Microemulsion systems and their potential as drug carriers

Microemulsions: Properties and Applications

Volumn , Issue , 2008, Pages 247-292

  Alany, Raid G ^a   Maghraby, Gamal M M El ^b   Krauel Goellner, Karen ^c   Graf, Anja ^d  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c MASSEY UNIVERSITY   (New Zealand)

^d UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85051162176     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420089608     Document Type: Chapter

References (160)

1. Danielsson, I. and Lindman, B. 1981. The definition of microemulsion. Colloid and Surfaces, 3, 391.
2. Tenjarla, S. 1999. Microemulsions: An overview and pharmaceutical applications. Critical Reviews in Therapeutic Drug Carrier Systems, 16(5), 461–521.
3. Attwood, D. 1994. Microemulsions. In Kreuter, J. (Ed.), Colloidal Drug Delivery Systems (pp. 31–71). New York: Marcel Dekker.
4. Lawrence, M. J. and Rees, G. D. 2000. Microemulsion-based media as novel drug delivery systems. Advanced Drug Delivery Reviews, 45(1), 89–121.
5. Mitchell, D. and Ninham, W. 1981. Micelles vesicles and microemulsions. Journal of Chemical Society Faraday Transactions, 77(2), 601–629.
6. Israelachvili, J. N., Mitchell, D., and Ninham, W. 1976. Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers. Journal of Chemical Society Faraday Transactions II, 72, 1525–1568.
7. Prince, L. M. 1977. Formulation. In Prince, L. M. (Ed.), Microemulsions: Theory and Practice (pp. 33–49). New York: Academic Press.
8. Shinoda, K. and Kuineda, H. 1973. Condition to produce so-called microemulsions: Factors to increase mutual solubility of oil and water solubilisers. Journal of Colloid and Interface Science, 42, 381–387.
9. Aboofazeli, R., Lawrence, C. B., Wicks, S. R., and Lawrence, M. J. 1994. Investigations into the formation and characterization of phospholipid microemulsions. Part 3. Pseudo-ternary phase diagrams of systems containing water–lecithin–isopropyl myristate and either an alkanoic acid, amine, alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant. International Journal of Pharmaceutics, 111, 63–72.
10. Kahlweit, M., Busse, G., and Faulhaber, B. 1995. Preparing microemulsions with alkyl monoglucosides and the role of n-alkanols. Langmuir, 11(9), 3382–3387.
11. Alany, R. G., Rades, T., Agatonovic-Kustrin, S., Davies, N. M., and Tucker, I. G. 2000. Effects of alcohols and diols on the phase behaviour of quaternary systems. International Journal of Pharmaceutics, 196(2), 141–145.
12. FDA. (Revised as of April 1, 2001). Food and Drugs, Chapter 1. Food and Drug Administration. In Department of Health and Human Services (Ed.), Code of Federal Regulations, Title 21 (Vol. 3): U.S. Government Printing Office via GPO Access.
13. Thevenin, M. A., Grossiord, J. L., and Poelman, M. C. 1996. Sucrose esters cosurfactant microemulsion systems for transdermal delivery—Assessment of bicontinuous structures. International Journal of Pharmaceutics, 137(2), 177–186.
14. Malcolmson, C., Satra, C., Kantaria, S., Sidhu, A., and Lawrence, M. J. 1998. Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-in-water microemulsions. Journal of Pharmaceutical Sciences, 87(1), 109–116.
15. Ho, H. O., Hsiao, C. C., and Sheu, M. T. 1996. Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. Journal of Pharmaceutical Sciences, 85(2), 138–143.
16. Kuineda, H., Hasegawa, Y., John, A. C., Naito, M., and Muto, M. 1996. Phase behaviour of polyoxyethylene hydrogenated caster oil in oil/water systems. Colloid and Surfaces, 109, 209–216.
17. Agatonovic-Kustrin, S., Glass, B. D., Wisch, M. H., and Alany, R. G. 2003. Prediction of a stable microemulsion formulation for the oral delivery of a combination of antitubercular drugs using ANN methodology. Pharmaceutical Research, 20(11), 1760–1765.
18. Aboofazeli, R. and Lawrence, M. J. 1993. Investigations into the formation and characterization of phospholipid microemulsions. Part 1. Pseudo-ternary phase diagrams of systems containing water–lecithin–alcohol–isopropyl myristate. International Journal of Pharmaceutics, 93(May 31), 161–175.
19. Aboofazeli, R. and Lawrence, M. J. 1994. Investigations into the formation and characterization of phospholipid microemulsions. Part 2. Pseudo-ternary phase diagrams of systems containing water–lecithin–isopropyl myristate and alcohol: Influence of purity of lecithin. International Journal of Pharmaceutics, 106, 51–61.
20. Aboofazeli, R., Patel, N., Thomas, M., and Lawrence, M. J. 1995. Investigations into the formation and characterization of phospholipid microemulsions. 4. Pseudoternary phase diagrams of systems containing water–lecithin–alcohol and oil—the influence of oil. International Journal of Pharmaceutics, 125(1), 107–116.
21. Shinoda, K., Araki, M., Sadaghiani, A., Khan, A., and Lindman, B. 1991. Lecithinbased microemulsions; phase behaviour and microstructure. Journal of Physical Chemistry, 95, 989–993.
22. Saint-Ruth, H., Attwood, D., Ktistis, G., and Taylor, C. J. 1995. Phase studies and particle size analysis of oil-in-water phospholipid microemulsions. International Journal of Pharmaceutics, 116, 253–261.
23. Warisnoicharoen, W., Lansley, A. B., and Lawrence, M. J. 2000. Nonionic oil-inwater microemulsions: The effect of oil type on phase behaviour. International Journal of Pharmaceutics, 198(1), 7–27.
24. Park, K. M., Lee, M. K., Hwang, K. J., and Kim, C. K. 1999. Phospholipid-based microemulsions of flurbiprofen by the spontaneous emulsification process. International Journal of Pharmaceutics, 183(2), 145–154.
25. Constantinides, P. P. 1995. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharmaceutical Research, 12(Nov.), 1561–1572.
26. Constantinides, P. P., Lancaster, C. M., Marcello, J., Chiossone, D. C., Orner, D., Hidalgo, I., et al. 1995. Enhanced intestinal absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle size. Journal of Controlled Release, 34, 109–116.
27. Constantinides, P. P. and Yiv, S. H. 1995. Particle size determination of phaseinverted water-in-oil microemulsions under different dilution and storage conditions. International Journal of Pharmaceutics, 115(Mar. 7), 225–234.
28. Constantinides, P. P., Welzel, G., Ellens, H., Smith, P. L., Sturgis, S., Yiv, S. H., et al. 1996. Water-in-oil microemulsions containing medium-chain fatty acids/salts: Formulation and intestinal absorption enhancement evaluation. Pharmaceutical Research, 13(2), 210–215.
29. Kahlweit, M., Busse, G., Faulhaber, B., and Eibl, H. 1995. Preparing nontoxic microemulsions. Langmuir, 11(11), 4185–4187.
30. Kahlweit, M., Busse, G., and Faulhaber, B. 1996. Preparing microemulsions with alkyl monoglucosides and the role of alkanediols as cosolvents. Langmuir, 12, 861–862.
31. Joubran, R., Parris, N., Lu, D., and Trevino, S. 1994. Synergetic effect of sucrose and ethanol on formation of triglyceride microemulsions. Journal of Dispersion Science and Technology, 15(6), 687–704.
32. Stubenrauch, C., Paeplow, B., and Findenegg, G. H. 1997. Microemulsions supported by octyl monoglucoside and geraniol. 1. The role of alcohol in the interfacial layer. Langmuir, 13, 3652–3658.
33. Bhargava, H. N., Narurkar, A., and Lieb, L. M. 1987. Using microemulsions for drug delivery. Pharmaceutical Technology, 11(Mar.), 46.
34. Bourrel, M., Schechter, R. S. 1988. The R-ratio. In Bourrel, M., Schechter, R. S. (Eds.), Microemulsions and Related Systems (pp. 1–30). New York, Basel: Marcel Dekker.
35. Alany, R. G., Davies, N. M., Tucker, I. G., and Rades, T. 2001. Characterising colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems. Drug Development and Industrial Pharmacy, 27(1), 33–41.
36. Alany, R. G., Agatonovic-Kustrin, S., Rades, T., and Tucker, I. G. 1999. Use of artificial neural networks to predict quaternery phase systems from limited experimental data. Journal of Pharmaceutical and Biomedical Analysis, 19(3–4), 443–452.
37. Richardson, C. J., Mbanefo, A., Aboofazeli, R., Lawrence, M. J., and Barlow, D. J. 1997. Prediction of phase behavior in microemulsion systems using artificial neural networks. Journal of Colloid and Interface Science, 187(2), 296–303.
38. Flanagan, J. and Singh, H. 2006. Recent Advances in the delivery of food-derived bioactives and drugs using microemulsions. In Mozafari, R. M. (Ed.), Nanocarrier Technologies: Frontiers of Nanotherapy (pp. 95–112). Dordrecht, The Netherlands: Springer.
39. Koshnevis, P., Mortazavi, S. A., Lawrence, M. J., and Aboofazeli, R. 1997. In-vitro release of sodium salicylate from water-in-oil phospholipid microemulsions. Journal of Pharmacy and Pharmacology, 49(S4), 47.
40. Krauel, K., Davies, N. M., and Rades, T. 2005. Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerisation. Journal of Controlled Release, 106(1–2), 76–87.
41. Podlogar, F., Gasperlin, M., Tomsic, M., Jamnik, A., and Bester Rogac, M. 2004. Structural characterisation of water–Tween 40/Imwitor 308–isopropyl myristate microemulsion using different experimental methods. International Journal of Pharmaceutics, 276, 115–128.
42. Stilbs, P. 1986. A comparative study of micellar solubilisation for combination of surfactants and solubilisates using Fourier transform pulsed-gradient spin-echo NMR multicomponent self-diffusion technique. Journal of Colloid and Interface Science, 94(2), 463–469.
43. Krauel, K., Girvan, L., Hook, S. M., and Rades, T. 2007. Characterisation of colloidal drug delivery systems: From the naked eye to cryoFESEM. Micron, 38, 796–803.
44. Regev, O., Ezrahi, S., Aserin, A., Garti, N., Wachtel, E., Kaler, E. W., Khan, A., and Talmon, Y. 1996. A study of the microstructure of a four-component nonionic microemulsion by Cryo-TEM, NMR, SAXS, and SANS. Langmuir, 12(3), 668–674.
45. Nagarajan, R. and Ruckenstein, E. 2000. Molecular theory of microemulsions. Langmuir, 16, 6400–6415.
46. Djordjevic, L., Primorac, M., Stupar, M., and Krajisnik, D. 2004. Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. International Journal of Pharmaceutics, 271(1–2), 11–19.
47. Mehta, S., Kaur, G., and Bhasin, K. 2007. Incorporation of antitubercular drug isoniazid in pharmaceutically accepted microemulsion: Effect on microstructure and physical parameters. Pharmaceutical Research, 25(1), 227–236.
48. Constantinides, P. P. and Scalart, J.-P. 1997. Formulation and physical characterization of water-in-oil microemulsions containing long- versus medium-chain glycerides. International Journal of Pharmaceutics, 158(1), 57–68.
49. Graetz, K., Helmstedt, M., Meyer, H. M., and Quitzsch, K. 1998. Structure and phase behaviour of the ternary system water, n-heptane and the nonionic surfactant Igepal CA 520. Colloid and Polymer Science, 276(2), 131–137.
50. Collings, P. J. 2002. Liquid crystals: Natures’s Delicate Phase of matter. Princeton, NJ: Princeton University Press.
51. Collings, P. J. and Hird, M. 1997. Introduction to Liquid Crystals: Chemistry and Physics. London, UK: Taylor & Francis Ltd.
52. Sinko, P. J. and Martin, A. N. 2006. Martin’s Physical Pharmacy and Pharmaceutical Sciences: Physical Chemical and Biopharmaceutical Principles in the Pharmaceutical Sciences. Philadelphia, PA: Lippincott Williams & Wilkins.
53. Laguës, M. and Sauterey, C. 1980. Percolation transition in water in oil microemulsions: Electrical conductivity measurements. Journal of Physical Chemistry, 84, 3503–3508.
54. Mehta, S. K. and Bala, K. 2000. Tween-based microemulsions: A percolation view. Fluid Phase Equilibria, 172(2), 197–209.
55. Mehta, S. K. and Bala, K. 1995. Volumetric and transport properties in microemulsions and the point of view of percolation theory. Physical Review E, 51(6), 5732.
56. Strey, R. 1994. Microemulsion microstructure and interfacial curvature. Colloid and Polymer Science, 272(8), 1005–1019.
57. Baroli, B., Lopez-Quintela, M. A., Delgado-Charro, M. B., Fadda, A. M., and Blanco-Mendez, J. 2000. Microemulsions for topical delivery of 8-methoxsalen. Journal of Controlled Release, 69(1), 209–218.
58. Kumar, P. and Mittal, K. L. 1999. Handbook of Microemulsion Science and Technology. New York: Marcel Dekker, Inc.
59. Einstein, A. 1906. New determination of molecular dimensions. Annalen der Physik, 19, 289–305.
60. Einstein, A. 1911. Eine neue Bestimmung der Moleküldimensionen. Annalen der Physik, 34, 591–592.
61. Attwood, D., Currie, L. R. J., and Elworthy, P. H. 1974. Studies of solubilised micellar solutions. Journal of Colloid and Interface Science, 46, 261–265.
62. Krauel, K. 2005. Formulation and Characterisation of Nanoparticles Based on Biocompatible Microemulsions. Dunedin: School of Pharmacy, University of Otago, p. 231.
63. D’Antona, P., Parker, W. O., Zanirato, M. C., Esposito, E., and Nastruzzi, C. 2000. Rheologic and NMR characterization of monoglyceride-based formulations. Journal of Biomedical Materials Research, 52(1), 40–52.
64. Kriwet, K. and Mueller-Goymann, C. C. 1995. Diclofenac release from phospholipid drug systems and permeation through excised human stratum corneum. International Journal of Pharmaceutics, 125(2), 231–242.
65. Craig, D. Q. M. and Reading M. 2006. Thermal Analysis of Pharmaceuticals. Boca Raton, FL: CRC Press.
66. Garti, N., Aserin, A., Tiunova, I., and Fanun, M. A. 2000. DSC study of water behaviour in water-in-oil microemulsions stabilized by sucrose esters and butanol. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 170(1), 1–18.
67. Moulik, S. P. and Paul, B. K. 1998. Structure, dynamics and transport properties of microemulsions. Advances in Colloid and Interface Science, 78(2), 99–195.
68. Price, W. S. 1997. Pulsed-field gradient nuclear magnetic resonance as a tool for studying translational diffusion: Part I. Basic theory. Concepts in Magnetic Resonance, 9(5), 299–336.
69. Stilbs, P. 1987. Fourier transform pulsed-gradient spin-echo studies of molecular diffusion. Progress in NMR Spectroscopy, 19(1), 1–45.
70. Södermann, O. and Stilbs, P. 1994. NMR studies of complex surfactant systems. Progress in NMR Spectroscopy, 26, 445–482.
71. Stilbs, P. 1999. Diffusion studied using NMR spectroscopy. In Tranter, G., Holmes, J., Lindon, J. (Eds.), Encyclopedia of Spectroscopy and Spectrometry (pp. 369–374). London, UK: Academic Press.
72. Kärger, J., Pfeiffer, H., and Heink, W. 1988. Principles and application for selfdiffusion measurements by nuclear magnetic resonance. Advances in Magnetic Resonance, 12, 2–89.
73. Stilbs, P. 1987. Fourier transform pulsed-gradient spin-echo studies of molecular diffusion. Progress in Nuclear Magnetic Resonance Spectroscopy, 19(1), 1–45.
74. Lindmann, B. and Stilbs, P. 1987. Molecular diffusion in microemulsions. In: Friberg, S. E., Bothorel, P. (Eds.), Microemulsions: Structure and Dynamics (pp. 119–152). Boca Raton, FL: CRC Press.
75. Jönsson, B., Lindman, B., Holmberg, K., and Kronberg, K. 1998. Surfactants and Polymers in Aqueous Solution. Chichester, UK: John Wiley & Sons.
76. Biruss, B., Kahlig, H., Valenta, C. 2007. Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones. International Journal of Pharmaceutics, 328(2), 142–151.
77. Kreilgaard, M., Pedersen, E. J., Jaroszewski, J. W. 2000. NMR characterisation and transdermal drug delivery potential of microemulsion systems. Journal of Controlled Release, 69(3), 421–433.
78. Burauer, S., Belkoura, L., Stubenrauch, C., and Strey, R. 2003. Bicontinuous microemulsions revisited: A new approach to freeze fracture electron microscopy (FFEM). Colloids and Surfaces A: Physicochemical Engineering Aspects, 228, 159–170.
79. Bellare, J. R., Davis, H. T., Scriven, L. E., and Talmon, Y. 1988. Controlled environment vitrification system: An improved sample preparation technique. Journal of Electron Microscopy Technique, 10(1), 87–111.
80. Marchand, K. E., Tarret, M., Lechaire, J. P., Normand, L., Kasztelan, S., and Cseri, T. 2003. Investigation of AOT-based microemulsions for the controlled synthesis of MoSx nanoparticles: An electron microscopy study. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 214(1–3), 239–248.
81. Magdassi, S., Ben Moshe, M., Talmon, Y., and Danino, D. 2003. Microemulsions based on anionic gemini surfactant. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 212(1), 1–7.
82. Spicer, P. T., Small, W. B., Lynch, M. L., and Burns, J. L. 2002. Dry powder precursors of cubic liquid crystalline nanoparticles (cubosomes). Journal of Nanoparticle Research, 4(4), 297–311.
83. Sanders, M., Brown, L., Deliyannis, G., and Pearse, M. 2005. ISCOM(TM)-based vaccines: The second decade. Immunology and Cell Biology, 83(2), 119–128.
84. Agarwal, V., Singh, M., McPherson, G., John, V., and Bose, A. 2004. Freeze fracture direct imaging of a viscous surfactant mesophase. Langmuir, 20(1), 11–15.
85. Krauel, K., Girvan, L., Hook, S., and Rades, T. 2007. Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. Micron, 38(8), 796–803.
86. Graf, A., Ablinger, E., Peters, S., Zimmer, A., Hook, S. M., and Rades, T. 2008. Microemulsions containing lecithin and sugar-based surfactants: Nanoparticle templates for delivery of proteins and peptides. International Journal of Pharmaceutics, 350(1–2), 351–360, 2008.
87. Narang, A. S., Delmarre, D., and Gao, D. 2007. Stable drug encapsulation in micelles and microemulsions. Advanced Drug Delivery Reviews, 345, 9–25.
88. Cho, Y. W. and Flynn, M. 1989. Oral delivery of insulin. Lancet, 2, 1518–1519.
89. Kraeling, M. E. and Ritschel, W. A. 1992. Development of a colonic release capsule dosage form and the absorption of insulin. Methods and Findings in Experimental and Clinical Pharmacology, 14, 199–209.
90. Cilek, A., Celebi, N., Tirnaksiz, F., and Tay, A. 2005. A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats. International Journal of Pharmaceutics, 298, 176–185.
91. Zheng, J. Y. and Fulu, M. Y. 2006. Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide micro emulsion. International Journal of Pharmaceutics, 307, 209–215.
92. Lyons, K. C., Charman, W. N., Miller, R., and Porter, C. J. 2000. Factors limiting the oral bioavailability of N-acetylglucosaminyl-N-acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion. International Journal of Pharmaceutics, 199, 17–28.
93. Celebi, N., Turkyilmaz, A., Gonul, B., and Ozogul, C. 2002. Effects of epidermal growth factor microemulsion formulation on the healing of stress-induced gastric ulcers in rats. Journal of Controlled Release, 83, 197–210.
94. Schuleit, M. and Luisi, P. L. 2001. Enzyme immobilization in silica-hardened organogels. Biotechnology and Bioengineering, 72, 249–253.
95. Madamwar, D. and Thakar, A. 2004. Entrapment of enzyme in water-restricted microenvironment for enzyme-mediated catalysis under microemulsion based organogels. Applied Biochemistry and Biotechnology, 118, 361–369.
96. Shah, N. H., Carvajal, M. T., Patel, C. I., Infeld, M. H., and Malick, A. W. 1994. Self emulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. International Journal of Pharmaceutics, 106, 15–23.
97. Ritschel, W.A. 1996. Microemulsion technology in the reformulation of cyclosporine: The reason behind the pharmacokinetic properties of Neoral. Clinical Transplantation, 10, 364–373.
98. Vondercher J, and Meizner A. 1994. Rationale for the development of Sandimmune Neoral. Transplantation Proceedings, 26, 2925–2927.
99. Meinzer A, Mueller E, and Vonderscher J. 1995. Microemulsion—a suitable galenical approach for the absorption enhancement of low soluble compounds? B T Gattefosse, 88, 21–26.
100. Gao, P., Rush, B. D., Pfund, W. P., Huang, T., Bauer, J. M., Morozowich, W., Kuo, M. S., and Hageman, M. J. 2003. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. Journalof Pharmaceutical Sciences, 92, 2386–2398.
101. Swenson ES. and Curatolo WJ. 1992. Means to enhance penetration. Advanced Drug Delivery Reviews, 8, 39–92.
102. Kim, H. J., Yoon, K. A., Hahn, M., Park, E. S., and Chi, S. C. 2000. Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone. Drug Development and Industrial Pharmacy, 26, 523–529.
103. Sha, X., Yan, G., Wu, Y., Li, J., and Fang, X. 2005. Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. European Journal of Pharmaceutical Science, 24, 477–486
104. Dahan, A. and Hoffman, A. 2006. Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: Correlation with in vivo data and the relationship to intra-enterocyte processes in rats. Pharmaceutical Research, 23, 2165–2174.
105. Hugger, E. D., Novak, B. L., Burton, P. S., Audus, K. L., and Borchardt, R. T. 2002. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. Jouranl of Pharmaceutical Sciences, 91, 1991–2002.
106. Cooney, G. F., Jeevanandam, V., Choudhury, S., Feutren, G., Mueller, E. A., and Eisen, H. J. 1998. Comparative bioavailability of Neoral and Sandimmune in cardiac transplant recipients over 1 year. Transplantation ProcEedings, 30, 1892–1894.
107. Porter, C. J. and Charman, W. N. 2001. In vitro assessment of oral lipid based formulations. Advanced Drug Delivery Reviews, 50 (Suppl 1), S127–S147.
108. Barry, B. W. 1983. Dermatological Formulations: Percutaneous Absorption. Marcel Dekker: New York and Basel.
109. Goodman, M. and Barry, B. W. 1988. Action of penetration enhancers on human skin as assessed by permeation of model drugs 5-fluorouracil and estradiol. I. Infi- nite dose technique. The Journal of Investigative Dermatology, 91, 323–327.
110. Megrab, N. A, Williams, A. C., and Barry, B. W. 1995. Oestradiol permeation across human skin and silastic membranes: Effects of propylene glycol and supersaturation. Journal of Controlled Release, 36, 277–294.
111. Miller, L. L., Kolaskie, C. J., Smith, G. A., and Rivier, J. 1990. Transdermal iontophoresis of gonadotropin releasing hormone and two analogues. Journal of Pharmaceutical Sciences, 79, 490–493.
112. Kost, J., Pliquett, U., Mitragotri, S., Yamamoto, A., Langer, R., and Weaver, J. 1996. Synergistic effect of electric field and ultrasound on transdermal transport. Pharmaceutical Research, 13, 633–638.
113. Banga, A. K., Bose, S., and Ghosh, T. K. 1999. Iontophoresis and electroporation: Comparisons and contrasts. International Journal of Pharmaceutics, 179, 1–19.
114. Mezei, M. and Gulasekharam, V. 1980. Liposomes—a selective drug delivery system for topical route of administration. 1. Lotion dosage form. Life Sciences, 26, 1473–1477.
115. El Maghraby, G. M., Williams, A. C., and Barry, B. W. 1999. Skin delivery of oestradiol from deformable and traditional liposomes: Mechanistic studies. Journal of Pharmaceutical Sciences, 51, 1123–1134.
116. El Maghraby, G. M., Williams, A. C., and Barry, B. W. 2006. Can drug bearing liposomes penetrate intact skin? The Journal of Pharmacy and Pharmacology, 58, 415–429.
117. Boltri, L., Morel, S., Trotta, M., and Gasco, M. R. 1994. In vitro transdermal permeation of nifedipine from thickened microemulsion. Journal de Pharmacie de Belgique, 49, 315–320.
118. Delgado-Charro, M. B., Iglesias-Vilas, G., Blanco-Mendez, J., Lopez-Quintela, M. A., and Guy, R. H. 1997. Delivery of a hydrophilic solute through the skin from novel microemulsion systems. European Journal of Pharmaceutics and Biopharmaceutics, 43, 37–42.
119. Kreilgaard, M. 2002. Influence of microemulsions on cutaneous drug delivery. Advanced Drug Delivery Reviews, 54, S77–S98.
120. Kogan, A. and Garti, N. 2006. Microemulsions as transdermal drug delivery vehicles. Advances in Colloid and Interface Science, 123–126, 369–385.
121. Trotta, M., Gasco, M. R., Caputo, O., and Sancin, P. 1994. Transcutaneous diffusion of hematoporphyrin in photodynamic therapy: In vitro release from microemulsions. STP Pharma Sciences 4, 150–154.
122. Trotta, M., Morel, S., and Gasco, M. R. 1997. Effect of oil phase composition on the skin permeation of felodipine from o/w microemulsions. Pharmazie, 52, 50–53.
123. Rhee, Y. S., Choi, J. G., Park, E. S., and Chi, S. C. 2001. Transdermal delivery of ketoprofen using microemulsions. International Journal of Pharmaceutics, 228, 161–170.
124. Boltri, L., Morel, S., Trotta, M., and Gasco, M. R. 1994. In vitro transdermal permeation of nifedipine from thickened microemulsions. Journal de Pharmacie de Belgique, 49, 315–320.
125. Osborne, D. W., Ward, A. J., and O’Neill, K. J. 1991. Microemulsions as topical drug delivery vehicles: In-vitro transdermal studies of a model hydrophilic drug. Journal of Pharmacy and Pharmacology, 43, 450–454.
126. Peltola, S., Saarinen-Savolainen, P., Kiesvaara, J., Suhonen, T. M., and Urtti, A. 2003. Microemulsions for topical delivery of estradiol. International Journal of Pharmaceutics, 254, 99–107.
127. El Maghraby, G. M. 2008. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants, International Journal of Pharmaceutics, 355(1–2), 285–292, 2008.
128. Dreher, F., Walde, P., Walther, P., and Wehrli, E. 1997. Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport. Journal of Controlled Release, 45, 131–140.
129. Kemken, J., Ziegler, A., and Muller, B. W. 1992. Influence of supersaturation on the pharmacodynamic effect of bupranolol after dermal administration using microemulsion as vehicle, Pharmaceutical Research, 9, 554–558.
130. Le Bourlais, C., Acar, L., Zia, H., and Sado, P. A. 1998. Ophthalmic drug delivery systems—recent advances. Progress in Retinal and Eye Research, 17(1), 33–55.
131. Meseguer, G., Gurny, R., Buri, P. 1994. In vivo evaluation of dosage forms: Application of gamma scintigraphy to non-enteral routes of administration. Journal of Drug Targeting, 2, 269–288.
132. Lang, J. C. 1995. Ocular drug delivery conventional ocular formulations. Advanced Drug Delivery Reviews, 16, 39–43.
133. Durrani, A. M., Farr, S. J., and Kellaway, I. W. 1995. Influence of molecular weight and formulation pH on the precorneal clearance rate of hyaluronic acid in rabbit eye. International Journal of Pharmaceutics, 118, 243–250.
134. Miller, S. C. and Donovan, M. D. 1982. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. International Journal of Pharmaceutics, 12, 147–152.
135. Unterman, S. R., Rootman, D. S., Hill, J. M., Parelman, J. J., Thompsom, H. W., and Kaufman, H. E. 1988. Collagen shield drug delivery: therapeutic concentrations of tobramycin in the rabbit cornea and aqueous humor. Journal of Cataract and Refractive Surgery, 14, 500–5004.
136. Fitzgerald, P., Hadgraft, J., Kreuter, J., and Wilson, C. G. 1987. A gamma scintigraphic evaluation of microparticulate ophthalmic delivery systems: Liposomes and nanoparticles. International Journal of Pharmaceutics, 40, 81–84.
137. Aggarwal, D. and Kaur, I. P. 2005. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. International Journal of Pharmaceutics, 290, 155–159.
138. Pepić, I., Jalšenjak, N., and Jalšenjak, I. 2004. Micellar solutions of triblock copolymer surfactants with pilocarpine. International Journal of Pharmaceutics, 272, 57–64.
139. Gasco, M. R., Gallarate, M., Trotta, M., Bauchiero, L., Gremmo, E., and Chiappero, O. 1989. Microemulsions as topical delivery vehicles: Ocular administration of timolol. Journal of Pharmaceutical and Biomedical Analysis, 7(4), 433–439.
140. Gallarate, M., Gasco, M. R., Trotta, M., Chetoni, P., and Saettone, M. F. 1993. Preparation and evaluation in vitro of solutions and o/w microemulsions containing levobunolol as ion-pair. International Journal of Pharmaceutics, 100(1–3), 219–225.
141. Siebenbrodt, I. and Keipert, S. 1993. Poloxamer-systems as potential ophthalmics II. Microemulsions. European Journal of Biopharmaceutics, 39, 25–30.
142. Lia, C., Abrahamsona, M., Kapoora, Y., and Chauhan, A. 2007. Timolol transport from microemulsions trapped in HEMA gels. Journal of Colloid and Interface Sciences, 315(1), 297–306.
143. Malina I. and Radomska-Soukharev A. 2006. Microemulsions with timolol as potential eye drops. Pharmazie, 61(7), 65.
144. Hasse, A. and Keipert, S. 1997. Development and characterization of microemulsions for ocular application. European Journal of Pharmaceutics and Biopharmaceutics, 43, 179–183.
145. Gulsen, D. and Chauhan, A. 2005. Dispersion of microemulsion drops in HEMA hydrogel: A potential ophthalmic drug delivery vehicle. International Journal of Pharmaceutics, 292, 95–117.
146. Alany, R. G., Rades, T., Nicoll, J., Tucker, I. G., and Davies, N. M. 2006. W/O microemulsions for ocular delivery: Evaluation of ocular irritation and precorneal retention. Journal of Controlled Release, 111(1–2), 145–152.
147. Chan J., El Maghraby, G. M. M., Craig, J. P., and Alany R.G. 2007. Ocular delivery of pilocarpine hydrochloride from phase transition microemulsions: In vitro in vivo evaluation. International Journal of Pharmaceutics, 328(1): 65–71.
148. Chan J., El Maghraby, G. M. M., Craig, J. P., and Alany R.G. 2008. Effect of phase transition water-in-oil microemulsions on the precorneal tear film of albino New Zealand rabbits. Clinical Ophthalmology, 2(1), 1–9.
149. Vyas, D. M. 1995. Paclitaxel (Taxol) formulation and prodrugs. In: Farina, V. (Ed.), The Chemistry and Pharmacology of Taxol and Its Derivatives. Vancouver, British Columbia: Elsevier Science, 165–245.
150. Strickley, R. G. 2004. Solubilizing excipients in oral and injectable formulations. Pharmaceutical Research, 21, 201–230.
151. Dupont, B. 2002. Overview of the lipid formulations of amphotericin B. The Journal of Antimicrobial Chemotherapy, 49 S1, 31–36.
152. Zhang, Y., Jiang, X. G., and Yao, J. 2001. Lowering of sodium deoxycholate-induced nasal ciliotoxicity with cyclodextrins. Acta Pharmacologica Sinica, 22, 1045–1050.
153. Bennett, S. N., McNeil, M. M., Bland, L. A., Arduino, M. J., Villarino, M. E., and Perrotta, D. M. 1995. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. New England Journal of Medicine, 333, 147–154.
154. Trissel, L. A. 1997. Pharmaceutical properties of paclitaxel and their effects on preparation and administration. Pharmacotherapy, 17, 133S–139S.
155. He L., Wang G., and Zhang Q. 2003. An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile. International Journal of Pharmaceutics, 250, 45–50.
156. Nornoo, A. O. and Chow, D. S. L. 2008. Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics. International Journal of Pharmaceutics, 349, 117–123.
157. Nornoo, A. O., Osborne, D. W., and Chow, D. S. L. 2008. Cremophor-free intravenous microemulsions for paclitaxel I: Formulation, cytotoxicity and hemolysis. International Journal of Pharmaceutics, 349, 108–116.
158. Zhang, X. N., Tang, L. H., Gong, J. H., Yan, X. Y., and Zhang, Q. 2006. An alternative paclitaxel self-emulsifying microemulsion formulation: Preparation, pharmacokinetic profile, and hypersensitivity evaluation. PDA Journal of Pharmaceutical Science and Technology, 60, 89–94.
159. Moreno, M. A., Frutos, P., and Ballesteros, M. P. 2001. Lyophilized lecithin based oil-water microemulsions as a new and low toxic delivery system for Amphotericin B. Pharmaceutical Research, 18, 344–351.
160. Brime, B., Molero, G., Frutos, P., and Frutos, G. 2004. Comparative therapeutic efficacy of a novel lyophilized amphotericin B lecithin-based oil–water microemulsion and deoxycholateamphotericin B in immunocompetent and neutropenic mice infected with Candida albicans. European Journal of Pharmaceutical Sciences, 22, 451–458.