Renal Tumor Necrosis Factor α Contributes to Hypertension in Dahl Salt-Sensitive Rats

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Huang, Baorui ^a,b,d   Cheng, Yuan ^c,d,e   Usa, Kristie ^c,d   Liu, Yong ^c,d   Baker, Maria Angeles ^c,d   Mattson, David L ^d   He, Yongcheng ^e   Wang, Niansong ^a   Liang, Mingyu ^c,d  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c Center of Systems Molecular Medicine   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

SALT INTAKE; TUMOR NECROSIS FACTOR;

ADVERSE EFFECTS; ANIMAL; ANIMAL MODEL; DAHL RAT; GENE EXPRESSION; GENETICS; HYPERTENSION; KIDNEY; KIDNEY DISEASE; MALE; METABOLISM; PATHOLOGY; RAT; SALT INTAKE;

ANIMALS; GENE EXPRESSION; HYPERTENSION; KIDNEY; KIDNEY DISEASES; MALE; MODELS, ANIMAL; RATS; RATS, INBRED DAHL; SODIUM CHLORIDE, DIETARY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84959422737     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21960     Document Type: Article

References (43)

1. Egan, B. M., Zhao, Y. & Axon, R. N. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 303, 2043-2050 (2010).
2. Pimenta, E. et al. Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: results from A randomized trial. Hypertension 54, 475-481 (2009).
3. Rapp, J. P. Dahl salt-susceptible and salt-resistant rats. A review. Hypertension 4, 753-763 (1982).
4. Shen, K., DeLano, F. A., Zweifach, B. W. & Schmid-Schonbein, G. W. Circulating leukocyte counts, activation, and degranulation in Dahl hypertensive rats. Circ Res 76, 276-283 (1995).
5. Siegel, A. K. et al. Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on A high-salt diet: comparison with spontaneously hypertensive rats. Physiol Genomics 18, 218-225 (2004).
6. Mattson, D. L. Infiltrating Immune Cells in the Kidney in Salt-Sensitive Hypertension and Renal Injury. Am J Physiol Renal Physiol 307, 499-508 (2014).
7. Rodriguez-Iturbe, B. et al. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure. Kidney Int 59, 2222-2232 (2001).
8. Rudemiller, N. et al. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension 63, 559-564 (2014).
9. Mattson, D. L. et al. Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. Am J Physiol Regul Integr Comp Physiol. 304, 407-414 (2013).
10. Mattson, D. L., James, L., Berdan, E. A. & Meister, C. J. Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 48, 149-156 (2006).
11. Bautista, L. E., Vera, L. M., Arenas, I. A. & Gamarra, G. Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension. J Hum Hypertens 19, 149-154, (2005).
12. Cottone, S. et al. Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients. J Hum Hypertens 12, 351-354 (1998).
13. Elmarakby, A. A., Quigley, J. E., Pollock, D. M. & Imig, J. D. Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. Hypertension 47, 557-562 (2006).
14. Guzik, T. J. et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 204 (2007).
15. Tran, L. T., MacLeod, K. M. & McNeill, J. H. Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats. Mol Cell Biochem 330, 219-228 (2009).
16. Gross, J. M., Berndt, T. J. & Knox, F. G. Effect of serotonin receptor antagonist on phosphate excretion. J Am Soc Nephrol: JASN 11, 1002-1007 (2000).
17. Li, N., Chen, L., Yi, F., Xia, M. & Li, P. L. Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla. Circ Res 102, 1101-1108 (2008).
18. Kemp, B. A. et al. AT(2) receptor activation induces natriuresis and lowers blood pressure. Circ Res 115, 388-399 (2014).
19. Kassab, S., Novak, J., Miller, T., Kirchner, K. & Granger, J. Role of endothelin in mediating the attenuated renal hemodynamics in Dahl salt-sensitive hypertension. Hypertension 30, 682-686 (1997).
20. He, X. et al. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol 306, 1190-1197 (2014).
21. Cowley, A. W., Jr. et al. Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension 37, 456-461 (2001).
22. Liang, M. et al. Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression. Physiol Genomics 12, 229-237 (2003).
23. Liu, Y., Liu, P., Yang, C., Cowley, A. W., Jr. & Liang, M. Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence. Hypertension 63, 827-838 (2014).
24. Liu, Y., Singh, R. J., Usa, K., Netzel, B. C. & Liang, M. Renal medullary 11 beta-hydroxysteroid dehydrogenase type 1 in Dahl saltsensitive hypertension. Physiol Genomics 36, 52-58 (2008).
25. Lu, L. et al. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics 41, 63-70 (2010).
26. Liang, M. & Pietrusz, J. L. Thiol-related genes in diabetic complications: A novel protective role for endogenous thioredoxin 2. Arterioscler Thromb Vasc Biol. 27, 77-83 (2007).
27. Liu, Y. et al. Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis. Physiol Genomics 32, 343-351 (2008).
28. Liu, Y. et al. Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes. Hypertension 55, 974-982 (2010).
29. Mattson, D. L., Lu, S., Nakanishi, K., Papanek, P. E. & Cowley, A. W., Jr. Effect of chronic renal medullary nitric oxide inhibition on blood pressure. Am J Physiol 266, 1918-1926 (1994).
30. Usa, K. et al. Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats. Am J Physiol Renal Physiol. 293, 186-192 (2007).
31. Tian, Z. et al. Novel role of fumarate metabolism in dahl-salt sensitive hypertension. Hypertension 54, 255-260 (2009).
32. Raij, L., Azar, S. & Keane, W. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int 26, 137-143 (1984).
33. Kriegel, A. J., Liu, Y., Cohen, B., Usa, K. & Liang, M. MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. Physiol Genomics 44, 259-267 (2012).
34. Mori, T. et al. High perfusion pressure accelerates renal injury in salt-sensitive hypertension. J Am Soc Nephrol: JASN 19, 1472-1482 (2008).
35. Wang F. et al. Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. Kidney Int. 88, 796-803 (2015).
36. Feng, D. et al. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell Metab 15, 201-208 (2012).
37. Lu, S., Roman, R. J., Mattson, D. L. & Cowley, A. W., Jr. Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats. Am J Physiol 263, 1064-1070 (1992).
38. Muller, D. N. et al. Immunosuppressive treatment protects against angiotensin II-induced renal damage. Am J Pathol 161, 1679-1693 (2002).
39. Elmarakby, A. A. et al. TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 294, 76-83 (2008).
40. Venegas-Pont, M. et al. Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in A mouse model of systemic lupus erythematosus. Hypertension 56, 643-649 (2010).
41. Ramseyer, V. D. & Garvin, J. L. Tumor necrosis factor-alpha: regulation of renal function and blood pressure. Am J Physiol Renal Physiol. 304, 1231-1242 (2013).
42. Gu, J. W. et al. Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl saltsensitive rats. Am J Physiol Regul Integr Comp Physiol. 291, 1817-1824 (2006).
43. Battula, S. et al. Tumor necrosis factor-alpha is An endogenous inhibitor of Na+-K+-2Cl-cotransporter (NKCC2) isoform A in the thick ascending limb. Am J Physiol Renal Physiol. 301, 94-100 (2011).