Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line

Journal of Viral Hepatitis

Volumn 18, Issue 10, 2011, Pages

  Yao, L ^a   Dong, H ^a   Zhu, H ^b   Nelson, D ^a   Liu, C ^a   Lambiase, L ^c   Li, X ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b HUNAN UNIVERSITY   (China)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

HCV IRES; hepatitis C virus; IFITM3 (1 8U); mouse oestrogen receptor; STAT1 dimerization

Indexed keywords

AFIMOXIFENE; COMPLEMENTARY DNA; ESTROGEN RECEPTOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; INTERFERON INDUCED TRANSMEMBRANE PROTEIN 3; MEMBRANE PROTEIN; MESSENGER RNA; STAT1 PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HELA CELL; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSLATION; VIRUS HEPATITIS; VIRUS REPLICATION; WESTERN BLOTTING;

ANIMALS; CARRIER PROTEINS; CELL LINE; GENE EXPRESSION; HEPACIVIRUS; HUMANS; MEMBRANE PROTEINS; MICE; PROTEIN BIOSYNTHESIS; PROTEIN MULTIMERIZATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; RNA, VIRAL; RNA-BINDING PROTEINS; STAT1 TRANSCRIPTION FACTOR; TAMOXIFEN; TRANSCRIPTIONAL ACTIVATION; VIRAL PROTEINS;

EID: 80052864616     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2011.01452.x     Document Type: Article

References (40)

1. Centers for Disease Control and Prevention. Recommendation for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. MMWR Recomm Rep 1998; 47: 1-39.
2. El-Serag HB,. Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 2002; 35: S72-S78. (Pubitemid 35278644)
3. Di Bisceglie AM, Hoofnagle JH,. Optimal therapy of hepatitis C. Hepatology 2002; 36: S121-S127. (Pubitemid 35253472)
4. Asselah T, Bieche I, Sabbagh A, et al. Gene expression and hepatitis C virus infection. Gut 2009; 58: 846-858.
5. Jiang D, Guo H, Xu C, et al. Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol 2008; 82: 1665-1678. (Pubitemid 351206918)
6. Kato J, Kato N, Moriyama M, et al. Interferons specifically suppress the translation from the internal ribosome entry site of hepatitis C virus through a double-stranded RNA-activated protein kinase-independent pathway. J Infect Dis 2002; 186: 155-163. (Pubitemid 34765502)
7. Honda M, Ping LH, Rijnbrand RC, et al. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 1996; 222: 31-42. (Pubitemid 26281356)
8. Lu HH, Wimmer E,. Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus. Proc Natl Acad Sci U S A 1996; 93: 1412-1417. (Pubitemid 26075136)
9. Zhao WD, Wimmer E, Lahser FC,. Poliovirus/Hepatitis C virus (internal ribosomal entry site-core) chimeric viruses: improved growth properties through modification of a proteolytic cleavage site and requirement for core RNA sequences but not for core-related polypeptides. J Virol 1999; 73: 1546-1554. (Pubitemid 29036810)
10. Dash S, Prabhu R, Hazari S, et al. Interferons alpha, beta, gamma each inhibit hepatitis C virus replication at the level of internal ribosome entry site-mediated translation. Liver Int 2005; 25: 580-594. (Pubitemid 40861908)
11. Hazari S, Patil A, Joshi V, et al. Alpha interferon inhibits translation mediated by the internal ribosome entry site of six different hepatitis C virus genotypes. J Gen Virol 2005; 86: 3047-3053. (Pubitemid 41555570)
12. Parsons J, Castaldi MP, Dutta S, Dibrov SM, Wyles DL, Hermann T,. Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA. Nat Chem Biol 2009; 5: 823-825.
13. Zhu H., Liu C,. Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway. J Virol 2003; 77: 5493-8. (Pubitemid 36460962)
14. Zhu H, Shang X, Terada N, Liu C,. STAT3 induces anti-hepatitis C viral activity in liver cells. Biochem Biophys Res Commun 2004; 324: 518-528. (Pubitemid 39345548)
15. Uddin S, Lekmine F, Sharma N, et al. The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J Biol Chem 2000; 275: 27634-27640.
16. Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005; 11: 791-796. (Pubitemid 41021213)
17. Honda M, Kaneko S, Matsushita E, Kobayashi K, Abell GA, Lemon SM,. Cell cycle regulation of hepatitis C virus internal ribosomal entry site-directed translation. Gastroenterology 2000; 118: 152-162. (Pubitemid 30020383)
18. Blight KJ, McKeating JA, Rice CM,. Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol 2002; 76: 13001-13014. (Pubitemid 35386984)
19. Zhu H, Dong H, Eksioglu E, et al. Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system. Gastroenterology 2007; 133: 1649-1659. (Pubitemid 350029762)
20. Li X, Mueller S, Wimmer E,. Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides. Virus Res 2009; 146: 29-35.
21. Matsuda T, Nakamura T, Nakao K, et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO 1999; 18: 4261-4269. (Pubitemid 29364128)
22. Brem R, Oraszlan-Szovik K, Foser S, Bohrmann B, Certa U,. Inhibition of proliferation by 1-8U in interferon-alpha-responsive and non-responsive cell lines. Cell Mol Life Sci 2003; 60: 1235-1248. (Pubitemid 36791925)
23. Zhu H, Butera M, Nelson DR, Liu C,. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virol J 2005; 2: 80.
24. Zhu H, Zhao H, Collins CD, et al. Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line. Hepatology 2003; 37: 1180-1188. (Pubitemid 36538696)
25. Kikuchi K, Umehara T, Nishikawa F, Fukuda K, Hasegawa T, Nishikawa S,. Increased inhibitory ability of conjugated RNA aptamers against the HCV IRES. Biochem Biophys Res Commun 2009; 386: 118-123.
26. Guo JT, Sohn JA, Zhu Q, Seeger C,. Mechanism of the interferon alpha response against hepatitis C virus replicons. Virology 2004; 325: 71-81. (Pubitemid 38844771)
27. Shimazaki T, Honda M, Kaneko S, Kobayashi K,. Inhibition of internal ribosomal entry site-directed translation of HCV by recombinant IFN-alpha correlates with a reduced La protein. Hepatology 2002; 35: 199-208. (Pubitemid 34032561)
28. Wang C, Pflugheber J, Sumpter R Jr, et al. Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication. J Virol 2003; 77: 3898-3912. (Pubitemid 36350931)
29. Martensen PM, Justesen J,. Small ISGs coming forward. J Interferon Cytokine Res 2004; 24: 1-19. (Pubitemid 38152967)
30. Yamashita T, Hashimoto S, Kaneko S, et al. Comprehensive gene expression profile of a normal human liver. Biochem Biophys Res Commun 2000; 269: 110-116.
31. Sizova DV, Kolupaeva VG, Pestova TV, Shatsky IN, Hellen CU,. Specific interaction of eukaryotic translation initiation factor 3 with the 5′ nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. J Virol 1998; 72: 4775-4782. (Pubitemid 28215653)
32. Ali N, Siddiqui A,. Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J Virol 1995; 69: 6367-6375.
33. Ali N, Siddiqui A,. The La antigen binds 5′ noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation. Proc Natl Acad Sci U S A 1997; 94: 2249-2254.
34. Gonzalez O, Fontanes V, Raychaudhuri S, et al. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology 2009; 50: 1756-1764.
35. Kim JH, Paek KY, Ha SH, et al. A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon. Mol Cell Biol 2004; 24: 7878-7890. (Pubitemid 39167439)
36. Weinlich S, Huttelmaier S, Schierhorn A, Behrens SE, Ostareck-Lederer A, Ostareck DH,. IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3′UTR. RNA 2009; 15: 1528-1542.
37. Domitrovich AM, Diebel KW, Ali N, Sarker S, Siddiqui A,. Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication. Virology 2005; 335: 72-86. (Pubitemid 40489053)
38. Hahm B, Kim YK, Kim JH, Kim TY, Jang SK,. Heterogeneous nuclear ribonucleoprotein L interacts with the 3′ border of the internal ribosomal entry site of hepatitis C virus. J Virol 1998; 72: 8782-8788. (Pubitemid 28471821)
39. Hwang B, Lim JH, Hahm B, Jang SK, Lee SW,. hnRNP L is required for the translation mediated by HCV IRES. Biochem Biophys Res Commun 2009; 378: 584-588.
40. Paek KY, Kim CS, Park SM, Kim JH, Jang SK,. RNA-binding protein hnRNP D modulates internal ribosome entry site-dependent translation of hepatitis C virus RNA. J Virol 2008; 82: 12082-12093.