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Volumn 55, Issue , 2018, Pages 9-14

IL-6: a cytokine at the crossroads of autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR ANTIBODY; JANUS KINASE INHIBITOR; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

EID: 85053520353     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2018.09.002     Document Type: Review
Times cited : (83)

References (60)
  • 3
    • 0025990288 scopus 로고
    • Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
    • Linker-Israeli, M., Deans, R.J., Wallace, D.J., Prehn, J., Ozeri-Chen, T., Klinenberg, J.R., Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 147 (1991), 117–123.
    • (1991) J Immunol , vol.147 , pp. 117-123
    • Linker-Israeli, M.1    Deans, R.J.2    Wallace, D.J.3    Prehn, J.4    Ozeri-Chen, T.5    Klinenberg, J.R.6
  • 4
    • 0031056456 scopus 로고    scopus 로고
    • IL-6 detection in multiple sclerosis brain
    • Maimone, D., Guazzi, G.C., Annunziata, P., IL-6 detection in multiple sclerosis brain. J Neurol Sci 146 (1997), 59–65.
    • (1997) J Neurol Sci , vol.146 , pp. 59-65
    • Maimone, D.1    Guazzi, G.C.2    Annunziata, P.3
  • 5
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter, C.A., Jones, S.A., IL-6 as a keystone cytokine in health and disease. Nat Immunol 16 (2015), 448–457.
    • (2015) Nat Immunol , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 6
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: regulator of Treg/Th17 balance
    • Kimura, A., Kishimoto, T., IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40 (2010), 1830–1835.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 8
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T.B., Oukka, M., Weiner, H.L., Kuchroo, V.K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006), 235–238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 9
    • 85046260593 scopus 로고    scopus 로고
    • Relative contributions of B cells and dendritic cells from Lupus-prone mice to CD4+ T cell polarization
    • Choi, S.-C., Xu, Z., Li, W., Yang, H., Roopenian, D.C., Morse, H.C., Morel, L., Relative contributions of B cells and dendritic cells from Lupus-prone mice to CD4+ T cell polarization. J Immunol, 2018, ji1701179.
    • (2018) J Immunol
    • Choi, S.-C.1    Xu, Z.2    Li, W.3    Yang, H.4    Roopenian, D.C.5    Morse, H.C.6    Morel, L.7
  • 10
    • 85041925915 scopus 로고    scopus 로고
    • IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation
    • Novel mechanism by which IL-6 drives Th17 function via the transcription factor RFX1.
    • Zhao, M., Tan, Y., Peng, Q., Huang, C., Guo, Y., Liang, G., Zhu, B., Huang, Y., Liu, A., Wang, Z., et al. IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Nat Commun, 9, 2018, 583 Novel mechanism by which IL-6 drives Th17 function via the transcription factor RFX1.
    • (2018) Nat Commun , vol.9 , pp. 583
    • Zhao, M.1    Tan, Y.2    Peng, Q.3    Huang, C.4    Guo, Y.5    Liang, G.6    Zhu, B.7    Huang, Y.8    Liu, A.9    Wang, Z.10
  • 11
    • 84975073436 scopus 로고    scopus 로고
    • The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression
    • Ichiyama, K., Gonzalez-Martin, A., Kim, B.-S., Jin, H.Y., Jin, W., Xu, W., Sabouri-Ghomi, M., Xu, S., Zheng, P., Xiao, C., The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression. Immunity 44 (2016), 1284–1298.
    • (2016) Immunity , vol.44 , pp. 1284-1298
    • Ichiyama, K.1    Gonzalez-Martin, A.2    Kim, B.-S.3    Jin, H.Y.4    Jin, W.5    Xu, W.6    Sabouri-Ghomi, M.7    Xu, S.8    Zheng, P.9    Xiao, C.10
  • 12
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., Medzhitov, R., Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299 (2003), 1033–1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 14
    • 84874099546 scopus 로고    scopus 로고
    • In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling
    • Schneider, A., Long, S.A., Cerosaletti, K., Ni, C.T., Samuels, P., Kita, M., Buckner, J.H., In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling. Sci Transl Med, 5, 2013, 170ra.
    • (2013) Sci Transl Med , vol.5
    • Schneider, A.1    Long, S.A.2    Cerosaletti, K.3    Ni, C.T.4    Samuels, P.5    Kita, M.6    Buckner, J.H.7
  • 16
    • 84997637138 scopus 로고    scopus 로고
    • Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
    • Initial characterization of cluster signaling in dendritic cells.
    • Heink, S., Yogev, N., Garbers, C., Herwerth, M., Aly, L., Gasperi, C., Husterer, V., Croxford, A.L., Moller-Hackbarth, K., Bartsch, H.S., et al. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol 18 (2017), 74–85 Initial characterization of cluster signaling in dendritic cells.
    • (2017) Nat Immunol , vol.18 , pp. 74-85
    • Heink, S.1    Yogev, N.2    Garbers, C.3    Herwerth, M.4    Aly, L.5    Gasperi, C.6    Husterer, V.7    Croxford, A.L.8    Moller-Hackbarth, K.9    Bartsch, H.S.10
  • 17
    • 84942876309 scopus 로고    scopus 로고
    • MiR-125a-5p decreases the sensitivity of Treg cells toward IL-6-mediated conversion by inhibiting IL-6R and STAT3 expression
    • Li, D., Kong, C., Tsun, A., Chen, C., Song, H., Shi, G., Pan, W., Dai, D., Shen, N., Li, B., MiR-125a-5p decreases the sensitivity of Treg cells toward IL-6-mediated conversion by inhibiting IL-6R and STAT3 expression. Sci Rep, 5, 2015, 14615.
    • (2015) Sci Rep , vol.5 , pp. 14615
    • Li, D.1    Kong, C.2    Tsun, A.3    Chen, C.4    Song, H.5    Shi, G.6    Pan, W.7    Dai, D.8    Shen, N.9    Li, B.10
  • 18
    • 47249145164 scopus 로고    scopus 로고
    • Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus
    • Venigalla, R.K., Tretter, T., Krienke, S., Max, R., Eckstein, V., Blank, N., Fiehn, C., Ho, A.D., Lorenz, H.M., Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum 58 (2008), 2120–2130.
    • (2008) Arthritis Rheum , vol.58 , pp. 2120-2130
    • Venigalla, R.K.1    Tretter, T.2    Krienke, S.3    Max, R.4    Eckstein, V.5    Blank, N.6    Fiehn, C.7    Ho, A.D.8    Lorenz, H.M.9
  • 19
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider, A., Rieck, M., Sanda, S., Pihoker, C., Greenbaum, C., Buckner, J.H., The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol 181 (2008), 7350–7355.
    • (2008) J Immunol , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5    Buckner, J.H.6
  • 20
    • 85051278007 scopus 로고    scopus 로고
    • Effector T cell resistance to suppression and STAT3 signaling during the development of human type 1 diabetes
    • ji1701199 Teff resistance in T1D patients is STAT3-dependent but not linked to the capacity of Teffs to produce or respond to IL-6.
    • Ihantola, E.-L., Viisanen, T., Gazali, A.M., Näntö-Salonen, K., Juutilainen, A., Moilanen, L., Rintamäki, R., Pihlajamäki, J., Veijola, R., Toppari, J., Effector T cell resistance to suppression and STAT3 signaling during the development of human type 1 diabetes. J Immunol, 2018 ji1701199 Teff resistance in T1D patients is STAT3-dependent but not linked to the capacity of Teffs to produce or respond to IL-6.
    • (2018) J Immunol
    • Ihantola, E.-L.1    Viisanen, T.2    Gazali, A.M.3    Näntö-Salonen, K.4    Juutilainen, A.5    Moilanen, L.6    Rintamäki, R.7    Pihlajamäki, J.8    Veijola, R.9    Toppari, J.10
  • 22
    • 85045006134 scopus 로고    scopus 로고
    • T cell receptor-regulated TGF-β type I receptor expression determines T cell quiescence and activation
    • Novel mechanism involving IL-6 in the enforcement of quiescence in naïve T cells.
    • Tu, E., Chia, C.P., Chen, W., Zhang, D., Park, S.A., Jin, W., Wang, D., Alegre, M.-L., Zhang, Y.E., Sun, L., T cell receptor-regulated TGF-β type I receptor expression determines T cell quiescence and activation. Immunity 48 (2018), 745–759.e746 Novel mechanism involving IL-6 in the enforcement of quiescence in naïve T cells.
    • (2018) Immunity , vol.48 , pp. 745-759.e746
    • Tu, E.1    Chia, C.P.2    Chen, W.3    Zhang, D.4    Park, S.A.5    Jin, W.6    Wang, D.7    Alegre, M.-L.8    Zhang, Y.E.9    Sun, L.10
  • 24
    • 84862298255 scopus 로고    scopus 로고
    • Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
    • Ma, J., Zhu, C., Ma, B., Tian, J., Baidoo, S.E., Mao, C., Wu, W., Chen, J., Tong, J., Yang, M., et al. Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol, 2012, 2012, 827480.
    • (2012) Clin Dev Immunol , vol.2012
    • Ma, J.1    Zhu, C.2    Ma, B.3    Tian, J.4    Baidoo, S.E.5    Mao, C.6    Wu, W.7    Chen, J.8    Tong, J.9    Yang, M.10
  • 26
    • 85033390839 scopus 로고    scopus 로고
    • B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity
    • IL-6 produced by B cells drives formation of germinal centers and Tfh differentiation.
    • Arkatkar, T., Du, S.W., Jacobs, H.M., Dam, E.M., Hou, B., Buckner, J.H., Rawlings, D.J., Jackson, S.W., B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity. J Exp Med 214 (2017), 3207–3217 IL-6 produced by B cells drives formation of germinal centers and Tfh differentiation.
    • (2017) J Exp Med , vol.214 , pp. 3207-3217
    • Arkatkar, T.1    Du, S.W.2    Jacobs, H.M.3    Dam, E.M.4    Hou, B.5    Buckner, J.H.6    Rawlings, D.J.7    Jackson, S.W.8
  • 28
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki, M., Yasukawa, K., Saito, T., Ohsugi, Y., Fukui, H., Koishihara, Y., Yancopoulos, G.D., Taga, T., Kishimoto, T., Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82 (1993), 1120–1126.
    • (1993) Blood , vol.82 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3    Ohsugi, Y.4    Fukui, H.5    Koishihara, Y.6    Yancopoulos, G.D.7    Taga, T.8    Kishimoto, T.9
  • 30
    • 0026828552 scopus 로고
    • Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
    • Lust, J.A., Donovan, K.A., Kline, M.P., Greipp, P.R., Kyle, R.A., Maihle, N.J., Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4 (1992), 96–100.
    • (1992) Cytokine , vol.4 , pp. 96-100
    • Lust, J.A.1    Donovan, K.A.2    Kline, M.P.3    Greipp, P.R.4    Kyle, R.A.5    Maihle, N.J.6
  • 31
    • 47249089967 scopus 로고    scopus 로고
    • Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
    • Briso, E.M., Dienz, O., Rincon, M., Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J Immunol 180 (2008), 7102–7106.
    • (2008) J Immunol , vol.180 , pp. 7102-7106
    • Briso, E.M.1    Dienz, O.2    Rincon, M.3
  • 32
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., Stockinger, B., TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006), 179–189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 35
    • 85006340445 scopus 로고    scopus 로고
    • Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation
    • Quintana, F.J., Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol 18 (2016), 8–10.
    • (2016) Nat Immunol , vol.18 , pp. 8-10
    • Quintana, F.J.1
  • 37
    • 84940598253 scopus 로고    scopus 로고
    • Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins
    • Amaral, W.Z., Krueger, R.F., Ryff, C.D., Coe, C.L., Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins. Brain Behav Immun 49 (2015), 171–181.
    • (2015) Brain Behav Immun , vol.49 , pp. 171-181
    • Amaral, W.Z.1    Krueger, R.F.2    Ryff, C.D.3    Coe, C.L.4
  • 40
    • 84988888015 scopus 로고    scopus 로고
    • Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression
    • A role for dysregulated IL-6 responsiveness in the pathogenesis of type 1 diabetes.
    • Hundhausen, C., Roth, A., Whalen, E., Chen, J., Schneider, A., Long, S.A., Wei, S., Rawlings, R., Kinsman, M., Evanko, S.P., et al. Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression. Sci Transl Med, 8, 2016, 356ra A role for dysregulated IL-6 responsiveness in the pathogenesis of type 1 diabetes.
    • (2016) Sci Transl Med , vol.8 , pp. 356ra
    • Hundhausen, C.1    Roth, A.2    Whalen, E.3    Chen, J.4    Schneider, A.5    Long, S.A.6    Wei, S.7    Rawlings, R.8    Kinsman, M.9    Evanko, S.P.10
  • 41
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: a multicenter, double‐blind, placebo‐controlled trial
    • Nishimoto, N., Yoshizaki, K., Miyasaka, N., Yamamoto, K., Kawai, S., Takeuchi, T., Hashimoto, J., Azuma, J., Kishimoto, T., Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: a multicenter, double‐blind, placebo‐controlled trial. Arthritis Rheum 50 (2004), 1761–1769.
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6    Hashimoto, J.7    Azuma, J.8    Kishimoto, T.9
  • 42
    • 84920285641 scopus 로고    scopus 로고
    • IL-6 biology: implications for clinical targeting in rheumatic disease
    • Calabrese, L.H., Rose-John, S., IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 10 (2014), 720–727.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 720-727
    • Calabrese, L.H.1    Rose-John, S.2
  • 48
    • 84983500182 scopus 로고    scopus 로고
    • The efficacy and safety of Clazakizumab, an anti–interleukin‐6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis
    • Mease, P.J., Gottlieb, A.B., Berman, A., Drescher, E., Xing, J., Wong, R., Banerjee, S., The efficacy and safety of Clazakizumab, an anti–interleukin‐6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis. Arthritis Rheum 68 (2016), 2163–2173.
    • (2016) Arthritis Rheum , vol.68 , pp. 2163-2173
    • Mease, P.J.1    Gottlieb, A.B.2    Berman, A.3    Drescher, E.4    Xing, J.5    Wong, R.6    Banerjee, S.7
  • 49
    • 84919683208 scopus 로고    scopus 로고
    • A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma
    • Orlowski, R.Z., Gercheva, L., Williams, C., Sutherland, H., Robak, T., Masszi, T., Goranova-Marinova, V., Dimopoulos, M.A., Cavenagh, J.D., Spicka, I., et al. A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma. Am J Hematol 90 (2015), 42–49.
    • (2015) Am J Hematol , vol.90 , pp. 42-49
    • Orlowski, R.Z.1    Gercheva, L.2    Williams, C.3    Sutherland, H.4    Robak, T.5    Masszi, T.6    Goranova-Marinova, V.7    Dimopoulos, M.A.8    Cavenagh, J.D.9    Spicka, I.10
  • 50
    • 85018193822 scopus 로고    scopus 로고
    • Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple myeloma: an open-label phase I trial
    • Shah, J.J., Feng, L., Thomas, S.K., Berkova, Z., Weber, D.M., Wang, M., Qazilbash, M.H., Champlin, R.E., Mendoza, T.R., Cleeland, C., et al. Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple myeloma: an open-label phase I trial. Blood Cancer J, 6, 2016, e396.
    • (2016) Blood Cancer J , vol.6 , pp. e396
    • Shah, J.J.1    Feng, L.2    Thomas, S.K.3    Berkova, Z.4    Weber, D.M.5    Wang, M.6    Qazilbash, M.H.7    Champlin, R.E.8    Mendoza, T.R.9    Cleeland, C.10
  • 53
    • 85016429607 scopus 로고    scopus 로고
    • Peficitinib, a JAK inhibitor, in the treatment of moderate-to-severe rheumatoid arthritis in patients with an inadequate response to methotrexate
    • Kivitz, A., Gutierrez-Ureña, S., Poiley, J., Genovese, M., Kristy, R., Shay, K., Wang, X., Garg, J., Zubrzycka-Sienkiewicz, A., Peficitinib, a JAK inhibitor, in the treatment of moderate-to-severe rheumatoid arthritis in patients with an inadequate response to methotrexate. Arthritis Rheum 69 (2017), 709–719.
    • (2017) Arthritis Rheum , vol.69 , pp. 709-719
    • Kivitz, A.1    Gutierrez-Ureña, S.2    Poiley, J.3    Genovese, M.4    Kristy, R.5    Shay, K.6    Wang, X.7    Garg, J.8    Zubrzycka-Sienkiewicz, A.9
  • 54
    • 84924324722 scopus 로고    scopus 로고
    • Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response
    • Kikuchi, J., Hashizume, M., Kaneko, Y., Yoshimoto, K., Nishina, N., Takeuchi, T., Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response. Arthritis Res Ther, 17, 2015, 10.
    • (2015) Arthritis Res Ther , vol.17 , pp. 10
    • Kikuchi, J.1    Hashizume, M.2    Kaneko, Y.3    Yoshimoto, K.4    Nishina, N.5    Takeuchi, T.6
  • 55
    • 84978389803 scopus 로고    scopus 로고
    • The balance between Foxp3 and Ror-gammat expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis
    • The ratio of Foxp3/Ror-ɣt decreased after abatacept treatment and increased after treatment with tocilizumab.
    • Tada, Y., Ono, N., Suematsu, R., Tashiro, S., Sadanaga, Y., Tokuda, Y., Ono, Y., Nakao, Y., Maruyama, A., Ohta, A., et al. The balance between Foxp3 and Ror-gammat expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis. BMC Musculoskelet Disord, 17, 2016, 290 The ratio of Foxp3/Ror-ɣt decreased after abatacept treatment and increased after treatment with tocilizumab.
    • (2016) BMC Musculoskelet Disord , vol.17 , pp. 290
    • Tada, Y.1    Ono, N.2    Suematsu, R.3    Tashiro, S.4    Sadanaga, Y.5    Tokuda, Y.6    Ono, Y.7    Nakao, Y.8    Maruyama, A.9    Ohta, A.10
  • 57
    • 84926471653 scopus 로고    scopus 로고
    • High levels of natural killer cells are associated with response to tocilizumab in patients with severe rheumatoid arthritis
    • Daïen, C.I., Gailhac, S., Audo, R., Mura, T., Hahne, M., Combe, B., Morel, J., High levels of natural killer cells are associated with response to tocilizumab in patients with severe rheumatoid arthritis. Rheumatology 54 (2014), 601–608.
    • (2014) Rheumatology , vol.54 , pp. 601-608
    • Daïen, C.I.1    Gailhac, S.2    Audo, R.3    Mura, T.4    Hahne, M.5    Combe, B.6    Morel, J.7
  • 58
    • 85043764994 scopus 로고    scopus 로고
    • Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers
    • Weinhold, K.J., Bukowski, J.F., Brennan, T.V., Noveck, R.J., Staats, J.S., Lin, L., Stempora, L., Hammond, C., Wouters, A., Mojcik, C.F., et al. Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers. Clin Immunol 191 (2018), 10–20.
    • (2018) Clin Immunol , vol.191 , pp. 10-20
    • Weinhold, K.J.1    Bukowski, J.F.2    Brennan, T.V.3    Noveck, R.J.4    Staats, J.S.5    Lin, L.6    Stempora, L.7    Hammond, C.8    Wouters, A.9    Mojcik, C.F.10
  • 60
    • 85049175389 scopus 로고    scopus 로고
    • A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases
    • Novel therapeutic targeting of IL-17A and IL-6R with potential for enhanced efficiency.
    • Lyman, M., Lieuw, V., Richardson, R., Timmer, A., Stewart, C., Granger, S., Woods, R., Silacci, M., Grabulovski, D., Newman, R., A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases. J Biol Chem 293 (2018), 9326–9334 Novel therapeutic targeting of IL-17A and IL-6R with potential for enhanced efficiency.
    • (2018) J Biol Chem , vol.293 , pp. 9326-9334
    • Lyman, M.1    Lieuw, V.2    Richardson, R.3    Timmer, A.4    Stewart, C.5    Granger, S.6    Woods, R.7    Silacci, M.8    Grabulovski, D.9    Newman, R.10


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