Enhancement of Bacitracin Production by NADPH Generation via Overexpressing Glucose-6-Phosphate Dehydrogenase Zwf in Bacillus licheniformis

Applied Biochemistry and Biotechnology

Volumn 187, Issue 4, 2019, Pages 1502-1514

  Zhu, Shan ^a   Cai, Dongbo ^a   Liu, Ziwei ^a   Zhang, Bowen ^a   Li, Junhui ^b   Chen, Shouwen ^a   Ma, Xin ^a  

^a HUBEI UNIVERSITY   (China)

^b Lifecome Biochemistry Co Ltd   (China)

Author keywords

Bacillus licheniformis; Bacitracin; Glucose 6 phosphate dehydrogenase Zwf; NADPH generation; Precursor amino acid

Indexed keywords

AMINO ACIDS; BACTERIOLOGY; GLUCOSE; INDUSTRIAL RESEARCH; PEPTIDES; TRANSCRIPTION;

AMINO ACID SYNTHESIS; BACILLUS LICHENIFORMIS; BACITRACIN; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; INDUSTRIAL PRODUCTION; NADPH GENERATION; OVEREXPRESSION STRAIN; TRANSCRIPTIONAL LEVELS;

ANTIBIOTICS;

BACITRACIN; CYSTEINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTAMIC ACID; ISOLEUCINE; LEUCINE; LYSINE; ORNITHINE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; ZWF ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SYNTHESIS; ANALYTIC METHOD; ARTICLE; BACILLUS LICHENIFORMIS; BACTERIAL STRAIN; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUSTRIAL PRODUCTION; NONHUMAN; PLASMID; PRECURSOR; BIOSYNTHESIS; BIOTECHNOLOGY; CYTOLOGY; EXTRACELLULAR SPACE; FERMENTATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; INTRACELLULAR SPACE; METABOLISM;

BACILLUS LICHENIFORMIS; BACITRACIN; BIOTECHNOLOGY; EXTRACELLULAR SPACE; FERMENTATION; GENE EXPRESSION; GLUCOSEPHOSPHATE DEHYDROGENASE; INTRACELLULAR SPACE; NAD; NADP; TRANSCRIPTION, GENETIC;

EID: 85054291119     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-018-2894-0     Document Type: Article

References (36)

1. Alpdagtas, S., Yucel, S., Kapkac, H. A., Liu, S., & Binay, B. (2018). Discovery of an acidic, thermostable and highly NADP(+) dependent formate dehydrogenase from Lactobacillus buchneri NRRL B-30929. Biotechnology Letters, 40(7), 1135–1147.
2. Bekker, V., Dodd, A., Brady, D., & Rumbold, K. (2014). Tools for metabolic engineering in Streptomyces. Bioengineered, 5(5), 293–299.
3. Bommareddy, R. R., Chen, Z., Rappert, S., & Zeng, A. P. (2014). A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase. Metabolic Engineering, 25, 30–37.
4. Cai, D., Chen, Y., He, P., Wang, S., Mo, F., Li, X., Wang, Q., Nomura, C. T., Wen, Z., Ma, X., & Chen, S. (2018). Enhanced production of poly-gamma-glutamic acid by improving ATP supply in metabolically engineered Bacillus licheniformis. Biotechnology and Bioengineering. 10.1002/bit.26774.
5. Cai, D., He, P., Lu, X., Zhu, C., Zhu, J., Zhan, Y., Wang, Q., Wen, Z., & Chen, S. (2017). A novel approach to improve poly-γ-glutamic acid production by NADPH regeneration in Bacillus licheniformis WX-02. Scientific Reports, 7(1), 43404.
6. Cai, D., Hu, S., Chen, Y., Liu, L., Yang, S., Ma, X., & Chen, S. (2018). Enhanced production of poly-γ-glutamic acid by overexpression of the global anaerobic regulator Fnr in Bacillus licheniformis WX-02. Applied Biochemistry and Biotechnology, 185(4), 958–970.
7. Cai, D., Wang, H., He, P., Zhu, C., Wang, Q., Wei, X., Nomura, C. T., & Chen, S. (2017). A novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in Bacillus licheniformis. Microbial Cell Factories, 16(1), 70.
8. Chen, X., Xie, F., Zhang, X., Li, D., Chen, S., Li, J., & Wang, Z. (2014). Supplementations of ornithine and KNO3 enhanced bacitracin production by Bacillus licheniformis LC-11. Annales de Microbiologie, 64(2), 509–514.
9. Chen, Y. (2018). Cofactor engineering strategy for enhanced S-adenosylmethionine production in Saccharomyces cerevisiae. Sheng Wu Gong Cheng Xue Bao, 34(2), 246–254.
10. Duan, Y. X., Chen, T., Chen, X., & Zhao, X. M. (2010). Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis. Applied Microbiology and Biotechnology, 85(6), 1907–1914.
11. Fu, J., Wang, Z., Chen, T., Liu, W., Shi, T., Wang, G., Tang, Y. J., & Zhao, X. (2014). NADH plays the vital role for chiral pure D-(-)-2,3-butanediol production in Bacillus subtilis under limited oxygen conditions. Biotechnology and Bioengineering, 111(10), 2126–2131.
12. Hwang, K. S., Kim, H. U., Charusanti, P., Palsson, B. O., & Lee, S. Y. (2014). Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites. Biotechnology Advances, 32(2), 255–268.
13. Jiang, L. Y., Zhang, Y. Y., Li, Z., & Liu, J. Z. (2013). Metabolic engineering of Corynebacterium glutamicum for increasing the production of L-ornithine by increasing NADPH availability. Journal of Industrial Microbiology & Biotechnology, 40(10), 1143–1151.
14. Jin, X. M., Chang, Y. K., Lee, J. H., & Hong, S. K. (2017). Effects of increased NADPH concentration by metabolic engineering of the pentose phosphate pathway on antibiotic production and sporulation in Streptomyces lividans TK24. Journal of Microbiology and Biotechnology, 27(10), 1867–1876.
15. Kim, S. Y., Lee, J., & Lee, S. Y. (2015). Metabolic engineering of Corynebacterium glutamicum for the production of L-ornithine. Biotechnology and Bioengineering, 112(2), 416–421.
16. Kim, W. J., Ahn, J. H., Kim, H. U., Kim, T. Y., & Lee, S. Y. (2017). Metabolic engineering of Mannheimia succiniciproducens for succinic acid production based on elementary mode analysis with clustering. Biotechnology Journal, 12(2).
17. Kleijn, R. J., Liu, F., van Winden, W. A., van Gulik, W. M., Ras, C., & Heijnen, J. J. (2007). Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum. Metabolic Engineering, 9(1), 112–123.
18. Lee, W. H., Kim, M. D., Jin, Y. S., & Seo, J. H. (2013). Engineering of NADPH regenerators in Escherichia coli for enhanced biotransformation. Applied Microbiology and Biotechnology, 97(7), 2761–2772.
19. Li, R., & Townsend, C. A. (2006). Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metabolic Engineering, 8(3), 240–252.
20. Li, Y., Cong, H., Liu, B., Song, J., Sun, X., Zhang, J., & Yang, Q. (2016). Metabolic engineering of Corynebacterium glutamicum for methionine production by removing feedback inhibition and increasing NADPH level. Antonie Van Leeuwenhoek, 109(9), 1185–1197.
21. Li, Y., Wu, F., Cai, D., Zhan, Y., Li, J., Chen, X., Chen, H., Chen, S., & Ma, X. (2018). Enhanced production of bacitracin by knocking out of amino acid permease gene yhdG in Bacillus Licheniformis DW2. Sheng Wu Gong Cheng Xue Bao, 34(6), 916–927.
22. Lim, S. J., Jung, Y. M., Shin, H. D., & Lee, Y. H. (2002). Amplification of the NADPH-related genes zwf and gnd for the oddball biosynthesis of PHB in an E. coli transformant harboring a cloned phbCAB operon. Journal of Bioscience and Bioengineering, 93(6), 543–549.
23. Liu, Z., Yu, W., Nomura, C. T., Chen, S., Yang, Y., & Wang, Q. (2018). Increased flux through the TCA cycle enhances bacitracin production by Bacillus licheniformis DW2. Applied Microbiology and Biotechnology, 102(16), 6935–6946. 10.1007/s00253-018-9133-z.
24. Ma, Q., Zhang, Q., Xu, Q., Zhang, C., Li, Y., Fan, X., Xie, X., & Chen, N. (2017). Systems metabolic engineering strategies for the production of amino acids. Synth Syst Biotechnol, 2(2), 87–96.
25. Perez-Zabaleta, M., Sjoberg, G., Guevara-Martinez, M., Jarmander, J., Gustavsson, M., Quillaguaman, J., & Larsson, G. (2016). Increasing the production of (R)-3-hydroxybutyrate in recombinant Escherichia coli by improved cofactor supply. Microbial Cell Factories, 15(1), 91.
26. Ryu, Y. G., Butler, M. J., Chater, K. F., & Lee, K. J. (2006). Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Applied and Environmental Microbiology, 72(11), 7132–7139.
27. Shi, F., Li, K., Huan, X., & Wang, X. (2013). Expression of NAD(H) kinase and glucose-6-phosphate dehydrogenase improve NADPH supply and L-isoleucine biosynthesis in Corynebacterium glutamicum ssp. lactofermentum. Applied Biochemistry and Biotechnology, 171(2), 504–521.
28. Shi, F., Li, K., & Li, Y. (2015). Comparative proteome analysis of global effect of POS5 and zwf-ppnK overexpression in L-isoleucine producing Corynebacterium glutamicum ssp. lactofermentum. Biotechnology Letters, 37(5), 1063–1071.
29. Shi, F., Zhang, M., Li, Y., & Fang, H. (2018). Sufficient NADPH supply and pknG deletion improve 4-hydroxyisoleucine production in recombinant Corynebacterium glutamicum. Enzyme and Microbial Technology, 115, 1–8.
30. Sundara Sekar, B., Seol, E., & Park, S. (2017). Co-production of hydrogen and ethanol from glucose in Escherichia coli by activation of pentose-phosphate pathway through deletion of phosphoglucose isomerase (pgi) and overexpression of glucose-6-phosphate dehydrogenase (zwf) and 6-phosphogluconate dehydrogenase (gnd). Biotechnology for Biofuels, 10, 85.
31. Tian, G., Wang, Q., Wei, X., Ma, X., & Chen, S. (2017). Glutamate dehydrogenase (RocG) in Bacillus licheniformis WX-02: enzymatic properties and specific functions in glutamic acid synthesis for poly-γ-glutamic acid production. Enzyme and Microbial Technology, 99, 9–15.
32. Wang, D., Wang, Q., Qiu, Y., Nomura, C. T., Li, J., & Chen, S. (2017). Untangling the transcription regulatory network of the bacitracin synthase operon in Bacillus licheniformis DW2. Research in Microbiology, 168(6), 515–523.
33. Wang, Q., Zheng, H., Wan, X., Huang, H., Li, J., Nomura, C. T., Wang, C., & Chen, S. (2017). Optimization of inexpensive agricultural by-products as raw materials for bacitracin production in Bacillus licheniformis DW2. Applied Biochemistry and Biotechnology, 183(4), 1146–1157.
34. Wang, Z., Wang, Y., Xie, F., Chen, S., Li, J., Li, D., & Chen, X. (2014). Improvement of acetoin reductase activity enhances bacitracin production by Bacillus licheniformis. Process Biochemistry, 49(12), 2039–2043.
35. Zhang, H., Li, Y., Wang, C., & Wang, X. (2018). Understanding the high L-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics. Scientific Reports, 8(1), 3632.
36. Zhou, S., Ding, R., Chen, J., Du, G., Li, H., & Zhou, J. (2017). Obtaining a panel of cascade promoter-5'-UTR complexes in Escherichia coli. ACS Synthetic Biology, 6(6), 1065–1075.