Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. Cancer Lett 231: 319-325.
    • (2006) Cancer Lett , vol.231 , pp. 319-325
    • Takahashia, T.1    Baba, M.2    Nishino, H.3    Okuyama, T.4
  • 65
    • 3042545271 scopus 로고    scopus 로고
    • Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
    • Takahashi T, Takasuka N, Iigo M, et al., 2004. Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci 95: 448-453.
    • (2004) Cancer Sci , vol.95 , pp. 448-453
    • Takahashi, T.1    Takasuka, N.2    Iigo, M.3
  • 66
    • 84879814057 scopus 로고    scopus 로고
    • Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway
    • Wang Z, Wang N, Han S, et al., 2013. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One 8: e68566.
    • (2013) PLoS One , vol.8
    • Wang, Z.1    Wang, N.2    Han, S.3
  • 67
    • 33750293043 scopus 로고    scopus 로고
    • Metallothionein mediates cardio protection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation
    • Wei AN, J Y, Ao Y,. 2006. Metallothionein mediates cardio protection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation. Acta Pharmacol Sin 27: 1431-1437.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 1431-1437
    • Wei, A.N.1    J, Y.2    Ao, Y.3
  • 68
    • 47249088748 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells
    • Woo SW, Lee SH, Ko G, Kim YC, Sohn DH,. 2008. Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells. Planta Med 74: 834-839.
    • (2008) Planta Med , vol.74 , pp. 834-839
    • Woo, S.W.1    Lee, S.H.2    Ko, G.3    Kim, Y.C.4    Sohn, D.H.5
  • 69
    • 79953767571 scopus 로고    scopus 로고
    • Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy
    • Wu CP, Ohnuma S, Ambudkar SV,. 2011. Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy. Curr Pharm Biotechnol 12: 609-620.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 609-620
    • Wu, C.P.1    Ohnuma, S.2    Ambudkar, S.V.3
  • 70
    • 84888611326 scopus 로고    scopus 로고
    • A Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model
    • 2013
    • Yamada C, Saegusa Y, Nakagawa K, et al., 2013. A Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. Biomed Res Int 2013. doi: 10.1155/2013/792940.
    • (2013) Biomed Res Int
    • Yamada, C.1    Saegusa, Y.2    Nakagawa, K.3
  • 71
    • 84861225244 scopus 로고    scopus 로고
    • Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction
    • Yang EJ, Min JS, Ku HY, et al., 2012. Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. Biochem Biophys Res Commun 421: 658-664.
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 658-664
    • Yang, E.J.1    Min, J.S.2    Ku, H.Y.3
  • 72
    • 84883744125 scopus 로고    scopus 로고
    • Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMITM, inhibit memory Th2 responses in vitro and in vivo
    • Yang N, Patil S, Zhuge J, et al., 2013. Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMITM, inhibit memory Th2 responses in vitro and in vivo. Phytother Res 27: 1381-1391.
    • (2013) Phytother Res , vol.27 , pp. 1381-1391
    • Yang, N.1    Patil, S.2    Zhuge, J.3
  • 73
    • 67349188370 scopus 로고    scopus 로고
    • Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells
    • Yoshida T, Horinaka M, Takara M, et al., 2008. Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. Environ Health Prev Med 13: 281-287.
    • (2008) Environ Health Prev Med , vol.13 , pp. 281-287
    • Yoshida, T.1    Horinaka, M.2    Takara, M.3
  • 74
    • 84875319418 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis
    • Yuan X, Yu B, Wang Y, et al., 2013a. Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis. Recent Pat Anticancer Drug Discov 8: 191-199.
    • (2013) Recent Pat Anticancer Drug Discov , vol.8 , pp. 191-199
    • Yuan, X.1    Yu, B.2    Wang, Y.3
  • 75
    • 84865983010 scopus 로고    scopus 로고
    • Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells
    • Yuan X, Zhang B, Chen N, et al., 2012. Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. J Asian Nat Prod Res 8: 789-798.
    • (2012) J Asian Nat Prod Res , vol.8 , pp. 789-798
    • Yuan, X.1    Zhang, B.2    Chen, N.3
  • 76
    • 84880223942 scopus 로고    scopus 로고
    • Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell
    • Yuan X, Zhang B, Gan L, et al., 2013b. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci 26: 268-276.
    • (2013) Biomed Environ Sci , vol.26 , pp. 268-276
    • Yuan, X.1    Zhang, B.2    Gan, L.3
  • 77
    • 32644454395 scopus 로고    scopus 로고
    • Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats
    • Zhan C, Yang J,. 2006. Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Pharmacol Res 53: 303-309.
    • (2006) Pharmacol Res , vol.53 , pp. 303-309
    • Zhan, C.1    Yang, J.2
  • 78
    • 84877812976 scopus 로고    scopus 로고
    • Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice
    • Zhang XY, Qiao H, Ni JM, Shi YB, Qiang Y,. 2013a. Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. Eur J Pharm Sci 49: 411-422.
    • (2013) Eur J Pharm Sci , vol.49 , pp. 411-422
    • Zhang, X.Y.1    Qiao, H.2    Ni, J.M.3    Shi, Y.B.4    Qiang, Y.5
  • 79
    • 77955100283 scopus 로고    scopus 로고
    • Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells
    • Zhang X, Yeung ED, Wang J, et al., 2010. Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. Clin Exp Pharmacol Physiol 37: 841-847.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 841-847
    • Zhang, X.1    Yeung, E.D.2    Wang, J.3
  • 80
    • 84885640858 scopus 로고    scopus 로고
    • Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway
    • Zhang X, Zhu P, Zhang X, et al., 2013b. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm 2013: 390890.
    • (2013) Mediators Inflamm , vol.2013
    • Zhang, X.1    Zhu, P.2    Zhang, X.3
  • 81
    • 67650435103 scopus 로고    scopus 로고
    • Primary research on Chinese medicine treatment of androgen-independent prostate cancer
    • Zhang SW, Zhou SY, Shao JC, Qu XW,. 2009. Primary research on Chinese medicine treatment of androgen-independent prostate cancer. Chin J Integr Med 15: 168-169.
    • (2009) Chin J Integr Med , vol.15 , pp. 168-169
    • Zhang, S.W.1    Zhou, S.Y.2    Shao, J.C.3    Qu, X.W.4
  • 82
    • 84883157630 scopus 로고    scopus 로고
    • Isoliquiritigenin enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide
    • Zhao H, Yuan X, Li D, et al., 2013. Isoliquiritigenin enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. Molecules 18: 8786-8798.
    • (2013) Molecules , vol.18 , pp. 8786-8798
    • Zhao, H.1    Yuan, X.2    Li, D.3
  • 83
    • 84555179029 scopus 로고    scopus 로고
    • Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum
    • Zhao X, Mei W, Gong M, Zuo W, Bai H, Dai H,. 2011. Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum. Molecules 16: 9775-9782.
    • (2011) Molecules , vol.16 , pp. 9775-9782
    • Zhao, X.1    Mei, W.2    Gong, M.3    Zuo, W.4    Bai, H.5    Dai, H.6
  • 84
    • 84873857035 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro
    • Zhou GS, Song LJ, Yang B,. 2013. Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. Mol Med Rep 7: 531-536.
    • (2013) Mol Med Rep , vol.7 , pp. 531-536
    • Zhou, G.S.1    Song, L.J.2    Yang, B.3
  • 85
    • 70350776722 scopus 로고    scopus 로고
    • Cytotoxic activity of isoliquiritigenin towards CCRF-CEM leukemia cells and its effect on DNA damage
    • Zu Y, Liu X, Fu Y, et al., 2009. Cytotoxic activity of isoliquiritigenin towards CCRF-CEM leukemia cells and its effect on DNA damage. Planta Med 75: 1134-1140.
    • (2009) Planta Med , vol.75 , pp. 1134-1140
    • Zu, Y.1    Liu, X.2    Fu, Y.3


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