메뉴 건너뛰기




Volumn 25, Issue 3, 2018, Pages 677-689.e4

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

Author keywords

blood pressure; hypertension; inflammasome; inflammation; ketone body; kidney; metabolomics; Nlrp3; salt; hydroxybutyrate

Indexed keywords

3 HYDROXYBUTYRIC ACID; CRYOPYRIN; INFLAMMASOME; KETONE BODY; FLAVORING AGENT; NLRP3 PROTEIN, RAT;

EID: 85054711695     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2018.09.058     Document Type: Article
Times cited : (128)

References (86)
  • 2
    • 85037728814 scopus 로고    scopus 로고
    • The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury
    • Anders, H.J., Suarez-Alvarez, B., Grigorescu, M., Foresto-Neto, O., Steiger, S., Desai, J., Marschner, J.A., Honarpisheh, M., Shi, C., Jordan, J., et al. The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury. Kidney Int. 93 (2018), 656–669.
    • (2018) Kidney Int. , vol.93 , pp. 656-669
    • Anders, H.J.1    Suarez-Alvarez, B.2    Grigorescu, M.3    Foresto-Neto, O.4    Steiger, S.5    Desai, J.6    Marschner, J.A.7    Honarpisheh, M.8    Shi, C.9    Jordan, J.10
  • 3
  • 6
    • 85009876198 scopus 로고    scopus 로고
    • Are the innate and adaptive immune systems setting hypertension on fire?
    • Bomfim, G.F., Rodrigues, F.L., Carneiro, F.S., Are the innate and adaptive immune systems setting hypertension on fire?. Pharmacol. Res. 117 (2017), 377–393.
    • (2017) Pharmacol. Res. , vol.117 , pp. 377-393
    • Bomfim, G.F.1    Rodrigues, F.L.2    Carneiro, F.S.3
  • 7
    • 66849093848 scopus 로고    scopus 로고
    • Salt intakes around the world: implications for public health
    • Brown, I.J., Tzoulaki, I., Candeias, V., Elliott, P., Salt intakes around the world: implications for public health. Int. J. Epidemiol. 38 (2009), 791–813.
    • (2009) Int. J. Epidemiol. , vol.38 , pp. 791-813
    • Brown, I.J.1    Tzoulaki, I.2    Candeias, V.3    Elliott, P.4
  • 8
    • 85007021133 scopus 로고    scopus 로고
    • Suppression of NLRP3 inflammasome activation ameliorates chronic kidney disease-induced cardiac fibrosis and diastolic dysfunction
    • Bugyei-Twum, A., Abadeh, A., Thai, K., Zhang, Y., Mitchell, M., Kabir, G., Connelly, K.A., Suppression of NLRP3 inflammasome activation ameliorates chronic kidney disease-induced cardiac fibrosis and diastolic dysfunction. Sci. Rep., 6, 2016, 39551.
    • (2016) Sci. Rep. , vol.6 , pp. 39551
    • Bugyei-Twum, A.1    Abadeh, A.2    Thai, K.3    Zhang, Y.4    Mitchell, M.5    Kabir, G.6    Connelly, K.A.7
  • 10
  • 11
    • 53849104768 scopus 로고    scopus 로고
    • Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
    • Collado, M.C., Isolauri, E., Laitinen, K., Salminen, S., Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am. J. Clin. Nutr. 88 (2008), 894–899.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 894-899
    • Collado, M.C.1    Isolauri, E.2    Laitinen, K.3    Salminen, S.4
  • 13
    • 0000026540 scopus 로고
    • Effects of chronic excess salt feeding. Induction of self-sustaining hypertension in rats
    • Dahl, L.K., Effects of chronic excess salt feeding. Induction of self-sustaining hypertension in rats. J. Exp. Med. 114 (1961), 231–236.
    • (1961) J. Exp. Med. , vol.114 , pp. 231-236
    • Dahl, L.K.1
  • 14
    • 0007625529 scopus 로고
    • Effects of chronic excess salt ingestion. vascular reactivity in two strains of rats with opposite genetic susceptibility to experimental hypertension
    • Dahl, L.K., Heine, M., Tassinari, L., Effects of chronic excess salt ingestion. vascular reactivity in two strains of rats with opposite genetic susceptibility to experimental hypertension. Circulation 30:Suppl 2 (1964), 11–22.
    • (1964) Circulation , vol.30 , pp. 11-22
    • Dahl, L.K.1    Heine, M.2    Tassinari, L.3
  • 15
    • 19244370722 scopus 로고
    • Genetic influence of the kidney in hypertension-prone rats
    • Dahl, L.K., Knudsen, K.D., Iwai, J., Genetic influence of the kidney in hypertension-prone rats. Circ. Res., 27(Suppl 2), 1970, 277.
    • (1970) Circ. Res. , vol.27 , pp. 277
    • Dahl, L.K.1    Knudsen, K.D.2    Iwai, J.3
  • 17
    • 84935913919 scopus 로고    scopus 로고
    • Inflammation and hypertension: new understandings and potential therapeutic targets
    • De Miguel, C., Rudemiller, N.P., Abais, J.M., Mattson, D.L., Inflammation and hypertension: new understandings and potential therapeutic targets. Curr. Hypertens. Rep., 17, 2015, 507.
    • (2015) Curr. Hypertens. Rep. , vol.17 , pp. 507
    • De Miguel, C.1    Rudemiller, N.P.2    Abais, J.M.3    Mattson, D.L.4
  • 20
    • 77957244650 scopus 로고    scopus 로고
    • Search and clustering orders of magnitude faster than BLAST
    • Edgar, R.C., Search and clustering orders of magnitude faster than BLAST. Bioinformatics 26 (2010), 2460–2461.
    • (2010) Bioinformatics , vol.26 , pp. 2460-2461
    • Edgar, R.C.1
  • 21
    • 85008264730 scopus 로고    scopus 로고
    • Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation
    • Evans, M., Cogan, K.E., Egan, B., Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation. J. Physiol. 595 (2017), 2857–2871.
    • (2017) J. Physiol. , vol.595 , pp. 2857-2871
    • Evans, M.1    Cogan, K.E.2    Egan, B.3
  • 23
    • 84930836001 scopus 로고    scopus 로고
    • DAMPs as mediators of sterile inflammation in aging-related pathologies
    • Feldman, N., Rotter-Maskowitz, A., Okun, E., DAMPs as mediators of sterile inflammation in aging-related pathologies. Ageing Res. Rev. 24:Pt A (2015), 29–39.
    • (2015) Ageing Res. Rev. , vol.24 , pp. 29-39
    • Feldman, N.1    Rotter-Maskowitz, A.2    Okun, E.3
  • 25
    • 0037408417 scopus 로고    scopus 로고
    • Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet
    • Garrett, M.R., Dene, H., Rapp, J.P., Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J. Am. Soc. Nephrol. 14 (2003), 1175–1187.
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 1175-1187
    • Garrett, M.R.1    Dene, H.2    Rapp, J.P.3
  • 26
    • 33645767223 scopus 로고    scopus 로고
    • Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains
    • Garrett, M.R., Joe, B., Yerga-Woolwine, S., Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains. Physiol. Genomics 25 (2006), 39–49.
    • (2006) Physiol. Genomics , vol.25 , pp. 39-49
    • Garrett, M.R.1    Joe, B.2    Yerga-Woolwine, S.3
  • 27
    • 0025329671 scopus 로고
    • Role of blood volume expansion in Dahl rat model of hypertension
    • Greene, A.S., Yu, Z.Y., Roman, R.J., Cowley, A.W. Jr., Role of blood volume expansion in Dahl rat model of hypertension. Am. J. Physiol. 258 (1990), H508–H514.
    • (1990) Am. J. Physiol. , vol.258 , pp. H508-H514
    • Greene, A.S.1    Yu, Z.Y.2    Roman, R.J.3    Cowley, A.W.4
  • 29
    • 0021686934 scopus 로고
    • Ketone body kinetics in humans: the effects of insulin-dependent diabetes, obesity, and starvation
    • Hall, S.E., Wastney, M.E., Bolton, T.M., Braaten, J.T., Berman, M., Ketone body kinetics in humans: the effects of insulin-dependent diabetes, obesity, and starvation. J. Lipid Res. 25 (1984), 1184–1194.
    • (1984) J. Lipid Res. , vol.25 , pp. 1184-1194
    • Hall, S.E.1    Wastney, M.E.2    Bolton, T.M.3    Braaten, J.T.4    Berman, M.5
  • 30
    • 84919337329 scopus 로고    scopus 로고
    • An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography-tandem mass spectrometry
    • Han, J., Lin, K., Sequeira, C., Borchers, C.H., An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 854 (2015), 86–94.
    • (2015) Anal. Chim. Acta , vol.854 , pp. 86-94
    • Han, J.1    Lin, K.2    Sequeira, C.3    Borchers, C.H.4
  • 31
    • 84924786246 scopus 로고    scopus 로고
    • Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome
    • Hattori, T., Murase, T., Takatsu, M., Nagasawa, K., Matsuura, N., Watanabe, S., Murohara, T., Nagata, K., Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome. J. Am. Heart Assoc., 3, 2014, e001312.
    • (2014) J. Am. Heart Assoc. , vol.3 , pp. e001312
    • Hattori, T.1    Murase, T.2    Takatsu, M.3    Nagasawa, K.4    Matsuura, N.5    Watanabe, S.6    Murohara, T.7    Nagata, K.8
  • 32
  • 35
    • 82955249021 scopus 로고    scopus 로고
    • NOD-like receptors and the innate immune system: coping with danger, damage and death
    • Kersse, K., Bertrand, M.J., Lamkanfi, M., Vandenabeele, P., NOD-like receptors and the innate immune system: coping with danger, damage and death. Cytokine Growth Factor Rev. 22 (2011), 257–276.
    • (2011) Cytokine Growth Factor Rev. , vol.22 , pp. 257-276
    • Kersse, K.1    Bertrand, M.J.2    Lamkanfi, M.3    Vandenabeele, P.4
  • 42
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001), 402–408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 43
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf, M., Rho, J.M., Mattson, M.P., The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res. Brain Res. Rev. 59 (2009), 293–315.
    • (2009) Brain Res. Brain Res. Rev. , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 44
    • 33746336247 scopus 로고    scopus 로고
    • Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans
    • Mahoney, L.B., Denny, C.A., Seyfried, T.N., Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans. Lipids Health Dis., 5, 2006, 13.
    • (2006) Lipids Health Dis. , vol.5 , pp. 13
    • Mahoney, L.B.1    Denny, C.A.2    Seyfried, T.N.3
  • 45
    • 84906896831 scopus 로고    scopus 로고
    • Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury
    • Mattson, D.L., Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury. Am. J. Physiol. Renal Physiol. 307 (2014), F499–F508.
    • (2014) Am. J. Physiol. Renal Physiol. , vol.307 , pp. F499-F508
    • Mattson, D.L.1
  • 46
    • 33746016265 scopus 로고    scopus 로고
    • Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat
    • Mattson, D.L., James, L., Berdan, E.A., Meister, C.J., Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 48 (2006), 149–156.
    • (2006) Hypertension , vol.48 , pp. 149-156
    • Mattson, D.L.1    James, L.2    Berdan, E.A.3    Meister, C.J.4
  • 49
  • 50
    • 84920587151 scopus 로고    scopus 로고
    • β-hydroxybutyrate: much more than a metabolite
    • Newman, J.C., Verdin, E., β-hydroxybutyrate: much more than a metabolite. Diabetes Res. Clin. Pract. 106 (2014), 173–181.
    • (2014) Diabetes Res. Clin. Pract. , vol.106 , pp. 173-181
    • Newman, J.C.1    Verdin, E.2
  • 51
    • 85028000671 scopus 로고    scopus 로고
    • β-hydroxybutyrate: a signaling metabolite
    • Newman, J.C., Verdin, E., β-hydroxybutyrate: a signaling metabolite. Annu. Rev. Nutr. 37 (2017), 51–76.
    • (2017) Annu. Rev. Nutr. , vol.37 , pp. 51-76
    • Newman, J.C.1    Verdin, E.2
  • 52
    • 85029869872 scopus 로고    scopus 로고
    • Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans
    • Padmanabhan, S., Joe, B., Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans. Physiol. Rev. 97 (2017), 1469–1528.
    • (2017) Physiol. Rev. , vol.97 , pp. 1469-1528
    • Padmanabhan, S.1    Joe, B.2
  • 54
    • 85013177882 scopus 로고    scopus 로고
    • Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics
    • Puchalska, P., Crawford, P.A., Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metab. 25 (2017), 262–284.
    • (2017) Cell Metab. , vol.25 , pp. 262-284
    • Puchalska, P.1    Crawford, P.A.2
  • 55
    • 0021858418 scopus 로고
    • Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats
    • Rapp, J.P., Dene, H., Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 7 (1985), 340–349.
    • (1985) Hypertension , vol.7 , pp. 340-349
    • Rapp, J.P.1    Dene, H.2
  • 56
    • 17144445419 scopus 로고
    • Genetic control of blood pressure and corticosteroid production in rats
    • Rapp, J.P., Knudsen, K.D., Iwai, J., Dahl, L.K., Genetic control of blood pressure and corticosteroid production in rats. Circ. Res. 32:Suppl 1 (1973), 139–149.
    • (1973) Circ. Res. , vol.32 , pp. 139-149
    • Rapp, J.P.1    Knudsen, K.D.2    Iwai, J.3    Dahl, L.K.4
  • 57
    • 84928704733 scopus 로고    scopus 로고
    • Metabolic signals and innate immune activation in obesity and exercise
    • Ringseis, R., Eder, K., Mooren, F.C., Krüger, K., Metabolic signals and innate immune activation in obesity and exercise. Exerc. Immunol. Rev. 21 (2015), 58–68.
    • (2015) Exerc. Immunol. Rev. , vol.21 , pp. 58-68
    • Ringseis, R.1    Eder, K.2    Mooren, F.C.3    Krüger, K.4
  • 59
    • 0034137696 scopus 로고    scopus 로고
    • Suppression of feed intake after parenteral administration of D-beta-hydroxybutyrate in pygmy goats
    • Rossi, R., Dörig, S., Del Prete, E., Scharrer, E., Suppression of feed intake after parenteral administration of D-beta-hydroxybutyrate in pygmy goats. J. Vet. Med. A Physiol. Pathol. Clin. Med. 47 (2000), 9–16.
    • (2000) J. Vet. Med. A Physiol. Pathol. Clin. Med. , vol.47 , pp. 9-16
    • Rossi, R.1    Dörig, S.2    Del Prete, E.3    Scharrer, E.4
  • 60
    • 84894492650 scopus 로고    scopus 로고
    • CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney
    • Rudemiller, N., Lund, H., Jacob, H.J., Geurts, A.M., Mattson, D.L., PhysGen Knockout Program. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension 63 (2014), 559–564.
    • (2014) Hypertension , vol.63 , pp. 559-564
    • Rudemiller, N.1    Lund, H.2    Jacob, H.J.3    Geurts, A.M.4    Mattson, D.L.5
  • 62
    • 84874280618 scopus 로고    scopus 로고
    • NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury
    • Savage, C.D., Lopez-Castejon, G., Denes, A., Brough, D., NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury. Front. Immunol., 3, 2012, 288.
    • (2012) Front. Immunol. , vol.3 , pp. 288
    • Savage, C.D.1    Lopez-Castejon, G.2    Denes, A.3    Brough, D.4
  • 63
    • 84947460237 scopus 로고    scopus 로고
    • Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
    • Schneeberger, M., Everard, A., Gómez-Valadés, A.G., Matamoros, S., Ramírez, S., Delzenne, N.M., Gomis, R., Claret, M., Cani, P.D., Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Sci. Rep., 5, 2015, 16643.
    • (2015) Sci. Rep. , vol.5 , pp. 16643
    • Schneeberger, M.1    Everard, A.2    Gómez-Valadés, A.G.3    Matamoros, S.4    Ramírez, S.5    Delzenne, N.M.6    Gomis, R.7    Claret, M.8    Cani, P.D.9
  • 67
    • 85046744429 scopus 로고    scopus 로고
    • Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes
    • Sutton, E.F., Beyl, R., Early, K.S., Cefalu, W.T., Ravussin, E., Peterson, C.M., Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. 27 (2018), 1212–1221.
    • (2018) Cell Metab. , vol.27 , pp. 1212-1221
    • Sutton, E.F.1    Beyl, R.2    Early, K.S.3    Cefalu, W.T.4    Ravussin, E.5    Peterson, C.M.6
  • 70
    • 84928663953 scopus 로고    scopus 로고
    • High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice
    • Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., et al. High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice. Lipids Health Dis., 14, 2015, 6.
    • (2015) Lipids Health Dis. , vol.14 , pp. 6
    • Uetake, Y.1    Ikeda, H.2    Irie, R.3    Tejima, K.4    Matsui, H.5    Ogura, S.6    Wang, H.7    Mu, S.8    Hirohama, D.9    Ando, K.10
  • 72
    • 85017123688 scopus 로고    scopus 로고
    • Ketone bodies mimic the life span extending properties of caloric restriction
    • Veech, R.L., Bradshaw, P.C., Clarke, K., Curtis, W., Pawlosky, R., King, M.T., Ketone bodies mimic the life span extending properties of caloric restriction. IUBMB Life 69 (2017), 305–314.
    • (2017) IUBMB Life , vol.69 , pp. 305-314
    • Veech, R.L.1    Bradshaw, P.C.2    Clarke, K.3    Curtis, W.4    Pawlosky, R.5    King, M.T.6
  • 74
    • 85054076360 scopus 로고    scopus 로고
    • Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians
    • Wan, Z., Wen, W., Ren, K., Zhou, D., Liu, J., Wu, Y., Zhou, J., Mu, J., Yuan, Z., Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians. Br. J. Nutr. 119 (2018), 228–237.
    • (2018) Br. J. Nutr. , vol.119 , pp. 228-237
    • Wan, Z.1    Wen, W.2    Ren, K.3    Zhou, D.4    Liu, J.5    Wu, Y.6    Zhou, J.7    Mu, J.8    Yuan, Z.9
  • 76
    • 84962032972 scopus 로고    scopus 로고
    • Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus
    • Wang, Y., Xu, Y., Sheng, H., Ni, X., Lu, J., Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus. Behav. Brain Res. 307 (2016), 18–24.
    • (2016) Behav. Brain Res. , vol.307 , pp. 18-24
    • Wang, Y.1    Xu, Y.2    Sheng, H.3    Ni, X.4    Lu, J.5
  • 77
    • 85018743856 scopus 로고    scopus 로고
    • β hydroxybutyrate levels in serum and cerebrospinal fluid under ketone body metabolism in rats
    • Wang, X., Liu, Q., Zhou, J., Wu, X., Zhu, Q., β hydroxybutyrate levels in serum and cerebrospinal fluid under ketone body metabolism in rats. Exp. Anim. 66 (2017), 177–182.
    • (2017) Exp. Anim. , vol.66 , pp. 177-182
    • Wang, X.1    Liu, Q.2    Zhou, J.3    Wu, X.4    Zhu, Q.5
  • 79
    • 0034799113 scopus 로고    scopus 로고
    • Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease
    • Willner, I.R., Waters, B., Patil, S.R., Reuben, A., Morelli, J., Riely, C.A., Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. Am. J. Gastroenterol. 96 (2001), 2957–2961.
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 2957-2961
    • Willner, I.R.1    Waters, B.2    Patil, S.R.3    Reuben, A.4    Morelli, J.5    Riely, C.A.6
  • 80
    • 0038507595 scopus 로고    scopus 로고
    • Diet, nutrition and the prevention of chronic diseases
    • World Health Organization. Diet, nutrition and the prevention of chronic diseases. WHO Tech. Rep. Ser. 916 (2003), 1–149.
    • (2003) WHO Tech. Rep. Ser. , vol.916 , pp. 1-149
  • 81
  • 82
    • 67849106535 scopus 로고    scopus 로고
    • MetaboAnalyst: a web server for metabolomic data analysis and interpretation
    • W652-60
    • Xia, J., Psychogios, N., Young, N., Wishart, D.S., MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res., 37, 2009 W652-60.
    • (2009) Nucleic Acids Res. , vol.37
    • Xia, J.1    Psychogios, N.2    Young, N.3    Wishart, D.S.4
  • 84
  • 85
    • 84984600068 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats
    • Zhu, Q., Li, X.X., Wang, W., Hu, J., Li, P.L., Conley, S., Li, N., Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats. Am. J. Physiol. Renal Physiol. 310 (2016), F621–F627.
    • (2016) Am. J. Physiol. Renal Physiol. , vol.310 , pp. F621-F627
    • Zhu, Q.1    Li, X.X.2    Wang, W.3    Hu, J.4    Li, P.L.5    Conley, S.6    Li, N.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.