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Volumn 38, Issue 7, 2013, Pages 1158-1169

Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress

Author keywords

Chronic stress; HPA axis; Hypothalamus; Interleukin 6; JAK STAT signaling

Indexed keywords

CORTICOSTERONE; GLYCOPROTEIN GP 130; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; NEUTRALIZING ANTIBODY; PROTEIN INHIBITOR; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

EID: 84877921458     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2012.11.004     Document Type: Article
Times cited : (55)

References (66)
  • 1
    • 33847157965 scopus 로고    scopus 로고
    • HPA axis activity in patients with panic disorder: review and synthesis of four studies
    • Abelson J.L., Khan S., Liberzon I., Young E.A. HPA axis activity in patients with panic disorder: review and synthesis of four studies. Depress. Anxiety 2007, 24:66-76.
    • (2007) Depress. Anxiety , vol.24 , pp. 66-76
    • Abelson, J.L.1    Khan, S.2    Liberzon, I.3    Young, E.A.4
  • 2
    • 0033625407 scopus 로고    scopus 로고
    • Regulation of vasopressin V1b receptors in the anterior pituitary gland of the rat
    • 85 Spec No: 19S-26S
    • Aguilera G., Rabadan-Diehl C. Regulation of vasopressin V1b receptors in the anterior pituitary gland of the rat. Exp. Physiol. 2000, 85 Spec No: 19S-26S.
    • (2000) Exp. Physiol.
    • Aguilera, G.1    Rabadan-Diehl, C.2
  • 3
    • 0034453195 scopus 로고    scopus 로고
    • Leukemia-inhibitory factor-neuroimmune modulator of endocrine function
    • Auernhammer C.J., Melmed S. Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Endocr. Rev. 2000, 21:313-345.
    • (2000) Endocr. Rev. , vol.21 , pp. 313-345
    • Auernhammer, C.J.1    Melmed, S.2
  • 4
    • 0028927970 scopus 로고
    • Hypothalamic-pituitary-adrenal function in chronic intermittently cold-stressed neonatally handled and non handled rats
    • Bhatnagar S., Meaney M.J. Hypothalamic-pituitary-adrenal function in chronic intermittently cold-stressed neonatally handled and non handled rats. J. Neuroendocrinol. 1995, 7:97-108.
    • (1995) J. Neuroendocrinol. , vol.7 , pp. 97-108
    • Bhatnagar, S.1    Meaney, M.J.2
  • 5
    • 33644948465 scopus 로고    scopus 로고
    • The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress
    • Blandino P., Barnum C.J., Deak T. The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress. J. Neuroimmunol. 2006, 173:87-95.
    • (2006) J. Neuroimmunol. , vol.173 , pp. 87-95
    • Blandino, P.1    Barnum, C.J.2    Deak, T.3
  • 6
    • 36949032115 scopus 로고    scopus 로고
    • Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment
    • Bondi C.O., Rodriguez G., Gould G.G., Frazer A., Morilak D.A. Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment. Neuropsychopharmacology 2008, 33:320-331.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 320-331
    • Bondi, C.O.1    Rodriguez, G.2    Gould, G.G.3    Frazer, A.4    Morilak, D.A.5
  • 11
    • 0346157324 scopus 로고    scopus 로고
    • Acquiring signalling specificity from the cytokine receptor gp130
    • Ernst M., Jenkins B.J. Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet. 2004, 20:23-32.
    • (2004) Trends Genet. , vol.20 , pp. 23-32
    • Ernst, M.1    Jenkins, B.J.2
  • 12
    • 77956338790 scopus 로고    scopus 로고
    • Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo
    • Frank M.G., Barrientos R.M., Watkins L.R., Maier S.F. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. J. Neuroimmunol. 2010, 226:181-184.
    • (2010) J. Neuroimmunol. , vol.226 , pp. 181-184
    • Frank, M.G.1    Barrientos, R.M.2    Watkins, L.R.3    Maier, S.F.4
  • 15
    • 0037219733 scopus 로고    scopus 로고
    • In vivo activation of the interleukin-6 receptor/gp130 signaling pathway in pituitary corticotropes of lipopolysaccharide-treated rats
    • Gautron L., Lafon P., Tramu G., Laye S. In vivo activation of the interleukin-6 receptor/gp130 signaling pathway in pituitary corticotropes of lipopolysaccharide-treated rats. Neuroendocrinology 2003, 77:32-43.
    • (2003) Neuroendocrinology , vol.77 , pp. 32-43
    • Gautron, L.1    Lafon, P.2    Tramu, G.3    Laye, S.4
  • 16
    • 0038482063 scopus 로고    scopus 로고
    • Microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal system
    • Ghorbel M.T., Sharman G., Leroux M., Barrett T., Donovan D.M., Becker K.G., Murphy D. Microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal system. J. Biol. Chem. 2003, 278:19280-19285.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19280-19285
    • Ghorbel, M.T.1    Sharman, G.2    Leroux, M.3    Barrett, T.4    Donovan, D.M.5    Becker, K.G.6    Murphy, D.7
  • 17
    • 19344375838 scopus 로고    scopus 로고
    • Hypercortisolemia and depression
    • Gillespie C.F., Nemeroff C.B. Hypercortisolemia and depression. Psychosom. Med. 2005, 67(Suppl. 1):S26-S28.
    • (2005) Psychosom. Med. , vol.67 , Issue.SUPPL. 1
    • Gillespie, C.F.1    Nemeroff, C.B.2
  • 18
    • 80051475263 scopus 로고    scopus 로고
    • Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain
    • Girotti M., Donegan J.J., Morilak D.A. Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain. Psychoneuroendocrinology 2011, 36:1164-1174.
    • (2011) Psychoneuroendocrinology , vol.36 , pp. 1164-1174
    • Girotti, M.1    Donegan, J.J.2    Morilak, D.A.3
  • 19
    • 84877924017 scopus 로고    scopus 로고
    • Determining the role of hypothalamic IL-6 in sensitization of the rat HPA axis by exposure to chronic cold stress
    • Abstr. 37 (online program 87.03)
    • Girotti M., Donegan J.J., Morilak D.A. Determining the role of hypothalamic IL-6 in sensitization of the rat HPA axis by exposure to chronic cold stress. Soc. Neurosci. 2011, Abstr. 37 (online program 87.03).
    • (2011) Soc. Neurosci.
    • Girotti, M.1    Donegan, J.J.2    Morilak, D.A.3
  • 20
    • 33644837923 scopus 로고    scopus 로고
    • Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain
    • Girotti M., Pace T.W., Gaylord R.I., Rubin B.A., Herman J.P., Spencer R.L. Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain. Neuroscience 2006, 138:1067-1081.
    • (2006) Neuroscience , vol.138 , pp. 1067-1081
    • Girotti, M.1    Pace, T.W.2    Gaylord, R.I.3    Rubin, B.A.4    Herman, J.P.5    Spencer, R.L.6
  • 23
    • 45549108338 scopus 로고    scopus 로고
    • Diurnal cortisol levels and cortisol response in youths with obsessive-compulsive disorder
    • Gustafsson P.E., Gustafsson P.A., Ivarsson T., Nelson N. Diurnal cortisol levels and cortisol response in youths with obsessive-compulsive disorder. Neuropsychobiology 2008, 57:14-21.
    • (2008) Neuropsychobiology , vol.57 , pp. 14-21
    • Gustafsson, P.E.1    Gustafsson, P.A.2    Ivarsson, T.3    Nelson, N.4
  • 25
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior
    • Haroon E., Raison C.L., Miller A.H. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2011, 37:137-162.
    • (2011) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 26
    • 0028859090 scopus 로고
    • Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm
    • Herman J.P., Adams D., Prewitt C. Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm. Neuroendocrinology 1995, 61:180-190.
    • (1995) Neuroendocrinology , vol.61 , pp. 180-190
    • Herman, J.P.1    Adams, D.2    Prewitt, C.3
  • 28
    • 79958837408 scopus 로고    scopus 로고
    • Stress-dependent changes in neuroinflammatory markers observed after common laboratory stressors are not seen following acute social defeat of the Sprague Dawley rat
    • Hueston C.M., Barnum C.J., Eberle J.A., Ferraioli F.J., Buck H.M., Deak T. Stress-dependent changes in neuroinflammatory markers observed after common laboratory stressors are not seen following acute social defeat of the Sprague Dawley rat. Physiol. Behav. 2010, 104:187-198.
    • (2010) Physiol. Behav. , vol.104 , pp. 187-198
    • Hueston, C.M.1    Barnum, C.J.2    Eberle, J.A.3    Ferraioli, F.J.4    Buck, H.M.5    Deak, T.6
  • 31
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones S.A., Scheller J., Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J. Clin. Invest. 2011, 121:3375-3383.
    • (2011) J. Clin. Invest. , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 32
    • 0028851968 scopus 로고
    • In vivo evidence that arginine vasopressin is involved in the adrenocorticotropin response induced by interleukin-6 but not by tumor necrosis factor-alpha in the rat
    • Kageyama K., Watanobe H., Takebe K. In vivo evidence that arginine vasopressin is involved in the adrenocorticotropin response induced by interleukin-6 but not by tumor necrosis factor-alpha in the rat. Neuroimmunomodulation 1995, 2:137-140.
    • (1995) Neuroimmunomodulation , vol.2 , pp. 137-140
    • Kageyama, K.1    Watanobe, H.2    Takebe, K.3
  • 33
    • 80054763773 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation
    • Kang J.G., Majerciak V., Uldrick T.S., Wang X., Kruhlak M., Yarchoan R., Zheng Z.M. Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation. J. Pathol. 2011, 225:378-389.
    • (2011) J. Pathol. , vol.225 , pp. 378-389
    • Kang, J.G.1    Majerciak, V.2    Uldrick, T.S.3    Wang, X.4    Kruhlak, M.5    Yarchoan, R.6    Zheng, Z.M.7
  • 34
    • 27144490650 scopus 로고    scopus 로고
    • Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis
    • Kariagina A., Zonis S., Afkhami M., Romanenko D., Chesnokova V. Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis. Am. J. Physiol. Endocrinol. Metab. 2005, 289:E857-E863.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Kariagina, A.1    Zonis, S.2    Afkhami, M.3    Romanenko, D.4    Chesnokova, V.5
  • 35
    • 78049284816 scopus 로고    scopus 로고
    • Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models
    • Kehne J.H., Cain C.K. Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models. Pharmacol. Ther. 2010, 128:460-487.
    • (2010) Pharmacol. Ther. , vol.128 , pp. 460-487
    • Kehne, J.H.1    Cain, C.K.2
  • 36
    • 77249129746 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior
    • Koo J.W., Russo S.J., Ferguson D., Nestler E.J., Duman R.S. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:2669-2674.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 2669-2674
    • Koo, J.W.1    Russo, S.J.2    Ferguson, D.3    Nestler, E.J.4    Duman, R.S.5
  • 37
    • 84863843763 scopus 로고    scopus 로고
    • The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome
    • Langlais D., Couture C., Balsalobre A., Drouin J. The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome. Mol. Cell 2012, 47:38-49.
    • (2012) Mol. Cell , vol.47 , pp. 38-49
    • Langlais, D.1    Couture, C.2    Balsalobre, A.3    Drouin, J.4
  • 38
    • 0028073528 scopus 로고
    • Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice
    • Laye S., Parnet P., Goujon E., Dantzer R. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Brain Res. Mol. Brain Res. 1994, 27:157-162.
    • (1994) Brain Res. Mol. Brain Res. , vol.27 , pp. 157-162
    • Laye, S.1    Parnet, P.2    Goujon, E.3    Dantzer, R.4
  • 40
    • 0142091544 scopus 로고    scopus 로고
    • STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene
    • Lerner L., Henriksen M.A., Zhang X., Darnell J.E. STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes Dev. 2003, 17:2564-2577.
    • (2003) Genes Dev. , vol.17 , pp. 2564-2577
    • Lerner, L.1    Henriksen, M.A.2    Zhang, X.3    Darnell, J.E.4
  • 41
    • 84864020078 scopus 로고    scopus 로고
    • Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress
    • Levy B.H., Tasker J.G. Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress. Front. Cell. Neurosci. 2012, 6:24.
    • (2012) Front. Cell. Neurosci. , vol.6 , pp. 24
    • Levy, B.H.1    Tasker, J.G.2
  • 42
    • 0032721624 scopus 로고    scopus 로고
    • Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines
    • Li Q.L., Jansen E., Friedman T.C. Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines. Mol. Cell. Endocrinol. 1999, 158:143-152.
    • (1999) Mol. Cell. Endocrinol. , vol.158 , pp. 143-152
    • Li, Q.L.1    Jansen, E.2    Friedman, T.C.3
  • 43
    • 0026781617 scopus 로고
    • Induction of adrenocorticotropic hormone release by interleukin-6 in vivo and in vitro
    • Lyson K., McCann S.M. Induction of adrenocorticotropic hormone release by interleukin-6 in vivo and in vitro. Ann. N. Y. Acad. Sci. 1992, 650:182-185.
    • (1992) Ann. N. Y. Acad. Sci. , vol.650 , pp. 182-185
    • Lyson, K.1    McCann, S.M.2
  • 44
    • 27644493000 scopus 로고    scopus 로고
    • Chronic intermittent cold stress sensitises the hypothalamic-pituitary-adrenal response to a novel acute stress by enhancing noradrenergic influence in the rat paraventricular nucleus
    • Ma S., Morilak D.A. Chronic intermittent cold stress sensitises the hypothalamic-pituitary-adrenal response to a novel acute stress by enhancing noradrenergic influence in the rat paraventricular nucleus. J. Neuroendocrinol. 2005, 17:761-769.
    • (2005) J. Neuroendocrinol. , vol.17 , pp. 761-769
    • Ma, S.1    Morilak, D.A.2
  • 45
    • 0030930439 scopus 로고    scopus 로고
    • Emergence of an isolated arginine vasopressin (AVP) response to stress after repeated restraint: a study of both AVP and corticotropin-releasing hormone messenger ribonucleic acid (RNA) and heteronuclear RNA
    • Ma X.M., Levy A., Lightman S.L. Emergence of an isolated arginine vasopressin (AVP) response to stress after repeated restraint: a study of both AVP and corticotropin-releasing hormone messenger ribonucleic acid (RNA) and heteronuclear RNA. Endocrinology 1997, 138:4351-4357.
    • (1997) Endocrinology , vol.138 , pp. 4351-4357
    • Ma, X.M.1    Levy, A.2    Lightman, S.L.3
  • 46
    • 0032826994 scopus 로고    scopus 로고
    • Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors
    • Marz P., Otten U., Rose-John S. Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors. Eur. J. Neurosci. 1999, 11:2995-3004.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 2995-3004
    • Marz, P.1    Otten, U.2    Rose-John, S.3
  • 47
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: central role of the brain
    • McEwen B.S. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol. Rev. 2007, 87:873-904.
    • (2007) Physiol. Rev. , vol.87 , pp. 873-904
    • McEwen, B.S.1
  • 48
    • 79959639352 scopus 로고    scopus 로고
    • Constant darkness induces IL-6-dependent depression-like behavior through the NF-kappaB signaling pathway
    • Monje F.J., Cabatic M., Divisch I., Kim E.J., Herkner K.R., Binder B.R., Pollak D.D. Constant darkness induces IL-6-dependent depression-like behavior through the NF-kappaB signaling pathway. J. Neurosci. 2011, 31:9075-9083.
    • (2011) J. Neurosci. , vol.31 , pp. 9075-9083
    • Monje, F.J.1    Cabatic, M.2    Divisch, I.3    Kim, E.J.4    Herkner, K.R.5    Binder, B.R.6    Pollak, D.D.7
  • 50
    • 33749072534 scopus 로고    scopus 로고
    • Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress
    • Pace T.W., Mletzko T.C., Alagbe O., Musselman D.L., Nemeroff C.B., Miller A.H., Heim C.M. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am. J. Psychiatry 2006, 163:1630-1633.
    • (2006) Am. J. Psychiatry , vol.163 , pp. 1630-1633
    • Pace, T.W.1    Mletzko, T.C.2    Alagbe, O.3    Musselman, D.L.4    Nemeroff, C.B.5    Miller, A.H.6    Heim, C.M.7
  • 52
    • 70449372203 scopus 로고    scopus 로고
    • CRH signaling molecular specificity for drug targeting in the CNS
    • Refojo D., Holsboer F. CRH signaling molecular specificity for drug targeting in the CNS. Ann. N. Y. Acad. Sci. 2009, 1179:106-119.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1179 , pp. 106-119
    • Refojo, D.1    Holsboer, F.2
  • 53
    • 0027220473 scopus 로고
    • Effects of glucocorticoids and chronic inflammatory stress upon anterior pituitary interleukin-6 mRNA expression in the rat
    • Sarlis N.J., Stephanou A., Knight R.A., Lightman S.L., Chowdrey H.S. Effects of glucocorticoids and chronic inflammatory stress upon anterior pituitary interleukin-6 mRNA expression in the rat. Br. J. Rheumatol. 1993, 32:653-657.
    • (1993) Br. J. Rheumatol. , vol.32 , pp. 653-657
    • Sarlis, N.J.1    Stephanou, A.2    Knight, R.A.3    Lightman, S.L.4    Chowdrey, H.S.5
  • 54
    • 0025775936 scopus 로고
    • Evidence for a specific role of vasopressin in sustaining pituitary-adrenocortical stress response in the rat
    • Scaccianoce S., Muscolo L.A., Cigliana G., Navarra D., Nicolai R., Angelucci L. Evidence for a specific role of vasopressin in sustaining pituitary-adrenocortical stress response in the rat. Endocrinology 1991, 128:3138-3143.
    • (1991) Endocrinology , vol.128 , pp. 3138-3143
    • Scaccianoce, S.1    Muscolo, L.A.2    Cigliana, G.3    Navarra, D.4    Nicolai, R.5    Angelucci, L.6
  • 55
    • 80054756091 scopus 로고    scopus 로고
    • Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    • Schmidt H.D., Shelton R.C., Duman R.S. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011, 36:2375-2394.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2375-2394
    • Schmidt, H.D.1    Shelton, R.C.2    Duman, R.S.3
  • 58
    • 0026773540 scopus 로고
    • Cytokines stimulate the CRH but not the vasopressin neuronal system: evidence for a median eminence site of interleukin-6 action
    • Spinedi E., Hadid R., Daneva T., Gaillard R.C. Cytokines stimulate the CRH but not the vasopressin neuronal system: evidence for a median eminence site of interleukin-6 action. Neuroendocrinology 1992, 56:46-53.
    • (1992) Neuroendocrinology , vol.56 , pp. 46-53
    • Spinedi, E.1    Hadid, R.2    Daneva, T.3    Gaillard, R.C.4
  • 59
    • 34548049265 scopus 로고    scopus 로고
    • The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis
    • Steptoe A., Hamer M., Chida Y. The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav. Immun. 2007, 21:901-912.
    • (2007) Brain Behav. Immun. , vol.21 , pp. 901-912
    • Steptoe, A.1    Hamer, M.2    Chida, Y.3
  • 61
    • 18844370367 scopus 로고    scopus 로고
    • Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    • Sun J., Blaskovich M.A., Jove R., Livingston S.K., Coppola D., Sebti S.M. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 2005, 24:3236-3245.
    • (2005) Oncogene , vol.24 , pp. 3236-3245
    • Sun, J.1    Blaskovich, M.A.2    Jove, R.3    Livingston, S.K.4    Coppola, D.5    Sebti, S.M.6
  • 62
    • 1842290972 scopus 로고    scopus 로고
    • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta
    • Vallieres L., Rivest S. Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta. J. Neurochem. 1997, 69:1668-1683.
    • (1997) J. Neurochem. , vol.69 , pp. 1668-1683
    • Vallieres, L.1    Rivest, S.2
  • 63
    • 62949099218 scopus 로고    scopus 로고
    • Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?
    • Van Houdenhove B., Van Den Eede F., Luyten P. Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?. Med. Hypotheses 2009, 72:701-705.
    • (2009) Med. Hypotheses , vol.72 , pp. 701-705
    • Van Houdenhove, B.1    Van Den Eede, F.2    Luyten, P.3
  • 64
    • 33746433010 scopus 로고    scopus 로고
    • Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications
    • Yehuda R. Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications. Ann. N. Y. Acad. Sci. 2006, 1071:137-166.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1071 , pp. 137-166
    • Yehuda, R.1
  • 65
    • 34249660614 scopus 로고    scopus 로고
    • SOCS proteins, cytokine signalling and immune regulation
    • Yoshimura A., Naka T., Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat. Rev. Immunol. 2007, 7:454-465.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 454-465
    • Yoshimura, A.1    Naka, T.2    Kubo, M.3
  • 66
    • 0027131192 scopus 로고
    • Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis
    • Zhou D., Kusnecov A.W., Shurin M.R., DePaoli M., Rabin B.S. Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 1993, 133:2523-2530.
    • (1993) Endocrinology , vol.133 , pp. 2523-2530
    • Zhou, D.1    Kusnecov, A.W.2    Shurin, M.R.3    DePaoli, M.4    Rabin, B.S.5


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