Sensing and alarm function of resident memory CD8 + T cells

Nature Immunology

Volumn 14, Issue 5, 2013, Pages 509-513

  Schenkel, Jason M ^a   Fraser, Kathryn A ^a   Vezys, Vaiva ^a   Masopust, David ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; GAMMA INTERFERON;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL POPULATION; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; IMMUNE RESPONSE; INFECTION; INNATE IMMUNITY; MICROBIAL CONTAMINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANTIGENS, VIRAL; ARENAVIRIDAE INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELLS, CULTURED; FEMALE; GENITALIA, FEMALE; HOST-PATHOGEN INTERACTIONS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION CHIMERA;

EID: 84876693895     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2568     Document Type: Article

References (31)

1. Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22, 745-763 (2004).
2. von Andrian, U.H. & Mackay, C.R. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343, 1020-1034 (2000).
3. + effector and memory T cell generation. Nat. Immunol. 4, 835-842 (2003).
4. + T cell precursor frequency regulates primary and memory responses to infection. Immunity 28, 859-869 (2008).
5. Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
6. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
7. Wherry, E.J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4, 225-234 (2003).
8. Masopust, D., Vezys, V., Marzo, A.L. & Lefrançois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413-2417 (2001).
9. Gebhardt, T. et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat. Immunol. 10, 524-530 (2009).
10. Wakim, L.M., Woodward-Davis, A. & Bevan, M.J. Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence. Proc. Natl. Acad. Sci. USA 107, 17872-17879 (2010).
11. Hofmann, M. & Pircher, H. E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands. Proc. Natl. Acad. Sci. USA 108, 16741-16746 (2011).
12. Masopust, D. et al. Dynamic T cell migration program provides resident memory within intestinal epithelium. J. Exp. Med. 207, 553-564 (2010).
13. + TRM cells providing global skin immunity. Nature 483, 227-231 (2012).
14. Gebhardt, T., Mueller, S.N., Heath, W.R. & Carbone, F.R. Peripheral tissue surveillance and residency by memory T cells. Trends Immunol. 34, 27-32 (2013).
15. Masopust, D. & Picker, L.J. Hidden memories: frontline memory T cells and early pathogen interception. J. Immunol. 188, 5811-5817 (2012).
16. Teijaro, J.R. et al. Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J. Immunol. 187, 5510-5514 (2011).
17. Cauley, L.S. & Lefrançois, L. Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells. Mucosal Immunol. 6, 14-23 (2013).
18. Shin, H. & Iwasaki, A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature 491, 463-467 (2012).
19. Wakim, L.M., Waithman, J., van Rooijen, N., Heath, W.R. & Carbone, F.R. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science 319, 198-202 (2008).
20. + T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc. Natl. Acad. Sci. USA 109, 19739-19744 (2012).
21. Bevan, M.J. Memory T cells as an occupying force. Eur. J. Immunol. 41, 1192-1195 (2011).
22. Mackay, L.K. et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc. Natl. Acad. Sci. USA 109, 7037-7042 (2012).
23. Collins, M.K., Tay, C.-S. & Erlebacher, A. Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice. J. Clin. Invest. 119, 2062-2073 (2009).
24. Bromley, S.K., Mempel, T.R. & Luster, A.D. Orchestrating the orchestrators: chemokines in control of T cell traffc. Nat. Immunol. 9, 970-980 (2008).
25. + T-cell help. Nature 462, 510-513 (2009).
26. Luster, A.D. The role of chemokines in linking innate and adaptive immunity. Curr. Opin. Immunol. 14, 129-135 (2002).
27. Wakim, L.M., Gebhardt, T., Heath, W.R. & Carbone, F.R. Cutting edge: local recall responses by memory T cells newly recruited to peripheral nonlymphoid tissues. J. Immunol. 181, 5837-5841 (2008).
28. + T cell responses. J. Clin. Invest. 122, 4606-4620 (2012).
29. + T cells induce innate responses independently of pathogen. Nat. Med. 16, 558-564 (2010).
30. Casey, K.A. et al. Antigen-independent differentiation and maintenance of effectorlike resident memory T cells in tissues. J. Immunol. 188, 4866-4875 (2012).
31. Eberlein, J. et al. Comprehensive assessment of chemokine expression profles by fow cytometry. J. Clin. Invest. 120, 907-923 (2010).