Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines

RMD Open

Volumn 2, Issue 2, 2016, Pages

  Tripp, Nadia Howard ^a,b   Tarn, Jessica ^a   Natasari, Andini ^a   Gillespie, Colin ^c   Mitchell, Sheryl ^b   Hackett, Katie L ^a   Bowman, Simon J ^d   Price, Elizabeth ^e   Pease, Colin T ^f   Emery, Paul ^f   Lanyon, Peter ^g   Hunter, John ^h   Gupta, Monica ^h   Bombardieri, Michele ⁱ   Sutcliffe, Nurhan ⁱ   Pitzalis, Costantino ⁱ   McLaren, John ^j   Cooper, Annie ^k   Regan, Marian ^l   Giles, Ian ^m   Isenberg, David A ^m   Saravanan, Vadivelu ⁿ   Coady, David ^o   Dasgupta, Bhaskar ^p   McHugh, Neil ^q   Young Min, Steven ^r   Moots, Robert ^s   Gendi, Nagui ^t   Akil, Mohammed ^u   Griffiths, Bridget ^b   Lendrem, Dennis W ^a,b   Ng, Wan Fai ^a,b   more..

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^e GREAT WESTERN HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF LEEDS   (United Kingdom)

^g NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^h GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

ⁱ BARTS HEALTH NHS TRUST   (United Kingdom)

^j NHS FIFE   (United Kingdom)

^k ROYAL HAMPSHIRE COUNTY HOSPITAL   (United Kingdom)

^l ROYAL DERBY HOSPITAL   (United Kingdom)

^m UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

ⁿ QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^o SUNDERLAND ROYAL HOSPITAL   (United Kingdom)

^p SOUTHEND UNIVERSITY HOSPITAL   (United Kingdom)

^q ROYAL NATIONAL HOSPITAL FOR RHEUMATIC DISEASES   (United Kingdom)

^r PORTSMOUTH HOSPITALS NHS TRUST   (United Kingdom)

^s ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^t BASILDON HOSPITAL   (United Kingdom)

^u ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84988447167     PISSN: None     EISSN: 20565933     Source Type: Journal    
DOI: 10.1136/rmdopen-2016-000282     Document Type: Article

References (38)

1. Cullen W, Kearney Y, Bury G. Prevalence of fatigue in general practice. Ir J Med Sci 2002;171:10-12.
2. Wessely S, Chalder T, Hirsch S, et al. The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study. Am J Public Health 1997;87:1449-55.
3. Reynolds KJ, Vernon SD, Bouchery E, et al. The economic impact of chronic fatigue syndrome. Cost Eff Resour Alloc 2004;2:4.
4. Overman CL, Kool MB, Da Silva JA, et al. The prevalence of severe fatigue in rheumatic diseases: an international study. Clin Rheumatol 2016;35:409-15.
5. Haldorsen K, Bjelland I, Bolstad AI, et al. A five-year prospective study of fatigue in primary Sjogren's syndrome. Arthritis Res Ther 2011;13:R167.
6. Bannister BA. Post-infectious disease syndrome. Postgrad Med J 1988;64:559-67.
7. Broderick G, Katz BZ, Fernandes H, et al. Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue. J Trans Med 2012;10:191.
8. Arnett SV, Clark IA. Inflammatory fatigue and sickness behaviour - lessons for the diagnosis and management of chronic fatigue syndrome. J Affect Disord 2012;141:130-42.
9. Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9:46-56.
10. Louati K, Berenbaum F. Fatigue in chronic inflammation - a link to pain pathways. Arthritis Res Ther 2015;17:254.
11. Fletcher MA, Zeng XR, Barnes Z, et al. Plasma cytokines in women with chronic fatigue syndrome. J Transl Med 2009;7:96.
12. Broderick G, Fuite J, Kreitz A, et al. A formal analysis of cytokine networks in chronic fatigue syndrome. Brain Behav Immun 2010;24:1209-17.
13. Blundell S, Ray KK, Buckland M, et al. Chronic fatigue syndrome and circulating cytokines: a systematic review. Brain Behav Immun 2015;50:186-95.
14. Malik UR, Makower DF, Wadler S. Interferon-mediated fatigue. Cancer 2001;92(6 Suppl):1664-8.
15. Ng WF, Bowman SJ. Primary Sjogren's syndrome: too dry and too tired. Rheumatology 2010;49:844-53.
16. Bax HI, Vriesendorp TM, Kallenberg CG, et al. Fatigue and immune activity in Sjogren's syndrome. Ann Rheum Dis 2002;61:284.
17. Bergman MJ, Shahouri SH, Shaver TS, et al. Is fatigue an inflammatory variable in rheumatoid arthritis (RA)? Analyses of fatigue in RA, osteoarthritis, and fibromyalgia. J Rheumatol 2009;36:2788-94.
18. Pollard LC, Choy EH, Gonzalez J, et al. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology 2006;45:885-7.
19. Burgos PI, Alarcon G, McGwin Jr G, et al. Disease activity and damage are not associated with increased levels of fatigue in systemic lupus erythematosus patients from a multiethnic cohort: LXVII. Arthritis Rheum 2009;61:1179-86.
20. Wang B, Gladman DD, Urowitz MB. Fatigue in lupus is not correlated with disease activity. J Rheumatol 1998;25:892-5.
21. James K, Al-Ali S, Tarn J, et al. A transcriptional signature of fatigue derived from patients with primary Sjogren's syndrome. PLoS One 2015;10:e0143970.
22. Natasari AS, Tarn J, Fischer R, et al. Exploring the biological basis of fatigue using primary Sjogren's syndrome as a disease model. BMC Musculoskel Disord 2013;14(Suppl 1):A1.
23. Ng WF, Bowman SJ, Griffiths B, et al. United Kingdom primary Sjogren's syndrome registry - a united effort to tackle an orphan rheumatic disease. Rheumatology 2011;50:32-9.
24. Neuberger GB. Measures of fatigue. Arthritis Rheum 2003;49:175-83.
25. Bjelland I, Dahl AA, Haug TT, et al. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002;52:69-77.
26. Seror R, Ravaud P, Bowman SJ, et al., EULAR Sjogren's Task Force. EULAR Sjogren's syndrome disease activity index; development of a consensus systemic disease activity index for primary Sjogren's syndrome. Ann Rheum Dis 2010;69:1103-9.
27. Seror R, Ravaud P, Mariette X, et al. EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjogren's syndrome. Ann Rheum Dis 2011;70:968-72
28. http://www.jmp.com/en-gb/home.html
29. https://www.r-project.org/
30. Harboe E, Tjensvoll AB, Vefring HK, et al. Fatigue in primary Sjogren's syndrome - a link to sickness behaviour in animals? Brain Behav Immun 2009;23:1104-8.
31. Hornig M, Montoya JG, Klimas NG, et al. Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Sci Adv 2015;1:e1400121.
32. ter Wolbeek M, van Doornenb LJ, Kavelaars A, et al. Longitudinal analysis of pro-and anti-inflammatory cytokine production in severely fatigued adolescents. Brain Behav Immun 2007;21:1063-74.
33. Visser J, Blaw B, Hinloopen B, et al. CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon production and increased sensitivity to dexamethasone. J Infect Dis 1998;177:451-4.
34. Dufour JH, Dziejman M, Liu MT, et al. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 2002;168:3195-204.
35. Skowera A, Cleare A, Blair D, et al. High levels of type 2 cytokineproducing cells in chronic fatigue syndrome. Clin Exp Immunol 2004;135:294-302.
36. Karageorgas T, Fragioudaki S, Nezos A, et al. Fatigue in primary Sjogren's syndrome: clinical, laboratory, psychometric and biological associations. Arthritis Care Res 2016;68:123-31.
37. van Leeuwen N, Bossema ER, Knoop H, et al. Psychological profiles in patients with Sjogren's syndrome related to fatigue: a cluster analysis. Rheumatology 2015;54:776-83.
38. Silva JC, Mariz HA, Rocha LF Jr, et al. Hydroxycholorquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients. Clinics (Sao Paulo) 2013;68:766-71.