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Volumn 68, Issue 7, 2016, Pages 1688-1699

Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD45RO ANTIGEN; INDOLEAMINE 2,3 DIOXYGENASE; INTERFERON; KYNURENINE; KYNURENINE 3 MONOOXYGENASE; KYNURENINE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE I; KYNURENINE AMINOTRANSFERASE III; KYNURENINE AMINOTRANSFERASE IV; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRYPTOPHAN; UNCLASSIFIED DRUG;

EID: 84976582003     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39629     Document Type: Article
Times cited : (51)

References (50)
  • 2
    • 0026610715 scopus 로고
    • Pathogenesis of Sjögren's syndrome
    • Fox RI, Kang HI. Pathogenesis of Sjögren's syndrome. Rheum Dis Clin North Am 1992;18:517–38.
    • (1992) Rheum Dis Clin North Am , vol.18 , pp. 517-538
    • Fox, R.I.1    Kang, H.I.2
  • 3
    • 64849100795 scopus 로고    scopus 로고
    • Unraveling the pathophysiology of Sjögren syndrome-associated dry eye disease
    • Nguyen CQ, Peck AB. Unraveling the pathophysiology of Sjögren syndrome-associated dry eye disease. Ocul Surf 2009;7:11–27.
    • (2009) Ocul Surf , vol.7 , pp. 11-27
    • Nguyen, C.Q.1    Peck, A.B.2
  • 4
    • 84875958991 scopus 로고    scopus 로고
    • Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression
    • Brkic Z, Maria NI, van Helden-Meeuwsen CG, van de Merwe JP, van Daele PL, Dalm VA, et al. Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression. Ann Rheum Dis 2013;72:728–35.
    • (2013) Ann Rheum Dis , vol.72 , pp. 728-735
    • Brkic, Z.1    Maria, N.I.2    van Helden-Meeuwsen, C.G.3    van de Merwe, J.P.4    van Daele, P.L.5    Dalm, V.A.6
  • 5
    • 84899902260 scopus 로고    scopus 로고
    • MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome
    • Maria NI, Brkic Z, Waris M, van Helden-Meeuwsen CG, Heezen K, van de Merwe JP, et al. MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome. Ann Rheum Dis 2014;73:1052–9.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1052-1059
    • Maria, N.I.1    Brkic, Z.2    Waris, M.3    van Helden-Meeuwsen, C.G.4    Heezen, K.5    van de Merwe, J.P.6
  • 7
    • 34548297826 scopus 로고    scopus 로고
    • An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome
    • Mackay F, Groom JR, Tangye SG. An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome. Curr Opin Rheumatol 2007;19:406–13.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 406-413
    • Mackay, F.1    Groom, J.R.2    Tangye, S.G.3
  • 8
    • 84922391089 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study
    • Mariette X, Seror R, Quartuccio L, Baron G, Salvin S, Fabris M, et al. Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study. Ann Rheum Dis 2015;74:526–31.
    • (2015) Ann Rheum Dis , vol.74 , pp. 526-531
    • Mariette, X.1    Seror, R.2    Quartuccio, L.3    Baron, G.4    Salvin, S.5    Fabris, M.6
  • 9
    • 84867907920 scopus 로고    scopus 로고
    • Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases
    • Hall JC, Casciola-Rosen L, Berger AE, Kapsogeorgou EK, Cheadle C, Tzioufas AG, et al. Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases. Proc Natl Acad Sci U S A 2012;109:17609–14.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17609-17614
    • Hall, J.C.1    Casciola-Rosen, L.2    Berger, A.E.3    Kapsogeorgou, E.K.4    Cheadle, C.5    Tzioufas, A.G.6
  • 11
    • 84940836792 scopus 로고    scopus 로고
    • Type I and II interferon signatures in Sjögren's syndrome pathogenesis: contributions in distinct clinical phenotypes and Sjögren's related lymphomagenesis
    • Nezos A, Gravani F, Tassidou A, Kapsogeorgou EK, Voulgarelis M, Koutsilieris M, et al. Type I and II interferon signatures in Sjögren's syndrome pathogenesis: contributions in distinct clinical phenotypes and Sjögren's related lymphomagenesis. J Autoimmun 2015;63:47–58.
    • (2015) J Autoimmun , vol.63 , pp. 47-58
    • Nezos, A.1    Gravani, F.2    Tassidou, A.3    Kapsogeorgou, E.K.4    Voulgarelis, M.5    Koutsilieris, M.6
  • 12
    • 34249741135 scopus 로고    scopus 로고
    • On watching the watchers: IDO and type I/II IFN
    • Puccetti P. On watching the watchers: IDO and type I/II IFN. Eur J Immunol 2007;37:876–9.
    • (2007) Eur J Immunol , vol.37 , pp. 876-879
    • Puccetti, P.1
  • 13
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: when physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012;13:465–77.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 14
    • 22144432194 scopus 로고    scopus 로고
    • Role of kynurenines in the central and peripheral nervous systems
    • Nemeth H, Toldi J, Vecsei L. Role of kynurenines in the central and peripheral nervous systems. Curr Neurovasc Res 2005;2:249–60.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 249-260
    • Nemeth, H.1    Toldi, J.2    Vecsei, L.3
  • 15
    • 84857625769 scopus 로고    scopus 로고
    • The kynurenine system and immunoregulation
    • Mandi Y, Vecsei L. The kynurenine system and immunoregulation. J Neural Transm (Vienna) 2012;119:197–209.
    • (2012) J Neural Transm (Vienna) , vol.119 , pp. 197-209
    • Mandi, Y.1    Vecsei, L.2
  • 16
    • 84898038703 scopus 로고    scopus 로고
    • Kynurenines in CNS disease: regulation by inflammatory cytokines
    • Campbell BM, Charych E, Lee AW, Moller T. Kynurenines in CNS disease: regulation by inflammatory cytokines. Front Neurosci 2014;8:12.
    • (2014) Front Neurosci , vol.8 , pp. 12
    • Campbell, B.M.1    Charych, E.2    Lee, A.W.3    Moller, T.4
  • 17
    • 80052016154 scopus 로고    scopus 로고
    • IDO: more than an enzyme
    • Chen W. IDO: more than an enzyme. Nat Immunol 2011;12:809–11.
    • (2011) Nat Immunol , vol.12 , pp. 809-811
    • Chen, W.1
  • 19
    • 80052020183 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
    • Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, et al. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol 2011;12:870–8.
    • (2011) Nat Immunol , vol.12 , pp. 870-878
    • Pallotta, M.T.1    Orabona, C.2    Volpi, C.3    Vacca, C.4    Belladonna, M.L.5    Bianchi, R.6
  • 20
    • 33646893538 scopus 로고    scopus 로고
    • The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells
    • Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006;176:6752–61.
    • (2006) J Immunol , vol.176 , pp. 6752-6761
    • Fallarino, F.1    Grohmann, U.2    You, S.3    McGrath, B.C.4    Cavener, D.R.5    Vacca, C.6
  • 22
    • 0038215374 scopus 로고    scopus 로고
    • Tolerance, DCs and tryptophan: much ado about IDO
    • Grohmann U, Fallarino F, Puccetti P. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 2003;24:242–8.
    • (2003) Trends Immunol , vol.24 , pp. 242-248
    • Grohmann, U.1    Fallarino, F.2    Puccetti, P.3
  • 23
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010;11:7–13.
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 24
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3+ regulatory T cells
    • Campbell DJ, Koch MA. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol 2011;11:119–30.
    • (2011) Nat Rev Immunol , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 26
    • 0036092482 scopus 로고    scopus 로고
    • Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
    • Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al, and the European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554–8.
    • (2002) Ann Rheum Dis , vol.61 , pp. 554-558
    • Vitali, C.1    Bombardieri, S.2    Jonsson, R.3    Moutsopoulos, H.M.4    Alexander, E.L.5    Carsons, S.E.6
  • 27
    • 77953705028 scopus 로고    scopus 로고
    • EULAR Sjögren's Syndrome Disease Activity Index: development of a consensus systemic disease activity index for primary Sjögren's syndrome
    • Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, et al, on behalf of the EULAR Sjögren's Task Force. EULAR Sjögren's Syndrome Disease Activity Index: development of a consensus systemic disease activity index for primary Sjögren's syndrome. Ann Rheum Dis 2010;69:1103–9.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1103-1109
    • Seror, R.1    Ravaud, P.2    Bowman, S.J.3    Baron, G.4    Tzioufas, A.5    Theander, E.6
  • 28
    • 84938082923 scopus 로고    scopus 로고
    • Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour
    • Gibney SM, Fagan EM, Waldron AM, O'Byrne J, Connor TJ, Harkin A. Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour. Int J Neuropsychopharmacol 2014;17:917–28.
    • (2014) Int J Neuropsychopharmacol , vol.17 , pp. 917-928
    • Gibney, S.M.1    Fagan, E.M.2    Waldron, A.M.3    O'Byrne, J.4    Connor, T.J.5    Harkin, A.6
  • 29
    • 9144271651 scopus 로고    scopus 로고
    • Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ‘real-time’ quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)—a Europe Against Cancer program
    • Beillard E, Pallisgaard N, van der Velden VH, Bi W, Dee R, van der Schoot E, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ‘real-time’ quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)—a Europe Against Cancer program. Leukemia 2003;17:2474–86.
    • (2003) Leukemia , vol.17 , pp. 2474-2486
    • Beillard, E.1    Pallisgaard, N.2    van der Velden, V.H.3    Bi, W.4    Dee, R.5    van der Schoot, E.6
  • 31
    • 10444248118 scopus 로고    scopus 로고
    • Coordinate overexpression of interferon-α–induced genes in systemic lupus erythematosus
    • Kirou KA, Lee C, George S, Louca K, Papagiannis IG, Peterson MG, et al. Coordinate overexpression of interferon-α–induced genes in systemic lupus erythematosus. Arthritis Rheum 2004;50:3958–67.
    • (2004) Arthritis Rheum , vol.50 , pp. 3958-3967
    • Kirou, K.A.1    Lee, C.2    George, S.3    Louca, K.4    Papagiannis, I.G.5    Peterson, M.G.6
  • 32
    • 33749331301 scopus 로고    scopus 로고
    • Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
    • Feng X, Wu H, Grossman JM, Hanvivadhanakul P, FitzGerald JD, Park GS, et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 2006;54:2951–62.
    • (2006) Arthritis Rheum , vol.54 , pp. 2951-2962
    • Feng, X.1    Wu, H.2    Grossman, J.M.3    Hanvivadhanakul, P.4    FitzGerald, J.D.5    Park, G.S.6
  • 33
    • 61649090825 scopus 로고    scopus 로고
    • GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis
    • Van Hamburg JP, Mus AM, de Bruijn MJ, de Vogel L, Boon L, Cornelissen F, et al. GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum 2009;60:750–9.
    • (2009) Arthritis Rheum , vol.60 , pp. 750-759
    • Van Hamburg, J.P.1    Mus, A.M.2    de Bruijn, M.J.3    de Vogel, L.4    Boon, L.5    Cornelissen, F.6
  • 34
    • 0036176273 scopus 로고    scopus 로고
    • More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC
    • Laich A, Neurauter G, Widner B, Fuchs D. More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC. Clin Chem 2002;48:579–81.
    • (2002) Clin Chem , vol.48 , pp. 579-581
    • Laich, A.1    Neurauter, G.2    Widner, B.3    Fuchs, D.4
  • 35
    • 25444463828 scopus 로고    scopus 로고
    • Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjögren's syndrome
    • Pertovaara M, Raitala A, Uusitalo H, Pukander J, Helin H, Oja SS, et al. Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjögren's syndrome. Clin Exp Immunol 2005;142:155–61.
    • (2005) Clin Exp Immunol , vol.142 , pp. 155-161
    • Pertovaara, M.1    Raitala, A.2    Uusitalo, H.3    Pukander, J.4    Helin, H.5    Oja, S.S.6
  • 36
    • 21244495606 scopus 로고    scopus 로고
    • IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
    • Wichers MC, Koek GH, Robaeys G, Verkerk R, Scharpe S, Maes M. IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 2005;10:538–44.
    • (2005) Mol Psychiatry , vol.10 , pp. 538-544
    • Wichers, M.C.1    Koek, G.H.2    Robaeys, G.3    Verkerk, R.4    Scharpe, S.5    Maes, M.6
  • 37
    • 84875261622 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and metabolic control of immune responses
    • Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol 2013;34:137–43.
    • (2013) Trends Immunol , vol.34 , pp. 137-143
    • Munn, D.H.1    Mellor, A.L.2
  • 38
    • 84864776540 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase: from catalyst to signaling function
    • Fallarino F, Grohmann U, Puccetti P. Indoleamine 2,3-dioxygenase: from catalyst to signaling function. Eur J Immunol 2012;42:1932–7.
    • (2012) Eur J Immunol , vol.42 , pp. 1932-1937
    • Fallarino, F.1    Grohmann, U.2    Puccetti, P.3
  • 39
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? [published erratum appears in J Neuroinflammation 2013;10:34]
    • Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, Sarnyai Z, et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? [published erratum appears in J Neuroinflammation 2013;10:34]. J Neuroinflammation 2011;8:94.
    • (2011) J Neuroinflammation , vol.8 , pp. 94
    • Steiner, J.1    Walter, M.2    Gos, T.3    Guillemin, G.J.4    Bernstein, H.G.5    Sarnyai, Z.6
  • 40
    • 84907486069 scopus 로고    scopus 로고
    • Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression
    • Agudelo LZ, Femenia T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 2014;159:33–45.
    • (2014) Cell , vol.159 , pp. 33-45
    • Agudelo, L.Z.1    Femenia, T.2    Orhan, F.3    Porsmyr-Palmertz, M.4    Goiny, M.5    Martinez-Redondo, V.6
  • 42
    • 84976571716 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3 dioxygenase-1 and -2 in focal sialoadenitis of patients with Sjögren's syndrome [abstract]
    • Vitali C, Prafioriti A, Sambataro D, Di Bernardo A, Admiraglio E, Nayar S, et al. Expression of indoleamine 2,3 dioxygenase-1 and -2 in focal sialoadenitis of patients with Sjögren's syndrome [abstract]. Arthritis Rheum 2014;66 Suppl:S230–1.
    • (2014) Arthritis Rheum , vol.66 , pp. 230-231
    • Vitali, C.1    Prafioriti, A.2    Di Sambataro, D.3    Bernardo, A.4    Admiraglio, E.5    Nayar, S.6
  • 43
  • 46
    • 77950536542 scopus 로고    scopus 로고
    • Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation
    • Bikker A, van Woerkom JM, Kruize AA, Wenting-van Wijk M, de Jager W, Bijlsma JW, et al. Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation. Arthritis Rheum 2010;62:969–77.
    • (2010) Arthritis Rheum , vol.62 , pp. 969-977
    • Bikker, A.1    van Woerkom, J.M.2    Kruize, A.A.3    Wenting-van Wijk, M.4    de Jager, W.5    Bijlsma, J.W.6
  • 47
    • 0026076136 scopus 로고
    • Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism
    • Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR. Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 1991;56:2007–17.
    • (1991) J Neurochem , vol.56 , pp. 2007-2017
    • Fukui, S.1    Schwarcz, R.2    Rapoport, S.I.3    Takada, Y.4    Smith, Q.R.5
  • 48
  • 49
    • 0027257930 scopus 로고
    • A mechanism for increased quinolinic acid formation following acute systemic immune stimulation
    • Saito K, Crowley JS, Markey SP, Heyes MP. A mechanism for increased quinolinic acid formation following acute systemic immune stimulation. J Biol Chem 1993;268:15496–503.
    • (1993) J Biol Chem , vol.268 , pp. 15496-15503
    • Saito, K.1    Crowley, J.S.2    Markey, S.P.3    Heyes, M.P.4
  • 50
    • 0027716965 scopus 로고
    • A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate
    • Heyes MP, Saito K, Major EO, Milstien S, Markey SP, Vickers JH. A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain 1993;116:1425–50.
    • (1993) Brain , vol.116 , pp. 1425-1450
    • Heyes, M.P.1    Saito, K.2    Major, E.O.3    Milstien, S.4    Markey, S.P.5    Vickers, J.H.6


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