메뉴 건너뛰기




Volumn 30, Issue 5, 2018, Pages 471-481

An update on the role of type I interferons in systemic lupus erythematosus and Sjögren’s syndrome

Author keywords

Genes; Sj gren s syndrome; Systemic lupus erythematosus; Therapy; Type I interferon

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 9; MICRORNA; UNTRANSLATED RNA; MIRN451 MICRORNA, HUMAN;

EID: 85054626112     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000524     Document Type: Review
Times cited : (56)

References (63)
  • 1
    • 84873404949 scopus 로고    scopus 로고
    • The interferon signature in autoimmune diseases
    • Ronnblom L, Eloranta ML. The interferon signature in autoimmune diseases. Curr Opin Rheumatol 2013; 25:248–253.
    • (2013) Curr Opin Rheumatol , vol.25 , pp. 248-253
    • Ronnblom, L1    Eloranta, ML.2
  • 2
    • 84989859132 scopus 로고    scopus 로고
    • Blood-borne Rna correlates with disease activity and Ifn-stimulated gene expression in systemic lupus erythematosus
    • Doedens JR, Jones WD, Hill K, et al. Blood-borne Rna correlates with disease activity and Ifn-stimulated gene expression in systemic lupus erythematosus. J Immunol 2016; 197:2854–2863.
    • (2016) J Immunol , vol.197 , pp. 2854-2863
    • Doedens, JR1    Jones, WD2    Hill, K3
  • 3
    • 84992560627 scopus 로고    scopus 로고
    • Expression of long interspersed nuclear element 1 retroelements and induction of type I interferon in patients with systemic autoimmune disease
    • Mavragani CP, Sagalovskiy I, Guo Q, et al. Expression of long interspersed nuclear element 1 retroelements and induction of type I interferon in patients with systemic autoimmune disease. Arthritis Rheumatol 2016; 68: 2686–2696.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 2686-2696
    • Mavragani, CP1    Sagalovskiy, I2    Guo, Q3
  • 4
    • 84992618510 scopus 로고    scopus 로고
    • Prion-like aggregation of mitochondrial antiviral signaling protein in lupus patients is associated with increased levels of type I interferon
    • Shao WH, Shu DH, Zhen Y, et al. Prion-like aggregation of mitochondrial antiviral signaling protein in lupus patients is associated with increased levels of type I interferon. Arthritis Rheumatol 2016; 68:2697–2707.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 2697-2707
    • Shao, WH1    Shu, DH2    Zhen, Y3
  • 5
    • 84997077008 scopus 로고    scopus 로고
    • Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response
    • Lee JY, Park JK, Lee EY, et al. Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response. Arthritis Res Ther 2016; 18:264.
    • (2016) Arthritis Res Ther , vol.18 , pp. 264
    • Lee, JY1    Park, JK2    Lee, EY3
  • 6
    • 85030425661 scopus 로고    scopus 로고
    • Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study
    • Rose T, Grutzkau A, Klotsche J, et al. Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study. Rheumatology (Oxford) 2017; 56: 1618–1626.
    • (2017) Rheumatology (Oxford) , vol.56 , pp. 1618-1626
    • Rose, T1    Grutzkau, A2    Klotsche, J3
  • 7
    • 85021075354 scopus 로고    scopus 로고
    • Detection of interferon alpha protein & reveals differential levels and cellular sources in disease
    • Using a single-molecule array (Simoa) digital ELISA technology with mAbs from two patients with APS1/APECED mutations, the authors were able to record attomolar concentrations of IFNa. An ultrasensitive and reliable IFNa protein assay for clinical use is much needed and this is a step towards that goal
    • Rodero MP, Decalf J, Bondet V, et al. Detection of interferon alpha protein & reveals differential levels and cellular sources in disease. J Exp Med 2017; 214:1547–1555. Using a single-molecule array (Simoa) digital ELISA technology with mAbs from two patients with APS1/APECED mutations, the authors were able to record attomolar concentrations of IFNa. An ultrasensitive and reliable IFNa protein assay for clinical use is much needed and this is a step towards that goal.
    • (2017) J Exp Med , vol.214 , pp. 1547-1555
    • Rodero, MP1    Decalf, J2    Bondet, V3
  • 8
    • 85024906085 scopus 로고    scopus 로고
    • Transances- && tral mapping and genetic load in systemic lupus erythematosus
    • This is the largest genetic study in patients with SLE and the study establishes that more than 100 risk loci are associated with the disease. Several ethnic groups were investigated and both shared and ancestry-dependent loci were identified
    • Langefeld CD, Ainsworth HC, Cunninghame Graham DS, et al. Transances- && tral mapping and genetic load in systemic lupus erythematosus. Nat Commun 2017; 8:16021. This is the largest genetic study in patients with SLE and the study establishes that more than 100 risk loci are associated with the disease. Several ethnic groups were investigated and both shared and ancestry-dependent loci were identified.
    • (2017) Nat Commun , vol.8 , pp. 16021
    • Langefeld, CD1    Ainsworth, HC2    Cunninghame Graham, DS3
  • 9
    • 85049948740 scopus 로고    scopus 로고
    • Exome-wide association study identifies four novel loci for systemic lupus erythematosus in Han Chinese population
    • Wen L, Zhu C, Zhu Z, et al. Exome-wide association study identifies four novel loci for systemic lupus erythematosus in Han Chinese population. Ann Rheum Dis 2018; 77:417.
    • (2018) Ann Rheum Dis , vol.77 , pp. 417
    • Wen, L1    Zhu, C2    Zhu, Z3
  • 10
    • 85018819254 scopus 로고    scopus 로고
    • Genome-wide association analysis reveals genetic heterogeneity of Sjogren’s syndrome according to ancestry
    • Taylor KE, Wong Q, Levine DM, et al. Genome-wide association analysis reveals genetic heterogeneity of Sjogren’s syndrome according to ancestry. Arthritis Rheumatol 2017; 69:1294–1305.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 1294-1305
    • Taylor, KE1    Wong, Q2    Levine, DM3
  • 11
    • 85019738660 scopus 로고    scopus 로고
    • Common variants near Ikzf1 are associated with primary Sjogren’s syndrome in Han Chinese
    • Qu SS, Du Y, Chang SH, et al. Common variants near Ikzf1 are associated with primary Sjogren’s syndrome in Han Chinese. PLos One 2017; 12: e0177320.
    • (2017) PLos One , vol.12 , pp. e0177320
    • Qu, SS1    Du, Y2    Chang, SH3
  • 12
    • 85052555303 scopus 로고    scopus 로고
    • The Stat4 Sle risk allele & Rs7574865[T] is associated with increased Il-12-induced IFN-g production in T cells from patients with SLE
    • [Epub ahead of print] The functional consequences of the STAT4 risk gene variant in intron 3 has been unknown for 10 years. This study establishes a molecular connection between the risk gene variant and an increased IL-12 and IFNa response in T cells from patients with SLE. JAK inhibitors could block the T cell response
    • Hagberg N, Joelsson M, Leonard D, et al. The Stat4 Sle risk allele & Rs7574865[T] is associated with increased Il-12-induced IFN-g production in T cells from patients with SLE. Ann Rheum Dis 2018. [Epub ahead of print] The functional consequences of the STAT4 risk gene variant in intron 3 has been unknown for 10 years. This study establishes a molecular connection between the risk gene variant and an increased IL-12 and IFNa response in T cells from patients with SLE. JAK inhibitors could block the T cell response.
    • (2018) Ann Rheum Dis
    • Hagberg, N1    Joelsson, M2    Leonard, D3
  • 13
    • 85010756188 scopus 로고    scopus 로고
    • Mirna-451a targets Ifn regulatory factor 8 for the progression of systemic lupus erythematosus
    • Cheng J, Wu R, Long L, et al. Mirna-451a targets Ifn regulatory factor 8 for the progression of systemic lupus erythematosus. Inflammation 2017; 40: 676–687.
    • (2017) Inflammation , vol.40 , pp. 676-687
    • Cheng, J1    Wu, R2    Long, L3
  • 14
    • 85015368237 scopus 로고    scopus 로고
    • Microrna-302d targets Irf9 to regulate the & Ifn-induced gene expression in Sle
    • MicroRNA can control the IFN response, and in this study, the authors show that microRNA-320d is low in monocytes from patients with SLE and correlates with an IFN signature. Treatment of pristane-induced lupus with miR-320d downregulated the IFN response, but effect on clinical disease activity remains to be established
    • Smith S, Fernando T, Wu PW, et al. Microrna-302d targets Irf9 to regulate the & Ifn-induced gene expression in Sle. J Autoimmun 2017; 79:105–111. MicroRNA can control the IFN response, and in this study, the authors show that microRNA-320d is low in monocytes from patients with SLE and correlates with an IFN signature. Treatment of pristane-induced lupus with miR-320d downregulated the IFN response, but effect on clinical disease activity remains to be established.
    • (2017) J Autoimmun , vol.79 , pp. 105-111
    • Smith, S1    Fernando, T2    Wu, PW3
  • 15
    • 85022326127 scopus 로고    scopus 로고
    • Brief report: deficiency of complement 1r subcomponent in early-onset systemic lupus erythematosus: the role of disease-modifying alleles in a monogenic disease
    • Demirkaya E, Zhou Q, Smith CK, et al. Brief report: deficiency of complement 1r subcomponent in early-onset systemic lupus erythematosus: the role of disease-modifying alleles in a monogenic disease. Arthritis Rheumatol 2017; 69:1832–1839.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 1832-1839
    • Demirkaya, E1    Zhou, Q2    Smith, CK3
  • 16
    • 85033442355 scopus 로고    scopus 로고
    • Lupus-associated functional polymorphism in Pnp causes cell cycle abnormalities and interferon pathway activation in human immune cells
    • Ghodke-Puranik Y, Dorschner JM, Vsetecka DM, et al. Lupus-associated functional polymorphism in Pnp causes cell cycle abnormalities and interferon pathway activation in human immune cells. Arthritis Rheumatol 2017; 69:2328–2337.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 2328-2337
    • Ghodke-Puranik, Y1    Dorschner, JM2    Vsetecka, DM3
  • 17
    • 84921605360 scopus 로고    scopus 로고
    • Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus
    • Kariuki SN, Ghodke-Puranik Y, Dorschner JM, et al. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. Genes Immun 2015; 16: 15–23.
    • (2015) Genes Immun , vol.16 , pp. 15-23
    • Kariuki, SN1    Ghodke-Puranik, Y2    Dorschner, JM3
  • 18
    • 85018666210 scopus 로고    scopus 로고
    • Cd11b activation suppresses TLR- && dependent inflammation and autoimmunity in systemic lupus erythematosus
    • ITGAM encodes CD11b and SLE-associated gene variants confer reduced inhibition of the type I IFN signalling pathway the present study, the authors show that activation of CD11b with a small molecule block the TLR4 activation and protects MLR/lpr mice from end organ damage. The effect on IFN production by TLR 7 and 9 activation was, however, not investigated
    • Faridi MH, Khan SQ, Zhao W, et al. Cd11b activation suppresses TLR- && dependent inflammation and autoimmunity in systemic lupus erythematosus. J Clin Invest 2017; 127:1271–1283. ITGAM encodes CD11b and SLE-associated gene variants confer reduced inhibition of the type I IFN signalling pathway. In the present study, the authors show that activation of CD11b with a small molecule block the TLR4 activation and protects MLR/lpr mice from end organ damage. The effect on IFN production by TLR 7 and 9 activation was, however, not investigated.
    • (2017) J Clin Invest , vol.127 , pp. 1271-1283
    • Faridi, MH1    Khan, SQ2    Zhao, W3
  • 19
    • 85021781632 scopus 로고    scopus 로고
    • Identification of a Sjogren’s syndrome & susceptibility locus at Oas1 that influences isoform switching, protein expression, and responsiveness to type I interferons
    • This study shows that a risk gene variant for pSS affects the transcription of a classical type I IFN-induced gene 2 5 oligoadenylate synthetase 1 (OAS1) and causes reduced protein expression. This could contribute to an increased sensitivity for viral infections in pSS patients
    • Li H, Reksten TR, Ice JA, et al. Identification of a Sjogren’s syndrome & susceptibility locus at Oas1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet 2017; 13:e1006820. This study shows that a risk gene variant for pSS affects the transcription of a classical type I IFN-induced gene - 2’-5’-oligoadenylate synthetase 1 (OAS1) and causes reduced protein expression. This could contribute to an increased sensitivity for viral infections in pSS patients.
    • (2017) PLoS Genet , vol.13 , pp. e1006820
    • Li, H1    Reksten, TR2    Ice, JA3
  • 20
    • 84995402666 scopus 로고    scopus 로고
    • Association of interferon-induced helicase C domain (Ifih1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis
    • Silva JA, Lima SC, Addobbati C, et al. Association of interferon-induced helicase C domain (Ifih1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis. Genet Mol Res 2016; 15:1–9.
    • (2016) Genet Mol Res , vol.15 , pp. 1-9
    • Silva, JA1    Lima, SC2    Addobbati, C3
  • 21
    • 85014020744 scopus 로고    scopus 로고
    • Association of Ifih1 and proinflammatory mediators: potential new clues in SLE-associated pathogenesis
    • Munroe ME, Pezant N, Brown MA, et al. Association of Ifih1 and proinflammatory mediators: potential new clues in SLE-associated pathogenesis. PLoS One 2017; 12:e0171193.
    • (2017) PLoS One , vol.12 , pp. e0171193
    • Munroe, ME1    Pezant, N2    Brown, MA3
  • 22
    • 84988447167 scopus 로고    scopus 로고
    • Fatigue in primary Sjogren’s syndrome is associated with lower levels of proinflammatory cytokines
    • Howard Tripp N, Tarn J, Natasari A, et al. Fatigue in primary Sjogren’s syndrome is associated with lower levels of proinflammatory cytokines. RMD Open 2016; 2:e000282.
    • (2016) RMD Open , vol.2 , pp. e000282
    • Howard Tripp, N1    Tarn, J2    Natasari, A3
  • 23
    • 84983735850 scopus 로고    scopus 로고
    • Nadph oxidase-derived superoxide provides a third signal for Cd4 T cell effector responses
    • Padgett LE, Tse HM. Nadph oxidase-derived superoxide provides a third signal for Cd4 T cell effector responses. J Immunol 2016; 197:1733–1742.
    • (2016) J Immunol , vol.197 , pp. 1733-1742
    • Padgett, LE1    Tse, HM.2
  • 24
    • 84938955513 scopus 로고    scopus 로고
    • B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production
    • Khmaladze I, Saxena A, Nandakumar KS, Holmdahl R. B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production. Eur J Immunol 2015; 45:2243–2251.
    • (2015) Eur J Immunol , vol.45 , pp. 2243-2251
    • Khmaladze, I1    Saxena, A2    Nandakumar, KS3    Holmdahl, R.4
  • 25
    • 84950147039 scopus 로고    scopus 로고
    • Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation
    • Holmdahl R, Sareila O, Olsson LM, et al. Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation. Immunol Rev 2016; 269:228–247.
    • (2016) Immunol Rev , vol.269 , pp. 228-247
    • Holmdahl, R1    Sareila, O2    Olsson, LM3
  • 26
    • 85010957414 scopus 로고    scopus 로고
    • A missense variant in Ncf1 is associated with && susceptibility to multiple autoimmune diseases
    • &&] show that a genetically determined reduced ROS function is strongly associated with an increased risk for SLE. The articles add new information to the previous reported association between SLE and NCF2 gene variants causing impaired ROS activity
    • &&] show that a genetically determined reduced ROS function is strongly associated with an increased risk for SLE. The articles add new information to the previous reported association between SLE and NCF2 gene variants causing impaired ROS activity.
    • (2017) Nat Genet , vol.49 , pp. 433-437
    • Zhao, J1    Ma, J2    Deng, Y3
  • 27
    • 85024929994 scopus 로고    scopus 로고
    • A single nucleotide poly- && morphism in the Ncf1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus
    • &&] show that a genetically determined reduced ROS function is strongly associated with an increased risk for SLE. The articles add new information to the previous reported association between SLE and NCF2 gene variants causing impaired ROS activity
    • &&] show that a genetically determined reduced ROS function is strongly associated with an increased risk for SLE. The articles add new information to the previous reported association between SLE and NCF2 gene variants causing impaired ROS activity.
    • (2017) Ann Rheum Dis , vol.76 , pp. 1607-1613
    • Olsson, LM1    Johansson, AC2    Gullstrand, B3
  • 28
    • 85028975317 scopus 로고    scopus 로고
    • Ifn-alpha negatively regulates the expression of endothelial nitric oxide synthase and nitric oxide production: implications for systemic lupus erythematosus
    • Buie JJ, Renaud LL, Muise-Helmericks R, Oates JC. Ifn-alpha negatively regulates the expression of endothelial nitric oxide synthase and nitric oxide production: implications for systemic lupus erythematosus. J Immunol 2017; 199:1979–1988.
    • (2017) J Immunol , vol.199 , pp. 1979-1988
    • Buie, JJ1    Renaud, LL2    Muise-Helmericks, R3    Oates, JC.4
  • 29
    • 85032581293 scopus 로고    scopus 로고
    • Endothelial dysfunction is associated with activation of the type I interferon system and platelets in patients with systemic lupus erythematosus
    • Tyden H, Lood C, Gullstrand B, et al. Endothelial dysfunction is associated with activation of the type I interferon system and platelets in patients with systemic lupus erythematosus. RMD Open 2017; 3:e000508.
    • (2017) RMD Open , vol.3 , pp. e000508
    • Tyden, H1    Lood, C2    Gullstrand, B3
  • 30
    • 85016047457 scopus 로고    scopus 로고
    • Siglec1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjogren’s syndrome
    • Rose T, Szelinski F, Lisney A, et al. Siglec1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjogren’s syndrome. RMD Open 2016; 2:e000292.
    • (2016) RMD Open , vol.2 , pp. e000292
    • Rose, T1    Szelinski, F2    Lisney, A3
  • 31
    • 85024382840 scopus 로고    scopus 로고
    • High maternal expression of siglec1 on & monocytes as a surrogate marker of a type i interferon signature is a risk factor for the development of autoimmune congenital heart block
    • This study shows that pregnant women with SSA antibodies and high expression of SIGLEC-1 on monocytes have an increased risk for giving birth to children with autoimmune congenital heart block. The study was small, but suggests that anti-SSA positive patients should be investigated for SIGLEC-1 expression and treated with hydroxychloroquine
    • Lisney AR, Szelinski F, Reiter K, et al. High maternal expression of siglec1 on & monocytes as a surrogate marker of a type i interferon signature is a risk factor for the development of autoimmune congenital heart block. Ann Rheum Dis 2017; 76:1476–1480. This study shows that pregnant women with SSA antibodies and high expression of SIGLEC-1 on monocytes have an increased risk for giving birth to children with autoimmune congenital heart block. The study was small, but suggests that anti-SSA positive patients should be investigated for SIGLEC-1 expression and treated with hydroxychloroquine.
    • (2017) Ann Rheum Dis , vol.76 , pp. 1476-1480
    • Lisney, AR1    Szelinski, F2    Reiter, K3
  • 32
    • 85028538972 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells and Rna-containing immune complexes drive expansion of peripheral B cell subsets with an Sle-like phenotype
    • Berggren O, Hagberg N, Alexsson A, et al. Plasmacytoid dendritic cells and Rna-containing immune complexes drive expansion of peripheral B cell subsets with an Sle-like phenotype. PLoS One 2017; 12:e0183946.
    • (2017) PLoS One , vol.12 , pp. e0183946
    • Berggren, O1    Hagberg, N2    Alexsson, A3
  • 33
    • 84960435612 scopus 로고    scopus 로고
    • A regulatory feedback between & plasmacytoid dendritic cells and regulatory B cells is aberrant in systemic lupus erythematosus
    • This study shows that pDCs from SLE patients promote plasmablast differentiation but fail to induce Breg cells. IFNa could induce the same aberration in cells from healthy individuals. Thus, type I IFN seems to promote a dysregulated pDC and B cell interaction in SLE
    • Menon M, Blair PA, Isenberg DA, Mauri C. A regulatory feedback between & plasmacytoid dendritic cells and regulatory B cells is aberrant in systemic lupus erythematosus. Immunity 2016; 44:683–697. This study shows that pDCs from SLE patients promote plasmablast differentiation but fail to induce Breg cells. IFNa could induce the same aberration in cells from healthy individuals. Thus, type I IFN seems to promote a dysregulated pDC and B cell interaction in SLE.
    • (2016) Immunity , vol.44 , pp. 683-697
    • Menon, M1    Blair, PA2    Isenberg, DA3    Mauri, C.4
  • 34
    • 84958551926 scopus 로고    scopus 로고
    • Association of plasmacytoid dendritic cells with b cell infiltration in minor salivary glands in patients with Sjogren’s syndrome
    • Zhao J, Kubo S, Nakayamada S, et al. Association of plasmacytoid dendritic cells with b cell infiltration in minor salivary glands in patients with Sjogren’s syndrome. Mod Rheumatol 2016; 26:716–724.
    • (2016) Mod Rheumatol , vol.26 , pp. 716-724
    • Zhao, J1    Kubo, S2    Nakayamada, S3
  • 35
    • 85044195662 scopus 로고    scopus 로고
    • Diminished Cxcr5 expression in peripheral blood of patients with Sjogren’s syndrome may relate to both genotype and salivary gland homing
    • [Epub ahead of print]
    • Aqrawi LA, Ivanchenko M, Bjork A, et al. Diminished Cxcr5 expression in peripheral blood of patients with Sjogren’s syndrome may relate to both genotype and salivary gland homing. Clin Exp Immunol 2018. [Epub ahead of print]
    • (2018) Clin Exp Immunol
    • Aqrawi, LA1    Ivanchenko, M2    Bjork, A3
  • 36
    • 68149179247 scopus 로고    scopus 로고
    • Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by dysregulating the Il-23-Th17 pathway
    • Espinosa A, Dardalhon V, Brauner S, et al. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by dysregulating the Il-23-Th17 pathway. J Exp Med 2009; 206:1661–1671.
    • (2009) J Exp Med , vol.206 , pp. 1661-1671
    • Espinosa, A1    Dardalhon, V2    Brauner, S3
  • 37
    • 85032996263 scopus 로고    scopus 로고
    • The Rna binding protein La/Ss-B promotes Rig-I-mediated Type I and Type III Ifn responses following sendai viral infection
    • Mahony R, Broadbent L, Maier-Moore JS, et al. The Rna binding protein La/Ss-B promotes Rig-I-mediated Type I and Type III Ifn responses following sendai viral infection. Sci Rep 2017; 7:14537.
    • (2017) Sci Rep , vol.7 , pp. 14537
    • Mahony, R1    Broadbent, L2    Maier-Moore, JS3
  • 38
    • 84991665836 scopus 로고    scopus 로고
    • Contrasting expression pattern of Rna-sensing receptors Tlr7, Rig-I and Mda5 in interferon-positive and interferon-negative patients with primary Sjogren’s syndrome
    • Maria NI, Steenwijk EC, IJpma AS, et al. Contrasting expression pattern of Rna-sensing receptors Tlr7, Rig-I and Mda5 in interferon-positive and interferon-negative patients with primary Sjogren’s syndrome. Ann Rheum Dis 2017; 76:721–730.
    • (2017) Ann Rheum Dis , vol.76 , pp. 721-730
    • Maria, NI1    Steenwijk, EC2    IJpma, AS3
  • 39
    • 84991245465 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells and type 1 interferon promote peripheral expansion of forkhead box protein 3(þ) regulatory T cells specific for the ubiquitous Rna-binding nuclear antigen La/ Sjogren’s syndrome (Ss)-B
    • Pan ZJ, Horton CG, Lawrence C, Farris AD. Plasmacytoid dendritic cells and type 1 interferon promote peripheral expansion of forkhead box protein 3(þ) regulatory T cells specific for the ubiquitous Rna-binding nuclear antigen La/ Sjogren’s syndrome (Ss)-B. Clin Exp Immunol 2016; 186:18–29.
    • (2016) Clin Exp Immunol , vol.186 , pp. 18-29
    • Pan, ZJ1    Horton, CG2    Lawrence, C3    Farris, AD.4
  • 40
    • 84976582003 scopus 로고    scopus 로고
    • Association of increased treg cell levels with elevated indoleamine 2,3-dioxygenase activity and an imbalanced kynurenine pathway in interferon-positive primary Sjogren’s syndrome
    • Maria NI, van Helden-Meeuwsen CG, Brkic Z, et al. Association of increased treg cell levels with elevated indoleamine 2,3-dioxygenase activity and an imbalanced kynurenine pathway in interferon-positive primary Sjogren’s syndrome. Arthritis Rheumatol 2016; 68:1688–1699.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 1688-1699
    • Maria, NI1    van Helden-Meeuwsen, CG2    Brkic, Z3
  • 41
    • 84958068675 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis in multiple tissues in primary Sjogren’s syndrome reveals regulatory effects at interferon-induced genes
    • Imgenberg-Kreuz J, Sandling JK, Almlof JC, et al. Genome-wide DNA methylation analysis in multiple tissues in primary Sjogren’s syndrome reveals regulatory effects at interferon-induced genes. Ann Rheum Dis 2016; 75: 2029–2036.
    • (2016) Ann Rheum Dis , vol.75 , pp. 2029-2036
    • Imgenberg-Kreuz, J1    Sandling, JK2    Almlof, JC3
  • 42
    • 85011032592 scopus 로고    scopus 로고
    • Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjogren’s syndrome
    • Charras A, Konsta OD, Le Dantec C, et al. Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjogren’s syndrome. Ann Rheum Dis 2017; 76:625–628.
    • (2017) Ann Rheum Dis , vol.76 , pp. 625-628
    • Charras, A1    Konsta, OD2    Le Dantec, C3
  • 43
    • 85046670210 scopus 로고    scopus 로고
    • Twin DNA methylation profiling & reveals flare-dependent interferon signature and B-cell promoter hyper-methylation in systemic lupus erythematosus
    • Several cell types from monozygotic and dizygotic twins discordant for SLE were investigated with the HumanMethylation450K BeadChip. The majority of differentially methylated genes were hypomethylated and nearly 40 were connected to the IFN pathway. Prominent hypomethylation in IFN-regulated genes were associated to risk for flare
    • Ulff-Moller CJ, Asmar F, Liu Y, et al. Twin DNA methylation profiling & reveals flare-dependent interferon signature and B-cell promoter hyper-methylation in systemic lupus erythematosus. Arthritis Rheumatol 2018; 70:878–890. Several cell types from monozygotic and dizygotic twins discordant for SLE were investigated with the HumanMethylation450K BeadChip. The majority of differentially methylated genes were hypomethylated and nearly 40% were connected to the IFN pathway. Prominent hypomethylation in IFN-regulated genes were associated to risk for flare.
    • (2018) Arthritis Rheumatol , vol.70 , pp. 878-890
    • Ulff-Moller, CJ1    Asmar, F2    Liu, Y3
  • 44
    • 85030615817 scopus 로고    scopus 로고
    • Type I interferons and the cytokine && Tnf cooperatively reprogram the macrophage epigenome to promote inflammatory activation
    • The tolerogenic effect of TNF on the TLR3 response by macrophages was abolished by IFNa exposure and this effect was mediated via epigenetic modifications
    • Park SH, Kang K, Giannopoulou E, et al. Type I interferons and the cytokine && Tnf cooperatively reprogram the macrophage epigenome to promote inflammatory activation. Nat Immunol 2017; 18:1104–1116. The tolerogenic effect of TNF on the TLR3 response by macrophages was abolished by IFNa exposure and this effect was mediated via epigenetic modifications.
    • (2017) Nat Immunol , vol.18 , pp. 1104-1116
    • Park, SH1    Kang, K2    Giannopoulou, E3
  • 45
    • 84954384327 scopus 로고    scopus 로고
    • A phase Ii study of the efficacy and safety of rontalizumab (rhumab interferon-alpha) in patients with systemic lupus erythematosus (Rose)
    • Kalunian KC, Merrill JT, Maciuca R, et al. A phase Ii study of the efficacy and safety of rontalizumab (rhumab interferon-alpha) in patients with systemic lupus erythematosus (Rose). Ann Rheum Dis 2016; 75:196–202.
    • (2016) Ann Rheum Dis , vol.75 , pp. 196-202
    • Kalunian, KC1    Merrill, JT2    Maciuca, R3
  • 46
    • 84962815312 scopus 로고    scopus 로고
    • Sifalimumab, an anti-interferon-alpha monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study
    • Khamashta M, Merrill JT, Werth VP, et al. Sifalimumab, an anti-interferon-alpha monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study. Ann Rheum Dis 2016; 75:1909–1916.
    • (2016) Ann Rheum Dis , vol.75 , pp. 1909-1916
    • Khamashta, M1    Merrill, JT2    Werth, VP3
  • 47
    • 84991079659 scopus 로고    scopus 로고
    • Interferon alpha kinoid induces neutralizing anti-interferon alpha antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon alpha kinoid phase I/Ii study
    • Ducreux J, Houssiau FA, Vandepapeliere P, et al. Interferon alpha kinoid induces neutralizing anti-interferon alpha antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon alpha kinoid phase I/Ii study. Rheumatology (Oxford) 2016; 55:1901–1905.
    • (2016) Rheumatology (Oxford) , vol.55 , pp. 1901-1905
    • Ducreux, J1    Houssiau, FA2    Vandepapeliere, P3
  • 48
    • 85010843590 scopus 로고    scopus 로고
    • Anifrolumab, an anti-interferon-alpha & receptor monoclonal antibody, in moderate-to-severe systemic lupus erythematosus
    • This is the first clinical trial with a mAb against the type I IFN receptor in SLE and the study suggests that patients with a high IFN score should be selected for this treatment
    • Furie R, Khamashta M, Merrill JT, et al. Anifrolumab, an anti-interferon-alpha & receptor monoclonal antibody, in moderate-to-severe systemic lupus erythematosus. Arthritis Rheumatol 2017; 69:376–386. This is the first clinical trial with a mAb against the type I IFN receptor in SLE and the study suggests that patients with a high IFN score should be selected for this treatment.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 376-386
    • Furie, R1    Khamashta, M2    Merrill, JT3
  • 49
    • 85021080879 scopus 로고    scopus 로고
    • Microglia-dependent synapse loss in type & I interferon-mediated lupus
    • Type I IFN can activate microglia to phagocytose synapses, which could be one mechanism behind neuropsychiatric lupus and the observed cognitive dysfunction in many patients
    • Bialas AR, Presumey J, Das A, et al. Microglia-dependent synapse loss in type & I interferon-mediated lupus. Nature 2017; 546:539–543. Type I IFN can activate microglia to phagocytose synapses, which could be one mechanism behind neuropsychiatric lupus and the observed cognitive dysfunction in many patients.
    • (2017) Nature , vol.546 , pp. 539-543
    • Bialas, AR1    Presumey, J2    Das, A3
  • 50
    • 85027989093 scopus 로고    scopus 로고
    • Jak Inhibitor has the amelioration effect in lupus-prone mice: the involvement of Ifn signature gene downregulation
    • Ikeda K, Hayakawa K, Fujishiro M, et al. Jak Inhibitor has the amelioration effect in lupus-prone mice: the involvement of Ifn signature gene downregulation. BMC Immunol 2017; 18:41.
    • (2017) BMC Immunol , vol.18 , pp. 41
    • Ikeda, K1    Hayakawa, K2    Fujishiro, M3
  • 51
    • 85007309278 scopus 로고    scopus 로고
    • Tofacitinib ameliorates murine lupus and its associated vascular dysfunction
    • Furumoto Y, Smith CK, Blanco L, et al. Tofacitinib ameliorates murine lupus and its associated vascular dysfunction. Arthritis Rheumatol 2017; 69: 148–160.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 148-160
    • Furumoto, Y1    Smith, CK2    Blanco, L3
  • 52
    • 85018743598 scopus 로고    scopus 로고
    • Jak inhibitor ruxolitinib inhibits the expression of cytokines characteristic of cutaneous lupus erythematosus
    • Klaeschen AS, Wolf D, Brossart P, et al. Jak inhibitor ruxolitinib inhibits the expression of cytokines characteristic of cutaneous lupus erythematosus. Exp Dermatol 2017; 26:728–730.
    • (2017) Exp Dermatol , vol.26 , pp. 728-730
    • Klaeschen, AS1    Wolf, D2    Brossart, P3
  • 53
    • 84953210532 scopus 로고    scopus 로고
    • The expression of Baff is controlled by Irf transcription factors
    • Sjostrand M, Johansson A, Aqrawi L, et al. The expression of Baff is controlled by Irf transcription factors. J Immunol 2016; 196:91–96.
    • (2016) J Immunol , vol.196 , pp. 91-96
    • Sjostrand, M1    Johansson, A2    Aqrawi, L3
  • 54
    • 84922391089 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in primary Sjogren’s syndrome: results of the Beliss open-label phase Ii study
    • Mariette X, Seror R, Quartuccio L, et al. Efficacy and safety of belimumab in primary Sjogren’s syndrome: results of the Beliss open-label phase Ii study. Ann Rheum Dis 2015; 74:526–531.
    • (2015) Ann Rheum Dis , vol.74 , pp. 526-531
    • Mariette, X1    Seror, R2    Quartuccio, L3
  • 55
    • 84983103174 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab given for 12 months in primary Sjogren’s syndrome: the Beliss open-label phase Ii study
    • De Vita S, Quartuccio L, Seror R, et al. Efficacy and safety of belimumab given for 12 months in primary Sjogren’s syndrome: the Beliss open-label phase Ii study. Rheumatology (Oxford) 2015; 54:2249–2256.
    • (2015) Rheumatology (Oxford) , vol.54 , pp. 2249-2256
    • De Vita, S1    Quartuccio, L2    Seror, R3
  • 56
    • 84940756502 scopus 로고    scopus 로고
    • Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjogren’s syndrome: results of the Beliss study
    • Seror R, Nocturne G, Lazure T, et al. Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjogren’s syndrome: results of the Beliss study. Arthritis Res Ther 2015; 17:241.
    • (2015) Arthritis Res Ther , vol.17 , pp. 241
    • Seror, R1    Nocturne, G2    Lazure, T3
  • 57
    • 70350517490 scopus 로고    scopus 로고
    • Differential effects on Baff and april levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis
    • Vallerskog T, Heimburger M, Gunnarsson I, et al. Differential effects on Baff and april levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Res Ther 2006; 8:R167.
    • (2006) Arthritis Res Ther , vol.8 , pp. R167
    • Vallerskog, T1    Heimburger, M2    Gunnarsson, I3
  • 58
    • 85020237160 scopus 로고    scopus 로고
    • Randomized controlled trial of rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren’s syndrome
    • Bowman SJ, Everett CC, O’Dwyer JL, et al. Randomized controlled trial of rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren’s syndrome. Arthritis Rheumatol 2017; 69: 1440–1450.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 1440-1450
    • Bowman, SJ1    Everett, CC2    O’Dwyer, JL3
  • 59
    • 84911462978 scopus 로고    scopus 로고
    • Belimumab after rituximab as maintenance therapy in lupus nephritis
    • Kraaij T, Huizinga TW, Rabelink TJ, Teng YK. Belimumab after rituximab as maintenance therapy in lupus nephritis. Rheumatology (Oxford) 2014; 53:2122–2124.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 2122-2124
    • Kraaij, T1    Huizinga, TW2    Rabelink, TJ3    Teng, YK.4
  • 60
    • 84904900825 scopus 로고    scopus 로고
    • Sequential therapy with belimumab followed by rituximab in Sjogren’s syndrome associated with B-cell lymphoproliferation and overexpression of Baff: evidence for long-term efficacy
    • De Vita S, Quartuccio L, Salvin S, et al. Sequential therapy with belimumab followed by rituximab in Sjogren’s syndrome associated with B-cell lymphoproliferation and overexpression of Baff: evidence for long-term efficacy. Clin Exp Rheumatol 2014; 32:490–494.
    • (2014) Clin Exp Rheumatol , vol.32 , pp. 490-494
    • De Vita, S1    Quartuccio, L2    Salvin, S3
  • 61
    • 85050263241 scopus 로고    scopus 로고
    • Successful sequential therapy with rituximab and belimumab in patients with active systemic lupus erythematosus: a case series
    • [Epub ahead of print]
    • Gualtierotti R, Borghi MO, Gerosa M, et al. Successful sequential therapy with rituximab and belimumab in patients with active systemic lupus erythematosus: a case series. Clin Exp Rheumatol 2018. [Epub ahead of print]
    • (2018) Clin Exp Rheumatol
    • Gualtierotti, R1    Borghi, MO2    Gerosa, M3
  • 62
    • 84926185226 scopus 로고    scopus 로고
    • Anti-Bdca2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fcindependent mechanisms
    • Pellerin A, Otero K, Czerkowicz JM, et al. Anti-Bdca2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fcindependent mechanisms. EMBO Mol Med 2015; 7:464–476.
    • (2015) EMBO Mol Med , vol.7 , pp. 464-476
    • Pellerin, A1    Otero, K2    Czerkowicz, JM3
  • 63
    • 85055064198 scopus 로고    scopus 로고
    • 83jBiib059, a monoclonal antibody targeting Bdca2, demonstrates evidence of proof of biological activity in subjects with cutaneous lupus
    • Furie R, Werth V, Merola J, et al. 83jBiib059, a monoclonal antibody targeting Bdca2, demonstrates evidence of proof of biological activity in subjects with cutaneous lupus. Lupus Sci Med 2017; 4:A35–A135.
    • (2017) Lupus Sci Med , vol.4 , pp. A35-A135
    • Furie, R1    Werth, V2    Merola, J3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.