Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

Molecular Cell

Volumn 61, Issue 1, 2016, Pages 125-137

  Thierry, Eric ^a   Guilligay, Delphine ^a   Kosinski, Jan ^b   Bock, Thomas ^b   Gaudon, Stephanie ^a   Round, Adam ^a   Pflug, Alexander ^a   Hengrung, Narin ^c,d   El Omari, Kamel ^d   Baudin, Florence ^a,b   Hart, Darren J ^a   Beck, Martin ^b   Cusack, Stephen ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; ENDONUCLEASE; MESSENGER RNA; RIBONUCLEOPROTEIN; RNA POLYMERASE; VIRUS RNA; NUCLEAR LOCALIZATION SIGNAL; PB2 PROTEIN, INFLUENZA VIRUS; PB2 PROTEIN, INFLUENZAVIRUS A; RNA DIRECTED RNA POLYMERASE; VIRAL PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ASSAY; GENETIC CONSERVATION; INFLUENZA A VIRUS (H5N1); INFLUENZA VIRUS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROMOTER REGION; PROTEIN DOMAIN; RNA REPLICATION; RNA SYNTHESIS; RNA TRANSCRIPTION; SMALL ANGLE SCATTERING; VIRUS GENOME; AMINO ACID SEQUENCE; CHEMISTRY; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HUMAN; INFLUENZA B VIRUS; INFLUENZAVIRUS C; LASER; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA B VIRUS; INFLUENZAVIRUS C; LASERS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PROTEIN INTERACTION DOMAINS AND MOTIFS; RIBONUCLEOPROTEINS; RNA REPLICASE; RNA, VIRAL; SCATTERING, SMALL ANGLE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 84953403658     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.11.016     Document Type: Article

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