pH optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs

Journal of Virology

Volumn 91, Issue 11, 2017, Pages

  Gerlach, Thomas ^a   Hensen, Luca ^a   Matrosovich, Tatyana ^a   Bergmann, Janina ^a   Winkler, Michael ^b   Peteranderl, Christin ^c   Klenk, Hans Dieter ^a   Weber, Friedemann ^d   Herold, Susanne ^c   Pöhlmann, Stefan ^b   Matrosovich, Mikhail ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b GERMAN PRIMATE CENTER   (Germany)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Fusion; H5N1; H7N9; Hemagglutinin; IFITM; Influenza; Interferon; Restriction

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; IFITM2 PROTEIN; IFITM3 PROTEIN; INTERFERON; INTERFERON BETA SERINE; INTERLEUKIN 29; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ; VIRUS SIALIDASE; DIFFERENTIATION ANTIGEN; IFITM2 PROTEIN, HUMAN; IFITM3 PROTEIN, HUMAN; INFLUENZA VIRUS HEMAGGLUTININ; LEU-13 ANTIGEN; RNA BINDING PROTEIN;

A-549 CELL LINE; ANIMAL CELL; ARTICLE; AVIAN INFLUENZA VIRUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)); INFLUENZA A VIRUS (H5N1); INFLUENZA A VIRUS (H7N9); LUNG ALVEOLUS EPITHELIUM CELL; MDCK CELL LINE; MEMBRANE FUSION; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS GENE; VIRUS MUTANT; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; CELL LINE; CHEMISTRY; DOG; DRUG EFFECTS; DUCK; EPITHELIUM CELL; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; VIRUS ENTRY;

A549 CELLS; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL LINE; DOGS; DUCKS; EPITHELIAL CELLS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA A VIRUS, H7N9 SUBTYPE; INTERFERON-BETA; INTERFERONS; MADIN DARBY CANINE KIDNEY CELLS; MEMBRANE FUSION; MEMBRANE PROTEINS; RNA-BINDING PROTEINS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 85019236301     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00246-17     Document Type: Article

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