The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

Nature

Volumn 559, Issue 7713, 2018, Pages 264-268

  Borges Da Silva, Henrique ^a   Beura, Lalit K ^a,b   Wang, Haiguang ^a   Hanse, Eric A ^a   Gore, Reshma ^b   Scott, Milcah C ^a,b   Walsh, Daniel A ^a   Block, Katharine E ^a   Fonseca, Raissa ^a,b   Yan, Yan ^a   Hippen, Keli L ^a   Blazar, Bruce R ^a   Masopust, David ^a,b   Kelekar, Ameeta ^a   Vulchanova, Lucy ^b   Hogquist, Kristin A ^a   Jameson, Stephen C ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PURINERGIC P2X7 RECEPTOR; P2RX7 PROTEIN, HUMAN; P2RX7 PROTEIN, MOUSE;

ACTIVATION ENERGY; CELL; FITNESS; HOMEOSTASIS; IMMUNE SYSTEM; INHIBITOR; MEMORY; METABOLISM; MITOCHONDRION; PROTEIN; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL METABOLISM; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOID TISSUE; MEMORY T LYMPHOCYTE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; P2RX7 GENE; PAIN THRESHOLD; PRIORITY JOURNAL; TISSUE INJURY; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; ENZYMOLOGY; GENETICS; HOMEOSTASIS; IMMUNOLOGY; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

EUKARYOTA; MUS;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; HOMEOSTASIS; HUMANS; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; MITOCHONDRIA; RECEPTORS, PURINERGIC P2X7;

EID: 85049828359     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0282-0     Document Type: Article

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