Mitochondrial dysfunction, depleted purinergic signaling, and Defective T cell vigilance and immune defense

Journal of Infectious Diseases

Volumn 213, Issue 3, 2016, Pages 456-464

  Ledderose, Carola ^a   Bao, Yi ^a   Ledderose, Stephan ^a   Woehrle, Tobias ^a,d   Heinisch, Maria ^a   Yip, Linda ^b,c   Zhang, Jingping ^a   Robson, Simon C ^a   Shapiro, Nathan I ^a   Junger, Wolfgang G ^a,b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

^e LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

mitochondrial dysfunction; purinergic signaling; sepsis; T cell suppression

Indexed keywords

INTERLEUKIN 2; MESSENGER RNA; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; PURINE DERIVATIVE; PURINERGIC RECEPTOR; SURAMIN;

ADULT; ANTIGEN RECOGNITION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTRACELLULAR SIGNALING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PURINERGIC SIGNALING; SEPSIS; T CELL SUPPRESSION; T CELL VIGILANCE; UPREGULATION; ADOLESCENT; IMMUNOLOGY; JURKAT CELL LINE; METABOLISM; MITOCHONDRION; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; CALCIUM SIGNALING; CD4-POSITIVE T-LYMPHOCYTES; HUMANS; JURKAT CELLS; MITOCHONDRIA; PURINES; RECEPTORS, PURINERGIC; SEPSIS; SURAMIN; YOUNG ADULT;

EID: 84960428526     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv373     Document Type: Article

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