The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory

Immunity

Volumn 49, Issue 4, 2018, Pages 615-626.e6

  Daniel, Bence ^a,j   Nagy, Gergely ^b   Czimmerer, Zsolt ^b   Horvath, Attila ^b   Hammers, David W ^h   Cuaranta Monroy, Ixchelt ^b   Poliska, Szilard ^b   Tzerpos, Petros ^b   Kolostyak, Zsuzsanna ^b   Hays, Tristan T ^a,j   Patsalos, Andreas ^a,j   Houtman, René ⁱ   Sauer, Sascha ^c,d,e   Francois Deleuze, Jean ^f   Rastinejad, Fraydoon ^a   Balint, Balint L ^b   Sweeney, H Lee ^h   Nagy, Laszlo ^a,b,g,j  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f DIF   (France)

^g UNIVERSITY OF DEBRECEN   (Hungary)

^h UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

ⁱ PamGene International BV   (Netherlands)

^j JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

coregulators; epigenomics; IFN ; IL 4; ligand insensitive enhancers; macrophage polarization; muscle regeneration; Nuclear receptor; PPAR ; progressive polarization; transcriptional memory

Indexed keywords

ARG1 PROTEIN; CARDIOTOXIN; DNA; E1A ASSOCIATED P300 PROTEIN; ESTROGEN RECEPTOR ALPHA; FATTY ACID BINDING PROTEIN 4; HBEGF PROTEIN; INTERLEUKIN 4; LIGAND; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; RAD21 PROTEIN; RETINOID X RECEPTOR; RNA POLYMERASE II; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHROMATIN; CONTROLLED STUDY; ENHANCER REGION; EPIGENETICS; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIGAND BINDING; MACROPHAGE; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE INJURY; MUSCLE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA SEQUENCE; TRANSCRIPTIONAL MEMORY; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; DBA MOUSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; METABOLISM; PROCEDURES;

ANIMALS; CELL LINE; CELLS, CULTURED; EPIGENESIS, GENETIC; EPIGENOMICS; GENE EXPRESSION REGULATION; INTERLEUKIN-4; LIGANDS; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; PPAR GAMMA;

EID: 85054182103     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.09.005     Document Type: Article

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