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IFITM3 and severe influenza virus infection. No evidence of genetic association
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Lopez-Rodriguez M, Herrera-Ramos E, Sole-Violan J, Ruiz-Hernandez JJ, Borderias L, Horcajada JP, et al. IFITM3 and severe influenza virus infection. No evidence of genetic association. Eur J Clin Microbiol Infect Dis. 2016;35(11):1811–7. 10.1007/s10096-016-2732-7.
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Hospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza A(H1N1)pdm09 infection: a case-control study
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Gaio V, Nunes B, Pechirra P, Conde P, Guiomar R, Dias CM, et al. Hospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza A(H1N1)pdm09 infection: a case-control study. PLoS One. 2016;11(6):e0158181. 10.1371/journal.pone.0158181.
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Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity
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David S, Correia V, Antunes L, Faria R, Ferrao J, Faustino P, et al. Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity. Immunogenetics. 2017;70:169–77. 10.1007/s00251-017-1026-2.
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Interferon-induced transmembrane protein 3 inhibits Hantaan virus infection, and its single nucleotide polymorphism rs12252 influences the severity of hemorrhagic fever with renal syndrome
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Xu-Yang Z, Pei-Yu B, Chuan-Tao Y, Wei Y, Hong-Wei M, Kang T, et al. Interferon-induced transmembrane protein 3 inhibits Hantaan virus infection, and its single nucleotide polymorphism rs12252 influences the severity of hemorrhagic fever with renal syndrome. Front Immunol. 2016;7:535. 10.3389/fimmu.2016.00535.
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64
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Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort
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Zhang YH, Makvandi-Nejad S, Qin L, Zhao Y, Zhang T, Wang LL, et al. Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort. AIDS. 2015;29(8):889–94. 10.1097/Qad.0000000000000632.
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65
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SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
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This study identifies a new SNP theIFITM3gene, rs34411844-A, associated with severe influenza virus infections humans. This SNP correlates with decreased IFITM3 protein and mRNA levels
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•• Allen EK, Randolph AG, Bhangale T, Dogra P, Ohlson M, Oshansky CM, et al. SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. Nat Med. 2017;23(8):975–83. 10.1038/nm.4370. This study identifies a new SNP in the IFITM3 gene, rs34411844-A, associated with severe influenza virus infections in humans. This SNP correlates with decreased IFITM3 protein and mRNA levels.
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(2017)
Nat Med
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Allen, E.K.1
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66
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85040590942
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Lack of truncated IFITM3 transcripts in cells homozygous for the rs12252-C variant that is associated with severe influenza infection
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This study provides evidence that refutes the predominant hypothesis the IFITM3 literature that the rs12252-C polymorphism altersIFITM3splicing. Alternatively, spliced transcripts were not detected via RNA sequencing
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• Makvandi-Nejad S, Laurenson-Schafer H, Wang L, Wellington D, Zhao Y, Jin B, et al. Lack of truncated IFITM3 transcripts in cells homozygous for the rs12252-C variant that is associated with severe influenza infection. J Infect Dis. 2018;217(2):257–62. 10.1093/infdis/jix512. This study provides evidence that refutes the predominant hypothesis in the IFITM3 literature that the rs12252-C polymorphism alters IFITM3 splicing. Alternatively, spliced transcripts were not detected via RNA sequencing.
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(2018)
J Infect Dis
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Makvandi-Nejad, S.1
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Kenney AD, Dowdle JA, Bozzacco L, McMichael TM, St Gelais C, Panfil AR, et al. Human genetic determinants of viral diseases. Annu Rev Genet. 2017;51:241–63. 10.1146/annurev-genet-120116-023425.
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68
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IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3
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Jiang LQ, Xia T, Hu YH, Sun MS, Yan S, Lei CQ, et al. IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cell Mol Immunol. 2017; 10.1038/cmi.2017.15.
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Cellular & Molecular Immunology
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69
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Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction
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Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, et al. Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell Rep. 2013;5(4):895–908. 10.1016/j.celrep.2013.10.033.
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Lin, T.Y.1
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Daugherty, M.D.1
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Constitutively expressed IFITM3 protein in human endothelial cells poses an early infection block to human influenza viruses
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Sun X, Zeng H, Kumar A, Belser JA, Maines TR, Tumpey TM. Constitutively expressed IFITM3 protein in human endothelial cells poses an early infection block to human influenza viruses. J Virol. 2016;90(24):11157–67. 10.1128/JVI.01254-16.
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72
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85019236301
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pH optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs
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Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, et al. pH optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs. J Virol. 2017;91(11) 10.1128/JVI.00246-17.
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J Virol
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HIV-1 mutates to evade IFITM1 restriction
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Ding S, Pan Q, Liu SL, Liang C. HIV-1 mutates to evade IFITM1 restriction. Virology. 2014;454–455:11–24. 10.1016/j.virol.2014.01.020.
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74
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Resistance of transmitted founder HIV-1 to IFITM-mediated restriction
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This study suggests that HIV-1 evolves to evade restriction by IFITMs humans. They provide evidence that transmitted founder viruses are resistant to IFITMs and that susceptibility to IFITMs increases as the virus mutates to evade adaptive immune mechanisms, such as antibodies
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•• Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, et al. Resistance of transmitted founder HIV-1 to IFITM-mediated restriction. Cell Host Microbe. 2016;20(4):429–42. 10.1016/j.chom.2016.08.006. This study suggests that HIV-1 evolves to evade restriction by IFITMs in humans. They provide evidence that transmitted founder viruses are resistant to IFITMs and that susceptibility to IFITMs increases as the virus mutates to evade adaptive immune mechanisms, such as antibodies.
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(2016)
Cell Host Microbe
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75
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The V3 Loop of HIV-1 Env Determines Viral Susceptibility to IFITM3 Impairment of Viral Infectivity
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Wang Y, Pan Q, Ding S, Wang Z, Yu J, Finzi A, et al. The V3 Loop of HIV-1 Env Determines Viral Susceptibility to IFITM3 Impairment of Viral Infectivity. J Virol. 2017;91(7) 10.1128/JVI.02441-16.
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J Virol
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Wang, Y.1
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