메뉴 건너뛰기




Volumn 201, Issue 4, 2018, Pages 1144-1153

Effector T cell resistance to suppression and stat3 signaling during the development of human type 1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 85051278007     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1701199     Document Type: Article
Times cited : (22)

References (38)
  • 1
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone, J. A., K. Herold, and G. Eisenbarth. 2010. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464: 1293-1300.
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 2
    • 73249136970 scopus 로고    scopus 로고
    • Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population
    • Siljander, H. T. A., S. Simell, A. Hekkala, J. Lähde, T. Simell, P. Vähäsalo, R. Veijola, J. Ilonen, O. Simell, and M. Knip. 2009. Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes 58: 2835-2842.
    • (2009) Diabetes , vol.58 , pp. 2835-2842
    • Siljander, H.T.A.1    Simell, S.2    Hekkala, A.3    Lähde, J.4    Simell, T.5    Vähäsalo, P.6    Veijola, R.7    Ilonen, J.8    Simell, O.9    Knip, M.10
  • 6
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider, A., M. Rieck, S. Sanda, C. Pihoker, C. Greenbaum, and J. H. Buckner. 2008. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J. Immunol. 181: 7350-7355.
    • (2008) J. Immunol. , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5    Buckner, J.H.6
  • 7
    • 55449111318 scopus 로고    scopus 로고
    • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
    • Lawson, J.M., J. Tremble, C. Dayan, H. Beyan, R. D. G. Leslie,M. Peakman, and T. I. M. Tree. 2008. Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin. Exp. Immunol. 154: 353-359.
    • (2008) Clin. Exp. Immunol. , vol.154 , pp. 353-359
    • Lawson, J.M.1    Tremble, J.2    Dayan, C.3    Beyan, H.4    Leslie, R.D.G.5    Peakman, M.6    Tree, T.I.M.7
  • 8
    • 47249145164 scopus 로고    scopus 로고
    • Reduced CD4+,CD25-T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus
    • Venigalla, R. K., T. Tretter, S. Krienke, R. Max, V. Eckstein, N. Blank, C. Fiehn, A. D. Ho, and H. M. Lorenz. 2008. Reduced CD4+,CD25-T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum. 58: 2120-2130.
    • (2008) Arthritis Rheum. , vol.58 , pp. 2120-2130
    • Venigalla, R.K.1    Tretter, T.2    Krienke, S.3    Max, R.4    Eckstein, V.5    Blank, N.6    Fiehn, C.7    Ho, A.D.8    Lorenz, H.M.9
  • 9
    • 84874099546 scopus 로고    scopus 로고
    • In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling
    • Schneider, A., S. A. Long, K. Cerosaletti, C. T. Ni, P. Samuels, M. Kita, and J. H. Buckner. 2013. In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling. Sci. Transl. Med. 5: 170ra15.
    • (2013) Sci. Transl. Med. , vol.5 , pp. 170ra15
    • Schneider, A.1    Long, S.A.2    Cerosaletti, K.3    Ni, C.T.4    Samuels, P.5    Kita, M.6    Buckner, J.H.7
  • 13
    • 84973517700 scopus 로고    scopus 로고
    • Breaking free of control: How conventional T cells overcome regulatory T cell suppression
    • Mercadante, E. R., and U. M. Lorenz. 2016. Breaking free of control: how conventional T cells overcome regulatory T cell suppression. Front. Immunol. 7: 193.
    • (2016) Front. Immunol. , vol.7 , pp. 193
    • Mercadante, E.R.1    Lorenz, U.M.2
  • 14
    • 79953172216 scopus 로고    scopus 로고
    • Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression
    • Goodman, W. A., A. B. Young, T. S. McCormick, K. D. Cooper, and A. D. Levine. 2011. Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression. J. Immunol. 186: 3336-3345.
    • (2011) J. Immunol. , vol.186 , pp. 3336-3345
    • Goodman, W.A.1    Young, A.B.2    McCormick, T.S.3    Cooper, K.D.4    Levine, A.D.5
  • 15
    • 84885406632 scopus 로고    scopus 로고
    • Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis. [Published erratum appears in 2013 PLoS One 8.]
    • Trinschek, B., F. Luessi, J. Haas, B.Wildemann, F. Zipp, H.Wiendl, C. Becker, and H. Jonuleit. 2013. Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis. [Published erratum appears in 2013 PLoS One 8.] PLoS One 8: e77634.
    • (2013) PLoS One , vol.8 , pp. e77634
    • Trinschek, B.1    Luessi, F.2    Haas, J.3    Wildemann, B.4    Zipp, F.5    Wiendl, H.6    Becker, C.7    Jonuleit, H.8
  • 16
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter, C. A., and S. A. Jones. 2015. IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16: 448-457.
    • (2015) Nat. Immunol. , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 19
    • 84891542721 scopus 로고    scopus 로고
    • Patterns of b-cell autoantibody appearance and genetic associations during the first years of life
    • Ilonen, J., A. Hammais, A.-P. Laine, J. Lempainen, O. Vaarala, R. Veijola, O. Simell, and M. Knip. 2013. Patterns of b-cell autoantibody appearance and genetic associations during the first years of life. Diabetes 62: 3636-3640.
    • (2013) Diabetes , vol.62 , pp. 3636-3640
    • Ilonen, J.1    Hammais, A.2    Laine, A.-P.3    Lempainen, J.4    Vaarala, O.5    Veijola, R.6    Simell, O.7    Knip, M.8
  • 20
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann, P., R. Eder, T. J. Boeld, K. Doser, B. Piseshka, R. Andreesen, and M. Edinger. 2006. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108: 4260-4267.
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3    Doser, K.4    Piseshka, B.5    Andreesen, R.6    Edinger, M.7
  • 24
    • 84924363000 scopus 로고    scopus 로고
    • Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6
    • Bhela, S., C. Kempsell, M. Manohar, M. Dominguez-Villar, R. Griffin, P. Bhatt, P. Kivisakk-Webb, R. Fuhlbrigge, T. Kupper, H. Weiner, and C. Baecher-Allan. 2015. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J. Immunol. 194: 2180-2189.
    • (2015) J. Immunol. , vol.194 , pp. 2180-2189
    • Bhela, S.1    Kempsell, C.2    Manohar, M.3    Dominguez-Villar, M.4    Griffin, R.5    Bhatt, P.6    Kivisakk-Webb, P.7    Fuhlbrigge, R.8    Kupper, T.9    Weiner, H.10    Baecher-Allan, C.11
  • 26
    • 78751690647 scopus 로고    scopus 로고
    • Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita, R., N. Schmitt, S.-E. Bentebibel, R. Ranganathan, L. Bourdery, G. Zurawski, E. Foucat, M. Dullaers, S. Oh, N. Sabzghabaei, et al. 2011. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 34: 108-121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.-E.3    Ranganathan, R.4    Bourdery, L.5    Zurawski, G.6    Foucat, E.7    Dullaers, M.8    Oh, S.9    Sabzghabaei, N.10
  • 28
    • 84894266980 scopus 로고    scopus 로고
    • Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes
    • Xu, X., Y. Shi, Y. Cai, Q. Zhang, F. Yang, H. Chen, Y. Gu, M. Zhang, L. Yu, and T. Yang. 2013. Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes. PLoS One 8: e79858.
    • (2013) PLoS One , vol.8 , pp. e79858
    • Xu, X.1    Shi, Y.2    Cai, Y.3    Zhang, Q.4    Yang, F.5    Chen, H.6    Gu, Y.7    Zhang, M.8    Yu, L.9    Yang, T.10
  • 29
    • 84955510046 scopus 로고    scopus 로고
    • Increased blood levels of growth factors, proinflammatory cytokines, and Th17 cytokines in patients with newly diagnosed type 1 diabetes
    • Alnek, K., K. Kisand, K. Heilman, A. Peet, K. Varik, and R. Uibo. 2015. Increased blood levels of growth factors, proinflammatory cytokines, and Th17 cytokines in patients with newly diagnosed type 1 diabetes. PLoS One 10: e0142976.
    • (2015) PLoS One , vol.10 , pp. e0142976
    • Alnek, K.1    Kisand, K.2    Heilman, K.3    Peet, A.4    Varik, K.5    Uibo, R.6
  • 30
    • 85016947362 scopus 로고    scopus 로고
    • Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the diabetes autoimmunity study in the young (DAISY)
    • Waugh, K., J. Snell-Bergeon, A. Michels, F. Dong, A. K. Steck, B. I. Frohnert, J. M. Norris, and M. Rewers. 2017. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the diabetes autoimmunity study in the young (DAISY). PLoS One 12: e0174840.
    • (2017) PLoS One , vol.12 , pp. e0174840
    • Waugh, K.1    Snell-Bergeon, J.2    Michels, A.3    Dong, F.4    Steck, A.K.5    Frohnert, B.I.6    Norris, J.M.7    Rewers, M.8
  • 31
    • 85014530182 scopus 로고    scopus 로고
    • Correlation between serum interleukin-6 level and type 1 diabetes mellitus: A systematic review and meta-analysis
    • Chen, Y.-L., Y.-C. Qiao, Y.-H. Pan, Y. Xu, Y.-C. Huang, Y.-H. Wang, L.-J. Geng, H.-L. Zhao, and X.-X. Zhang. 2017. Correlation between serum interleukin-6 level and type 1 diabetes mellitus: a systematic review and meta-analysis. Cytokine 94: 14-20.
    • (2017) Cytokine , vol.94 , pp. 14-20
    • Chen, Y.-L.1    Qiao, Y.-C.2    Pan, Y.-H.3    Xu, Y.4    Huang, Y.-C.5    Wang, Y.-H.6    Geng, L.-J.7    Zhao, H.-L.8    Zhang, X.-X.9
  • 35
    • 80755148666 scopus 로고    scopus 로고
    • Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
    • Ferraro, A., C. Socci, A. Stabilini, A. Valle, P. Monti, L. Piemonti, R. Nano, S. Olek, P. Maffi, M. Scavini, et al. 2011. Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes 60: 2903-2913.
    • (2011) Diabetes , vol.60 , pp. 2903-2913
    • Ferraro, A.1    Socci, C.2    Stabilini, A.3    Valle, A.4    Monti, P.5    Piemonti, L.6    Nano, R.7    Olek, S.8    Maffi, P.9    Scavini, M.10
  • 38
    • 84959275546 scopus 로고    scopus 로고
    • Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes
    • Buckner, J. H., and G. T. Nepom. 2016. Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes. J. Autoimmun. 71: 44-50.
    • (2016) J. Autoimmun. , vol.71 , pp. 44-50
    • Buckner, J.H.1    Nepom, G.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.