Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2

Journal of Biological Chemistry

Volumn 293, Issue 32, 2018, Pages 12634-12646

  Sudom, Athena ^a   Talreja, Santosh ^a   Danao, Jean ^a   Bragg, Eric ^a   Kegel, Rob ^a,b   Min, Xiaoshan ^a   Richardson, Jason ^a   Zhang, Zhongqi ^a   Sharkov, Nikolai ^a,c   Marcora, Edoardo ^a,d   Thibault, Steve ^a   Bradley, Jodi ^a   Wood, Steve ^a   Lim, Ai Ching ^a   Chen, Hang ^a,e   Wang, Songli ^a   Foltz, Ian N ^a   Sambashivan, Shilpa ^a,f   Wang, Zhulun ^a  

^a AMGEN INC   (United States)

^b USA   (United States)

^c NGM Biopharmaceuticals   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e Denali Therapeutics   (United States)

^f Proneurotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS;

ALZHEIMER'S DISEASE; COMPLEMENTARITY-DETERMINING REGIONS; EXTRACELLULAR LIGANDS; FUNCTIONAL ACTIVITIES; HIGH-RESOLUTION STRUCTURES; LIGAND INTERACTIONS; MOLECULAR MECHANISM; PHOSPHATIDYLSERINE;

NEURODEGENERATIVE DISEASES;

ARGININE; PHOSPHATIDYLSERINE; R47H PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; CDR2 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; LIGAND; MEMBRANE PROTEIN; MUTANT PROTEIN; NERVE PROTEIN; TREM2 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LOSS OF FUNCTION MUTATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; RISK FACTOR; WILD TYPE; CHEMISTRY; DENDRITIC CELL; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; MACROPHAGE; MICROGLIA; OSTEOCLAST; PATHOLOGY; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; CRYSTALLOGRAPHY, X-RAY; DENDRITIC CELLS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LIGANDS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICROGLIA; MUTANT PROTEINS; NERVE TISSUE PROTEINS; OSTEOCLASTS; PROTEIN CONFORMATION; PROTEIN DOMAINS; RECEPTORS, IMMUNOLOGIC;

EID: 85051322986     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.RA118.00235     Document Type: Article

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